Structure of bax: Coregulation of dimer formation and intracellular localization

Cell

Volumn 103, Issue 4, 2000, Pages 645-654

  Suzuki, Motoshi ^a   Youle, Richard J ^a   Tjandra, Nico ^b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MEMBRANE PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X;

APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; MITOCHONDRIAL MEMBRANE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

EID: 0033713002     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00167-7     Document Type: Article

References (41)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
3. 15N relaxation using inverse detected two-dimensional NMR spectroscopy: The central helix is flexible
4. Dynamics of proteintyrosine phosphatases in rat adipocytes
5. Solution structure of BID, an intracellular amplifier of apoptotic signaling
6. A robust method for determining the magnitude of the fully asymmetric alignment tensor of oriented macromolecules in the absence of structural information
7. Validation of protein structure from anisotropic carbonyl chemical shifts in a dilute liquid crystalline phase
8. Protein backbone angle restraints from searching a database for chemical shift and sequence homology
9. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
10. Regulated targeting of BAX to mitochondria
11. Mitochondria and apoptosis
12. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
13. BCL-2 family members and the mitochondria in apoptosis
14. 15N-enriched proteins
15. Refined solution structure and backbone dynamics of HIV-1 Nef
16. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions
17. Nonionic detergents induce dimerization among members of the Bcl-2 family
18. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
19. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
20. Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH
21. Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences
22. MOLMOL: A program for display and analysis of macromolecular structures
23. Sampling and efficiency of metric matrix distance geometry: A novel partial metrization algorithm
24. +-antiport
25. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
26. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
27. Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
28. Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists
29. BclxL regulates apoptosis by heterodimerization-dependent and -independent mechanisms
30. X-ray and NMR structure of human Bcl-X(L), an inhibitor of programmed cell death
31. Conformation of the Bax C-terminus regulates subcellular location and cell death
32. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
33. Bicelle-based liquid crystals for NMRmeasurement of dipolar couplings at acidic and basic pH values
34. Measurement of dipolar couplings for methylene and methyl sites in weakly oriented macromolecules and their use in structure determination
35. Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
36. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
37. Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium
38. BID: A novel BH3 domain-only death agonist
39. Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing
40. Movement of Bax from the cytosol to mitochondria during apoptosis