Identification of a novel regulatory domain in Bcl-x(L) and Bcl-2

EMBO Journal

Volumn 16, Issue 5, 1997, Pages 968-977

  Chang, Brian S ^a   Minn, Andy J ^a   Muchmore, Steven W ^b   Fesik, Stephen W ^c   Thompson, Craig B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b Laboratory of Protein Crystallography D 46Y AP 10 LL 07   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

Apoptosis; Bcl 2; Bcl x; Programed cell death; Protein structure

Indexed keywords

IMMUNOGLOBULIN M ANTIBODY; PROTEIN BCL 2;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; DELETION MUTANT; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CLONE CELLS; DIMERIZATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

ANIMALIA;

EID: 0031041089     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.5.968     Document Type: Article

References (52)

1. Allsopp, T.E., Wyatt, S., Paterson, H.F. and Davies, A.M. (1993) The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell, 73, 295-307.
2. Baffy, G., Miyashita, T., Williamson, J.R. and Reed, J.C. (1993) Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J. Biol. Chem., 268, 6511-6519.
3. Boise, L.H., González-García, M., Pastema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nuñez, G. and Thompson, C.B. (1993) bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
4. Boyd, J.M., Malstrom, S., Subramanian, T., Venkatesh, L.K., Schaeper, U., Elangovan, B., D'Sa-Eipper, C. and Chinnadurai, G. (1994) Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell, 79, 341-351.
5. L and Bcl-2 repress a common pathway of cell death. J. Exp. Med., 182, 821-828.
6. ras-generated signals toward cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene, 11, 1487-1498.
7. Ras in Ras-induced apoptosis. J. Biol. Chem., 271, 2376-2379.
8. L. Nature, 379, 554-556.
9. Chinnaiyan, A.M., Orth, K., O'Rourke, K., Duan, H., Poirier, G.G. and Dixit, V.M. (1996) Molecular ordering of the cell death pathway. J. Biol. Chem., 271, 4573-4576.
10. Chittenden, T., Flemington, C., Houghton, A.B., Ebb, R.G., Gallo, G.J., Elangovan, B., Chinnadurai, G. and Lutz, R.J. (1995a) A conserved domain in Bax, distinct from BH1 and BH2 mediates cell death and protein binding functions. EMBO J., 14, 5589-5596.
11. Chittenden, T., Harrington, E.A., O'Connor, R., Flemington, C., Lutz, R.J., Evan, G.I. and Guild, B.C. (1995b) Induction of apoptosis by the Bcl-2 homologue Bak. Nature, 374, 733-736.
12. L in CD40-mediated rescue from anti-μ-induced apoptosis in WEHI-231 B lymphoma cells. Eur. J. Immunol., 25, 1352-1357.
13. Ciechanover, A. (1994) The ubiquitin-proteasome proteolytic pathway. Cell, 79, 13-21.
14. Cuende, E., Alés-Martínez, J.E., Ding, L., Gónzalez-Garcia, M., Martínez-A.,C. and Nunez, G. (1993) Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells. EMBO J., 12, 1555-1560.
15. DeFranco, A.L., Gold, M.R. and Jakway, J.P. (1987) B-Lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide. Immunol. Rev., 95, 161-176.
16. Erlich, H.A. (1989) PCR Technology - Principles and Applications for DNA Amplification. Stockton Press, New York, USA.
17. Farrow, S.N., White, J.H.M., Martinou, I., Raven, T., Pun, K.-T., Grinham, C.J., Martinou, J.-C. and Brown, R. (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature, 374, 731-733.
18. Fernandez-Sarabia, M.J. and Bischoff, J.R. (1993) Bcl-2 associates with the ras-related protein R-ras p23. Nature, 366, 274-275.
19. Fraser, A. and Evan, G. (1996) A license to kill. Cell, 85, 781-784.
20. Gottschalk, A.R., Boise, L.H., Thompson, C.B. and Quintáns, J. (1994) Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc. Natl Acad Sci. USA, 91, 7350-7354.
21. Haldar, S., Jena, N. and Croce, C.M. (1995) Inactivation of Bcl-2 by phosphorylation. Proc. Natl Acad. Sci. USA, 92, 4507-4511.
22. Hanada, M., Aimé-Sempé, C., Sato, T. and Reed, J.C. (1995) Structure-function analysis of Bcl-2 protein. J. Biol. Chem., 270, 11962-11969.
23. Hasbold, J. and Klaus, G.G.B. (1990) Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas. Eur. J. Immunol., 20, 1685-1690.
24. Hengartner, M.O. and Horvitz, H.R. (1994) C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncosene bcl-2. Cell, 76, 665-676.
25. Hockenbery, D.M., Oltvai, Z.N., Yin, X.-M, Milliman, C.L. and Korsmeyer, S.J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell, 75, 241-251.
26. Kane, D.J., Sarafian, T.A, Anton, R., Hahn, H., Gralla, E.B., Valentine, J.S., Örd, T. and Bredesen, D.E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science, 262, 1274-1277.
27. Kiefer, M.C., Brauer, M.J., Powers, V.C., Wu, J.J., Umansky, S.R., Tomel, L.D. and Barr, P.J. (1995) Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature, 374, 736-739.
28. 2+ fluxes. Proc. Natl Acad. Sci. USA, 91, 6569-6573.
29. May, W.S., Tyler, P.G., Ito, T., Armstrong, D.K., Qatsha, K.A. and Davidson, N.E. (1994) Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of Bcl2α in association with suppression of apoptosis. J. Biol. Chem., 269, 26865-26870.
30. L. J. Biol. Chem., 271, 6306-6312.
31. Miura, M., Zhu, H., Rotello, R., Hartwieg, E.A. and Yuan, J. (1993) Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell, 75, 653-660.
32. L, an inhibitor of programmed cell death. Nature, 381, 335-341.
33. Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J.P. and Korsmeyer, S.J. (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol., 144, 3602-3610.
34. Oltvai, Z.N. and Korsmeyer, S.J. (1994) Checkpoints of dueling dimers foil death wishes. Cell, 79, 189-192.
35. Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog. Bax, that accelerates programmed cell death. Cell, 74, 609-619.
36. Sato, T. et al. (1994) Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl Acad. Sci. USA, 91, 9238-9242.
37. Sattler, M. et al. (1997) Structure of Bcl-xL-Bak protein complex reveals how regulators of apoptosis interact. Science, in press.
38. Sedlak, T.W., Oltvai, Z.N., Yang, E., Wang, K., Boise, L.H., Thompson, C.B. and Korsmeyer, S.J. (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad. Sci. USA, 92, 7834-7838.
39. Sentman, C.L., Shutter, J.R., Hockenbery, D., Kanagawa, O. and Korsmeyer, S.J. (1991) bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67, 879-888.
40. Strasser, A., Harris, A.W. and Cory, S. (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell, 67, 889-899.
41. Tanaka, S., Louie, D., Kant, J. and Reed, J.C. (1992a) Application of a PCR-mismatch technique to the Bcl-2 gene: detection of point mutations in Bcl-2 genes of malignancies with A t(14,18). Leukemia, 3 (suppl.), 15S-19S.
42. Tanaka, S., Louie, D.C., Kant, J.A. and Reed, J.C. (1992b) Frequent incidence of somatic mutations in translocated Bcl2 oncogenes of non-Hodgkin's lymphomas. Blood, 79, 229-237.
43. Thompson, C.B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science, 267, 1456-1462.
44. Wang, H.-G. et al. (1994) Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene, 9, 2751-2756.
45. White, E. (1996) Life, death, and the pursuit of apoptosis. Genes Dev., 10, 1-15.
46. Yang, E. and Korsmeyer, S.J. (1996) Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood, 2, 386-401.
47. L and Bcl-2, displaces Bax and promotes cell death. Cell, 80, 285-291.
48. Yin, X.-M., Oltvai, Z.N. and Korsmeyer, S.J. (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature, 369, 321-323.
49. Zamzami, N. et al. (1995a) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med., 182, 367-377.
50. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J.-L., Petit, P.X. and Kroemer, G. (1995b) Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med., 181, 1661-1672.
51. Zamzami, N., Susin, S.A., Marchetti, P., Hirsch, T., Gómez-Monterrey, I., Castedo, M. and Kroemer, G. (1996) Mitochondrial control of nuclear apoptosis. J. Exp. Med., 183, 1533-1544.
52. Zha, H., Aimé-Sempé, C., Sato, T. and Reed, J.C. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem., 271, 7440-7444.