Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 17, 2001, Pages 9977-9982

  Condorelli, Gianluigi ^a,f   Roncarati, Roberta ^a   Ross Jr , John ^b   Pisani, Angela ^a   Stassi, Giorgio ^e   Todaro, Matilde ^e   Trocha, Stephen ^g   Drusco, Alessandra ^a   Gu, Yusu ^b   Russo, Matteo A ^f   Frati, Giacomo ^a,f   Jones, Steven P ^g   Lefer, David J ^g   Napoli, Claudio ^c,d   Croce, Carlo M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF PALERMO   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; MYOSIN; PROTEIN BCL 2; PROTEIN BCL 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE OVEREXPRESSION; GENOTYPE; HEART FAILURE; HEART INFARCTION SIZE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPERFUSION INJURY; TRANSGENIC MOUSE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; DNA FRAGMENTATION; DNA, COMPLEMENTARY; ECHOCARDIOGRAPHY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MICE; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; ORGAN SPECIFICITY; PHENOTYPE; RECOMBINANT FUSION PROTEINS; VENTRICULAR DYSFUNCTION, LEFT;

ANIMALIA; MUS MUSCULUS;

EID: 0035859891     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.161120198     Document Type: Article

References (24)