The calpain family and human disease

Trends in Molecular Medicine

Volumn 7, Issue 8, 2001, Pages 355-362

  Huang, Yuanhui ^a   Wang, Kevin K W ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CALPAIN; CALPAIN 11; CALPAIN 12; CALPAIN 3; CALPAIN 8; CALPAIN 9; CALPAIN I; CALPAIN II; MESSENGER RNA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; DEGENERATIVE DISEASE; GENE MUTATION; HUMAN; LIMB GIRDLE MUSCULAR DYSTROPHY; MUSCULAR DYSTROPHY; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVIEW; SKELETAL MUSCLE;

EID: 0034903587     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)02049-4     Document Type: Review

References (67)

1. A neutral calcium-activated proteinase from the soluble fraction of rat brain
2. 2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney
3. 2+-activated neutral protease (muCANP) deduced from its cDNA sequence
4. 2+-activated neutral protease
5. Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease
6. Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?
7. Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation
8. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
9. Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding
10. Calpain and caspase: Can you tell the difference?
11. Calpain: A protease in search of a function?
12. Disruption of the mouse mu-calpain gene reveals an essential role in platelet function
13. Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle
14. Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle
15. Cloning and expression of mRNA for calpain Lp82 from rat lens: Splice variant of p94
16. Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82
17. Identification and characterization of a retina-specific calpain (Rt88) from rat
18. Calpains in the lens and cataractogenesis
19. 2+-binding domain
20. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract
21. Isolation of two novel genes, down-regulated in gastric cancer
22. CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6
23. Gene structure, chromosomal localization, and expression pattern of capn12, a new member of the calpain large subunit gene family
24. Proteolysis in Caenorhabditis elegans sex determination: Cleavage of TRA-2A by TRA-3
25. Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene
26. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: Implications for calpain regulation and evolution
27. Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily
28. Capn7: A highly divergent vertebrate calpain with a novel C-terminal domain
29. Structure and physiological function of calpains
30. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
31. CAPN 8: Isolation of a new mouse calpain-isoenzyme
32. Calpain inhibition: An overview of its therapeutic potential
33. Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases
34. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
35. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
36. Immunohistochemical study of calpain-mediated breakdown products to alpha-spectrin following controlled cortical impact injury in the rat
37. Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats
38. Calpain-mediated alpha-spectrin degradation in a mouse model of diffuse head injury and the benefit of the calpain inhibitor SJA6017 on functional recovery
39. mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage
40. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
41. Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
42. Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture
43. New aspect of the research on limb-girdle muscular dystrophy 2A: A molecular biologic and biochemical approach to pathology
44. Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A
45. Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A
46. Decreased sensitivity of lens-specific calpain Lp82 to calpastatin inhibitor
47. Activation of calpain in lens: A review and proposed mechanism
48. β-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubitized during cataract
49. Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice
50. Superior prevention of calcium ionophore cataract by E64d
51. Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal
52. Calcium ionophore induced proteolysis and cataract: Inhibition by cell permeable calpain antagonists
53. SJA6017, a newly synthesized peptide aldehyde inhibitor of calpain: Amelioration of cataract in cultured rat lenses
54. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas
55. 2+-dependent proteinases (calpains) and muscle cell differentiation
56. SOLH, a human homologue of the Drosophila melanogaster small optic lobes gene is a member of the calpain and zinc-finger gene families and maps to human chromosome 16p13.3 near CATM (cataract with microphthalmia)
57. Expression of calpain I messenger RNA in human renal cell carcinoma: Correlation with lymph node metastasis and histological type
58. 2+-dependent neutral protease (calpain) activity in breast cancer tissue and estrogen receptor status
59. Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis
60. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
61. Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: A potential molecular basis for neuronal degeneration
62. Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease
63. Neurotoxicity induces cleavage of p35 to p25 by calpain
64. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
65. Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells
66. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains