Caspases: Key players in programmed cell death

Current Opinion in Structural Biology

Volumn 10, Issue 6, 2000, Pages 649-655

  Grutter M G ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; INTERLEUKIN 1BETA CONVERTING ENZYME;

APOPTOSIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBUNIT; INBORN ERROR OF METABOLISM; PHYLOGENY; PRIORITY JOURNAL; REVIEW;

EID: 0034522342     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00146-9     Document Type: Review

References (53)

1. Cell suicide for beginners
2. Programmed cell death in animal development
3. The cutting edge: Caspases in apoptosis and disease
4. Suicidal tendencies: Apoptotic cell death by caspase family proteinases
5. Caspases: Enemies within
6. Apoptotic pathways: The roads to ruin
7. Death receptors: Signaling and modulation
8. Mitochondria and apoptosis
9. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
10. Caspase structure, proteolytic substrates, and function during apoptotic cell death
11. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
12. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
13. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
14. Inhibition of human caspases by peptide-based and macromolecular inhibitors
15. Activation of the enative 45-kDa precursor form of interleukin-1-converting enzyme
16. An induced proximity model for caspase-8 activation
17. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
18. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
19. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
20. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
21. Catalytic properties of the caspases
22. Structure and mechanism of interleukin-1 beta converting enzyme
23. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)2 homodimer
24. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
25. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone
26. The three-dimensional structure of caspase-8: An initiator enzyme in apoptosis
27. The atomic-resolution structure of human caspase-8, a key activator of apoptosis
28. The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
29. Caspase-8 specificity probed at subsite S4: Crystal structure of the caspase-8-Z-DEVD-CHO complex
30. Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site
31. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
32. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
33. Postmitochondrial regulation of apoptosis during heart failure
34. Neuroprotection by caspase inhibitors
35. Molecular basis of the neurodegenerative disorders
36. Caspases as treatment targets in stroke and neurodegenerative diseases
37. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
38. A caspase inhibitor blocks ischemia-induced delayed neuronal death in the gerbil
39. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
40. Caspases: Key mediators of apoptosis
41. Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor
42. First examples of peptidomimetic inhibitors of interleukin-1 beta converting enzyme
43. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
44. Target protease specificity of the viral serpin CrmA. Analysis of five caspases
45. Caspase inhibitors
46. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35
47. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex
48. Crystal structure of baculovirus P35: Role of a novel reactive site loop in apoptotic caspase inhibition
49. Prediction of the tertiary structure and substrate binding site of caspase-8
50. Prediction of the tertiary structure of a caspase-9/inhibitor complex
51. Crystal structure of gingipain R: An Arg-specific bacterial cysteine proteinase with a caspase-like fold
52. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases
53. The structure of the pre-apoptotic protease granzyme B reveals the molecular determinants of its specificity