Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 7320-7326

  Slee, Elizabeth A ^a   Adrain, Colin ^a   Martin, Seamus J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONDENSATION; DNA; PROTEINS;

FRAGMENTATION;

BIOCHEMISTRY;

CASPASE 3; CASPASE 6; CASPASE 7; CYSTEINE PROTEINASE; CYTOCHROME C; DEOXYADENOSINE TRIPHOSPHATE; DNA FRAGMENT; DNA TOPOISOMERASE; FODRIN; GELSOLIN; INHIBITOR OF APOPTOSIS PROTEIN; LAMIN A; LAMIN B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE (CALCIUM,CALMODULIN); RETINOBLASTOMA PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; STAT1 PROTEIN; STRUCTURAL PROTEIN; VIMENTIN; ACTIN BINDING PROTEIN; ADENOSINE TRIPHOSPHATE; BIRC4 PROTEIN, HUMAN; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASP6 PROTEIN, HUMAN; CASP7 PROTEIN, HUMAN; CASPASE; DNA BINDING PROTEIN; DNA FRAGMENTATION FACTOR, HUMAN; LAMIN; NUCLEAR PROTEIN; PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CELL NUCLEUS; CHROMATIN; CONTROLLED STUDY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN DEGRADATION; ANIMAL; BIOLOGICAL MODEL; METABOLISM; PHYSIOLOGY; TIME;

MAMMALIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASE 6; CASPASE 7; CASPASES; CELL NUCLEUS; CELL-FREE SYSTEM; CHROMATIN; CYTOCHROME C GROUP; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; DNA-BINDING PROTEINS; GELSOLIN; HUMANS; JURKAT CELLS; LAMIN TYPE A; LAMIN TYPE B; LAMINS; MICROFILAMENT PROTEINS; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PROTEINS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TRANS-ACTIVATORS; VIMENTIN; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 0035831473     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008363200     Document Type: Article

References (59)

1. Cohen, G. M. (1997) Biochem. J. 326, 1-16
2. Salvesen, G. S and Dixit, V. M. (1997) Cell 91, 443-446
3. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
4. Nicholson, D. W. (1999) Cell Death Differ. 6, 1028-1042
5. Wolf, B. B., and Green, D. R. (1999) J. Biol. Chem. 274, 20049-20052
6. Earnshaw, W. C., Martins, L. M., and Kaufmann, S. H. (1999) Annu. Rev. Biochem. 68, 383-424
7. Slee, E. A., Adrain, C., and Martin, S. J. (1999) Cell Death Differ. 6, 1067-1074
8. Stennicke, H. R., and Salvesen, G. S. (1999) Cell Death Differ. 6, 1054-1059
9. Green, D. R. (1998) Cell 94, 695-698
10. Kumar, S. (1999) Cell Death Differ. 6, 1060-1066
11. Salvesen, G. S and Dixit, V. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10964-10967
12. Martin, S. J., and Green, D. R. (1995) Cell 82, 349-352
13. Ashkenazi, A., and Dixit, V. M. (1998) Science 281, 1305-1308
14. Jänicke, R. U., Sprengart, M. L., Wati, M. R., and Porter, A. G. (1998) J. Biol. Chem. 273, 9357-9360
15. Jänicke, R. U., Ng, P., Sprengart M. L., and Porter, A. G. (1998) J. Biol. Chem. 273, 15540-15545
16. Zheng, T. S., Schlosser, S. F., Dao, T., Hingorani, R., Crispe, I. N., Boyer, J. L., and Flavell, R. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13618-13623
17. Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kagi, D., Hakem, A., McCurrach, M., Khoo, W., Kaufman, S. A., Sanaldi, G., Howard, T., Lowe, S. W., and Mak, T. W. (1998) Genes Dev. 12, 806-819
18. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Cell 86, 147-157
19. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. (1997) Cell 90, 405-413
20. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. (1997) Cell 91, 479-489
21. Srinivasula, S., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. (1998) Mol. Cell 1, 949-957
22. Slee, E. A., Harte, M. T., Kluck, R. M., Wolf, B. B., Casiano, C. A., Newmeyer, D. D., Wang, H. G., Reed, J. C., Nicholson, D. W., Alnemri, E. S., Green, D. R., and Martin, S. J. (1999) J. Cell Biol. 144, 281-292
23. Slee, E. A., Keogh, S. A., and Martin, S. J. (2000) Cell Death Differ. 7, 556-565
24. Martin, S. J., Newmeyer, D. D., Mathias, S., Farschon, D. M., Wang, H. G., Reed, J. C., Kolesnick, R. N., and Green, D. R. (1995) EMBO J. 14, 5191-5200
25. Martin, S. J., Amarante-Mendes, G. P., Shi, L., Chuang, T. H., Casiano, C. A., O'Brien, G. A., Fitzgerald, P., Tan, E. M., Bokoch, G. M., Greenberg, A. H., and Green, D. R. (1996) EMBO J. 15, 2407-2416
26. Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E., and Poirier, G. G. (1993) Cancer. Res. 53, 3976-3985
27. Casciola-Rosen, L. A., Miller, D. K., Anhalt, G. J., and Rosen, A. (1994) J. Biol. Chem. 269, 30757-30760
28. Martin, S. J., O'Brien, G. A., Nishioka, W. K., McGahon, A. J., Mahboubi, A., Saido, T. C., and Green, D. R. (1995) J. Biol. Chem. 270, 6425-6428
29. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T. J., Kirschner, M. W., Koths, K., Kwiatkowski, D. J., and Williams, L. T. (1997) Science 278, 294-298
30. Nath, R., Raser, K. J., Stafford, D., Hajimohammadreza, I., Posner, A., Allen, H., Talanian, R. V., Yuen, P., Gilbertsen, R. B., and Wang, K. K. (1996) Biochem. J. 319, 683-690
31. Waterhouse, N. J., Finucane, D. M., Green, D. R., Elce, J. S., Kumar, S., Alnemri, E. S., Litwack, G., Khanna, K., Lavin, M. F., and Watters, D. J. (1998) Cell Death Differ. 12, 1051-1061
32. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
33. Garcia-Calvo, M., Peterson, E. P., Rasper, D. M., Vaillancourt, J. P., Zamboni, R., Nicholson, D. W., and Thornberry, N. A. (1999) Cell Death Differ. 6, 362-369
34. Liu, X., Zou, H., Slaughter, C., and Wang, X. (1997) Cell 89, 175-184
35. Casiano, C. A., Martin, S. J., Green, D. R., and Tan, E. M. (1996) J. Exp. Med. 184, 765-770
36. Jänicke, R. U., Walker, P. A., Lin, X. Y., and Porter, A. G. (1996) EMBO J. 15, 6969-6978
37. Tan, X., Martin, S. J., Green, D. R., and Wang, J. Y. J. (1997) J. Biol. Chem. 272, 9613-9616
38. King, P., and Goodbourn, S. (1998) J. Biol. Chem. 273, 8699-8704
39. Lin, Y., Devin, A., Rodriguez, Y., and Liu, Z. G. (1999) Genes Dev. 13, 2514-2526
40. Morishima, N. (1999) Genes Cells 4, 401-414
41. Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., and Reed, J. C. (1999) EMBO J. 18, 5242-5251
42. Samejima, K., Svingen, P. A., Basi, G. S., Kottke, T., Mesner, P. W. Jr., Stewart, L., Durrieu, F., Poirier, G. G., Alnemri, E. S., Champoux, J. J., Kaufmann, S. H., and Earnshaw, W. C. (1999) J. Biol. Chem. 274, 4335-4340
43. McGinnis, K. M., Whitton, M. M., Gnegy, M. E., and Wang, K. K. W. (1998) J. Biol. Chem. 273, 19993-20000
44. Wolf, B. B., Schuler, M., Echeverri, F., and Green, D. R. (1999) J. Biol. Chem. 274, 30651-30656
45. Kaufmann, S. H. (1989) Cancer Res. 49, 5870-5878
46. Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9042-9046
47. Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernandes-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8395-8400
48. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., and Dixit, V. M. (1996) J. Biol. Chem. 271, 16443-16446
49. Neamati, N., Fernandez, A., Wright, S., Kiefer, J., and McConkey, D. J. (1995) J. Immunol. 154, 3788-3795
50. Voelkel-Johnson, C., Entingh, A. J., Wold, W. S. M., Gooding, L. R., and Laster, S. M. (1995) J. Immunol. 154, 1707-1716
51. Kerr, J. F. R., Wyllie, A. H. and Currie, A. R. (1972) Br. J. Cancer 26, 239-257
52. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998) Nature 391, 43-50
53. Sakahira, H., Enari, M., and Nagata, S. (1998) Nature 391, 96-99
54. Martin, S. J., Finucane, D. M., Amarante-Mendes, G. P., O'Brien, G. A., and Green, D. R. (1996) J. Biol. Chem. 271, 28753-28756
55. Liu, X., Li, P., Widlak, P., Zou, H., Luo, X., Garrard, W. T., and Wang, X. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8461-8466
56. Vanags, D. M., Pörn-Ares, M. I., Coppola, S., Burgess, D. H., and Orrenius, S. (1996) J. Biol. Chem. 271, 31075-31085
57. Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A. (1996) Nature 384, 368-372
58. Zheng, T. S., Hunot, S., Kuida, K., and Flavell, R. A. (1999) Cell Death Differ. 6, 1043-1053
59. Bergeron, L., Perez, G. I., MacDonald, G., Shi, L., Sun, Y., Juriscova, A., Varmuza, S., Latham, K. E., Flaws, J. A., Salter, J. C., Hara, H., Moskowitz, M. A., Li, E., Greenberg, A., Tilly, J. L., and Yuan, J. (1998) Genes Dev. 12, 1304-1314