Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

Protein Science

Volumn 9, Issue 12, 2000, Pages 2528-2534

  Petros, Andrew M ^a   Nettesheim, David G ^a   Wang, Yi ^a   Olejniczak, Edward T ^a   Meadows, Robert P ^a   Mack, Jamey ^a   Swift, Kerry ^a   Matayoshi, Edmund D ^a   Zhang, Haichao ^a   Thompson, Craig B ^b   Fesik, Stephen W ^a  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bad protein; Bcl xL; Helix propensity; NMR spectroscopy

Indexed keywords

PROTEIN BAD; PROTEIN BAK; PROTEIN BCL X; BAD PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; CARRIER PROTEIN; PEPTIDE; PROTEIN BCL 2;

ARTICLE; BINDING AFFINITY; BIOPHYSICS; COMPLEX FORMATION; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; HUMAN; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID SEQUENCE; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; BINDING SITES; CARRIER PROTEINS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17744396094     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1017/S096183680000331X     Document Type: Article

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