Signal transduction by tumor necrosis factor and its relatives

Trends in Cell Biology

Volumn 11, Issue 9, 2001, Pages 372-377

  Baud, Véronique ^a   Karin, Michael ^b  

^a CNRS UPR 9079 Oncogenese Differenciation et Transduction du Signal   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR SUBTYPE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVATION; HUMAN; IMMUNITY; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANTIGENS, CD95; APOPTOSIS; CASPASES; ENZYME ACTIVATION; INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035444539     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02064-5     Document Type: Review

References (75)

1. Tumor necrosis factor, other cytokines and disease
2. The TNF and TNF receptor superfamilies: Integrating mammalian biology
3. TNFα and the TNF receptor superfamily: Structure-function relationship(s)
4. Apoptosis control by death and decoy receptors
5. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
6. Proteases for cell suicide: Functions and regulation of caspases
7. Nuclear factor-ΚB: A pivotal transcription factor in chronic inflammatory diseases
8. AP-1 function and regulation
9. The NF-ΚB and IΚB proteins: New discoveries and insights
10. Phosphorylation meets ubiquitination: The control of NF-ΚB activity
11. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
12. Two tumor necrosis factor receptors: Structure and function
13. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
14. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
15. TRAF2-mediated activation of NF-ΚB by TNF receptor 2 and CD40
16. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
17. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
18. Tumor necrosis factor receptor-associated factors (TRAFs) - A family of adapter proteins that regulates life and death
19. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
20. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-ΚB activation prevents cell death
21. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-ΚB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
22. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
23. Structural basis for self-association and receptor recognition of human TRAF2
24. RIP mediates tumor necrosis factor receptor 1 activation of NF-ΚB but not Fas/APO-1-initiated apoptosis
25. Identification of RIP3, a RIP-like kinase that activates apoptosis and NF-ΚB
26. RIP2 is a novel NF-ΚB-activating and cell death-inducing kinase
27. The death domain kinase RIP mediates the TNF-induced NF-ΚB signal
28. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
29. TRAF2 is essential for JNK but not NF-ΚB activation and regulates lymphocyte proliferation and survival
30. Impaired TNF-induced NF-ΚB activation and high sensitivity to TNF-induced cell death in TRAF2- and TRAF5-double deficient mice
31. Fas ligand-induced apoptosis
32. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
33. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway
34. ASK1 is essential for JNK/SAPK activation by TRAF2
35. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38
36. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
37. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
38. Activation of the IΚBα kinase complex by MEKK1, a kinase of the JNK pathway
39. JNK or IKK, AP-1 or NF-ΚB, which are the targets for MEKK1 action?
40. MEKK1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
41. MEKK1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-ΚB activation
42. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
43. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
44. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
45. Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor-ΚB activation
46. Positive and negative regulation of IΚB kinase activity through IKKβ subunit phosphorylation
47. MAP3K-related kinase involved in NF-ΚB induction by TNF, CD95 and IL-1
48. IΚB kinase β: NF-ΚB activation and complex formation with IΚB kinase α and NIK
49. NF-ΚB-inducing kinase activates IKKα by phosphorylation of Ser-176
50. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IΚB kinase
51. Defective lymphotoxin-β receptor-induced NF-ΚB transcriptional activity in NIK-deficient mice
52. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-ΚB-inducing kinase
53. NF-ΚB-inducing kinase regulates the processing of NF-ΚB2 p100
54. Nuclear factor NF-ΚB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
55. MEKK1 activates both IΚB kinase α and IΚB kinase β
56. Regulation of the MEF2 family of transcription factors by p38
57. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-ΚB acting through the NF-ΚB-inducing kinase and IΚB kinases
58. NF-ΚB activation by tumour necrosis factor requires the Akt serine-threonine kinase
59. The kinase TAK1 can activate the NIK-IΚB as well as the MAP kinase cascade in the IL-1 signalling pathway
60. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO/IKKγ upon receptor stimulation
61. Modulation of tumor necrosis factor and interleukin-1-dependent NF-ΚB activity by mPLK/IRAK
62. Activation of the IΚB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
63. Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-ΚB through utilization of the IΚB kinase and activation of the mitogen activated protein kinase p38
64. Kinase regulation in inflammatory response
65. Requirement for glycogen synthase kinase-3β in cell survival and NF-ΚB activation
66. The interaction of p62 with RIP links the atypical PKCs to NF-ΚB activation
67. p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
68. TNF-induced signaling in apoptosis
69. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
70. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
71. IAP family proteins - Suppressors of apoptosis
72. TNF is here to stay!
73. TNFRSF1A mutations and autoinflammatory syndromes
74. Tumor necrosis factor inhibitors for rheumatoid arthritis
75. Antibodies to tumour necrosis factor alpha as treatment for Crohn's disease