Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

Cell

Volumn 102, Issue 1, 2000, Pages 33-42

  Du, Chunying ^a   Fang, Min ^a   Li, Yucheng ^a   Li, Lily ^a   Wang, Xiaodong ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CELL PROTEIN; CYTOCHROME C; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN PURIFICATION;

INTRACISTERNAL A-PARTICLES;

EID: 0034616945     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00008-8     Document Type: Article

References (33)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Drosophila p53 binds a damage response element at the reaper Locus
3. Grim, a novel cell death gene in drosophila
4. An apoptosis inhibiting baculovirus gene with a zinc finger like motif
5. Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c
6. IAPs block apoptosis events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
7. IAP family of proteins-suppressors of apoptosis
8. Induction of apoptosis by drosophila reaper, hid and grim through inhibition of IAP function
9. The head involution defective gene of drosophila melanogaster functions in programmed cell death
10. BCL-2 family members and the mitochondria in apoptosis
11. The proapoptotic function of Drosophila Hid is conserved in mammalian cells
12. The release of cytochrome c from mitochondria: A primary site for bcl-2 regulation of apoptosis
13. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release
14. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
15. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
16. Processsing/Activation of at least four interleukin-1 converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells
17. Apoptosis induced by drosophila reaper, and grim in a human system. Atenuation by inhibitor of apoptosis proteins (cIAP)
18. Stoichiometry, free energy, and kinetic aspects of cytochrome c:Apaf-1 binding in apoptosis
19. Cytochrome c: Can't live with it-can't live without it
20. The TRAF2-TRAF signaling complex contains two novel proteins related to baculoviral-inhibitor of apoptosis proteins
21. Common principles of protein translocation across membranes
22. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
23. A single BIR domain of XIAP is sufficient for inhibiting caspases
24. Caspase: Enemies within
25. Cloning and expression of apoptosis inhibitory protein homologues that function to inhibit apoptosis and/or bind tumor necrosis factor-associated factors
26. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing inhibitor of apoptosis (IAP) proteins
27. Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM
28. Genetic control of programmed cell death in drosophila
29. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
30. The C. elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
31. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
32. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9