A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

Molecular Cell

Volumn 8, Issue 3, 2001, Pages 613-621

  Suzuki, Yasuyuki ^a   Imai, Yuzuru ^a   Nakayama, Hiroshi ^b   Takahashi, Kazuko ^a   Takio, Koji ^b   Takahashi, Ryosuke ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; CASPASE INHIBITOR; PROTEIN INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STIMULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; MITOCHONDRION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION;

EID: 0034785591     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00341-0     Document Type: Article

References (37)

1. An emerging blueprint for apoptosis in Drosophila
2. Structural and biochemical basis of apoptotic activation by Smac/DIABLO
3. IAP family proteins - Suppressors of apoptosis
4. X-linked IAP is a direct inhibitor of cell-death proteases
5. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
6. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
7. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
8. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
9. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
10. The protein disulphide-isomerase family: Unravelling a string of folds
11. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
12. Mitochondria and apoptosis
13. OPINIONXIAP, the guardian angel
14. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
15. Programmed cell death in animal development
16. Production and separation of peptides from proteins stained with Coomassie brilliant blue R-250 after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis
17. Caspase-independent programmed cell death with necrotic morphology
18. Mitochondrial control of cell death
19. Sequence analysis and regulation of the htrA gene of Escherichia coli: A sigma 32-independent mechanism of heat-inducible transcription
20. The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase
21. Studies on a new proteolytic enzyme from A chromobacter lyticus M497-1. I. Purification and some enzymatic properties
22. An exegesis of IAPs: Salvation and surprises from BIR motifs
23. The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity
24. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
25. Expression, purification, and functional analysis of the human serine protease HtrA2
26. Protease Do is essential for survival of Escherichia coli at high temperatures: Its identity with the htrA gene product
27. An alternative, nonapoptotic form of programmed cell death
28. A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein
29. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
30. NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP
31. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes
32. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
33. A single BIR domain of XIAP sufficient for inhibiting caspases
34. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
35. Apoptosis in the pathogenesis and treatment of disease
36. Caspases: Enemies within
37. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins