The three-dimensional solution structure and dynamic properties of the human FADD death domain

Journal of Molecular Biology

Volumn 302, Issue 1, 2000, Pages 171-188

  Berglund, Helena ^a   Olerenshaw, Dionne ^b   Sankar, Andrew ^a   Federwisch, Matthias ^c   McDonald, Neil Q ^b,d   Driscoll, Paul C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Apoptosis; Death domain; NMR; Polypeptide dynamics; Protein structure

Indexed keywords

ADAPTOR PROTEIN; CASPASE 8; CYSTEINE PROTEINASE; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MEMBRANE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID COMPOSITION; APOPTOSIS; ARTICLE; DNA FLANKING REGION; DYNAMICS; GENE ACTIVATION; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

EID: 0034622940     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4011     Document Type: Article

References (70)

1. Death receptors: Signaling and modulation
2. Crystal structure of the soluble human 55 kD TNF receptor-human TNFβ complex: Implications for TNF receptor activation
3. 13C-labeled proteins
4. Self-association of the death domains of the p55 tumor necrosis factor (TNF) receptor and Fas/APO1 prompts signaling for TNF and Fas/APO1 effects
5. A novel protein that interacts with the death domain of Fas/ APO1 contains a sequence motif related to the death domain
6. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO1- and TNF receptor-induced cell death
7. CHARMM - A program for macromolecular energy, minimization, and dynamics calculations
8. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
9. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment
10. Determination of 3-dimensional structures of proteins and nucleic-acids in solution by nuclear magnetic-resonance spectroscopy
11. Applications of 3-dimensional and 4-dimensional heteronuclear NMR spectroscopy to protein structure determination
12. Structures of larger proteins in solution - 3-dimensional and 4-dimensional heteronuclear NMR spectroscopy
13. New methods of structure refinement for macromolecular structure determination by NMR
14. 1H NMR spectroscopy
15. 15N nuclear magnetic-relaxation of proteins
16. NMRPIPE - A multidimensional spectral processing system based on UNIX pipes
17. The lymphoproliferation mutation in Fas locally unfolds the Fas death domain
18. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
19. The death domain - A nodule shared by proteins with diverse cellular functions
20. The CARD domain: A new apoptotic signalling motif
21. The death domain motif found in Fas (APO-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance
22. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
23. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
24. Neuronal apoptosis induced by β-amyloid is mediated by caspase-8
25. The solution structure of FADD death domain - Structural basis of death domain interactions of Fas and FADD
26. NMR structure calculation methods for large proteins - Application of torsion angle dynamics and distance geometry/ simulated annealing to the 269-residue protein serine protease PB92
27. 2O
28. 15N inverse detected heteronuclear NMR-spectroscopy - Application to staphylococcal nuclease
29. 2O samples of proteins
30. MOLMOL: A program for display and analysis of macromolecular structures
31. 1H 2D-NMR spectra by interactive computer-graphics
32. MOLSCRIPT - A program to produce both detailed and schematic plots of protein structures
33. Backbone dynamics of the C-terminal SH2 domain of the p85α subunit of phosphoinositide 3-kinase. Effect of phosphotyrosine peptide binding and characterization of slow conformational exchange processes
34. Measurement of H(N)-H(α) J-couplings in calcium-free calmodulin using new 2D and 3D water-flip-back methods
35. 13C(α) chemical-shifts on protein-structure determination by NMR
36. PROCHECK - A program to check the stereochemical quality of protein structures
37. Mature T lymphocyte apoptosis - Immune regulation in a dynamic and unpredictable antigenic environment
38. NMR structure of the death domain of the p75 neurotrophin receptor
39. Model-free approach to the interpretation of nuclear magnetic- resonance relaxation in macromolecules. 1. Theory and range of validity
40. Model-free approach to the interpretation of nuclear magnetic-resonance relaxation in macromolecules. 2. Analysis of experimental results
41. High resolution solution structure of apo calcyclin and structural variations in the S100 family of calcium-binding proteins
42. Backbone dynamics of Escherichia coli ribonuclease H1 - Correlations with structure and function in an active enzyme
43. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal
44. Defective CD95/ APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
45. RASTER3D version 2.0 - A program for photorealistic molecular graphics
46. Gradient-enhanced triple-resonance 3-dimensional NMR experiments with improved sensitivity
47. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
48. An induced proximity model for caspase-8 activation
49. 13C labeling
50. 2O
51. Glutamine repeats and neurodegenerative diseases: Molecular aspects
52. NMR exchange broadening arising from specific low affinity protein self-association: Analysis of nitrogen-15 nuclear relaxation for rat CD2 domain 1
53. Multiple quantum filters for elucidating nmr coupling networks
54. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
55. Caspase-8 is required for cell death induced by expanded polyglutamine repeats
56. Nuclear inclusions in glutamine repeat disorders: Are they pernicious, coincidental, or beneficial?
57. Aggregation of the intracellular domain of the type-1 tumor-necrosis-factor receptor defined by the 2-hybrid system
58. Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation
59. A novel domain within the 55 kD TNF receptor signals cell death
60. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
61. The molecular basis for apoptotic defects in patients with CD95 (Fas/APO-1) mutations
62. 13C decoupling
63. Tumor necrosis factor receptor and Fas signaling mechanisms
64. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
65. HNCACB, a high-sensitivity 3D NMR experiment to correlate amide-proton and nitrogen resonances with the α-carbon and β-carbon resonances in proteins
66. 13C-labeled proteins via scalar couplings
67. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
68. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1