Cellular function of phosphoinositide 3-Kinase: Implications for development, immunity, homeostasis, and cancer

Annual Review of Cell and Developmental Biology

Volumn 17, Issue , 2001, Pages 615-675

  Katso, R ^a   Okkenhaug, K ^a   Ahmadi, K ^a   White, S ^a   Timms, J ^a   Waterfield, M D ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

3 phosphoinositide; Development; Gene targeting; Insulin

Indexed keywords

CD28 ANTIGEN; GLUCOSE; INSULIN; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; STEM CELL FACTOR;

ANGIOGENESIS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPORT; CHEMOTAXIS; CONFERENCE PAPER; DIABETES MELLITUS; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FERTILITY; GENE AMPLIFICATION; GLUCOSE HOMEOSTASIS; HOMEOSTASIS; HUMAN; IMMUNITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEOSTASIS; HUMANS; IMMUNITY; ISOENZYMES; LIPID METABOLISM; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

MUS MUSCULUS;

EID: 0035190026     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.17.1.615     Document Type: Conference Paper

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183. Signalling networks that cause cancer
184. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
185. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
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203. A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration
204. NF-kappaB activation by tumour necrosis factor requires the Akt serine- threonine kinase
205. Role of protein kinase C zeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression
206. Vascular endothelial cells synthesize nitric oxide from L-arginine
207. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
208. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex
209. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
210. Requirement for B cell linker protein (BLNK) in B cell development
211. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
212. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
213. Phosphatidylinositol 3-kinase activity regulates alpha-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity
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215. Role of mesenchymal cell death in lung remodeling after injury
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219. Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma
220. Vascular endothelial growth factor upregulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells
221. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium
222. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
223. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
224. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
225. Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat
226. Role of endothelium-derived nitric oxide in the regulation of blood pressure
227. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
228. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
229. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
230. A function for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction
231. Phosphatidylinositol-3-OH kinase as a direct target of Ras
232. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
233. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
234. A novel physiological function for platelet-derived growth factor-BB in rat dermis
235. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
236. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
237. The Steel/W transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
238. cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3KC2 gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12
239. Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells
240. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
241. Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma
242. Function of PI3K gamma in thymocyte development, T cell activation, and neutrophil migration
243. PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin
244. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
245. Role of the beta3 integrin subunit in human primary melanoma progression: Multifunctional activities associated with alpha(v)beta3 integrin expression
246. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
247. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
248. Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of phosphatidylinositol (PI) 3-kinase and for c-kit- associated PI 3-kinase activity in COS-1 cells
249. A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis
250. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
251. Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae
252. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
253. PIK3CA is implicated as an oncogene in ovarian cancer
254. Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus
255. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle
256. Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes
257. Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
258. CDK inhibitors: Positive and negative regulators of G1-phase progression
259. The conserved phosphoinositide 3-kinase pathway determines heart size in mice
260. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
261. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
262. Regulation of the cdk inhibitor p27 and its deregulation in cancer
263. Role of nitric oxide synthesis in the regulation of coronary vascular tone in the isolated perfused rabbit heart
264. Role of alphav-beta3 integrin in the activation of vascular endothelial growth factor receptor-2
265. Transgene expression of Bcl-XL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells
266. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
267. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
268. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
269. A prospective study of postmenopausal estrogen therapy and coronary heart disease
270. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
271. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
272. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
273. The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism
274. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
275. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
276. Role of IRS-2 in insulin and cytokine signaling
277. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
278. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
279. Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt-1, and PI3-kinase -Akt dependent pathways in retinal vascular ells
280. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2
281. 2+ mobilization through distinct pathways
282. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
283. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
284. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
285. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
286. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
287. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
288. The role of phosphatidylinositol 3-kinase in vascular endothelial growth factor signaling
289. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
290. Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation
291. Signalling through the lipid products of phosphoinositide-3-OH kinase
292. Rho family GTPases bind to phosphoinositide kinases
293. Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal to stimulate DNA synthesis
294. Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax
295. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K- C2 alpha
296. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
297. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion
298. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit
299. The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs
300. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
301. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
302. Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin
303. The PI3K-PDK1 connection: More than just a road to PKB
304. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
305. Signaling by distinct classes of phosphoinositide 3-kinases
306. P110delta, a novel phosphoinositide 3-kinase in leukocytes
307. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies
308. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
309. An SH2 domain-containing 5′ inositolphosphatase inhibits insulin- induced GLUT4 translocation and growth factor-induced actin filament rearrangement
310. c-kit receptor signaling through its phosphatidylinositide-3′-kinase- binding site and protein kinase C: Role in mast cell enhancement of degranulation, adhesion, and membrane ruffling
311. Structural insights into phosphoinositide 3-kinase catalysis and signalling
312. Cell death by apoptosis during involution of the lactating breast in mice and rats
313. Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction
314. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors
315. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
316. Actin filaments participate in the relocalization of phosphatidylinositol3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes
317. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
318. PI 3-kinase: A pivotal pathway in T-cell activation?
319. Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation
320. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin
321. Akt/PKB localisation and 3′ phosphoinositide generation at sites
322. p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110
323. p21 (Waf1/Cip1) is an assembly factor required for platelet-derived growth factor-induced vascular smooth muscle cell proliferation
324. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
325. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
326. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase
327. Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: Possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase
328. Disruption of IRS-2 causes type 2 diabetes in mice
329. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
330. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor
331. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
332. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
333. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
334. Upstream mechanisms of glycogen synthase activation by insulin and insulin-like growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras
335. Vascular-specific growth factors and blood vessel formation
336. Regulation of the p85/p110 phosphatidylinositol 3′-kinase: Stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit
337. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
338. Substrate specificity of alpha(v)beta(3) integrin-mediated cell migration and phosphatidylinositol 3-kinase/AKT pathway activation
339. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
340. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway
341. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
342. Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: Relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway