The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

Molecular Cell

Volumn 3, Issue 3, 1999, Pages 287-296

  Puthalakath, Hamsa ^a   Huang, David C S ^a   O'Reilly, Lorraine A ^a   King, Stephen M ^b   Strasser, Andreas ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYTOPLASM PROTEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; CELL STRAIN MCF 7; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYBRID CELL; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; YEAST CELL;

EID: 0033104996     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80456-6     Document Type: Article

References (47)

1. Adams, J.M., and Cory, S. (1998). The Bcl-2 protein family: Arbiters of cell survival. Science 281, 1322-1326.
2. Benashski, S.E., Harrison, A., Patel-King, R.S., and King, S.M. (1997). Dimerization of the highly conserved light chain shared by dynein and myosin V. J. Biol. Chem. 272, 20929-20935.
3. Chien, C.T., Bartel, P.L., Sternglanz, R., and Fields, S. (1991). The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest. Proc. Natl. Acad. Sci. USA 88, 9578-9582.
4. Chinnaiyan, A.M., O'Rourke, K., Lane, B.R., and Dixit, V.M. (1997). Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science 275, 1122-1126.
5. Conradt, B., and Horvitz, H.R. (1998). The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529.
6. Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M.E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
7. Del Peso, L., González-Garcia, M., Page, C., Herrera, R., and Nuñez, G. (1997). Interleukin-3-induced phosphorylation of BAD through the protein kinase akt. Science 278, 687-689.
8. Duttweiler, H.M. (1996). A highly sensitive and non-lethal β-galactosidase plate assay for yeast. Trends Genet. 12, 340-341.
9. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998). A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50.
10. Gietz, R.D., and Woods, R.A. (1994). High efficiency transformation with lithium acetate. In Molecular Genetics of Yeast: A Practical Approach, J.R. Johnston, ed. (Oxford: IRL Press), pp. 121-134.
11. Grussenmeyer, T., Scheidtmann, K.H., Hutchinson, M.A., Eckhart, W., and Walter, G. (1985). Complexes of polyoma virus medium T antigen and cellular proteins. Proc. Natl. Acad. Sci. USA 82, 7952-7954.
12. Hagenbüchle, O., and Wellauer, P.K. (1992). A rapid method for the isolation of DNA-binding proteins from purified nuclei of tissues and cells in culture. Nucleic Acids Res. 20, 3555-3559.
13. Hengartner, M.O. (1998). Death cycle and Swiss army knives. Nature 391, 441-442.
14. Hengartner, M.O., and Horvitz, H.R. (1994). C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76, 665-676.
15. Hirokawa, N. (1998). Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526.
16. Hsu, S.Y., Lin, P., and Hsueh, A.J.W. (1998). BOD (bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic bcl-2 protein capable of dimerization with diverse antiapoptotic bcl-2 members. Mol. Endocrinol. 12, 1432-1440.
17. Huang, D.C.S., Cory, S., and Strasser, A. (1997). Bcl-2, bcl-xl and adenovirus protein e1b19kd are functionally equivalent in their ability to inhibit cell death. Oncogene 14, 405-414.
18. Jaffrey, S.R., and Snyder, S.H. (1996). PIN: An associated protein inhibitor of neuronal nitric oxide synthase. Science 274, 774-777.
19. King, S.M., Barbarese, E., Dillman, J.F., III, Patel-King, R.S., Carson, J.H., and Pfister, K.K. (1996). Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved M, 8,000 light chain. J. Biol. Chem. 271, 19358-19366.
20. Li, H., Zhu, H., Xu, C.-J., and Yuan, J. (1998). Cleavage of BID by caspase 8 mediates the mitochondrial damage in the fas pathway of apoptosis. Cell 94, 491-501.
21. Liu, X., Zou, H., Slaughter, C., and Wang, X. (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175-184.
22. Luo, X., Budlhardjo, I., Zou, H., Slaughter, C., and Wang, X. (1998). Bid, a bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481-490.
23. Martin, D.A., Siegel, R.M., Zheng, L., and Lenardo, M.J. (1998). Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHα1) death signal. J. Biol. Chem. 273, 4345-4349.
24. Muzio, M., Stockwell, B.R., Stennicke, H.R., Salvesen, G.S., and Dixit, V.M. (1998). An induced proximity model for caspase-8 activation. J. Biol. Chem. 273, 2926-2930.
25. O'Connor, L., Strasser, A., O'Reilly, L.A., Hausmann, G., Adams, J.M., Cory, S., and Huang, D.C.S. (1998). Bim - A novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 17, 384-395.
26. O'Reilly, L.A., Cullen, L., Moriishi, K., O'Connor, L., Huang, D.C.S., and Strasser, A. (1998). A rapid hybridoma screening method for the identification of monoclonal antibodies to low abundant cytoplasmic proteins. Biotechniques 25, 824-830.
27. Oltvai, Z.N., and Korsmeyer, S.J. (1994). Checkpoints of dueling dimers foil death wishes. Cell 79, 189-192.
28. Pezzella, F., Tse, A.G.D., Cordell, J.L., Pulford, K.A.F., Gatter, K.C., and Mason, D.Y. (1990). Expression of the Bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am. J. Pathol. 137, 225-232.
29. Ruoslahti, E., and Reed, J.C. (1994). Anchorage dependence, integrins, and apoptosis. Cell 77, 477-478.
30. Seshagiri, S., and Miller, L.K. (1997). Caenorhabditis elegans ced-4 stimulates ced-3 processing and ced-3-induced apoptosis. Curr. Biol. 7, 455-460.
31. Shaham, S., and Horvitz, H.R. (1996). Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. Genes Dev. 10, 578-591.
32. Solomon, F. (1986). Direct identification of microtubule-associated proteins by selective extraction of cultured cells. Methods Enzymol. 134, 139-147.
33. Spector, M.S., Desnoyers, S., Hoeppner, D.J., and Hengartner, M.O. (1997). Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385, 653-656.
34. Srinivasula, S.M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E.S. (1998). Autoactivation of procaspase-9 by apaf-1-mediated oligomerization. Mol. Cell 1, 949-957.
35. Strasser, A., Harris, A.W., Huang, D.C.S., Krammer, P.H., and Cory, S. (1995). Bcl-2 and fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14, 6136-6147.
36. Tatu, U., Hammond, C., and Helenius, A. (1995). Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment. EMBO J. 14, 1340-1348.
37. Thornberry, N.A., and Lazebnik, Y. (1998). Caspases: Enemies within. Science 281, 1312-1316.
38. Vanhaesebroeck, B., Reed, J.C., de Valck, D., Grooten, J., Miyashita, T., Tanaka, S., Beyaert, R., van Roy, F., and Fiers, W. (1993). Effect of Bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene 8, 1075-1081.
39. Vaux, D.L., and Strasser, A. (1996). The molecular biology of apoptosis. Proc. Natl. Acad. Sci. USA 93, 2239-2244.
40. Vaux, D.L., Weissman, I.L., and Kim, S.K. (1992). Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 258, 1955-1957.
41. Vidal, M., Brachmann, R.K., Fattaey, A., Harlow, E., and Boeke, J.D. (1996). Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc. Natl. Acad. Sci. USA 93, 10315-10320.
42. Wach, A., Pick, H., and Phillipsen, P. (1994). Procedures for isolating yeast DNA for different purposes. In Molecular Genetics of Yeast: A Practical Approach, J.R. Johnston, ed. (Oxford: IRL Press), pp. 1-16.
43. Wang, K., Yin, X.-M., Chao, D.T., Milliman, C.L., and Korsmeyer, S.J. (1996). BID: A novel BH3 domain-only death agonist. Genes Dev. 10, 2859-2869.
44. Wu, D., Wallen, H.D., and Nuñez, G. (1997). Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275, 1126-1129.
45. Yang, X., Chang, H.Y., and Baltimore, D. (1998). Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281, 1355-1357.
46. l. Cell 87, 619-628.
47. Zou, H., Henzel, W.J., Liu, X., Lutschg, A., and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-41 3.