X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

Nature

Volumn 381, Issue 6580, 1996, Pages 335-341

  Muchmore, Steven W ^a   Sattler, Michael ^a   Liang, Heng ^a   Meadows, Robert P ^a   Harlan, John E ^a   Yoon, Ho Sup ^a   Nettesheim, David ^a   Chang, Brian S ^b   Thompson, Craig B ^b   Wong, Sui Lam ^a,c   Ng, Shi Chung ^a   Fesik, Stephen W ^a  

^a ABBOTT LABORATORIES   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; PROTEIN BCL 2;

ALPHA HELIX; APOPTOSIS; ARTICLE; CRYSTAL STRUCTURE; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

AMINO ACID SEQUENCE; APOPTOSIS; BCL-X PROTEIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 5244224827     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/381335a0     Document Type: Article

References (30)

1. Korsmeyer, S J. Trends Genet 11, 101-105 (1995).
2. Boise, L H. et al. Cell 74, 597-608 (1993).
3. Yin, X.-M., Oltvai, Z. N. & Korsmeyer, S J. Nature 369, 321-323 (1994).
4. Chittenden, T. et al. EMBO J. 14, 5589-5596 (1995).
5. Boyd, J. M. et al. Oncogene 11, 1921-1928 (1995).
6. Parker, M W. & Pattus, F. Trends biochem. Sci. 18, 391-395 (1993).
7. Cheng, E. H.-Y., Levine, B., Boise, L. H., Thompson, C. B. & Hardwick, J. M. Nature 379, 554-557 (1996).
8. Bomer, C. J. Cell Biol 126, 1059-1068 (1994).
9. Hanada, M., Aime-Sempe, C., Sato, T. & Reed, J. C. J. biol. Chem. 270, 11962-11969 (1995).
10. Sedlak, T. W. et al. Proc. natn. Acad. of Sci. U.S.A. 92, 7834-7838 (1995).
11. Yang, E. et al. Cell 80, 285-291 (1995).
12. London, E. Biochim. biophys. Acta 1113, 25-51 (1992).
13. Lam, M et al. Proc. natn. Acad. Sci U.S.A. 91, 6569-6573 (1994).
14. Zamzami, et al. J. exp. Med. 182, 367-377 (1995).
15. Carson, M. J. J. Molec. Graph. 5, 103-106 (1987)
16. Fang, W., Rivard, J. J., Mueller, D. L. & Behrens, T. W. J Immunol. 153, 4388-4398 (1994).
17. Otwinowski, Z. Proceedings of the CCP4 Study Weekend, Isomorpnous Replacement and Anomalous Scattering (eds Wolf, W., Evans, P. R. & Leslie, A. G. W.) 80-86 (SERC Daresbury Laboratory, Warrington, UK, 1991).
18. CCP4. A Suite of Programs for Protein Crystallography (SERC Daresbury Laboratory, Warrington, UK, 1979).
19. Jones, T. A., Zou, J.-Y., Cowan, S W. & Kjelgaard, M. Acta crystallogr A 47, 110 (1991).
20. Reed, R. J. Acta crystallogr. A 42, 140-149 (1986).
21. Brunger, A. T. X-PLOR 3.1 (Yale University, New Haven, CT, 1992).
22. Yamazaki, T., Lee, W., Arrowsmith, S. H., Muhandiram, D. R. & Kay, L. E. J. Am. chem. Soc. 116, 11655-11666 (1994).
23. Clore, G. M. & Gronenbom, A. M Meth. Enzym. 239, 349-363 (1994)
24. Logan, T. M., Olejniczak, E. T , Xu, R X & Fesik, S. W. FEBS Lett. 314, 413-418 (1992).
25. Neri, D., Szperski, T., Otting, G., Senn, H. & Wüthrich, K. Biochemistry 28, 7510-7516 (1989).
26. Vuister, G. W , Kim, S.-J., Wu, C. & Bax, A. J. Am. chem. Soc. 116, 9206-9210 (1994).
27. Kuboniwa, H , Grzesiek, S., Delaglio, F. & Bax, A. J. Biomolec. NMR 4, 871-878 (1994).
28. Kuszewski, J , Nilges, M. & Brünger, A. T. J. Biomolec. NMR 2, 33-56 (1992).
29. Farrow, N. A. et al. Biochemistry 33, 5984-6003 (1994).
30. Choe, S. et al. Nature 357, 216-222 (1992).