Apoptotic DNA fragmentation

Experimental Cell Research

Volumn 256, Issue 1, 2000, Pages 12-18

  Nagata, Shigekazu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Caspases; DNase; Programmed cell death

Indexed keywords

CASPASE; DNA FRAGMENT;

ANIMAL CELL; APOPTOSIS; DNA DAMAGE; DNA DEGRADATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SHORT SURVEY;

ANIMALIA;

EID: 0034630317     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4834     Document Type: Article

References (56)

1. Vaux D. L., Korsmeyer S. J. Cell death in development. Cell. 96:1999;245-254.
2. Jacobson M. D., Weil M., Raff M. C. Programmed cell death in animal development. Cell. 88:1997;347-354.
3. Wyllie A. H., Kerr J. F. R., Currie A. R. Cell death: The significance of apoptosis. Int. Rev. Cytol. 68:1980;251-306.
4. Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
5. Ashkenazi A., Dixit V. M. Death receptors: Signaling and modulation. Science. 281:1998;1305-1308.
6. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
7. Raff M. Cell suicide for beginners. Nature. 396:1998;119-122.
8. Green D. R., Reed J. C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
9. Thornberry N. A., Lazebnik Y. Caspases: Enemies within. Science. 281:1998;1312-1316.
10. Stroh C., Schulze-Osthoff K. Death by a thousand cuts: An ever-increasing list of caspase substrates. Cell Death Diff. 5:1998;997-1000.
11. Earnshaw W. C. Nuclear changes in apoptosis. Curr. Biol. 7:1995;337-343.
12. Gavrieli Y., Sherman Y., Ben-Sasson S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
13. Itoh N., Yonehara S., Ishii A., Yonehara M., Mizushima S., Sameshima M., Hase A., Seto Y., Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66:1991;233-243.
14. Suda T., Takahashi T., Golstein P., Nagata S. Molecular cloning and expression of the Fas ligand: A novel member of the tumor necrosis factor family. Cell. 75:1993;1169-1178.
15. Suda T., Okazaki T., Naito Y., Yokota T., Arai N., Ozaki S., Nakao K., Nagata S. Expression of the Fas ligand in T-cell-lineage. J. Immunol. 154:1995;3806-3813.
16. Griffith T. S., Brunner T., Fletcher S. M., Green D. R., Ferguson T. A. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 270:1995;1189-1192.
17. Bellgrau D., Gold D., Selawry H., Moore J., Franzusoff A., Duke R. C. A role for CD95 ligand in preventing graft rejection. Nature. 377:1995;630-632.
18. Nagata S., Golstein P. The Fas death factor. Science. 267:1995;1449-1456.
19. Schulze-Osthoff K., Walczak H., Droge W., Krammer P. H. Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127:1994;15-20.
20. Nagata S. Biddable death. Nat. Cell Biolog. 1:1999;E143-E145.
21. Gross A., Yin X. M., Wang K., Wei M. C., Jockel J., Milliman C., Erdjument B. H., Tempst P., Korsmeyer S. J. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274:1999;1156-1163.
22. Li H., Zhu H., Xu C. J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:1998;491-501.
23. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 94:1998;481-490.
24. Woo M., Hakem A., Elia A. J., Hakem R., Duncan G. S., Patterson B. J., Mak T. W. In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. J. Immunol. 163:1999;4909-4916.
25. Enari M., Hase A., Nagata S. Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J. 14:1995;5201-5208.
26. Martin S. J., Newmeyer D. D., Mathias S., Farschon D. M., Wang H.-G., Reed J. C., Kolesnik R. N., Green D. R. Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis. EMBO J. 14:1995;5191-5200.
27. Chow S. C., Weis M., Kass G. E. N., Holmstrom T. H., Eriksson J. E., Orrenius S. Involvement of multiple proteases during Fas-mediated apoptosis in T lymphocytes. FEBS Lett. 364:1995;134-138.
28. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature. 391:1998;43-50.
29. Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
30. Halenbeck R., MacDonald H., Roulston A., Chen T. T., Conroy L., Williams L. T. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45. Curr. Biol. 8:1998;537-540.
31. Mukae N., Enari M., Sakahira H., Fukuda Y., Inazawa J., Toh H., Nagata S. Molecular cloning and characterization of human caspase-activated DNase. Proc. Natl. Acad. Sci. USA. 95:1998;9123-9128.
32. Liu X., Li P., Widlak P., Zou H., Luo X., Garrard W. T., Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. USA. 95:1998;8461-8466.
33. Sakahira H., Iwamatsu A., Nagata S. Specific Chaperone-like Activity of Inhibitor of Caspase-activated DNase for Caspase-activated DNase. J. Biol. Chem. 2000.
34. Kawane K., Fukuyama H., Adachi M., Sakahira H., Copeland N. G., Gilbert D. J., Jenkins N. A., Nagata S. Structure and promoter analysis of murine CAD and ICAD genes. Cell Death Differ. 6:1999;745-752.
35. Sabol S. L., Li R., Lee T. Y., Abdul-Khalek R. Inhibition of apoptosis-associated DNA fragmentation activity in nonapoptotic cells: The role of DNA fragmentation factor-45 (DFF45/ICAD). Biochem. Biophys. Res. Commun. 253:1998;151-158.
36. Gu J., Dong R. P., Zhang C., McLaughlin D. F., Wu M. X., Schlossman S. F. Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40. J. Biol. Chem. 274:1999;20759-20762.
37. Inohara N., Koseki T., Chen S., Wu X., Nunez G. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17:1998;2526-2533.
38. Lugovskoy A., Zhou P., Chou J., McCarty J., Li P., Wagner G. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interaction in the DNA fragmentation pathway of apoptosis. Cell. 99:1999;747-755.
39. Sakahira H., Enari M., Nagata S. Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L and ICAD-S. J. Biol. Chem. 274:1999;15740-15744.
40. McIlroy D., Sakahira H., Talanian R. V., Nagata S. Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli. Oncogene. 18:1999;4401-4408.
41. Wolf B. B., Schuler M., Echeverri F., Green D. R. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation. J. Biol. Chem. 274:1999;30651-30656.
42. Sakahira H., Enari M., Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:1998;96-99.
43. McCarty J. S., Toh S. Y., Li P. Multiple domains of DFF45 bind synergistically to DFF40: Roles of caspase cleavage and sequestration of activator domain of DFF40. Biochem. Biophys. Res. Commun. 264:1999;181-185.
44. Hartl F. U. Molecular chaperones in cellular protein folding. Nature. 381:1996;571-579.
45. Liu X., Zou H., Widlak P., Garrard W., Wang X. Activation of the apoptotic endonuclease DFF40 (caspase-activated DNase or nuclease). Oligomerization and direct interaction with histone H1. J. Biol. Chem. 274:1999;13836-13840.
46. Zhang J., Liu X., Scherer D. C., van Kaer L., Wang X., Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. USA. 95:1998;12480-12485.
47. Woo M., Hakem R., Soengas M. S., Duncan G. S., Shahinian A., Kagi D., Hakem A., McCrrach M., Khoo W., Kaufman S. A., Senaldi G., Howard T., Lowe S. W., Mak T. W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 12:1998;806-819.
48. Zheng T. S., Schlosser S. F., Dao T., Hingorani R., Crispe I. N., Boyer J. L., Flavell R. A. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc. Natl. Acad. Sci. USA. 95:1998;13618-13623.
49. Oberhammer F., Wilson J. W., Dive C., Morris I. D., Hickman J. A., Wakeling A. E., Walker P. R., Sikorska M. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:1993;3679-3684.
50. Lagarkova M. A., Iarovaia O. V., Razin S. V. Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers. J. Biol. Chem. 270:1995;20239-20241.
51. Susin S. A., Lorenzo H. K., Zamzami N., Marzo I., Snow B. E., Brothers G. M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D. R., Aebersold R., Siderovski D. P., Penninger J. M., Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397:1999;441-446.
52. Sakahira H., Enari M., Ohsawa Y., Uchiyama Y., Nagata S. Apoptotic nuclear morphological change without DNA fragmentation. Curr. Biol. 9:1999;543-546.
53. Sahara S., Aoto M., Eguchi Y., Imamoto N., Yoneda Y., Tsujimoto Y. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature. 401:1999;168-173.
54. Zhang J., Wang X., Bove K., Xu M. DNA fragmentation factor 45-deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J. Biol. Chem. 274:1999;37450-37454.
55. Holmgren L., Szeles A., Rajnavolgyi E., Folkman J., Klein G., Ernberg I., Falk K. I. Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood. 93:1999;3956-3963.
56. Yokoyama H., Mukae N., Sakahira H., Okawa K., Iwamatsu A., Nagata S. A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster. J. Biol. Chem. 2000.