Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C ε and δ in neonatal rat ventricular myocytes

Circulation Research

Volumn 89, Issue 10, 2001, Pages 882-890

  Heidkamp, Maria C ^a   Bayer, Allison L ^a   Martin, Jody L ^a   Samarel, Allen M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenovirus; Cardiomyocyte; Hypertrophy; Signal transduction

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; BETA GALACTOSIDASE; CALPHOSTIN C; CHELERYTHRINE; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; ROTTLERIN; STAUROSPORINE;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VIRUS INFECTION;

EID: 0035834817     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh2201.099434     Document Type: Article

References (36)

1. Cytoplasmic signaling pathways that regulate cardiac hypertrophy
2. Cellular mechanisms of cardiac hypertrophy
3. MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes
4. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes
5. Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts
6. Endothelin-1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes
7. Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes
8. Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy
9. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
10. Isoenzyme-specific protein kinase C and c-Jun N-terminal kinase activation by electrically stimulated contraction of neonatal rat ventricular myocytes
11. Collaborative roles for c-Jun N-terminal kinase, c-Jun, serum response factor, and Sp1 in calcium-regulated myocardial gene expression
12. Cell density and contraction regulate p38 MAP kinase-dependent responses in neonatal rat cardiac myocytes
13. PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits
14. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits
15. Regulation of Ras-GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras
16. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
17. Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C
18. Many pathways to cardiac hypertrophy
19. Contractile activity modulates myosin heavy chain-β expression in neonatal rat heart cells
20. Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor β gene by protein kinase C, Ras plays multiple roles
21. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
22. Role of protein kinase C-epsilon in hypertrophy of cultured neonatal rat ventricular myocytes
23. PKC-activation induces dichotomous cardiac phenotypes and modulates PKC-RACK interactions and RACK expression
24. Endothelin-dependent actions in cultured AT-1 cardiac myocytes: The role of the isoform of protein kinase C
25. The Raf-MEK-ERK cascade represents a common pathway for alteration of intracellular calcium by Ras and protein kinase C in cardiac myocytes
26. Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-I kinase and extracellular signal-regulated protein kinases in cardiac myocytes
27. PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase
28. Protein kinase Ca activates RAF-1 by direct phosphorylation
29. Activation of Ras by phorbol esters in cardiac myocytes: Role of guanine nucleotide exchange factors
30. JNK is involved in signal integration during costimulation of T lymphocytes
31. Translocation of protein kinase C-and protein kinase C-to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis
32. The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes
33. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38
34. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
35. Loss of protein kinase C function induces an apoptotic response
36. PKC-Is required for mitochondrial-dependent apoptosis in salivary epithelial cells