Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

Journal of Cell Biology

Volumn 153, Issue 5, 2001, Pages 999-1009

  Foghsgaard, Lasse ^a,b   Wissing, Dorte ^a,c   Mauch, Daniel ^a   Lademann, Ulrik ^a,d   Bastholm, Lone ^a,e   Boes, Marianne ^a,b,c   Elling, Folmer ^a,b   Leist, Marcel ^d   Jäättelä, Marja ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d HARVARD MEDICAL SCHOOL   (United States)

^e H LUNDBECK A S   (Denmark)

Author keywords

Apoptosis; Cancer; Caspase independent; Cathepsins; Tumor necrosis factor

Indexed keywords

CASPASE; CASPASE INHIBITOR; CATHEPSIN B; PROTEINASE; STEFIN A; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INVASION; CYTOTOXICITY; FIBROSARCOMA; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASES; CATHEPSIN B; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CHROMATIN; CYSTATINS; CYTOSOL; ENZYME ACTIVATION; FIBROBLASTS; FIBROSARCOMA; GENES, DOMINANT; LYSOSOMES; MICE; NF-KAPPA B; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHATIDYLSERINES; PROTEIN TRANSPORT; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0035947776     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.5.999     Document Type: Article

References (51)

1. Apoptosis control by death and decoy receptors
2. Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
3. Interdigital cell death can occur through a necrotic and caspase-independent pathway
4. Catepsin D protease mediates programmed cell death induced by interferon-γ Fas/APO-1, and TNF-α
5. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
6. Caspase enzyme activity is not essential for apoptosis during thymocyte development
7. Intracellular ATP levels determine cell death fate by apoptosis or necrosis
8. Genetic control of programmed cell death in nematode C. elegans
9. Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage
10. Inhibition of human caspases by peptide-based and macromolecular inhibitors
11. Apoptosis and the proteasome
12. Cathepsin B contributes to TNF-α-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
13. Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
14. Escaping cell death: Survival proteins in cancer
15. 2 in breast carcinoma cells
16. A20 zinc finger protein inhibits TNF and IL-1 signaling
17. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases
18. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line
19. Caspase-independent cell killing by Fas-associated protein with death domain
20. Resistance to the cytotoxic effects of tumor necrosis factor α can be overcome by inhibition of a FADD/caspase-dependent signaling pathway
21. Cysteine proteinases and their endogenous inhibitors: Target proteins for prognosis, diagnosis and therapy in cancer
22. Cysteine proteinase inhibitor cystatin A in breast cancer
23. Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis
24. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
25. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-α requires transcriptional arrest
26. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
27. Induction of cell death by the lysosomotropic detergent MSDH
28. Apoptosis in cancer
29. Sensitization to death receptor cytotoxicity by inhibition of FADD/Caspase signaling: Requirement of cell cycle progression
30. Cell surface complex of cathepsin B/annexin II tetramer in malignant progression
31. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53
32. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2
33. Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
34. Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
35. Cathepsins as effector proteases in hepatocyte apoptosis
36. Protection from tumor necrosis factor cytotoxicity by protease inhibitors
37. Non-specific effects of methyl ketone peptide inhibitors of caspases
38. Cathepsin S required for normal MHC class II peptide loading and germinal center development
39. Cathepsin B and its endogenous inhibitors: The role in tumor malignancy
40. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
41. Lysosomal protease pathways to apoptosis. Cleavage of Bid, not pro-caspases, is the most likely route
42. The two different receptors for tumor necrosis factor mediate distinct cellular responses
43. Caspases: Enemies within
44. Tumor necrosis factor: Specific binding and internalization in sensitive and resistant cells
45. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis
46. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor
47. Tumor necrosis factor receptor and Fas signaling mechanisms
48. Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis
49. Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation
50. Activation of CPP32-like proteases is not sufficient to trigger apoptosis: Inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity
51. More than one way to go