Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy

Circulation Research

Volumn 89, Issue 3, 2001, Pages 279-286

  Cesselli, Daniela ^a   Jakoniuk, Igor ^a   Barlucchi, Laura ^a   Beltrami, Antonio P ^a   Hintze, Thomas H ^a   Nadal Ginard, Bernardo ^a   Kajstura, Jan ^a   Leri, Annarosa ^a   Anversa, Piero ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Caspases; Heart failure; Oxidative stress response; p53 fragments; p66shc

Indexed keywords

3 NITROTYROSINE; CASPASE; CASPASE 9; CYTOCHROME C; PROTEIN P53; PROTEIN P66;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; CELL DEATH; CONTROLLED STUDY; DOG; ENZYME ACTIVATION; HEART DILATATION; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE FAILURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 0035800882     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1501.094115     Document Type: Article

References (42)

1. The cellular basis of pacing-induced dilated cardiomyopathy: Myocyte cell loss and myocyte cellular reactive hypertrophy
2. Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes
3. Apoptosis in myocytes in end-stage heart failure
4. Myocyte death in the failing human heart is gender dependent
5. Cardiac intracellular calcium release channels role in heart failure
6. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium
7. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
8. Oxidative stress in the human heart is associated with changes in the antioxidative defense as shown after heart transplantation
9. Age related changes in anti-oxidative enzymes in cardiomyopathic hamster hearts
10. Triggering and modulation of apoptosis by oxidative stress
11. shc adaptor protein controls oxidative stress response and life span in mammals
12. Oxidative DNA damage and mutagenesis
13. p53: DNA damage, DNA repair, and apoptosis
14. Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40 kDa and 35 kDa fragments competent for sequence-specific DNA binding
15. Induced N-, and C-terminal cleavage of p53: A core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53
16. Cytochrome c is released from mitochondria in a ROS-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death
17. Myocyte nuclear mitotic division and programmed cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs
18. Mechanisms of nitrate accumulation in plasma during pacing-induced heart failure in conscious dogs
19. Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice
20. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release
21. Myocardial cell death in human diabetes
22. Alterations in myocardial contractility in conscious dogs with dilated cardiomyopathy
23. Stretch induced programmed myocyte cell death
24. Caspase activation involves the formation of the aposome, a large (∼700 kDa) caspase-activating complex
25. An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
26. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
27. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
28. Inactivation of DNA-dependent protein kinase by protein kinase Cδ: Implication for apoptosis
29. Executioner caspase-3, -6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis
30. A novel transforming protein (SHC) with a SH2 domain is implicated in mitogenic signal transduction
31. shc splicing isoforms on the EGF receptor-MAP kinase-fos signaling pathway
32. Reactive oxygen species-induced molecular damage and its application in pathology
33. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis
34. Molecular cloning and characterization of human caspase-activated DNase
35. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes
36. The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase
37. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
38. Apoptosis and cardiomyopathy
39. Cellular basis of physiologic and pathologic myocardial growth
40. Congestive heart failure induces endothelial cell apoptosis: Protective role of carvedilol
41. Apoptosis: Basic mechanisms and implications for cardiovascular diseases
42. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis