The oxidative stress hypothesis of congestive heart failure: Radical thoughts

Chest

Volumn 120, Issue 6, 2001, Pages 2035-2046

  Mak, Susanna ^a   Newton, Gary E ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Antioxidants; Congestive heart failure; Free radicals; Oxidative stress

Indexed keywords

ALDEHYDE DERIVATIVE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAROTENE; CARVEDILOL; FREE RADICAL; METOPROLOL; UBIQUINONE;

CANCER; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG USE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE CONTRACTILITY; HUMAN; HYPOTHESIS; IN VITRO STUDY; LIPID PEROXIDATION; METHODOLOGY; MYOCARDIAL DISEASE; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; VITAMIN SUPPLEMENTATION;

EID: 0035680903     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.120.6.2035     Document Type: Article

References (93)

1. Oxygen radicals and human disease
2. The biology of oxygen radicals: The superoxide radical is an agent of oxygen toxicity; superoxide dismutases provide an important defense
3. Free radicals and antioxidants: A personal view
4. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure
5. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
6. The effect of spironolactone on morbidity and mortality in patients with severe heart failure: Randomized Aldactone Evaluation Study Investigators
7. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation
8. Potential oxidative pathways of catecholamines in the formation of catecholamines in the formation of lipid peroxidation
9. Tumour necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy
10. Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo
11. Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy
12. Role of oxidative stress in transition of hypertrophy to heart failure
13. Right and left myocardial antioxidant responses during heart failure subsequent to myocardial infarction
14. Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle
15. +-ATP'ase
16. 2+-pump activity by oxygen free radicals
17. Hydrogen peroxide and hydroxyl radical mediate leukocyte depression of cardiac sarcoplasmic reticulum: Participation of the cyclooxygenase pathway
18. Influence of exogenously generated oxidant species on myocardial function
19. Quantitative identification of superoxide anion as a negative inotropic species
20. Myocardial alterations due to free-radical generation
21. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
22. Attenuation of dysfunction in the postischemic "stunned" myocardium by dimethylthiourea
23. Recurrent ischemia in the canine heart causes recurrent bursts of free radical production that have a cumulative effect on contractile function: A pathophysiological basis for chronic myocardial "stunning"
24. Effect of anthracycline antibiotics on oxygen radical formation in rat heart
25. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats
26. Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure
27. Role of oxidative stress in cardiovascular diseases
28. Oxidative stress and the pathogenesis of heart failure
29. Adriamycin: The role of lipid peroxidation in cardiac toxicity and tumor response
30. Subcellular effects of adriamycin in the heart: A concise review
31. Dexrazoxane: A review of its use as a cardioprotective agent in patients receiving anthracycline-based chemotherapy
32. Myocardial lipid peroxidation in rats after chronic alcohol ingestion and the effects of different antioxidants
33. Further investigation on the role of selenium deficiency in the etiology and pathogenesis of Keshan disease
34. Evidence for enhanced free radical activity in chronic congestive heart failure secondary to coronary artery disease
35. Oxygen free radical and congestive heart failure
36. Evidence of oxidative stress in chronic heart failure in humans
37. Increased malondialdehyde in peripheral blood of patients with congestive heart failure
38. Oxidative stress is related to exercise intolerance in patients with heart failure
39. Increased oxidative stress in patients with congestive heart failure
40. 2α in pericardial fluid of patients with heart failure: A potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure
41. Unsaturated aldehydes including 4-OH-nonenal are elevated in patients with congestive heart failure
42. Reactive oxygen-mediated protein oxidation in aging and disease
43. The measurement and mechanism of lipid peroxidation in biological systems
44. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
45. Thiobarbituric acid-reactivity following iron dependent free radical damage to amino acids and carbohydrates
46. Measuring free radical reactions in vivo
47. Methods for determination of aldehydic lipid peroxidation products
48. Assay of malondialdehyde in biological fluids by gas chromatography-mass spectrometry
49. Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography-mass spectrometry
50. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes
51. Biological interactions of α,β-unsaturated aldehydes
52. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids
53. 2-isoprostanes) in smokers: Smoking as a cause of oxidative damage
54. 2α generation during coronary reperfusion: A potential quantitative marker of oxidant stress in vivo
55. Modulation of oxidant stress in vivo in chronic cigarette smokers
56. Isoprostane generation is not increased in chronic heart failure in man
57. Electron spin resonance spectroscopy, exercise, and oxidative stress: An ascorbic acid intervention study
58. Hyperbaric oxygen therapy increases free radical levels in the blood of humans
59. Increased oxidative stress in dilated cardiomyopathic heart failure
60. Comparison of effects of ascorbic acid on endothelium-dependent vasodilation in patients with chronic congestive heart failure secondary to idiopathic dilated cardiomyopathy versus patients with effort angina pectoris secondary to coronary artery disease
61. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats
62. A relative deficit in antioxidant reserve may contribute in cardiac failure
63. Gene expression of antioxidative enzymes in the human heart: Increased expression of catalase in the end-stage failing heart
64. Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy
65. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure
66. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
67. Vitamin C improved endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia
68. Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence and disease-specific mortality in the general population
69. The Alpha-Tocopherol BCCPSG: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
70. Oxy free radical system in heart failure and therapeutic role of oral vitamin E
71. A controlled clinical trial of vitamin E supplementation in patients with congestive heart failure
72. Lack of effect of long term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease
73. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
74. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)
75. Effects of α tocopherol and β carotene supplements on symptoms, progression, and prognosis of angina pectoris
76. Vitamin E supplementation and cardiovascular events in high-risk patients
77. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial
78. New insights into the physiology and pharmacology of vitamin C
79. 10 in health and disease
80. 10 therapy in patients with congestive heart failure: A long-term multicenter randomized study
81. 10
82. 10) in the long-term treatment of idiopathic dilated cardiomyopathy
83. 10 as an adjunctive in the treatment of chronic congestive heart failure
84. Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure
85. 10 in patients with congestive heart failure
86. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
87. Carvedilol: An effective antihypertensive drug with antiischemic/antioxidant cardioprotective properties
88. Differential effects of β-blockers in patients with heart failure: A prospective, randomized, double-blind comparison of the long-term effects of metoprolol versus carvedilol
89. β-Blockade in heart failure: A comparison of carvedilol with metoprolol
90. Prospective, randomized comparison of effect of long-term treatment with metoprolol or carvedilol on symptoms, exercise, ejection fraction, and oxidative stress in heart failure
91. Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart
92. To E or not to E: How do we tell?
93. Vitamin C augments the inotropic response to dobutamine in humans with normal left ventricular function