Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

Circulation Research

Volumn 88, Issue 12, 2001, Pages 1267-1275

  Akao, Masaharu ^a   Ohler, Andreas ^a,b   O'Rourke, Brian ^a   Marbán, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Apoptosis; Ischemia; Oxidative stress

Indexed keywords

CYTOCHROME C; MITOCHONDRIAL DNA; POTASSIUM CHANNEL;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL KILLING; CELL SURVIVAL; ELECTRON TRANSPORT; ENZYME ACTIVATION; FLOW CYTOMETRY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMAGE ANALYSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0035933436     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1201.092094     Document Type: Article

References (36)

1. Apoptosis and myocardial infarction
2. Apoptosis: Basic mechanisms and implications for cardiovascular disease
3. Mitochondria and apoptosis
4. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
5. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
6. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
7. ATP-sensitive potassium channels and myocardial preconditioning
8. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
9. + channels: Possible mechanism of cardioprotection
10. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis
11. Regulation of Bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: Association with changes in mitochondrial membrane potential
12. Reperfusion injury induces apoptosis in rabbit cardiomyocytes
13. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion
14. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium
15. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs
16. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
17. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
18. + channels by protein kinase C
19. Diazoxide, an inhibitor of succinate oxidation
20. Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria
21. Characterization of succinate dehydrogenase and α-glycerophosphate dehydrogenase in pancreatic islets
22. ATP channel as a receptor for potassium channel openers
23. + channel of heart mitochondria
24. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
25. ATP channel by glyburide and 5-hydroxydecanoate
26. 2+ overload in rat cardiac mitochondria
27. From bench to clinic with apoptosis-based therapeutic agents
28. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
29. Caspase inhibition and limitation of myocardial infarct size: Protection against lethal reperfusion injury
30. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
31. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL
32. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes
33. + channels modulate cardiac mitochondrial function
34. ATP channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway
35. Toward antiapoptosis as a new treatment modality
36. Apoptosis in the nervous system