Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes

American Journal of Pathology

Volumn 152, Issue 5, 1998, Pages 1151-1156

  Roberg, Karin ^a   Öllinger, Karin ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CATHEPSIN D; DNA FRAGMENT; LYSOSOME ENZYME; NAPHTHAZARIN; QUINONE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRUCTURE; CHROMATIN CONDENSATION; FEMALE; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CATHEPSIN D; CELLS, CULTURED; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEART; HYDROGEN-ION CONCENTRATION; L-LACTATE DEHYDROGENASE; LYSOSOMES; MALE; MICROSCOPY, IMMUNOELECTRON; MYOCARDIUM; NAPHTHOQUINONES; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

EID: 0031897739     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Buttke TM, Sandstrom PA: Oxidative stress as a mediator of apoptosis. Immunol Today 1994, 15:7-10
2. Gardner AM, Xu F, Fady C, Jacoby FJ, Duffey DC, Tu Y, Lichtenstein A: Apoptotic vs nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radical Biol Med 1997, 22:73-83
3. Kane DJ, Sarafian TA, Antonio R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE: BCL-2 inhibition of neutral death: decreased generation of reactive oxygen species. Science 1993, 262:1274-1277
4. Forrest VJ, Kang Y-H, McClain DE, Robinson DH, Ramakrishnan N: Oxidative stress-induced apoptosis prevented by trolox. Free Radical Biol Med 1994, 16:675-684
5. Slater AFG, Nobel SI, Orrenius S: The role of intracellular oxidants in apoptosis. Biochim Biophys Acta 1995, 1271:59-62
6. Kerr JFR, Winterford CM, Harmon BV: Apoptosis: its significance in cancer and cancer therapy. Cancer 1994, 73:2013-2026
7. Colburn NH: Gene regulation by active oxygen and other stress inducers: role in tumor promotion and progression. Biological Consequences of Oxidative Stress. Edited by Spatz L, Bloom AD. New York, Oxford University Press, 1992, pp 121-137
8. Cerutti P, Larsson R, Krupitza G, Muehlematter D, Crawford D, Amstad P: Pathophysiological mechanisms of oxidants. Oxy-Radicals in Molecular Biology and Pathology Edited by Cerutti PA, Fridovich I, McCord JM. Liss, New York, 1988, pp 493-507
9. Steller H: Mechanisms and genes of cellular suicide. Science 1995, 267:1445-1449
10. Enoch T, Norbury C: Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM. Trends Biol Sci 1995, 20:426-430
11. Zhivotovsky B, Burgess DH, Vanags DM, Orrenius S: Involvement of cellular proteolytic machinery in apoptosis. Biochem Biophys Res Commun 1997, 230:481-488
12. Deiss LP, Galinka H, Barissi H, Cohen O, Kimichi A: Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J 1996, 15:3861-3870
13. Öllinger K, Roberg K: Nutrient deprivation of cultured rat hepatocytes increases the desferrioxamine-available iron pool and augments the sensitivity to hydrogen peroxide. J Biol Chem 1997, 272:23707-23711
14. Brunk UT, Jones CB, Sohal RS: A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis. Mutat Res 1992, 275:395-403
15. Öllinger K, Brunk UT: Oxidative stress-induced cellular injury is mediated through lysosomal damage. Free Radical Biol Med 1995, 19:565-574
16. Zhang H, Dalen H, Öllinger K, Brunk UT: Exposure of cells to non-lethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization. Free Radical Biol Med 1995, 19:813-822
17. Brunk UT, Zhang H, Roberg K, Öllinger K: Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage. Redox Rep 1995, 1:267-277
18. Öllinger K, Brunmark A: Effect of different oxygen pressures and N, N′-diphenyl-p-phenylenediamine on adriamycin toxicity to cultured neonatal rat heart myocytes. Biochem Pharmacol 1994, 48:1707-1715
19. Lang JK, Gohil K, Packer L: Simultaneous determination of tocopherols, ubiquinols, and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal Biochem 1986, 157:106-116
20. Vassault A: Lactate dehydrogenase: UV method with lactate and NADH. Methods of Enzymatic Analysis, vol 3. Edited by Bergemayer HU. London, Academic Press, 1985, pp 118-126
21. Gottlieb RA, Gruol DL, Zhu JY, Engler RL: Preconditioning in rabbit cardiomyocytes: role of pH, vacuolar proton ATPase and apoptosis. J Clin Invest 1996, 97:3291-3298
22. Brunk UT, Dalen H, Roberg K, Hellquist HB: Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radical Biol Med 1997, 23:616-626
23. Roberg K, Öllinger K: A pre-embedding technique for immunocytochemical visualization of cathepsin D in cultured cells subjected to oxidative stress. J Histochem Cytochem 1998, 46:411-418
24. Lah JJ, Hayes D, Burry RW: A neutral pH silver development method for the visualization of 1-nanometer gold particles in pre-embedding electron microscopic immunohistochemistry. J Histochem Cytochem 1991, 39:461-464
25. Olive PL: DNA precipitation assay: a rapid and simple method for detecting DNA damage in mammalian cells. Environ Mol Mutagen 1988, 11:487-495
26. Burton K: A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 1956, 62:315-323
27. Howell KE, Reuter-Carlsson U, Devaney E, Luzio JP, Fuller SD: One antigen, one gold? A quantitative analysis of immunogold labeling of plasma membrane 5′-nucleotidase. Eur J Cell Biol 1987, 44:318-327
28. Griffiths G, Hoppeler H: Quantitation in immunocytochemistry: correlation of immunogold labeling to absolute number of membrane antigens. J Histochem Cytochem 1986, 34:1389-1398
29. Öllinger K, Brunmark A: Effect of hydroxy substituent position on 1,4-naphthoquinone toxicity to rat hepatocytes. J Biol Chem 1991, 266:21496-21503
30. Colucci WS: Apoptosis in the heart. N Engl J Med 1996, 335:1224-1226
31. Montague JW, Cidlowski JA: Cellular catabolism in apoptosis: DNA degradation and endonuclease activity. Experientia 1996, 52:957-962
32. Wyllie AH: Apoptosis and carcinogenesis. Eur J Cell Biol 1997, 73: 189-197