Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

Physiological Reviews

Volumn 81, Issue 2, 2001, Pages 807-869

  Kyriakis, John M ^b   Avruch, Joseph ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; BRAIN DEVELOPMENT; CANCER THERAPY; CARDIOVASCULAR DISEASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; DIABETES MELLITUS; DNA DAMAGE; EMBRYO DEVELOPMENT; HUMAN; IMMUNITY; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; STRESS; STROKE; TRANSCRIPTION INITIATION;

EID: 0035066383     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.2.807     Document Type: Review

References (369)

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100. Mitogen-activated protein kinase activation resulting from selective oncogenic expression in N1H3T3 and rat la cells
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102. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
103. Cloning of a novel mitogen-activated protein kinase-kinase-kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
104. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
105. Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
106. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6): Comparison of its substrate specificity with that of other SAP kinases
107. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
108. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction
109. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
110. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
111. Selective interaction of JNK protein kinase isoforms with transcription factors
112. Transcription factor ATF2 regulation by the JNK signal transduction pathway
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114. Rho GTPases and the actin cytoskeleton
115. The many faces of G protein signaling
116. MEF2C participates in inflammatory responses via p38-mediated activation
117. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
118. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
119. 2-terminal kinases
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122. Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2
123. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
124. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemopterous
125. Thioredoxin
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133. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades
134. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
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138. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a
139. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
140. Characterization of the structure and function of the fourth member of the p38 group mitogen-activated protein kinases, p38δ
141. 12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain
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144. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
145. Nrk: A murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle
146. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
147. AP-1 function and regulation
148. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphosytes via the activation of NF-κB and AP-1
149. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
150. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
151. Differential expression of a novel protein kinase in human B lymphocytes: Preferential localization in the germinal center
152. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls
153. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity
154. Heterotrimeric G protein signaling: Roles in immune function and fine-tuning by RGS proteins
155. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
156. The death domain kinase RIP mediates the TNF-induced NF-κB signal
157. Activation of the c-Abl tyrosine kinase in the stress response to DNA damaging agents
158. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
159. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
160. The protein kinase Pak3 positively regulates Raf-1 through phosphorylation of serine 338
161. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
162. LOK is a novel mouse STE-20-like protein kinase that is expressed predominantly in lymphocytes
163. Signaling by the germinal center kinase family of protein kinases
164. pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity
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166. The stress-activated protein kinase subfamily of c-Jun kinases
167. pp54 MAP2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
168. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
169. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
170. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
171. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
172. ERK6, a mitogen-activated protein kinase, is involved in C2C12 myoblast differentiation
173. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
174. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
175. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
176. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
177. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis
178. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
179. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2
180. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
181. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase
182. Activation of apoptosis signal-regulating kinase-1 (ASK1) by TNF receptor-associated factor-2 requires prior dissociation of the ASK1 inhibitor thioredoxin
183. A Drosophila TNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase
184. Three distinct signalling responses by muring fibroblasts to genotoxic stress
185. Dissection of TNF receptor-1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death
186. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
187. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase3 (mkk3)-deficient mice
188. Identification of c-Jun NH-2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38
189. 3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase is targeted by three MAP kinase pathways
190. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
191. MAP3K-related kinase involved in NF-κB induction by TNF, CD-95 and IL-1
192. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family
193. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
194. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
195. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal regulated kinase activation
196. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK1 and is required for tumor necrosis factor-α activation of SAPK in mammalian cells
197. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20
198. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
199. TGFβ signal transduction
200. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
201. Activators and effectors of ras p21 proteins
202. Interactions between Ras proteins and their effectors
203. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
204. Crystallographic analysis of CD40 recognition and signaling by human TRAF2
205. Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells
206. Protein damaging stresses activate JNK via inhibition of its phosphatase: A novel pathway controlled by HSP72
207. SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
208. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development
209. MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes
210. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
211. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
212. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
213. 1/S through a mechanism requiring p38/RK
214. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization
215. +/CDC28-related kinase activity is required for signaling from the ER to the nucleus
216. Evidence for multiple activators for stress-activated protein kinases/c-Jun amino terminal kinases
217. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
218. A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses
219. Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-Jun promoter
220. An array of insulin-activated, proline-directed (Ser/Thr) protein kinases phosphorylate the p70 S6 kinase
221. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
222. The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3
223. Activation of SAPK/JNK by TNF receptor-1 through a noncytotoxic TRAF2-dependent pathway
224. PRAK, a novel protein kinase regulated by the p38 MAP kinase
225. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
226. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
227. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
228. ASK1 is essential for JNK/SAPK activation by TRAF2
229. 1
230. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms
231. Structural basis for self-association and receptor recognition of human TRAF2
232. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation
233. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase
234. Signaling through scaffold, anchoring, and adaptor proteins
235. Physical contact between lipopolysaccaride and Toll-like receptor 4 revealed by genetic complementation
236. Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes
237. The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion
238. Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway
239. Activation of the SAPK pathway by the human STE20 homologue germinal center kinase
240. Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death
241. Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor
242. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK
243. 13
244. Phosphorylation of c-jun mediated by MAP kinases
245. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
246. An essential role for Rac in Ras transformation
247. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
248. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
249. The mixed lineage protein kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1
250. Transcription factors of the NFAT family: Regulation and function
251. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylate microtubule-associated protein 2 in vitro
252. Tumor necrosis factor-α-induced E-selectin expression is activated by the nuclear factor-κB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways
253. Tumor necrosis factor-α-induced activation of c-jun N-terminal kinase is mediated by TRAF2
254. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK
255. Phosphatidylinositol-3-OH kinase as a direct target of Ras
256. Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
257. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75-kDa tumor necrosis factor receptor
258. The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
259. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
260. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)
261. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
262. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
263. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
264. Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase
265. TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway
266. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
267. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
268. Live cell fluorescence imaging of T cell MEKK2: Redistribution and activation in response to antigen stimulation of the T cell receptor
269. Cloning and characterization of a human STE-20-like protein kinase with unusual cofactor requirements
270. The mechanism of action of cyclosporin A and FK506
271. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
272. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
273. Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation
274. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
275. The seven transmembrane-spanning receptors for endothelin and thrombin cause proliferation of airway smooth muscle cells and activation of the extracellular signal regulated kinase and c-Jun NH2-terminal kinase groups of mitogen-activated protein kinases
276. Stress-induced JNK activation is independent of gadd45 induction
277. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-κB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway
278. TNF-mediated activation of the stress-activated protien kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related
279. TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
280. MD2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
281. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
282. Identification of two essential phosphorylated threonine residues in the catalytic domain of MEKK1
283. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
284. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation and death
285. The mRNA 5′ cap-binding protein eIF-4E and control of cell growth
286. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
287. RIP. A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
288. p38-2, a novel mitogen-activated protein kinase with distinct properties
289. MAPAKP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase
290. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
291. Cell crawling two decades after Abercrombie
292. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
293. JNK is involved in signal integration during costimulation of T lymphocytes
294. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
295. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway
296. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: Glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK
297. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
298. A family of stress-inducible GADD45-like proteins mediates activation of the stress-responsive MTK1/MEKK4 MAPKKK
299. Anatomy of TRAF2
300. FGF and stress regulate CREB and ATF1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
301. A conserved docking motif in MAP kinases common to substrates, activators and regulators
302. A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways
303. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor
304. Newly indentified stress-responsive protein kinases Krs-1 and Krs-2
305. Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets
306. The small GTP binding protein RhoA activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells
307. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
308. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 is a potential H3/HMG-14 kinase
309. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
310. RIP mediates tumour necrosis factor receptor 1 activation of NF-κB but not Fas/APO-1-initiated apoptosis
311. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonucleuase (Ire1p) in mammalian cells
312. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway
313. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs)
314. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
315. 2-terminal kinase kinases
316. Tumor necrosis factor, other cytokines and disease
317. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
318. Regulation of transcription by MAP kinase cascades
319. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase
320. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity
321. Coupling of stress in the ER to activation of JNK protein kinase by transmembrane protein kinase IRE1
322. Two tumour necrosis factor receptors: Structure and function
323. Tumor necrosis factor receptor and fas signaling mechanisms
324. gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress
325. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
326. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
327. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
328. Cloning of mammalian Ire1 reveals diversity in the ER stress response
329. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
330. 2-terminal kinase in ventricular muscle cells
331. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
332. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
333. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
334. Multiple Ras functions can contribute to mammalian cell transformation
335. The IRS-signalling system: A network of docking proteins that mediate insulin action
336. A mammalian scaffold complex that selectively mediates MAP kinase activation
337. Integration of MAP kinase signal transduction pathways at the serum response element
338. MEK Kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis
339. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
340. 2-terminal kinase-specific kinase
341. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
342. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino terminal extension
343. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
344. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
345. XIAP, a cellular member of the inhibitor of apoptosis protein family links the receptors to TAB1-TAK1 in the BMP signaling pathway
346. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
347. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
348. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
349. Mekk3 is essential for early embryonic cardiovascular development
350. Signaling events induced by lipopolysaccharide-activated toll-like receptor 2
351. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
352. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
353. Activation of stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7)
354. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway
355. The JIP group of mitogen-activated protein kinase scaffold proteins
356. The structural basis for the recognition of diverse receptor sequences by TRAF2
357. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
358. Transducing signals of life and death
359. Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38
360. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
361. Bridging the gap: Composition, regulation and physiological function of the IκB kinase complex
362. The stress-activated protein kinase pathway mediates cell death following injury-induced by cis-platinum, UV irradiation or heat
363. Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
364. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
365. Regulation of the MEF2 family of transcription factors by p38
366. The factigenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor
367. Components of a new human protein kinase signal transduction pathway
368. Intramolecular masking of nuclear import signal on NFAT4 by casein kinase I and MEKK1
369. Angiotensin II stimulates the calcium-dependent activation of c-Jun N-terminal kinase