Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic bcl-2 family member

Genomics

Volumn 44, Issue 2, 1997, Pages 195-200

  Ulrich, Eugen ^a   Kauffmann Zeh, Andrea ^a   Hueber, Anne Odile ^a   Williamson, Jill ^a   Chittenden, Thomas ^b   Ma, Averil ^c   Evan, Gerard ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b Apoptosis Technology Inc   (United States)

^c UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CHROMOSOMAL LOCALIZATION; COMPLEX FORMATION; DNA SEQUENCE; EXON; GENE EXPRESSION REGULATION; GENE STRUCTURE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; SEMINIFEROUS TUBULE;

MURINAE;

EID: 0031239034     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4858     Document Type: Article

References (23)

1. Antequera, F., and Bird, A. (1993). Number of CpG islands and genes in human and mouse. Proc. Natl. Acad. Sci. USA 90: 11995-11999.
2. Boise, L. H., Gonzalez, G. M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. (1993). bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608.
3. Boyd, J. M., Gallo, G. J., Elangovan, B., Houghton, A. B., Malstrom, S., Avery, B. J., Ebb, R. G., Subramanian, T., Chittenden, T., Lutz, R. J., et al. (1995). Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene 11: 1921-1928.
4. Chittenden, T., Flemington, C., Houghton, A. B., Ebb, R. G., Gallo, G. J., Elangovan, B., Chinnadurai, G., and Lutz, R. J. (1995a). A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 14: 5589-5596.
5. Chittenden, T., Harrington, E., O'Connor, R., Evan, G., and Guild, B. (1995b). Induction of apoptosis by the Bcl-2 homologue Bak. Nature 374: 733-736.
6. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
7. Farrow, S., White, J., Martinou, I., Raven, T., Pun, K.-T., Grinham, C., Martinou, J.-C., and Brown, R. (1995). Cloning of a novel bcl-2 homologue by interaction with adenovirus E1B 19K. Nature 374: 731-733.
8. Frampton, J., Ramqvist, T., and Graf, T. (1996). v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells. Genes Dev. 10: 2720-2731.
9. Jost, J., and Saluz, H. (1990). "DNA Methylation: Molecular Biology and Biological Significance," pp. 169-185, Birkhaeuser Verlag, Basel.
10. Kiefer, M., Brauer, M., VC, P., Wu, J., Umansky, S., Tomei, L., and Barr, P. (1995). Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature 374: 736-739.
11. Knudson, C., Tunk, K., Tourtellotte, W., Brown, G., and Korsmeyer, S. (1995). Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96-99.
12. Motoyama, N., Wang, F. P., Roth, K. A., Sawa, H., Nakayama, K., Nakayama, K., and Negishi (1995). Massive cell-death of immature hematopoietic-cells and neurons. Science 267: 1506-1510.
13. Mount, S. M. (1982). A catalogue of splice junction sequences. Nucleic-Acids Res. 10: 459-472.
14. Oltvai, Z., Milliman, C., and Korsmeyer, S. (1993). Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619.
15. Pfeifer, G. P., and Riggs, A. D. (1991). Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev. 5: 1102-1113.
16. Ragoussis, J., Senger, G., Trowsdale, J., and Campbell, I. G. (1992). Genomic organization of the human folate receptor genes on chromosome 11q13. Genomics 14: 423-430.
17. Sambrook, J., Fritsch, E., and Maniatis, T. (1991). "Molecular Cloning: A Laboratory Manual," 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J. (1991). bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67: 879-888.
19. Somma, M. P., Pisano, C., and Lavia, P. (1991). The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant. Nucleic Acids Res. 19: 2817-2824.
20. Taylor, D., Badiani, P., and Weston, K. (1996). A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev. 10: 2732-2744.
21. Veis, D., Sorenson, C., Shutter, J., and Korsmeyer, S. (1993). Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair. Cell 75: 229-240.
22. Wang, K., Yin, X., Chao, D., Milliman, C., and Korsmeyer, S. (1996). BID: A novel BH3 domain-only death agonist. Genes Dev. 10: 2859-2869.
23. Yin, X.-M., Oltvai, Z., and Korsemeyer, S. (1994). Bh1 and bh2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369: 321-323.