Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 5 49-5, 2001, Pages

  Chen, Zhongyi ^a   Chua, Chu Chang ^a   Ho, Ye Shih ^b   Hamdy, Ronald C ^a   Chua, Balvin H L ^a,c  

^a EAST TENNESSEE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c East Tennessee State University   (United States)

Author keywords

Heart apoptosis; Ischemia reperfusion injury

Indexed keywords

COMPLEMENTARY DNA; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HEART FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; TRANSGENIC MOUSE;

EID: 0008996894     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.5.h2313     Document Type: Article

References (41)

1. Acedia T, Watanabe M, Engelman DT, Engelman RM, Schhley JA, Maulik N, Ho YS, Oberley TD, and Das DK. Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol 28: 11759-111767, 1996.
2. Akao Y, Otsuki Y, Kataoka S, Ito Y, and Tsujimoto Y. Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes. Cancer Res 54: 2468-2471, 1994.
3. Bialik S, Geenen DL, Sasson IE, Cheng R, Horner JW, Evans SM, Lord EM, Koch CJ, and Kitsis RN. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest 100: 1363-1372, 1997.
4. Bogdanov MB, Ferrante RJ, Mueller G, Ramos LE, Martinou JC, and Beal MF. Oxidative stress is attenuated in mice overexpressing BCL-2. Neurosci Lett 262: 33-36, 1999.
5. Bolli R. The late phase of preconditioning. Circ Res 87: 972-983, 2000.
6. Chen Z, Siu B, Ho YS, Vicent R, Chua CC, Hamdy RC, and Chua BHL. Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol 30: 2281-2289, 1998.
7. Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, Hintze TH, Olivetti G, and Anversa P. Stretched-induced programmed myocyte cell death. J Clin Invest 96: 2247-2259, 1995.
8. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
9. Coopersmith CM, O'Donnel D, and Gordan JI. Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice. Am J Physiol Gastrointest Liver Physiol 276: G677-G686, 1999.
10. DeMoissac D, Mustapha S, Greenberg AH, and Kirshenbaum LA. Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBa. J Biol Chem 273: 23946-23951, 1998.
11. Didenko W, Boudreaux DJ, and Baskin DS. Substantial background reduction in ligase-based apoptosis detection using newly designed hairpin oligonucleotide probes. Biotechniques 27: 1130-1132, 1999.
12. Feuerstein G, Ruffolo RR Jr, and Yue TL. Apoptosis and congestive heart failure. Trends Cardiovasc Med 7: 249-255, 1997.
13. Fliss H and Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res 79: 949-956, 1996.
14. 2+ concentration within the endoplasmic reticulum. Proc Natl Acad Sci USA 97: 5723-5728, 2000.
15. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, and Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94: 1621-1628, 1994.
16. Gross A, McDonnell JM, and Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
17. Guo Y, Wu WJ, Qiu Y, Tang XL, Yang Z, and Bolli R. Demonstration of an early and a late phase of ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol 275: H1375-H1387, 1998.
18. Halestrap AP, Kerr PM, Javadov S, and Woodfield KY. Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart. Biochim Biophys Acta 1366: 79-94, 1998.
19. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, and Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251, 1993.
20. Hutter JJ, Mestril R, Tam EK, Sievers RE, Dillmann WH, and Wolfe CL. Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo. Circulation 94: 1408-1411, 1996.
21. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, Reed JC, Olivetti G, and Anversa P. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107, 1996.
22. Kang YJ, Zhou ZX, Wang GW, Buridi A, and Klein JB. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. J Biol Chem 275: 13690-13698, 2000.
23. Kirshenbaum LA and de Moissac D. The bcl-2 gene product prevents programmed cell death of ventricular myocytes. Circulation 96: 1580-1585, 1997.
24. Krajewski S, Tanaka S, Takayama S, Schibier MJ, Fenton W, and Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53: 4701-4714, 1993.
25. Kroemer G, Dallaporta B, and Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60; 619-642, 1998.
26. Li C, Browder W, and Kao RL. Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol Heart Circ Physiol 276: H543-H552, 1999.
27. Liu L, Azhar G, Gao W, Zhang X, and Wei JY. Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: age-associated differences. Am J Physiol Regulatory Integrative Comp Physiol 275: R315-R322, 1998.
28. Martinou JC, Dubois-Dauphin M, Staple JK, Rodriguez I, Frankowski H, Missotten M, Albertini P, Talabot D, Catsicas S, Pietra C, and Huarte J. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030, 1994.
29. Maulik N, Goswami S, Galang N, and Das DK. Differential regulation of Bcl-2, AP-1 and NF-kappaB on cardiomyocyte apoptosis during myocardial ischemic stress adaptation. FEBS Lett 443: 331-336, 1999.
30. Maulik N, Sato M, Price BD, and Das DK. An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia. FEBS Lett 429: 365-369, 1998.
31. Merad-Saidoune M, Boiteier E, Nicole A, Marsac C, Martino JC, Sola B, Sinet PM, and Ceballos-Picot I. Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion. Exp Neurol 158: 428-436, 1999.
32. Misao J, Hayakawa Y, Ohno M, Kato S, Fujiwara T, and Fujiwara H. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 94: 1506-1512, 1996.
33. Morgan EN, Boyle EM Jr, Yun W, Griscavage-Ennis JM, Farr AL, Canty TG Jr, Pohlman TH, and Verrier ED. An essential role for NF-kappaB in the cardioadaptive response to ischemia. Ann Thorac Surg 68: 377-382, 1999.
34. Plumier JC, Ross BM, Currie RW, Angelidis CE, Kazlaris H, Kollias G, and Pagoulatos GN. Transgenic mice overexpressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 95: 1854-1860, 1995.
35. Reed JC. Bcl-2 family proteins. Oncogene 17: 3225-3236, 1998.
36. Subramaniam A, Jones WK, Gulick J, Wert S, Neumann J, and Robbins J. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 266: 24613-24620, 1991.
37. Suzuki YJ, Forman HJ, and Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 22: 269-285, 1997.
38. Vanden Hoek TL, Becker LB, Shao Z, Li C, and Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in myocytes. J Biol Chem 273: 18092-18098, 1998.
39. Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B, and Kroemer G. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med 182: 367-377, 1995.
40. Zhu L, Ling S, Yu XD, Venkatesh LK, Subramanian T, Chinnadurai G, and Kuo TH. Modulation of mitochondrial Ca(2-) homeostasis by Bcl-2. J Biol Chem 274: 33267-33273, 1999.
41. Zhu W, Zou Y, Aikawa R, Harada K, Kudoh S, Uozumi H, Hayashi D, Gu Y, Yamazaki T, Nagai R, Yazaki Y, and Komuro I. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes. Circulation 100: 2100-2107, 1999.