Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

Diabetes

Volumn 50, Issue 10, 2001, Pages 2363-2375

  Fiordaliso, Fabio ^a   Leri, Annarosa ^a   Cesselli, Daniela ^a,b   Limana, Federica ^a   Safai, Bijan ^a,b   Nadal Ginard, Bernardo ^a   Anversa, Piero ^a   Kajstura, Jan ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; DNA; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; GLYCOSYLATION; HEART MUSCLE; HEART VENTRICLE; HYPERGLYCEMIA; MALE; METABOLISM; PATHOPHYSIOLOGY; PH; PHOSPHORYLATION; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANGIOTENSIN II; ANIMALS; APOPTOSIS; CELLS, CULTURED; DNA; GENE EXPRESSION REGULATION; GLYCOSYLATION; HEART VENTRICLES; HYDROGEN-ION CONCENTRATION; HYPERGLYCEMIA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LOSARTAN; MALE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035490419     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.10.2363     Document Type: Article

References (56)

1. Brownlee M, Cerami A, Vlassara H: Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315-1321, 1988
2. Ramamurthy B, Hook P, Larsson L: An overview of carbohydrate-protein interactions with specific reference to myosin and ageing. Acta Physiol Scand 167:327-329, 1999
3. Haltiwanger RS, Busby S, Grove K, Li S, Mason D, Medina L, Moloney D, Philipsberg G, Scartozzi R: O-glycosylation of nuclear and cytoplasmic proteins: regulation analogous to phosphorylation? Biochem Biophys Res Commun 231:237-242, 1997
4. Lubas WA, Frank DW, Krause M, Hanover JA: O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. J Biol Chem 272:9316-9324, 1997
5. Kennelly PJ, Krebs EG: Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 266: 15555-15558
6. Hart GW, Greis KD, Dong LY, Blomberg MA, Chou TY, Jiang MS, Roquemore FP, Snow DM, Kreppel LK, Cole RN, Comer FL, Arnold CS, Hayes BK: O-linked N-acetylglucosamine: the "yin-yang" of ser/thr phosphorylation? Nuclear and cytoplasmic glycosylation. Adv Exp Med Biol 376:115-123, 1995
7. Jackson SP, Tjian R: O-glycosylation of eukaryotic transcription factors: implications for mechanism of transcriptional regulation. Cell 55:125-133, 1988
8. Shaw P, Freeman J, Bovey R, Iggo R: Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. Oncogene 12:921-930, 1996
9. Hupp TR, Lane DP: Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases. Cold Spring Harbor Symp Quant Biol 59:195-206, 1994
10. Ashcroft M, Kubbutat MHG, Vousden KH: Regulation of p53 function and stability by phosphorylation. Mol Cell Biol 19:1751-1758, 1999
11. Leri A, Claudio PP, Li Q, Wang X, Cheng W, Kajstura J, Anversa P: Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 101:1326-1342, 1998
12. Leri A, Liu Y, Wang X, Kajstura J, Malhotra A, Meggs LG, Anversa P: Overexpression of IGF-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ Res 84:752-762, 1999
13. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299, 1995
14. Ushio-Fukai M, Alexander RW, Akers M, Griendling KK: p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II: role in vascular smooth muscle cell hypertrophy. J Biol Chem 273:15022-15029, 1998
15. Huang C, Ma WY, Maxiner A, Sun Y, Dong Z: p38 Kinase mediates UV-induced phosphorylation of p53 protein at serine 389. J Biol Chem 274:12229-12235, 1999
16. Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD: Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A 96:13777-13782, 1999
17. Chao C, Saito S, Anderson CW, Appella E, Xu Y: Phosphorylation of murine p53 at Ser-18 regulates the p53 response to DNA damage. Proc Natl Acad Sci U S A 97:11936-11941, 2000
18. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102:849-862, 2000
19. 2-terminal kinase and caspase-3. Circulation 101:2618-2624, 2000
20. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Burke TR, Quon MJ, Reed BC, Dikic I, Noel LE, Newgard CB, Farese R: Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. J Biol Chem 275:40817-40826, 2000
21. Liu W, Schoenkerman, Lowe WL: Activation of members of the mitogen-activated protein kinase family by glucose in endothelial cells. Am J Physiol 279: E782-E790, 2000
22. Leri A, Fiordaliso F, Setoguchi M, Limana F, Bishopric NH, Kajstura J, Webster K, Anversa P: Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis. Am J Pathol 157:843-857, 2000
23. Borg WP, Sherwin RS: Classification of diabetes mellitus. Adv Intern Med 45:279-295, 2000
24. Liu Y, Leri A, Li B, Wang X, Cheng W, Kajstura J. Anversa P: Angiotensin II stimulation in vitro induces hypertrophy of normal and postinfarcted ventricular myocytes. Circ Res 82:1145-1159, 1998
25. Dennis JW, Laferte S, Waghorne C, Breitman ML, Kerbee RS: Beta-1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236:582-585, 1987
26. Sayeski PP, Kudlow JE: Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-alpha gene transcription. J Biol Chem 271:15237-15243, 1996
27. Delphin C, Baudier J: The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblast growth arrest. J Biol Chem 269:29579-29587, 1994
28. Hupp TR, Lane DP: Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner. J Biol Chem 270:18165-18174, 1995
29. Guerra S, Leri A, Wang X, Finato N, Di Loreto C, Beltrami CA, Kajstura K, Anversa P: Myocyte death in the failing human heart is gender dependent. Circ Res 85:856-866, 1999
30. Fiordaliso F, Li B, Latini R, Sonnenblick EH, Anversa P, Leri A, Kajstura J: Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II-dependent. Lab Invest 80:513-517, 2000
31. Frustaci A, Kajstura J, Chimenti C, Jakoniuk I, Leri A, Maseri A, Nadal-Ginard B, Anversa P: Myocardial cell death in human diabetes. Circ Res 87:1123-1132, 2000
32. Kajstura J, Fiordaliso F, Andreoli A-M, Li B, Chimenti S, Medow MS, Limana F, Nadal-Ginard B, Leri A, Anversa P: IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 50:1414-1424, 2001
33. Darzynkiewicz Z, Juan G, Li X, Gorczyca W, Murakami T, Traganos F: Cytometry in cell necrobiology: analysis of apoptosis, accidental death and necrosis. Cytometry 27:1-20, 1997
34. Bissell MJ, Hatié C, Rubin H: Patterns of glucose metabolism in normal and virus-transformed chick cells in tissue culture. J Natl Cancer Inst 49:555-565, 1972
35. Fuchs SY, Adler V, Buschmann T, Yin Z, Wu X, Jones SN, Ronai Z: JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev 12:2658-2663, 1998
36. Wang J, Friedman E: Downregulation of p53 by sustained JNK activation during apoptosis. Mol Carcinog 29:179-188, 2000
37. Giardino I, Edelstein D, Brownlee M: Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. J Clin Invest 94:110-117, 1994
38. Brownlee M: Negative consequences of glycation. Metabolism 49 (Suppl. 1):9-13, 2000
39. Fiscella M, Zambrano N, Ullrich SJ, Unger T, Lin D, Cho B, Mercer WE, Anderson CW, Appella E: The carboxy-terminal serine 392 phosphorylation site of human p53 is not required for wild-type activities. Oncogene 9:3249-3257, 1994
40. Higashimoto Y, Saito S, Tong X-H, Hong A, Sakaguchi K, Appella E, Anderson CW: Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents. J Biol Chem 275:23199-23203, 2000
41. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281:1677-1679, 1998
42. Duzgun SA, Rasque H, Kito H, Azuma N, Li W, Basson MD, Gahtan V, Dudrick SJ, Sumpio BE: Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. J Cell Biochem 76:567-571, 2000
43. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ, King GL: Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 103:185-195, 1999
44. Natarajan R, Scott S, Bai W, Yerneni KK, Nadler J: Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions. Hypertension 33:378-384, 1999
45. 2-terminal kinase via SHP-1 tyrosine phosphatase activity, Biochem Biophys Res Commun 282:1085-1091, 2001
46. Francis GS: ACE inhibition in cardiovascular disease. N Engl J Med 342:201-202, 2000
47. Heart Outcomes Prevention Evaluation (HOPE) Study Investigators: Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 355:253-259, 2000
48. Al-Merani SA, Brooks DP, Chapman BJ, Munday KA: The half-lives of angiotensin II, angiotensin II-amide, angiotensin III, Sar1-Ala8-angiotensin II and renin in the circulatory system of the rat. J Physiol 278:471-490, 1978
49. Wallace KB, Oparil S, Bailie MD: Angiotensin II metabolism by tissues from developing rats. Pediatr Res 15:1088-1092, 1981
50. Cigola E, Kajstura J, Li B, Meggs LG, Anversa P: Angiotensin II activates programmed myocyte cell death in vitro. Exp Cell Res 231:363-371, 1997
51. Yamada T, Horiuchi M, Dzau VJ: Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci U S A 93:156-160, 1996
52. Horiuchi M, Hayashida W, Kambe T, Yamada T, Dzau VJ: Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinases phosphatase-1 and induces apoptosis. J Biol Chem 272:19022-19026, 1997
53. Horiuchi M, Akishita M, Dzau VJ: Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 33:613-621, 1999
54. Yamada T, Akishita M, Pollman MJ, Gibbons GH, Dzau VJ, Horiuchi M: Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. Life Sci 63:289-295, 1998
55. Hayashida W, Horiuchi M, Grandchamp J, Dzau VJ: Antagonistic actions of angiotensin II type-1 and -2 receptors on apoptosis in cultured neonatal rat ventricular myocytes (Abstract). Hypertension 28:535, 1996
56. Daviet L, Horiuchi M, Hayashida W, Lehtonen JYA, Bishopric NH, Dzau VJ: Antagonistic actions of type-1 and -2 angiotensin II receptors on rat cardio-myocyte apoptosis (Abstract). Circulation 98: I-741, 1998