Structural basis for the inhibition of caspase-3 by XIAP

Cell

Volumn 104, Issue 5, 2001, Pages 791-800

  Riedl, Stefan J ^a   Renatus, Martin ^a   Schwarzenbacher, Robert ^a   Zhou, Qiao ^a   Sun, Chaohong ^b   Fesik, Stephen W ^b   Liddington, Robert C ^a   Salvesen, Guy S ^a  

^a BURNHAM INSTITUTE   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0035831019     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00274-4     Document Type: Article

References (61)

1. The three-dimensional structure of caspase-8: An initiator enzyme in apoptosis
2. Ligand binding: Proteinase-proteinase inhibitor interactions
3. Structural basis of the endoproteinase-protein inhibitor interaction
4. Crystallography & NMR system (CNS): A new software suite for macromolecular structure determination
5. Analysis of protein and peptide mixtures: Evaluation of three sodium dodecyl sulphate-polyacrylamide gel electrophoresis buffer systems
6. Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions
7. The CCP4 suite: Programs for protein crystallography
8. X-linked IAP is a direct inhibitor of cell death proteases
9. IAPs block apoptotic events induced by caspase 8 and cytochrome C by direct inhibition of distinct caspases
10. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
11. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
12. Caspase inhibitors
13. Accurate bond and angle parameters for X-ray protein-structure refinement
14. Inhibition of human caspases by peptide-based and macromolecular inhibitors
15. Differential requirement for caspase 9 in apoptotic pathways in vivo
16. Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat
17. Structure of a serpin-protease complex shows inhibition by deformation
18. Livin, a novel inhibitor-of-apoptosis (IAP) family member
19. CD95's deadly mission in the immune system
20. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
21. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
22. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
23. Raster3D version 2.0 - A program for photorealistic molecular graphics
24. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone
25. The behavior and significance of slow-binding enzyme inhibitors
26. Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin
27. AMoRe: An automated package for molecular replacement. Acta crystallogr
28. Caspase structure, proteolytic substrates, and function during apoptotic cell death
29. Processing of X-ray diffraction data collected in oscillation mode
30. Mechanism of serpin action: Evidence that C1 inhibitor functions as a suicide substrate
31. Introduction to the protein inhibitors: X-ray crystallography
32. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
33. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
34. The structure of a complex of recombinant hirudin and human α-thrombin
35. Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway
36. Caspases: Preparation and characterization
37. Pro-caspase-3 is a major physiologic target of caspase-8
38. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
39. The refined 2.4 Å X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: A novel type of proteinase inhibitor interaction
40. NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
41. NMR structure and mutagenesis of the third bir domain of the inhibitor of apoptosis protein XIAP
42. A single BIR domain of XIAP sufficient for inhibiting caspases
43. Automated MAD and MIR structure solution
44. Caspases: Enemies within
45. A combinatorial approach defines specificities of members of the caspase family and granzyme B
46. Lysosomal cysteine proteases: More than scavengers
47. Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts
48. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
49. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
50. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
51. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas
52. Crystal structure of the cysteine protease interleukin-1beta-converting enzyme: A (p20/p10)2 homodimer
53. The atomic resolution structure of human caspase-8, a key activator of apoptosis
54. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
55. Structure and mechanism of interleukin-1 beta converting enzyme
56. Structural basis of IAP recognition by Smac/DIABLO
57. Caspase knockouts: Matters of life and death
58. Viral caspase inhibitors CrmA and p35
59. Target protease specififity of the viral serpin CrmA: Analysis of five caspases
60. Interaction of the baculovirus anti-apoptotic protein p35 with caspases: Specificity, kinetics, and characterization of the caspase/p35 complex