메뉴 건너뛰기




Volumn , Issue , 2011, Pages 63-105

Genetics of Lupus in Mice

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84859412811     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374994-9.10004-X     Document Type: Chapter
Times cited : (7)

References (420)
  • 2
    • 67849099131 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Moser K.L., Kelly J.A., Lessard C.J., Harley J.B. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009, 10:373-379.
    • (2009) Genes Immun , vol.10 , pp. 373-379
    • Moser, K.L.1    Kelly, J.A.2    Lessard, C.J.3    Harley, J.B.4
  • 3
    • 0022273898 scopus 로고
    • Murine models of systemic lupus erythematosus
    • Theofilopoulos A.N., Dixon F.J. Murine models of systemic lupus erythematosus. Adv Immunol 1985, 37:269-390.
    • (1985) Adv Immunol , vol.37 , pp. 269-390
    • Theofilopoulos, A.N.1    Dixon, F.J.2
  • 4
    • 0000397436 scopus 로고    scopus 로고
    • Murine lupus models: gene-specific and genome-wide studies
    • Academic Press, San Diego, R.G. Lahita (Ed.)
    • Theofilopoulos A.N., Kono D.H. Murine lupus models: gene-specific and genome-wide studies. Systemic Lupus Erythematosus 1999, 145-181. Academic Press, San Diego. R.G. Lahita (Ed.).
    • (1999) Systemic Lupus Erythematosus , pp. 145-181
    • Theofilopoulos, A.N.1    Kono, D.H.2
  • 5
    • 13844297168 scopus 로고    scopus 로고
    • Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice
    • Mountz J.D., Yang P., Wu Q., Zhou J., Tousson A., Fitzgerald A., et al. Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice. Scand J Immunol 2005, 61:128-138.
    • (2005) Scand J Immunol , vol.61 , pp. 128-138
    • Mountz, J.D.1    Yang, P.2    Wu, Q.3    Zhou, J.4    Tousson, A.5    Fitzgerald, A.6
  • 6
    • 0031570375 scopus 로고    scopus 로고
    • Functional dissection of systemic lupus erythematosus using congenic mouse strains
    • Morel L., Mohan C., Yu Y., Croker B.P., Tian N., Deng A., et al. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J Immunol 1997, 158:6019-6028.
    • (1997) J Immunol , vol.158 , pp. 6019-6028
    • Morel, L.1    Mohan, C.2    Yu, Y.3    Croker, B.P.4    Tian, N.5    Deng, A.6
  • 7
    • 0031179651 scopus 로고    scopus 로고
    • Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity
    • Mohan C., Morel L., Yang P., Wakeland E.K. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 1997, 159:454-465.
    • (1997) J Immunol , vol.159 , pp. 454-465
    • Mohan, C.1    Morel, L.2    Yang, P.3    Wakeland, E.K.4
  • 8
    • 0032520923 scopus 로고    scopus 로고
    • Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes
    • Mohan C., Alas E., Morel L., Yang P., Wakeland E.K. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. J Clin Invest 1998, 101:1362-1372.
    • (1998) J Clin Invest , vol.101 , pp. 1362-1372
    • Mohan, C.1    Alas, E.2    Morel, L.3    Yang, P.4    Wakeland, E.K.5
  • 9
    • 0033151971 scopus 로고    scopus 로고
    • Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death
    • Mohan C., Yu Y., Morel L., Yang P., Wakeland E.K. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol 1999, 162:6492-6502.
    • (1999) J Immunol , vol.162 , pp. 6492-6502
    • Mohan, C.1    Yu, Y.2    Morel, L.3    Yang, P.4    Wakeland, E.K.5
  • 10
    • 0035852650 scopus 로고    scopus 로고
    • The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
    • Morel L., Blenman K.R., Croker B.P., Wakeland E.K. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci USA 2001, 98:1787-1792.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1787-1792
    • Morel, L.1    Blenman, K.R.2    Croker, B.P.3    Wakeland, E.K.4
  • 11
    • 0034814052 scopus 로고    scopus 로고
    • Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus
    • Rozzo S.J., Allard J.D., Choubey D., Vyse T.J., Izui S., Peltz G., et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001, 15:435-443.
    • (2001) Immunity , vol.15 , pp. 435-443
    • Rozzo, S.J.1    Allard, J.D.2    Choubey, D.3    Vyse, T.J.4    Izui, S.5    Peltz, G.6
  • 12
    • 0042090547 scopus 로고    scopus 로고
    • Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation
    • Wither J.E., Lajoie G., Heinrichs S., Cai Y.C., Chang N., Ciofani A., et al. Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation. J Immunol 2003, 171:1697-1706.
    • (2003) J Immunol , vol.171 , pp. 1697-1706
    • Wither, J.E.1    Lajoie, G.2    Heinrichs, S.3    Cai, Y.C.4    Chang, N.5    Ciofani, A.6
  • 13
    • 0141955062 scopus 로고    scopus 로고
    • The Sgp3 locus on mouse chromosome 13 regulates nephritogenic gp70 autoantigen expression and predisposes to autoimmunity
    • Laporte C., Ballester B., Mary C., Izui S., Reininger L. The Sgp3 locus on mouse chromosome 13 regulates nephritogenic gp70 autoantigen expression and predisposes to autoimmunity. J Immunol 2003, 171:3872-3877.
    • (2003) J Immunol , vol.171 , pp. 3872-3877
    • Laporte, C.1    Ballester, B.2    Mary, C.3    Izui, S.4    Reininger, L.5
  • 14
    • 1342282319 scopus 로고    scopus 로고
    • The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression
    • Kong P.L., Morel L., Croker B.P., Craft J. The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. J Immunol 2004, 172:2785-2794.
    • (2004) J Immunol , vol.172 , pp. 2785-2794
    • Kong, P.L.1    Morel, L.2    Croker, B.P.3    Craft, J.4
  • 15
    • 10344252778 scopus 로고    scopus 로고
    • Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus
    • Wandstrat A.E., Nguyen C., Limaye N., Chan A.Y., Subramanian S., Tian X.H., et al. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity 2004, 21:769-780.
    • (2004) Immunity , vol.21 , pp. 769-780
    • Wandstrat, A.E.1    Nguyen, C.2    Limaye, N.3    Chan, A.Y.4    Subramanian, S.5    Tian, X.H.6
  • 16
    • 4644328058 scopus 로고    scopus 로고
    • Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease
    • Haywood M.E., Rogers N.J., Rose S.J., Boyle J., McDermott A., Rankin J.M., et al. Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. J Immunol 2004, 173:4277-4285.
    • (2004) J Immunol , vol.173 , pp. 4277-4285
    • Haywood, M.E.1    Rogers, N.J.2    Rose, S.J.3    Boyle, J.4    McDermott, A.5    Rankin, J.M.6
  • 17
    • 1642540587 scopus 로고    scopus 로고
    • Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    • Waters S.T., McDuffie M., Bagavant H., Deshmukh U.S., Gaskin F., Jiang C., et al. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med 2004, 199:255-264.
    • (2004) J Exp Med , vol.199 , pp. 255-264
    • Waters, S.T.1    McDuffie, M.2    Bagavant, H.3    Deshmukh, U.S.4    Gaskin, F.5    Jiang, C.6
  • 19
    • 25444443628 scopus 로고    scopus 로고
    • Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval
    • Wither J.E., Loh C., Lajoie G., Heinrichs S., Cai Y.C., Bonventi G., et al. Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval. J Immunol 2005, 175:4309-4319.
    • (2005) J Immunol , vol.175 , pp. 4309-4319
    • Wither, J.E.1    Loh, C.2    Lajoie, G.3    Heinrichs, S.4    Cai, Y.C.5    Bonventi, G.6
  • 20
    • 23244460929 scopus 로고    scopus 로고
    • Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb
    • Subramanian S., Yim Y.S., Liu K., Tus K., Zhou X.J., Wakeland E.K. Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb. J Immunol 2005, 175:1062-1072.
    • (2005) J Immunol , vol.175 , pp. 1062-1072
    • Subramanian, S.1    Yim, Y.S.2    Liu, K.3    Tus, K.4    Zhou, X.J.5    Wakeland, E.K.6
  • 21
    • 19944427970 scopus 로고    scopus 로고
    • Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis
    • Kikuchi S., Fossati-Jimack L., Moll T., Amano H., Amano E., Ida A., et al. Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 2005, 174:1111-1117.
    • (2005) J Immunol , vol.174 , pp. 1111-1117
    • Kikuchi, S.1    Fossati-Jimack, L.2    Moll, T.3    Amano, H.4    Amano, E.5    Ida, A.6
  • 23
    • 36949001130 scopus 로고    scopus 로고
    • Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis
    • Liu K., Li Q.Z., Yu Y., Liang C., Subramanian S., Zeng Z., et al. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes Immun 2007, 8:634-645.
    • (2007) Genes Immun , vol.8 , pp. 634-645
    • Liu, K.1    Li, Q.Z.2    Yu, Y.3    Liang, C.4    Subramanian, S.5    Zeng, Z.6
  • 24
    • 33846906478 scopus 로고    scopus 로고
    • Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice
    • Carlucci F., Cortes-Hernandez J., Fossati-Jimack L., Bygrave A.E., Walport M.J., Vyse T.J., et al. Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice. J Immunol 2007, 178:2352-2360.
    • (2007) J Immunol , vol.178 , pp. 2352-2360
    • Carlucci, F.1    Cortes-Hernandez, J.2    Fossati-Jimack, L.3    Bygrave, A.E.4    Walport, M.J.5    Vyse, T.J.6
  • 25
    • 33846477488 scopus 로고    scopus 로고
    • Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in b6 mice with an introgressed new zealand black chromosome 4 interval
    • Loh C., Cai Y.C., Bonventi G., Lajoie G., Macleod R., Wither J.E. Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in b6 mice with an introgressed new zealand black chromosome 4 interval. J Immunol 2007, 178:1608-1617.
    • (2007) J Immunol , vol.178 , pp. 1608-1617
    • Loh, C.1    Cai, Y.C.2    Bonventi, G.3    Lajoie, G.4    Macleod, R.5    Wither, J.E.6
  • 26
    • 84863986924 scopus 로고    scopus 로고
    • Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ
    • Ichii O., Konno A., Sasaki N., Endoh D., Hashimoto Y., Kon Y. Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ. Histol Histopathol 2008, 23:411-422.
    • (2008) Histol Histopathol , vol.23 , pp. 411-422
    • Ichii, O.1    Konno, A.2    Sasaki, N.3    Endoh, D.4    Hashimoto, Y.5    Kon, Y.6
  • 27
    • 44849087072 scopus 로고    scopus 로고
    • A lupus-suppressor BALB/c locus restricts IgG2 autoantibodies without altering intrinsic B cell-tolerance mechanisms
    • Tarasenko T., Kole H.K., Bolland S. A lupus-suppressor BALB/c locus restricts IgG2 autoantibodies without altering intrinsic B cell-tolerance mechanisms. J Immunol 2008, 180:3807-3814.
    • (2008) J Immunol , vol.180 , pp. 3807-3814
    • Tarasenko, T.1    Kole, H.K.2    Bolland, S.3
  • 28
    • 59149087296 scopus 로고    scopus 로고
    • A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice
    • Heidari Y., Fossati-Jimack L., Carlucci F., Walport M.J., Cook H.T., Botto M. A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Genes Immun 2009, 10:47-55.
    • (2009) Genes Immun , vol.10 , pp. 47-55
    • Heidari, Y.1    Fossati-Jimack, L.2    Carlucci, F.3    Walport, M.J.4    Cook, H.T.5    Botto, M.6
  • 29
    • 19344369383 scopus 로고    scopus 로고
    • Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice
    • Bygrave A.E., Rose K.L., Cortes-Hernandez J., Warren J., Rigby R.J., Cook H.T., et al. Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice. PLoS Biol. 2004, 2:E243.
    • (2004) PLoS Biol. , vol.2
    • Bygrave, A.E.1    Rose, K.L.2    Cortes-Hernandez, J.3    Warren, J.4    Rigby, R.J.5    Cook, H.T.6
  • 30
    • 2542580839 scopus 로고    scopus 로고
    • Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
    • Gillmore J.D., Hutchinson W.L., Herbert J., Bybee A., Mitchell D.A., Hasserjian R.P., et al. Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?. Immunology 2004, 112:255-264.
    • (2004) Immunology , vol.112 , pp. 255-264
    • Gillmore, J.D.1    Hutchinson, W.L.2    Herbert, J.3    Bybee, A.4    Mitchell, D.A.5    Hasserjian, R.P.6
  • 31
    • 33750308551 scopus 로고    scopus 로고
    • Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus
    • Heidari Y., Bygrave A.E., Rigby R.J., Rose K.L., Walport M.J., Cook H.T., et al. Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus. Genes Immun 2006, 7:592-599.
    • (2006) Genes Immun , vol.7 , pp. 592-599
    • Heidari, Y.1    Bygrave, A.E.2    Rigby, R.J.3    Rose, K.L.4    Walport, M.J.5    Cook, H.T.6
  • 33
    • 7344261878 scopus 로고    scopus 로고
    • Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE)
    • Fujimura T., Hirose S., Jiang Y., Kodera S., Ohmuro H., Zhang D., et al. Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE). Int Immunol 1998, 10:1467-1472.
    • (1998) Int Immunol , vol.10 , pp. 1467-1472
    • Fujimura, T.1    Hirose, S.2    Jiang, Y.3    Kodera, S.4    Ohmuro, H.5    Zhang, D.6
  • 34
    • 0030584791 scopus 로고    scopus 로고
    • Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3'-untranslated region in the genetic predisposition to lupus-like autoimmune disease
    • Jacob C.O., Lee S.K., Strassmann G. Mutational analysis of TNF-alpha gene reveals a regulatory role for the 3'-untranslated region in the genetic predisposition to lupus-like autoimmune disease. J Immunol 1996, 156:3043-3050.
    • (1996) J Immunol , vol.156 , pp. 3043-3050
    • Jacob, C.O.1    Lee, S.K.2    Strassmann, G.3
  • 35
    • 0033990632 scopus 로고    scopus 로고
    • The role of complement in B cell activation and tolerance
    • Carroll M.C. The role of complement in B cell activation and tolerance. Adv Immunol 2000, 74:61-88.
    • (2000) Adv Immunol , vol.74 , pp. 61-88
    • Carroll, M.C.1
  • 36
    • 0037154253 scopus 로고    scopus 로고
    • Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
    • Zhang Y., Schlossman S.F., Edwards R.A., Ou C.N., Gu J., Wu M.X. Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. Proc Natl Acad Sci USA 2002, 99:878-883.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 878-883
    • Zhang, Y.1    Schlossman, S.F.2    Edwards, R.A.3    Ou, C.N.4    Gu, J.5    Wu, M.X.6
  • 37
    • 0033180576 scopus 로고    scopus 로고
    • Epistatic modifiers of autoimmunity in a murine model of lupus nephritis
    • Morel L., Tian X.H., Croker B.P., Wakeland E.K. Epistatic modifiers of autoimmunity in a murine model of lupus nephritis. Immunity 1999, 11:131-139.
    • (1999) Immunity , vol.11 , pp. 131-139
    • Morel, L.1    Tian, X.H.2    Croker, B.P.3    Wakeland, E.K.4
  • 38
    • 0034665505 scopus 로고    scopus 로고
    • Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice
    • Mary C., Laporte C., Parzy D., Santiago M.L., Stefani F., Lajaunias F., et al. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol 2000, 165:2987-2996.
    • (2000) J Immunol , vol.165 , pp. 2987-2996
    • Mary, C.1    Laporte, C.2    Parzy, D.3    Santiago, M.L.4    Stefani, F.5    Lajaunias, F.6
  • 39
    • 0036681622 scopus 로고    scopus 로고
    • C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis
    • Miura-Shimura Y., Nakamura K., Ohtsuji M., Tomita H., Jiang Y., Abe M., et al. C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis. J Immunol 2002, 169:1334-1339.
    • (2002) J Immunol , vol.169 , pp. 1334-1339
    • Miura-Shimura, Y.1    Nakamura, K.2    Ohtsuji, M.3    Tomita, H.4    Jiang, Y.5    Abe, M.6
  • 41
    • 33644798445 scopus 로고    scopus 로고
    • The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products
    • Elliott J.I., McVey J.H., Higgins C.F. The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Arthritis Res Ther 2005, 7:R468-475.
    • (2005) Arthritis Res Ther , vol.7
    • Elliott, J.I.1    McVey, J.H.2    Higgins, C.F.3
  • 42
    • 0035709440 scopus 로고    scopus 로고
    • Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype
    • Jiang Y., Ohtsuji M., Abe M., Li N., Xiu Y., Wen S., et al. Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype. Immunogenetics 2001, 53:810-813.
    • (2001) Immunogenetics , vol.53 , pp. 810-813
    • Jiang, Y.1    Ohtsuji, M.2    Abe, M.3    Li, N.4    Xiu, Y.5    Wen, S.6
  • 43
    • 61449261856 scopus 로고    scopus 로고
    • A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells
    • Rogers N.J., Lees M.J., Gabriel L., Maniati E., Rose S.J., Potter P.K., et al. A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. J Immunol 2009, 182:1982-1990.
    • (2009) J Immunol , vol.182 , pp. 1982-1990
    • Rogers, N.J.1    Lees, M.J.2    Gabriel, L.3    Maniati, E.4    Rose, S.J.5    Potter, P.K.6
  • 44
    • 2942620983 scopus 로고    scopus 로고
    • Illuminating autoimmune regulators through controlled variation of the mouse genome sequence
    • Vinuesa C.G., Goodnow C.C. Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. Immunity 2004, 20:669-679.
    • (2004) Immunity , vol.20 , pp. 669-679
    • Vinuesa, C.G.1    Goodnow, C.C.2
  • 45
    • 0028784215 scopus 로고
    • Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    • Hibbs M.L., Tarlinton D.M., Armes J., Grail D., Hodgson G., Maglitto R., et al. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 1995, 83:301-311.
    • (1995) Cell , vol.83 , pp. 301-311
    • Hibbs, M.L.1    Tarlinton, D.M.2    Armes, J.3    Grail, D.4    Hodgson, G.5    Maglitto, R.6
  • 46
    • 0028806216 scopus 로고
    • Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
    • Nishizumi H., Taniuchi I., Yamanashi Y., Kitamura D., Ilic D., Mori S., et al. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity 1995, 3:549-560.
    • (1995) Immunity , vol.3 , pp. 549-560
    • Nishizumi, H.1    Taniuchi, I.2    Yamanashi, Y.3    Kitamura, D.4    Ilic, D.5    Mori, S.6
  • 48
    • 0032055828 scopus 로고    scopus 로고
    • Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    • Cornall R.J., Cyster J.G., Hibbs M.L., Dunn A.R., Otipoby K.L., Clark E.A., et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 1998, 8:497-508.
    • (1998) Immunity , vol.8 , pp. 497-508
    • Cornall, R.J.1    Cyster, J.G.2    Hibbs, M.L.3    Dunn, A.R.4    Otipoby, K.L.5    Clark, E.A.6
  • 49
    • 0030901968 scopus 로고    scopus 로고
    • The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
    • Tedder T.F., Inaoki M., Sato S. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 1997, 6:107-118.
    • (1997) Immunity , vol.6 , pp. 107-118
    • Tedder, T.F.1    Inaoki, M.2    Sato, S.3
  • 50
    • 0033695963 scopus 로고    scopus 로고
    • Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis
    • Bolland S., Ravetch J.V. Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis. Immunity 2000, 13:277-285.
    • (2000) Immunity , vol.13 , pp. 277-285
    • Bolland, S.1    Ravetch, J.V.2
  • 52
    • 27144446783 scopus 로고    scopus 로고
    • Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment
    • Kumanogoh A., Shikina T., Watanabe C., Takegahara N., Suzuki K., Yamamoto M., et al. Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Int Immunol 2005, 17:1277-1282.
    • (2005) Int Immunol , vol.17 , pp. 1277-1282
    • Kumanogoh, A.1    Shikina, T.2    Watanabe, C.3    Takegahara, N.4    Suzuki, K.5    Yamamoto, M.6
  • 53
    • 28844498739 scopus 로고    scopus 로고
    • The juxtamembrane wedge negatively regulates CD45 function in B cells
    • Hermiston M.L., Tan A.L., Gupta V.A., Majeti R., Weiss A. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 2005, 23:635-647.
    • (2005) Immunity , vol.23 , pp. 635-647
    • Hermiston, M.L.1    Tan, A.L.2    Gupta, V.A.3    Majeti, R.4    Weiss, A.5
  • 54
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay F., Woodcock S.A., Lawton P., Ambrose C., Baetscher M., Schneider P., et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999, 190:1697-1710.
    • (1999) J Exp Med , vol.190 , pp. 1697-1710
    • Mackay, F.1    Woodcock, S.A.2    Lawton, P.3    Ambrose, C.4    Baetscher, M.5    Schneider, P.6
  • 56
    • 17344380531 scopus 로고    scopus 로고
    • TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
    • Gross J.A., Johnston J., Mudri S., Enselman R., Dillon S.R., Madden K., et al. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000, 404:995-999.
    • (2000) Nature , vol.404 , pp. 995-999
    • Gross, J.A.1    Johnston, J.2    Mudri, S.3    Enselman, R.4    Dillon, S.R.5    Madden, K.6
  • 59
    • 0036134879 scopus 로고    scopus 로고
    • Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease
    • Higuchi T., Aiba Y., Nomura T., Matsuda J., Mochida K., Suzuki M., et al. Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 2002, 168:9-12.
    • (2002) J Immunol , vol.168 , pp. 9-12
    • Higuchi, T.1    Aiba, Y.2    Nomura, T.3    Matsuda, J.4    Mochida, K.5    Suzuki, M.6
  • 60
    • 5644271413 scopus 로고    scopus 로고
    • Act1, a negative regulator in CD40- and BAFF-mediated B cell survival
    • Qian Y., Qin J., Cui G., Naramura M., Snow E.C., Ware C.F., et al. Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity 2004, 21:575-587.
    • (2004) Immunity , vol.21 , pp. 575-587
    • Qian, Y.1    Qin, J.2    Cui, G.3    Naramura, M.4    Snow, E.C.5    Ware, C.F.6
  • 61
    • 63149172878 scopus 로고    scopus 로고
    • The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation
    • Claudio E., Sonder S.U., Saret S., Carvalho G., Ramalingam T.R., Wynn T.A., et al. The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol 2009, 182:1617-1630.
    • (2009) J Immunol , vol.182 , pp. 1617-1630
    • Claudio, E.1    Sonder, S.U.2    Saret, S.3    Carvalho, G.4    Ramalingam, T.R.5    Wynn, T.A.6
  • 62
    • 0037097681 scopus 로고    scopus 로고
    • VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
    • Shimizu T., Mundt C., Licence S., Melchers F., Martensson I.L. VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J Immunol 2002, 168:6286-6293.
    • (2002) J Immunol , vol.168 , pp. 6286-6293
    • Shimizu, T.1    Mundt, C.2    Licence, S.3    Melchers, F.4    Martensson, I.L.5
  • 63
  • 64
  • 65
    • 0037171731 scopus 로고    scopus 로고
    • Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta
    • Miyamoto A., Nakayama K., Imaki H., Hirose S., Jiang Y., Abe M., et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 2002, 416:865-869.
    • (2002) Nature , vol.416 , pp. 865-869
    • Miyamoto, A.1    Nakayama, K.2    Imaki, H.3    Hirose, S.4    Jiang, Y.5    Abe, M.6
  • 66
    • 20244380494 scopus 로고    scopus 로고
    • Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry
    • Yu P., Constien R., Dear N., Katan M., Hanke P., Bunney T.D., et al. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 2005, 22:451-465.
    • (2005) Immunity , vol.22 , pp. 451-465
    • Yu, P.1    Constien, R.2    Dear, N.3    Katan, M.4    Hanke, P.5    Bunney, T.D.6
  • 68
    • 0028876127 scopus 로고
    • An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
    • Zhang L., Eddy A., Teng Y.T., Fritzler M., Kluppel M., Melet F., et al. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Mol Cell Biol. 1995, 15:6961-6970.
    • (1995) Mol Cell Biol. , vol.15 , pp. 6961-6970
    • Zhang, L.1    Eddy, A.2    Teng, Y.T.3    Fritzler, M.4    Kluppel, M.5    Melet, F.6
  • 69
    • 8444226276 scopus 로고    scopus 로고
    • Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice
    • Zhang X.K., Gallant S., Molano I., Moussa O.M., Ruiz P., Spyropoulos D.D., et al. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. J Immunol 2004, 173:6481-6489.
    • (2004) J Immunol , vol.173 , pp. 6481-6489
    • Zhang, X.K.1    Gallant, S.2    Molano, I.3    Moussa, O.M.4    Ruiz, P.5    Spyropoulos, D.D.6
  • 70
    • 51249113631 scopus 로고    scopus 로고
    • A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis
    • Bradshaw S., Zheng W.J., Tsoi L.C., Gilkeson G., Zhang X.K. A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis. Clin Immunol 2008, 129:19-30.
    • (2008) Clin Immunol , vol.129 , pp. 19-30
    • Bradshaw, S.1    Zheng, W.J.2    Tsoi, L.C.3    Gilkeson, G.4    Zhang, X.K.5
  • 71
    • 59849103454 scopus 로고    scopus 로고
    • Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation
    • Savino M.T., Ortensi B., Ferro M., Ulivieri C., Fanigliulo D., Paccagnini E., et al. Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation. J Immunol 2009, 182:301-308.
    • (2009) J Immunol , vol.182 , pp. 301-308
    • Savino, M.T.1    Ortensi, B.2    Ferro, M.3    Ulivieri, C.4    Fanigliulo, D.5    Paccagnini, E.6
  • 72
    • 33645960108 scopus 로고    scopus 로고
    • Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells
    • Ishida D., Su L., Tamura A., Katayama Y., Kawai Y., Wang S.F., et al. Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Immunity 2006, 24:417-427.
    • (2006) Immunity , vol.24 , pp. 417-427
    • Ishida, D.1    Su, L.2    Tamura, A.3    Katayama, Y.4    Kawai, Y.5    Wang, S.F.6
  • 73
    • 0036659914 scopus 로고    scopus 로고
    • Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease
    • Wilkinson R., Lyons A.B., Roberts D., Wong M.X., Bartley P.A., Jackson D.E. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease. Blood 2002, 100:184-193.
    • (2002) Blood , vol.100 , pp. 184-193
    • Wilkinson, R.1    Lyons, A.B.2    Roberts, D.3    Wong, M.X.4    Bartley, P.A.5    Jackson, D.E.6
  • 74
    • 39749163245 scopus 로고    scopus 로고
    • Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    • Xiao C., Srinivasan L., Calado D.P., Patterson H.C., Zhang B., Wang J., et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008.
    • (2008) Nat Immunol
    • Xiao, C.1    Srinivasan, L.2    Calado, D.P.3    Patterson, H.C.4    Zhang, B.5    Wang, J.6
  • 75
    • 0026799402 scopus 로고
    • Trageted disruption of the mouse transforming growth factor-1 gene results in multifocal inflammatory disease
    • Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., et al. Trageted disruption of the mouse transforming growth factor-1 gene results in multifocal inflammatory disease. Nature 1992, 359:693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3    Pawlowski, S.4    Diebold, R.J.5    Yin, M.6
  • 76
    • 0027724228 scopus 로고
    • Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease
    • Kulkarni A.B., Karlsson S. Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease. Am J Pathol 1993, 143:3-9.
    • (1993) Am J Pathol , vol.143 , pp. 3-9
    • Kulkarni, A.B.1    Karlsson, S.2
  • 77
    • 0028990699 scopus 로고
    • SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF- knockout mice
    • Dang H., Geiser A.G., Letterio J.J., Nakabayashi T., Kong L., Fernandes G., et al. SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF- knockout mice. J Immunol 1995, 155:3205-3212.
    • (1995) J Immunol , vol.155 , pp. 3205-3212
    • Dang, H.1    Geiser, A.G.2    Letterio, J.J.3    Nakabayashi, T.4    Kong, L.5    Fernandes, G.6
  • 78
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P., Penninger J.M., Timms E., Wakeham A., Shahinian A., Lee K.P., et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995, 270:985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3    Wakeham, A.4    Shahinian, A.5    Lee, K.P.6
  • 79
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol E.A., Borriello F., Schweitzer A.N., Lynch W.P., Bluestone J.A., Sharpe A.H. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995, 3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 80
    • 0031154577 scopus 로고    scopus 로고
    • CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice
    • Tivol E.A., Boyd S.D., McKeon S., Borriello F., Nickerson P., Strom T.B., et al. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol 1997, 158:5091-5094.
    • (1997) J Immunol , vol.158 , pp. 5091-5094
    • Tivol, E.A.1    Boyd, S.D.2    McKeon, S.3    Borriello, F.4    Nickerson, P.5    Strom, T.B.6
  • 81
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y., Agata Y., Shibahara K., Honjo T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. Embo J 1992, 11:3887-3895.
    • (1992) Embo J , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 83
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000, 192:1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 84
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
    • Nishimura H., Minato N., Nakano T., Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol 1998, 10:1563-1572.
    • (1998) Int Immunol , vol.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 85
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H., Nose M., Hiai H., Minato N., Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999, 11:141-151.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 86
    • 10744220884 scopus 로고    scopus 로고
    • Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
    • Okazaki T., Tanaka Y., Nishio R., Mitsuiye T., Mizoguchi A., Wang J., et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 2003, 9:1477-1483.
    • (2003) Nat Med , vol.9 , pp. 1477-1483
    • Okazaki, T.1    Tanaka, Y.2    Nishio, R.3    Mitsuiye, T.4    Mizoguchi, A.5    Wang, J.6
  • 87
    • 13244277850 scopus 로고    scopus 로고
    • A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
    • Prokunina L., Castillejo-Lopez C., Oberg F., Gunnarsson I., Berg L., Magnusson V., et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet. 2002, 32:666-669.
    • (2002) Nat Genet. , vol.32 , pp. 666-669
    • Prokunina, L.1    Castillejo-Lopez, C.2    Oberg, F.3    Gunnarsson, I.4    Berg, L.5    Magnusson, V.6
  • 88
    • 1542343979 scopus 로고    scopus 로고
    • Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus
    • Lin S.C., Yen J.H., Tsai J.J., Tsai W.C., Ou T.T., Liu H.W., et al. Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus. Arthritis Rheum 2004, 50:770-775.
    • (2004) Arthritis Rheum , vol.50 , pp. 770-775
    • Lin, S.C.1    Yen, J.H.2    Tsai, J.J.3    Tsai, W.C.4    Ou, T.T.5    Liu, H.W.6
  • 89
    • 2642575164 scopus 로고    scopus 로고
    • Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
    • Prokunina L., Padyukov L., Bennet A., de Faire U., Wiman B., Prince J., et al. Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope. Arthritis Rheum 2004, 50:1770-1773.
    • (2004) Arthritis Rheum , vol.50 , pp. 1770-1773
    • Prokunina, L.1    Padyukov, L.2    Bennet, A.3    de Faire, U.4    Wiman, B.5    Prince, J.6
  • 91
    • 21844451620 scopus 로고    scopus 로고
    • A PD-1 polymorphism is associated with disease progression in multiple sclerosis
    • Kroner A., Mehling M., Hemmer B., Rieckmann P., Toyka K.V., Maurer M., et al. A PD-1 polymorphism is associated with disease progression in multiple sclerosis. Ann Neurol 2005, 58:50-57.
    • (2005) Ann Neurol , vol.58 , pp. 50-57
    • Kroner, A.1    Mehling, M.2    Hemmer, B.3    Rieckmann, P.4    Toyka, K.V.5    Maurer, M.6
  • 92
    • 53149113444 scopus 로고    scopus 로고
    • Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice
    • Lucas J.A., Menke J., Rabacal W.A., Schoen F.J., Sharpe A.H., Kelley V.R. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol 2008, 181:2513-2521.
    • (2008) J Immunol , vol.181 , pp. 2513-2521
    • Lucas, J.A.1    Menke, J.2    Rabacal, W.A.3    Schoen, F.J.4    Sharpe, A.H.5    Kelley, V.R.6
  • 93
    • 38849127548 scopus 로고    scopus 로고
    • Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles
    • Menke J., Lucas J.A., Zeller G.C., Keir M.E., Huang X.R., Tsuboi N., et al. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J Immunol 2007, 179:7466-7477.
    • (2007) J Immunol , vol.179 , pp. 7466-7477
    • Menke, J.1    Lucas, J.A.2    Zeller, G.C.3    Keir, M.E.4    Huang, X.R.5    Tsuboi, N.6
  • 94
    • 0035660806 scopus 로고    scopus 로고
    • The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
    • Wang J., Lo J.C., Foster A., Yu P., Chen H.M., Wang Y., et al. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest 2001, 108:1771-1780.
    • (2001) J Clin Invest , vol.108 , pp. 1771-1780
    • Wang, J.1    Lo, J.C.2    Foster, A.3    Yu, P.4    Chen, H.M.5    Wang, Y.6
  • 95
    • 0035576394 scopus 로고    scopus 로고
    • Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction
    • Shaikh R.B., Santee S., Granger S.W., Butrovich K., Cheung T., Kronenberg M., et al. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J Immunol 2001, 167:6330-6337.
    • (2001) J Immunol , vol.167 , pp. 6330-6337
    • Shaikh, R.B.1    Santee, S.2    Granger, S.W.3    Butrovich, K.4    Cheung, T.5    Kronenberg, M.6
  • 97
    • 0034768532 scopus 로고    scopus 로고
    • Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65
    • Yablonski D., Weiss A. Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Adv Immunol 2001, 79:93-128.
    • (2001) Adv Immunol , vol.79 , pp. 93-128
    • Yablonski, D.1    Weiss, A.2
  • 98
    • 0037076975 scopus 로고    scopus 로고
    • A LAT mutation that inhibits T cell development yet induces lymphoproliferation
    • Sommers C.L., Park C.S., Lee J., Feng C., Fuller C.L., Grinberg A., et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 2002, 296:2040-2043.
    • (2002) Science , vol.296 , pp. 2040-2043
    • Sommers, C.L.1    Park, C.S.2    Lee, J.3    Feng, C.4    Fuller, C.L.5    Grinberg, A.6
  • 99
    • 0023258987 scopus 로고
    • Specificity and molecular characteristics of monoclonal IgM rheumatoid factors from arthritic and non-arthritic mice
    • Aguado M.T., Balderas R.S., Rubin R.L., Duchosal M.A., Kofler R., Birshtein B.K., et al. Specificity and molecular characteristics of monoclonal IgM rheumatoid factors from arthritic and non-arthritic mice. J Immunol 1987, 139:1080-1087.
    • (1987) J Immunol , vol.139 , pp. 1080-1087
    • Aguado, M.T.1    Balderas, R.S.2    Rubin, R.L.3    Duchosal, M.A.4    Kofler, R.5    Birshtein, B.K.6
  • 100
    • 3142726114 scopus 로고    scopus 로고
    • The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling
    • Duan L., Reddi A.L., Ghosh A., Dimri M., Band H. The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling. Immunity 2004, 21:7-17.
    • (2004) Immunity , vol.21 , pp. 7-17
    • Duan, L.1    Reddi, A.L.2    Ghosh, A.3    Dimri, M.4    Band, H.5
  • 102
    • 0034642499 scopus 로고    scopus 로고
    • Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    • Bachmaier K., Krawczyk C., Kozieradzki I., Kong Y.Y., Sasaki T., Oliveira-dos-Santos A., et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 2000, 403:211-216.
    • (2000) Nature , vol.403 , pp. 211-216
    • Bachmaier, K.1    Krawczyk, C.2    Kozieradzki, I.3    Kong, Y.Y.4    Sasaki, T.5    Oliveira-dos-Santos, A.6
  • 103
    • 34248512113 scopus 로고    scopus 로고
    • Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b
    • Kitaura Y., Jang I.K., Wang Y., Han Y.C., Inazu T., Cadera E.J., et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 2007, 26:567-578.
    • (2007) Immunity , vol.26 , pp. 567-578
    • Kitaura, Y.1    Jang, I.K.2    Wang, Y.3    Han, Y.C.4    Inazu, T.5    Cadera, E.J.6
  • 104
    • 0035020493 scopus 로고    scopus 로고
    • Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome
    • Le L.Q., Kabarowski J.H., Weng Z., Satterthwaite A.B., Harvill E.T., Jensen E.R., et al. Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity 2001, 14:561-571.
    • (2001) Immunity , vol.14 , pp. 561-571
    • Le, L.Q.1    Kabarowski, J.H.2    Weng, Z.3    Satterthwaite, A.B.4    Harvill, E.T.5    Jensen, E.R.6
  • 105
    • 0035808778 scopus 로고    scopus 로고
    • CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus
    • Vratsanos G.S., Jung S., Park Y.M., Craft J. CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus. J Exp Med 2001, 193:329-337.
    • (2001) J Exp Med , vol.193 , pp. 329-337
    • Vratsanos, G.S.1    Jung, S.2    Park, Y.M.3    Craft, J.4
  • 106
    • 0037150731 scopus 로고    scopus 로고
    • The genetics of the E2F family of transcription factors: shared functions and unique roles
    • DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim Biophys Acta 2002, 1602:131-150.
    • (2002) Biochim Biophys Acta , vol.1602 , pp. 131-150
    • DeGregori, J.1
  • 107
    • 18244409134 scopus 로고    scopus 로고
    • Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity
    • Murga M., Fernandez-Capetillo O., Field S.J., Moreno B., Borlado LR., Fujiwara Y., Balomenos D., et al. Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity. Immunity 2001, 15:959-970.
    • (2001) Immunity , vol.15 , pp. 959-970
    • Murga, M.1    Fernandez-Capetillo, O.2    Field, S.J.3    Moreno, B.4    Borlado, L.R.5    Fujiwara, Y.6    Balomenos, D.7
  • 108
    • 34447513028 scopus 로고    scopus 로고
    • Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
    • Hardy W.R., Li L., Wang Z., Sedy J., Fawcett J., Frank E., et al. Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science 2007, 317:251-256.
    • (2007) Science , vol.317 , pp. 251-256
    • Hardy, W.R.1    Li, L.2    Wang, Z.3    Sedy, J.4    Fawcett, J.5    Frank, E.6
  • 109
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 1999, 402:309-313.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3    Pelicci, G.4    Reboldi, P.5    Pandolfi, P.P.6
  • 110
    • 46749102196 scopus 로고    scopus 로고
    • The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity
    • Finetti F., Pellegrini M., Ulivieri C., Savino M.T., Paccagnini E., Ginanneschi C., et al. The proapoptotic and antimitogenic protein p66SHC acts as a negative regulator of lymphocyte activation and autoimmunity. Blood 2008, 111:5017-5027.
    • (2008) Blood , vol.111 , pp. 5017-5027
    • Finetti, F.1    Pellegrini, M.2    Ulivieri, C.3    Savino, M.T.4    Paccagnini, E.5    Ginanneschi, C.6
  • 111
    • 34047149396 scopus 로고    scopus 로고
    • Dok-1 and Dok-2 are negative regulators of T cell receptor signaling
    • Yasuda T., Bundo K., Hino A., Honda K., Inoue A., Shirakata M., et al. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int Immunol 2007, 19:487-495.
    • (2007) Int Immunol , vol.19 , pp. 487-495
    • Yasuda, T.1    Bundo, K.2    Hino, A.3    Honda, K.4    Inoue, A.5    Shirakata, M.6
  • 112
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa C.G., Cook M.C., Angelucci C., Athanasopoulos V., Rui L., Hill K.M., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005, 435:452-458.
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1    Cook, M.C.2    Angelucci, C.3    Athanasopoulos, V.4    Rui, L.5    Hill, K.M.6
  • 114
    • 0035825644 scopus 로고    scopus 로고
    • Negative regulation of T-cell activation and autoimmunity by Mgat5 N- glycosylation
    • Demetriou M., Granovsky M., Quaggin S., Dennis J.W. Negative regulation of T-cell activation and autoimmunity by Mgat5 N- glycosylation. Nature 2001, 409:733-739.
    • (2001) Nature , vol.409 , pp. 733-739
    • Demetriou, M.1    Granovsky, M.2    Quaggin, S.3    Dennis, J.W.4
  • 116
    • 0033555408 scopus 로고    scopus 로고
    • Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation
    • Vespa G.N., Lewis L.A., Kozak K.R., Moran M., Nguyen J.T., Baum L.G., et al. Galectin-1 specifically modulates TCR signals to enhance TCR apoptosis but inhibit IL-2 production and proliferation. J Immunol 1999, 162:799-806.
    • (1999) J Immunol , vol.162 , pp. 799-806
    • Vespa, G.N.1    Lewis, L.A.2    Kozak, K.R.3    Moran, M.4    Nguyen, J.T.5    Baum, L.G.6
  • 117
    • 0030995490 scopus 로고    scopus 로고
    • Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice
    • Kim E., Lowenson J.D., MacLaren D.C., Clarke S., Young S.G. Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Proc Natl Acad Sci U S A 1997, 94:6132-6137.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6132-6137
    • Kim, E.1    Lowenson, J.D.2    MacLaren, D.C.3    Clarke, S.4    Young, S.G.5
  • 118
    • 0042834349 scopus 로고    scopus 로고
    • A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production
    • Doyle H.A., Gee R.J., Mamula M.J. A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production. J Immunol 2003, 171:2840-2847.
    • (2003) J Immunol , vol.171 , pp. 2840-2847
    • Doyle, H.A.1    Gee, R.J.2    Mamula, M.J.3
  • 119
    • 0033547359 scopus 로고    scopus 로고
    • Cytokine response gene 6 induces p21 and regulates both cell growth and arrest
    • Fan W., Richter G., Cereseto A., Beadling C., Smith K.A. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. Oncogene 1999, 18:6573-6582.
    • (1999) Oncogene , vol.18 , pp. 6573-6582
    • Fan, W.1    Richter, G.2    Cereseto, A.3    Beadling, C.4    Smith, K.A.5
  • 120
    • 0029922537 scopus 로고    scopus 로고
    • The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1
    • Vairapandi M., Balliet A.G., Fornace A.J., Hoffman B., Liebermann D.A. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 1996, 12:2579-2594.
    • (1996) Oncogene , vol.12 , pp. 2579-2594
    • Vairapandi, M.1    Balliet, A.G.2    Fornace, A.J.3    Hoffman, B.4    Liebermann, D.A.5
  • 122
    • 27944451519 scopus 로고    scopus 로고
    • Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity
    • Liu L., Tran E., Zhao Y., Huang Y., Flavell R., Lu B. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. J Exp Med 2005, 202:1341-1347.
    • (2005) J Exp Med , vol.202 , pp. 1341-1347
    • Liu, L.1    Tran, E.2    Zhao, Y.3    Huang, Y.4    Flavell, R.5    Lu, B.6
  • 123
    • 70350370714 scopus 로고    scopus 로고
    • SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells
    • Becart S., Altman A. SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells. Immunol Rev. 2009, 232:319-333.
    • (2009) Immunol Rev. , vol.232 , pp. 319-333
    • Becart, S.1    Altman, A.2
  • 124
    • 33644637826 scopus 로고    scopus 로고
    • Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity
    • Fanzo J.C., Yang W., Jang S.Y., Gupta S., Chen Q., Siddiq A., et al. Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest 2006, 116:703-714.
    • (2006) J Clin Invest , vol.116 , pp. 703-714
    • Fanzo, J.C.1    Yang, W.2    Jang, S.Y.3    Gupta, S.4    Chen, Q.5    Siddiq, A.6
  • 125
    • 68249144834 scopus 로고    scopus 로고
    • Does Def6 deficiency cause autoimmunity?
    • author reply 2-3
    • Altman A., Becart S. Does Def6 deficiency cause autoimmunity?. Immunity 2009, 31:1-2. author reply 2-3.
    • (2009) Immunity , vol.31 , pp. 1-2
    • Altman, A.1    Becart, S.2
  • 126
    • 0343114288 scopus 로고    scopus 로고
    • The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
    • Balomenos D., Martin-Caballero J., Garcia M.I., Prieto I., Flores J.M., Serrano M., et al. The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development. Nat Med 2000, 6:171-176.
    • (2000) Nat Med , vol.6 , pp. 171-176
    • Balomenos, D.1    Martin-Caballero, J.2    Garcia, M.I.3    Prieto, I.4    Flores, J.M.5    Serrano, M.6
  • 128
    • 0036604349 scopus 로고    scopus 로고
    • Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice
    • Lawson B.R., Kono D.H., Theofilopoulos A.N. Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice. J Immunol 2002, 168:5928-5932.
    • (2002) J Immunol , vol.168 , pp. 5928-5932
    • Lawson, B.R.1    Kono, D.H.2    Theofilopoulos, A.N.3
  • 129
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P., Metcalf D., Huang D.C., Tarlinton D.M., Kay T.W., Kontgen F., et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999, 286:1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5    Kontgen, F.6
  • 130
    • 38949209522 scopus 로고    scopus 로고
    • Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity
    • Hutcheson J., Scatizzi J.C., Siddiqui A.M., Haines G.K., Wu T., Li Q.Z., et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity 2008, 28:206-217.
    • (2008) Immunity , vol.28 , pp. 206-217
    • Hutcheson, J.1    Scatizzi, J.C.2    Siddiqui, A.M.3    Haines, G.K.4    Wu, T.5    Li, Q.Z.6
  • 131
    • 0025939204 scopus 로고
    • Enforced bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser A., Whittingham S., Vaux D.L., Bath M.L., Adams J.M., Cory S., et al. Enforced bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA 1991, 88:8661-8665.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8661-8665
    • Strasser, A.1    Whittingham, S.2    Vaux, D.L.3    Bath, M.L.4    Adams, J.M.5    Cory, S.6
  • 132
    • 0029933460 scopus 로고    scopus 로고
    • Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease
    • Ray S.K., Putterman C., Diamond B. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc Natl Acad Sci U S A 1996, 93:2019-2024.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2019-2024
    • Ray, S.K.1    Putterman, C.2    Diamond, B.3
  • 133
    • 0032811233 scopus 로고    scopus 로고
    • Crossreactive B cells are present during a primary but not secondary response in BALB/c mice expressing a bcl-2 transgene
    • Kuo P., Bynoe M., Diamond B. Crossreactive B cells are present during a primary but not secondary response in BALB/c mice expressing a bcl-2 transgene. Mol Immunol 1999, 36:471-479.
    • (1999) Mol Immunol , vol.36 , pp. 471-479
    • Kuo, P.1    Bynoe, M.2    Diamond, B.3
  • 135
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H., Holtschke T., Hunig T., Schimpl A., Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991, 352:621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 137
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • Sadlack B., Lohler J., Schorle H., Klebb G., Haber H., Sickel E., et al. Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Eur J Immunol 1995, 25:3053-3059.
    • (1995) Eur J Immunol , vol.25 , pp. 3053-3059
    • Sadlack, B.1    Lohler, J.2    Schorle, H.3    Klebb, G.4    Haber, H.5    Sickel, E.6
  • 138
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford D.M., Chen J., Ferry J.A., Davidson L., Ma A., Alt F.W. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995, 3:521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 139
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki H., Kundig T.M., Furlonger C., Wakeham A., Timms E., Matsuyama T., et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995, 268:1472-1476.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3    Wakeham, A.4    Timms, E.5    Matsuyama, T.6
  • 140
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B., Merz H., Schorle H., Schimpl A., Feller A.C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 141
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman Y., Spolski R., Leonard W.J. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol 2009, 9:480-490.
    • (2009) Nat Rev Immunol , vol.9 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 142
    • 14744274237 scopus 로고    scopus 로고
    • The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man
    • Marti F., Lapinski P.E., King P.D. The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. Immunol Lett. 2005, 97:165-170.
    • (2005) Immunol Lett. , vol.97 , pp. 165-170
    • Marti, F.1    Lapinski, P.E.2    King, P.D.3
  • 143
    • 18844462419 scopus 로고    scopus 로고
    • The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity
    • Sundvold-Gjerstad V., Granum S., Mustelin T., Andersen T.C., Berge T., Shapiro M.J., et al. The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity. Eur J Immunol 2005, 35:1612-1620.
    • (2005) Eur J Immunol , vol.35 , pp. 1612-1620
    • Sundvold-Gjerstad, V.1    Granum, S.2    Mustelin, T.3    Andersen, T.C.4    Berge, T.5    Shapiro, M.J.6
  • 144
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999, 96:4240-4245.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 145
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • Di Cristofano A., Pandolfi P.P. The multiple roles of PTEN in tumor suppression. Cell 2000, 100:387-390.
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 147
    • 70449701417 scopus 로고    scopus 로고
    • Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
    • Browne C.D., Del Nagro C.J., Cato M.H., Dengler H.S., Rickert R.C. Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity 2009, 31:749-760.
    • (2009) Immunity , vol.31 , pp. 749-760
    • Browne, C.D.1    Del Nagro, C.J.2    Cato, M.H.3    Dengler, H.S.4    Rickert, R.C.5
  • 148
    • 62849106939 scopus 로고    scopus 로고
    • IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation
    • Shen L., Zhi L., Hu W., Wu M.X. IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation. Cell Death Differ 2009, 16:603-612.
    • (2009) Cell Death Differ , vol.16 , pp. 603-612
    • Shen, L.1    Zhi, L.2    Hu, W.3    Wu, M.X.4
  • 150
    • 0042432047 scopus 로고    scopus 로고
    • Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1
    • Layer K., Lin G., Nencioni A., Hu W., Schmucker A., Antov A.N., et al. Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. Immunity 2003, 19:243-255.
    • (2003) Immunity , vol.19 , pp. 243-255
    • Layer, K.1    Lin, G.2    Nencioni, A.3    Hu, W.4    Schmucker, A.5    Antov, A.N.6
  • 151
    • 0035175548 scopus 로고    scopus 로고
    • Defective T cell activation and autoimmune disorder in Stra13-deficient mice
    • Sun H., Lu B., Li R.Q., Flavell R.A., Taneja R. Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat Immunol 2001, 2:1040-1047.
    • (2001) Nat Immunol , vol.2 , pp. 1040-1047
    • Sun, H.1    Lu, B.2    Li, R.Q.3    Flavell, R.A.4    Taneja, R.5
  • 152
    • 2942711497 scopus 로고    scopus 로고
    • Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice
    • Seimiya M., Wada A., Kawamura K., Sakamoto A., Ohkubo Y., Okada S., et al. Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice. Eur J Immunol 2004, 34:1322-1332.
    • (2004) Eur J Immunol , vol.34 , pp. 1322-1332
    • Seimiya, M.1    Wada, A.2    Kawamura, K.3    Sakamoto, A.4    Ohkubo, Y.5    Okada, S.6
  • 153
    • 0031778836 scopus 로고    scopus 로고
    • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto M., Dell'Agnola C., Bygrave A.E., Thompson E.M., Cook H.T., Petry F., et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet. 1998, 19:56-59.
    • (1998) Nat Genet. , vol.19 , pp. 56-59
    • Botto, M.1    Dell'Agnola, C.2    Bygrave, A.E.3    Thompson, E.M.4    Cook, H.T.5    Petry, F.6
  • 155
    • 0034613725 scopus 로고    scopus 로고
    • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2
    • Chen Z., Koralov S.B., Kelsoe G. Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. J Exp Med 2000, 192:1339-1352.
    • (2000) J Exp Med , vol.192 , pp. 1339-1352
    • Chen, Z.1    Koralov, S.B.2    Kelsoe, G.3
  • 158
  • 159
    • 0345731228 scopus 로고    scopus 로고
    • The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
    • Akakura S., Singh S., Spataro M., Akakura R., Kim J.I., Albert M.L., et al. The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Exp Cell Res. 2004, 292:403-416.
    • (2004) Exp Cell Res. , vol.292 , pp. 403-416
    • Akakura, S.1    Singh, S.2    Spataro, M.3    Akakura, R.4    Kim, J.I.5    Albert, M.L.6
  • 160
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune Disease and Impaired Uptake of Apoptotic Cells in
    • Hanayama R., Tanaka M., Miyasaka K., Aozasa K., Koike M., Uchiyama Y., et al. Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice. Science 2004, 304:1147-1150.
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5    Uchiyama, Y.6
  • 162
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes
    • Boule M.W., Broughton C., Mackay F., Akira S., Marshak-Rothstein A., Rifkin I.R. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 2004, 199:1631-1640.
    • (2004) J Exp Med , vol.199 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 163
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat F.J., Meeker T., Gregorio J., Chan J.H., Uematsu S., Akira S., et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005, 202:1131-1139.
    • (2005) J Exp Med , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6
  • 164
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau C.M., Broughton C., Tabor A.S., Akira S., Flavell R.A., Mamula M.J., et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005, 202:1171-1177.
    • (2005) J Exp Med , vol.202 , pp. 1171-1177
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3    Akira, S.4    Flavell, R.A.5    Mamula, M.J.6
  • 165
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer J., Tluk S., Schmitz C., Hamm S., Jurk M., Forsbach A., et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005, 202:1575-1585.
    • (2005) J Exp Med , vol.202 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3    Hamm, S.4    Jurk, M.5    Forsbach, A.6
  • 166
    • 33645741218 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7
    • Savarese E., Chae O.W., Trowitzsch S., Weber G., Kastner B., Akira S., et al. U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood 2006, 107:3229-3234.
    • (2006) Blood , vol.107 , pp. 3229-3234
    • Savarese, E.1    Chae, O.W.2    Trowitzsch, S.3    Weber, G.4    Kastner, B.5    Akira, S.6
  • 167
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke G., Rothlin C.V. Immunobiology of the TAM receptors. Nat Rev Immunol 2008, 8:327-336.
    • (2008) Nat Rev Immunol , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 168
    • 0035854442 scopus 로고    scopus 로고
    • Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family
    • Lu Q., Lemke G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 2001, 293:306-311.
    • (2001) Science , vol.293 , pp. 306-311
    • Lu, Q.1    Lemke, G.2
  • 170
    • 0036645294 scopus 로고    scopus 로고
    • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    • Cohen P.L., Caricchio R., Abraham V., Camenisch T.D., Jennette J.C., Roubey R.A., et al. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 2002, 196:135-140.
    • (2002) J Exp Med , vol.196 , pp. 135-140
    • Cohen, P.L.1    Caricchio, R.2    Abraham, V.3    Camenisch, T.D.4    Jennette, J.C.5    Roubey, R.A.6
  • 171
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson D.B., Ko J.S., Heidmann T., Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008, 134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 172
    • 49549122469 scopus 로고    scopus 로고
    • Linking retroelements to autoimmunity
    • Bhoj V.G., Chen Z.J. Linking retroelements to autoimmunity. Cell 2008, 134:569-571.
    • (2008) Cell , vol.134 , pp. 569-571
    • Bhoj, V.G.1    Chen, Z.J.2
  • 173
    • 17144427307 scopus 로고    scopus 로고
    • Anti-Ro/SSA and La/SSB antibodies
    • Franceschini F., Cavazzana I. Anti-Ro/SSA and La/SSB antibodies. Autoimmunity 2005, 38:55-63.
    • (2005) Autoimmunity , vol.38 , pp. 55-63
    • Franceschini, F.1    Cavazzana, I.2
  • 174
    • 0038272058 scopus 로고    scopus 로고
    • A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen
    • Xue D., Shi H., Smith J.D., Chen X., Noe D.A., Cedervall T., et al. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proc Natl Acad Sci U S A 2003, 100:7503-7508.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7503-7508
    • Xue, D.1    Shi, H.2    Smith, J.D.3    Chen, X.4    Noe, D.A.5    Cedervall, T.6
  • 175
    • 68149179247 scopus 로고    scopus 로고
    • Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway
    • Espinosa A., Dardalhon V., Brauner S., Ambrosi A., Higgs R., Quintana F.J., et al. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med 2009, 206:1661-1671.
    • (2009) J Exp Med , vol.206 , pp. 1661-1671
    • Espinosa, A.1    Dardalhon, V.2    Brauner, S.3    Ambrosi, A.4    Higgs, R.5    Quintana, F.J.6
  • 176
    • 76249132173 scopus 로고    scopus 로고
    • Comment on "Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappa B-dependent cytokine expression in fibroblasts"
    • author reply 7720-7611
    • Ozato K., Yoshimi R., Chang T.H., Wang H., Atsumi T., Morse H.C. Comment on "Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappa B-dependent cytokine expression in fibroblasts". J Immunol 2009, 183:7619. author reply 7720-7611.
    • (2009) J Immunol , vol.183 , pp. 7619
    • Ozato, K.1    Yoshimi, R.2    Chang, T.H.3    Wang, H.4    Atsumi, T.5    Morse, H.C.6
  • 177
    • 0033059667 scopus 로고    scopus 로고
    • Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
    • Bickerstaff M.C., Botto M., Hutchinson W.L., Herbert J., Tennent G.A., Bybee A., et al. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med 1999, 5:694-697.
    • (1999) Nat Med , vol.5 , pp. 694-697
    • Bickerstaff, M.C.1    Botto, M.2    Hutchinson, W.L.3    Herbert, J.4    Tennent, G.A.5    Bybee, A.6
  • 178
    • 0035801477 scopus 로고    scopus 로고
    • Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity
    • Mehling A., Loser K., Varga G., Metze D., Luger T.A., Schwarz T., et al. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med 2001, 194:615-628.
    • (2001) J Exp Med , vol.194 , pp. 615-628
    • Mehling, A.1    Loser, K.2    Varga, G.3    Metze, D.4    Luger, T.A.5    Schwarz, T.6
  • 179
    • 0030702821 scopus 로고    scopus 로고
    • Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis
    • Seery J.P., Carroll J.M., Cattell V., Watt F.M. Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. J Exp Med 1997, 186:1451-1459.
    • (1997) J Exp Med , vol.186 , pp. 1451-1459
    • Seery, J.P.1    Carroll, J.M.2    Cattell, V.3    Watt, F.M.4
  • 180
    • 38949149313 scopus 로고    scopus 로고
    • Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells
    • Fujikado N., Saijo S., Yonezawa T., Shimamori K., Ishii A., Sugai S., et al. Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells. Nat Med 2008, 14:176-180.
    • (2008) Nat Med , vol.14 , pp. 176-180
    • Fujikado, N.1    Saijo, S.2    Yonezawa, T.3    Shimamori, K.4    Ishii, A.5    Sugai, S.6
  • 181
    • 1842417145 scopus 로고    scopus 로고
    • Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice
    • Erb K.J., Ruger B., von Brevern M., Ryffel B., Schimpl A., Rivett K. Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice. J Exp Med 1997, 185:329-339.
    • (1997) J Exp Med , vol.185 , pp. 329-339
    • Erb, K.J.1    Ruger, B.2    von Brevern, M.3    Ryffel, B.4    Schimpl, A.5    Rivett, K.6
  • 182
    • 0025736362 scopus 로고
    • Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia
    • Muller W., Kuhn R., Rajewsky K. Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia. Eur J Immunol 1991, 21:921-925.
    • (1991) Eur J Immunol , vol.21 , pp. 921-925
    • Muller, W.1    Kuhn, R.2    Rajewsky, K.3
  • 183
    • 0025990537 scopus 로고
    • Humoral immune functions in IL-4 transgenic mice
    • Burstein H.J., Tepper R.I., Leder P., Abbas A.K. Humoral immune functions in IL-4 transgenic mice. J Immunol 1991, 147:2950-2956.
    • (1991) J Immunol , vol.147 , pp. 2950-2956
    • Burstein, H.J.1    Tepper, R.I.2    Leder, P.3    Abbas, A.K.4
  • 184
    • 0025083185 scopus 로고
    • IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice
    • Tepper R.I., Levinson D.A., Stanger B.Z., Campos-Torres J., Abbas A.K., Leder P. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 1990, 62:457-467.
    • (1990) Cell , vol.62 , pp. 457-467
    • Tepper, R.I.1    Levinson, D.A.2    Stanger, B.Z.3    Campos-Torres, J.4    Abbas, A.K.5    Leder, P.6
  • 185
  • 186
    • 0031036084 scopus 로고    scopus 로고
    • Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome
    • Santiago M., Fossati L., Jacquiet C., Muller W., Izui S., Reininger L. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 1997, 185:65-70.
    • (1997) J Exp Med , vol.185 , pp. 65-70
    • Santiago, M.1    Fossati, L.2    Jacquiet, C.3    Muller, W.4    Izui, S.5    Reininger, L.6
  • 187
    • 0032516626 scopus 로고    scopus 로고
    • Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    • Carballo E., Lai W.S., Blackshear P.J. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 1998, 281:1001-1005.
    • (1998) Science , vol.281 , pp. 1001-1005
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 188
    • 16044369031 scopus 로고    scopus 로고
    • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
    • Taylor G.A., Carballo E., Lee D.M., Lai W.S., Thompson M.J., Patel D.D., et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 1996, 4:445-454.
    • (1996) Immunity , vol.4 , pp. 445-454
    • Taylor, G.A.1    Carballo, E.2    Lee, D.M.3    Lai, W.S.4    Thompson, M.J.5    Patel, D.D.6
  • 189
    • 0030882906 scopus 로고    scopus 로고
    • Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction
    • Carballo E., Gilkeson G.S., Blackshear P.J. Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction. J Clin Invest 1997, 100:986-995.
    • (1997) J Clin Invest , vol.100 , pp. 986-995
    • Carballo, E.1    Gilkeson, G.S.2    Blackshear, P.J.3
  • 190
    • 0030584786 scopus 로고    scopus 로고
    • Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I
    • Zhou T., Edwards C.K., Yang P., Wang Z., Bluethmann H., Mountz J.D. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol 1996, 156:2661-2665.
    • (1996) J Immunol , vol.156 , pp. 2661-2665
    • Zhou, T.1    Edwards, C.K.2    Yang, P.3    Wang, Z.4    Bluethmann, H.5    Mountz, J.D.6
  • 191
    • 61449147025 scopus 로고    scopus 로고
    • Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway
    • Jacob N., Yang H., Pricop L., Liu Y., Gao X., Zheng S.G., et al. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol 2009, 182:2532-2541.
    • (2009) J Immunol , vol.182 , pp. 2532-2541
    • Jacob, N.1    Yang, H.2    Pricop, L.3    Liu, Y.4    Gao, X.5    Zheng, S.G.6
  • 192
    • 69949191016 scopus 로고    scopus 로고
    • Chapter 3: Role of SOCS in allergic and innate immune responses
    • Cassel S.L., Rothman P.B. Chapter 3: Role of SOCS in allergic and innate immune responses. Adv Immunol 2009, 103:49-76.
    • (2009) Adv Immunol , vol.103 , pp. 49-76
    • Cassel, S.L.1    Rothman, P.B.2
  • 193
    • 10744227089 scopus 로고    scopus 로고
    • Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
    • Fujimoto M., Tsutsui H., Xinshou O., Tokumoto M., Watanabe D., Shima Y., et al. Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int Immunol 2004, 16:303-314.
    • (2004) Int Immunol , vol.16 , pp. 303-314
    • Fujimoto, M.1    Tsutsui, H.2    Xinshou, O.3    Tokumoto, M.4    Watanabe, D.5    Shima, Y.6
  • 194
    • 0028997875 scopus 로고
    • Of ITAMs and ITIMs:turning on and off the B cell antigen receptor
    • Thomas M.L. Of ITAMs and ITIMs:turning on and off the B cell antigen receptor. J Exp Med 1995, 181:1953-1956.
    • (1995) J Exp Med , vol.181 , pp. 1953-1956
    • Thomas, M.L.1
  • 195
    • 0027197067 scopus 로고
    • Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene
    • Shultz L.D., Schweitzer P.A., Rajan T.V., Yi T., Ihle J.N., Matthews R.J., et al. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 1993, 73:1445-1454.
    • (1993) Cell , vol.73 , pp. 1445-1454
    • Shultz, L.D.1    Schweitzer, P.A.2    Rajan, T.V.3    Yi, T.4    Ihle, J.N.5    Matthews, R.J.6
  • 196
    • 0027195626 scopus 로고
    • Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene
    • Tsui H.W., Siminovitch K.A., deSouza L., Tsui F.W.L. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nature Genet. 1993, 4:124-129.
    • (1993) Nature Genet. , vol.4 , pp. 124-129
    • Tsui, H.W.1    Siminovitch, K.A.2    deSouza, L.3    Tsui, F.W.L.4
  • 199
    • 0030062935 scopus 로고    scopus 로고
    • B and T cells are not required for the viable motheaten phenotype
    • Yu C.C., Tsui H.W., Ngan B.Y., Shulman M.J., Wu G.E., Tsui F.W. B and T cells are not required for the viable motheaten phenotype. J Exp Med 1996, 183:371-380.
    • (1996) J Exp Med , vol.183 , pp. 371-380
    • Yu, C.C.1    Tsui, H.W.2    Ngan, B.Y.3    Shulman, M.J.4    Wu, G.E.5    Tsui, F.W.6
  • 200
    • 0031455984 scopus 로고    scopus 로고
    • Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis
    • Chui D., Oh-Eda M., Liao Y.F., Panneerselvam K., Lal A., Marek K.W., et al. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 1997, 90:157-167.
    • (1997) Cell , vol.90 , pp. 157-167
    • Chui, D.1    Oh-Eda, M.2    Liao, Y.F.3    Panneerselvam, K.4    Lal, A.5    Marek, K.W.6
  • 201
    • 0028213490 scopus 로고
    • Glycosidases of the asparagine-linked oligosaccharide processing pathway
    • Moremen K.W., Trimble R.B., Herscovics A. Glycosidases of the asparagine-linked oligosaccharide processing pathway. Glycobiology 1994, 4:113-125.
    • (1994) Glycobiology , vol.4 , pp. 113-125
    • Moremen, K.W.1    Trimble, R.B.2    Herscovics, A.3
  • 204
    • 0033215228 scopus 로고    scopus 로고
    • EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways
    • Bessone S., Vidal F., Le Bouc Y., Epelbaum J., Bluet-Pajot M.T., Darmon M. EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways. Dev Biol. 1999, 214:87-101.
    • (1999) Dev Biol. , vol.214 , pp. 87-101
    • Bessone, S.1    Vidal, F.2    Le Bouc, Y.3    Epelbaum, J.4    Bluet-Pajot, M.T.5    Darmon, M.6
  • 205
    • 0037183998 scopus 로고    scopus 로고
    • The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
    • Zipper L.M., Mulcahy R.T. The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm. J Biol Chem. 2002, 277:36544-36552.
    • (2002) J Biol Chem. , vol.277 , pp. 36544-36552
    • Zipper, L.M.1    Mulcahy, R.T.2
  • 206
    • 0036371485 scopus 로고    scopus 로고
    • Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
    • Ishii T., Itoh K., Yamamoto M. Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements. Methods Enzymol 2002, 348:182-190.
    • (2002) Methods Enzymol , vol.348 , pp. 182-190
    • Ishii, T.1    Itoh, K.2    Yamamoto, M.3
  • 208
    • 0030886381 scopus 로고    scopus 로고
    • Heme oxygenase 1 is required for mammalian iron reutilization
    • Poss K.D., Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A 1997, 94:10919-10924.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10919-10924
    • Poss, K.D.1    Tonegawa, S.2
  • 209
    • 2342479119 scopus 로고    scopus 로고
    • Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr
    • Morito N., Yoh K., Hirayama A., Itoh K., Nose M., Koyama A., et al. Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr. Kidney Int 2004, 65:1703-1713.
    • (2004) Kidney Int , vol.65 , pp. 1703-1713
    • Morito, N.1    Yoh, K.2    Hirayama, A.3    Itoh, K.4    Nose, M.5    Koyama, A.6
  • 210
    • 46649086595 scopus 로고    scopus 로고
    • Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice
    • Lu X., Kovalev G.I., Chang H., Kallin E., Knudsen G., Xia L., et al. Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem. 2008, 283:13825-13833.
    • (2008) J Biol Chem. , vol.283 , pp. 13825-13833
    • Lu, X.1    Kovalev, G.I.2    Chang, H.3    Kallin, E.4    Knudsen, G.5    Xia, L.6
  • 211
    • 67349167059 scopus 로고    scopus 로고
    • Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay
    • Matsushita K., Takeuchi O., Standley D.M., Kumagai Y., Kawagoe T., Miyake T., et al. Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 2009, 458:1185-1190.
    • (2009) Nature , vol.458 , pp. 1185-1190
    • Matsushita, K.1    Takeuchi, O.2    Standley, D.M.3    Kumagai, Y.4    Kawagoe, T.5    Miyake, T.6
  • 213
    • 0033214474 scopus 로고    scopus 로고
    • B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity
    • Chan O.T., Madaio M.P., Shlomchik M.J. B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity. J Immunol 1999, 163:3592-3596.
    • (1999) J Immunol , vol.163 , pp. 3592-3596
    • Chan, O.T.1    Madaio, M.P.2    Shlomchik, M.J.3
  • 214
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan O.T., Hannum L.G., Haberman A.M., Madaio M.P., Shlomchik M.J. A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648.
    • (1999) J Exp Med , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 215
    • 53349167095 scopus 로고    scopus 로고
    • Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis
    • Hao Z., Duncan G.S., Seagal J., Su Y.W., Hong C., Haight J., et al. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 2008, 29:615-627.
    • (2008) Immunity , vol.29 , pp. 615-627
    • Hao, Z.1    Duncan, G.S.2    Seagal, J.3    Su, Y.W.4    Hong, C.5    Haight, J.6
  • 216
    • 34249826624 scopus 로고    scopus 로고
    • Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice
    • Jiang C., Foley J., Clayton N., Kissling G., Jokinen M., Herbert R., et al. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol 2007, 178:7422-7431.
    • (2007) J Immunol , vol.178 , pp. 7422-7431
    • Jiang, C.1    Foley, J.2    Clayton, N.3    Kissling, G.4    Jokinen, M.5    Herbert, R.6
  • 217
    • 0028326095 scopus 로고
    • Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice
    • Jevnikar A.M., Grusby M.J., Glimcher L.H. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med 1994, 179:1137-1143.
    • (1994) J Exp Med , vol.179 , pp. 1137-1143
    • Jevnikar, A.M.1    Grusby, M.J.2    Glimcher, L.H.3
  • 219
    • 0029070099 scopus 로고
    • CD8+ T cell-deficient lpr/lpr mice, CD4+B220+ and CD4+B220- T cells replace B220+ double-negative T cells as the predominant populations in enlarged lymph nodes
    • Giese T., Davidson W.F. CD8+ T cell-deficient lpr/lpr mice, CD4+B220+ and CD4+B220- T cells replace B220+ double-negative T cells as the predominant populations in enlarged lymph nodes. J Immunol 1995, 154:4986-4995.
    • (1995) J Immunol , vol.154 , pp. 4986-4995
    • Giese, T.1    Davidson, W.F.2
  • 220
    • 0028985378 scopus 로고
    • Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules
    • Ohteki T., Iwamoto M., Izui S., MacDonald H.R. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur J Immunol 1995, 25:37-41.
    • (1995) Eur J Immunol , vol.25 , pp. 37-41
    • Ohteki, T.1    Iwamoto, M.2    Izui, S.3    MacDonald, H.R.4
  • 221
    • 0028898599 scopus 로고
    • Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I
    • Maldonado M.A., Eisenberg R.A., Roper E., Cohen P.L., Kotzin B.L. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 1995, 181:641-648.
    • (1995) J Exp Med , vol.181 , pp. 641-648
    • Maldonado, M.A.1    Eisenberg, R.A.2    Roper, E.3    Cohen, P.L.4    Kotzin, B.L.5
  • 223
    • 0035451795 scopus 로고    scopus 로고
    • Deficiency in beta(2)-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Fas(lpr) nice: an example of disease regulation at the organ level
    • Chan O.T., Paliwal V., McNiff J.M., Park S.H., Bendelac A., Shlomchik M.J. Deficiency in beta(2)-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Fas(lpr) nice: an example of disease regulation at the organ level. J Immunol 2001, 167:2985-2990.
    • (2001) J Immunol , vol.167 , pp. 2985-2990
    • Chan, O.T.1    Paliwal, V.2    McNiff, J.M.3    Park, S.H.4    Bendelac, A.5    Shlomchik, M.J.6
  • 224
    • 3242734150 scopus 로고    scopus 로고
    • CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice
    • Yang J.Q., Chun T., Liu H., Hong S., Bui H., Van Kaer L., et al. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur J Immunol 2004, 34:1723-1732.
    • (2004) Eur J Immunol , vol.34 , pp. 1723-1732
    • Yang, J.Q.1    Chun, T.2    Liu, H.3    Hong, S.4    Bui, H.5    Van Kaer, L.6
  • 225
    • 0043136663 scopus 로고    scopus 로고
    • Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis
    • Yang J.Q., Singh A.K., Wilson M.T., Satoh M., Stanic A.K., Park J.J., et al. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J Immunol 2003, 171:2142-2153.
    • (2003) J Immunol , vol.171 , pp. 2142-2153
    • Yang, J.Q.1    Singh, A.K.2    Wilson, M.T.3    Satoh, M.4    Stanic, A.K.5    Park, J.J.6
  • 226
    • 34247216264 scopus 로고    scopus 로고
    • Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model
    • Yang J.Q., Wen X., Liu H., Folayan G., Dong X., Zhou M., et al. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum 2007, 56:1219-1233.
    • (2007) Arthritis Rheum , vol.56 , pp. 1219-1233
    • Yang, J.Q.1    Wen, X.2    Liu, H.3    Folayan, G.4    Dong, X.5    Zhou, M.6
  • 227
    • 0030587080 scopus 로고    scopus 로고
    • The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice
    • Chen S.Y., Takeoka Y., Ansari A.A., Boyd R., Klinman D.M., Gershwin M.E. The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol 1996, 157:2676-2684.
    • (1996) J Immunol , vol.157 , pp. 2676-2684
    • Chen, S.Y.1    Takeoka, Y.2    Ansari, A.A.3    Boyd, R.4    Klinman, D.M.5    Gershwin, M.E.6
  • 230
    • 0030856589 scopus 로고    scopus 로고
    • The regulation of murine lupus
    • Peng S.L., Craft J. The regulation of murine lupus. Ann N Y Acad Sci. 1997, 815:128-138.
    • (1997) Ann N Y Acad Sci. , vol.815 , pp. 128-138
    • Peng, S.L.1    Craft, J.2
  • 231
    • 0032797012 scopus 로고    scopus 로고
    • Autoreactive T cells in murine lupus: origins and roles in autoantibody production
    • Craft J., Peng S., Fujii T., Okada M., Fatenejad S. Autoreactive T cells in murine lupus: origins and roles in autoantibody production. Immunol Res. 1999, 19:245-257.
    • (1999) Immunol Res. , vol.19 , pp. 245-257
    • Craft, J.1    Peng, S.2    Fujii, T.3    Okada, M.4    Fatenejad, S.5
  • 232
    • 0031974934 scopus 로고    scopus 로고
    • Perforin protects against autoimmunity in lupus-prone mice
    • Peng S.L., Moslehi J., Robert M.E., Craft J. Perforin protects against autoimmunity in lupus-prone mice. J Immunol 1998, 160:652-660.
    • (1998) J Immunol , vol.160 , pp. 652-660
    • Peng, S.L.1    Moslehi, J.2    Robert, M.E.3    Craft, J.4
  • 233
    • 33645451123 scopus 로고    scopus 로고
    • Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus
    • Zeller G.C., Hirahashi J., Schwarting A., Sharpe A.H., Kelley V.R. Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. J Am Soc Nephrol 2006, 17:122-130.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 122-130
    • Zeller, G.C.1    Hirahashi, J.2    Schwarting, A.3    Sharpe, A.H.4    Kelley, V.R.5
  • 234
    • 33746093259 scopus 로고    scopus 로고
    • Role of inducible costimulator in the development of lupus in MRL/lpr mice
    • Tada Y., Koarada S., Tomiyoshi Y., Morito F., Mitamura M., Haruta Y., et al. Role of inducible costimulator in the development of lupus in MRL/lpr mice. Clin Immunol 2006, 120:179-188.
    • (2006) Clin Immunol , vol.120 , pp. 179-188
    • Tada, Y.1    Koarada, S.2    Tomiyoshi, Y.3    Morito, F.4    Mitamura, M.5    Haruta, Y.6
  • 236
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson K.M., Christensen S.R., Shupe J., Kashgarian M., Kim D., Elkon K., et al. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 2010, 184:1840-1848.
    • (2010) J Immunol , vol.184 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3    Kashgarian, M.4    Kim, D.5    Elkon, K.6
  • 237
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
    • Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., Shlomchik M.J. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Immunity 2006, 25:417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 238
    • 59649107055 scopus 로고    scopus 로고
    • TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus
    • Lee P.Y., Kumagai Y., Li Y., Takeuchi O., Yoshida H., Weinstein J., et al. TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J Exp Med 2008, 205:2995-3006.
    • (2008) J Exp Med , vol.205 , pp. 2995-3006
    • Lee, P.Y.1    Kumagai, Y.2    Li, Y.3    Takeuchi, O.4    Yoshida, H.5    Weinstein, J.6
  • 239
    • 67749135880 scopus 로고    scopus 로고
    • Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    • Kono D.H., Haraldsson M.K., Lawson B.R., Pollard K.M., Koh Y.T., Du X., et al. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 2009, 106(29):12061-12066.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.29 , pp. 12061-12066
    • Kono, D.H.1    Haraldsson, M.K.2    Lawson, B.R.3    Pollard, K.M.4    Koh, Y.T.5    Du, X.6
  • 241
    • 34249915031 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    • Pawar R.D., Ramanjaneyulu A., Kulkarni O.P., Lech M., Segerer S., Anders H.J. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol 2007, 18:1721-1731.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1721-1731
    • Pawar, R.D.1    Ramanjaneyulu, A.2    Kulkarni, O.P.3    Lech, M.4    Segerer, S.5    Anders, H.J.6
  • 242
    • 34247891509 scopus 로고    scopus 로고
    • Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease
    • Marshak-Rothstein A., Rifkin I.R. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 2007, 25:419-441.
    • (2007) Annu Rev Immunol , vol.25 , pp. 419-441
    • Marshak-Rothstein, A.1    Rifkin, I.R.2
  • 243
    • 68949181883 scopus 로고    scopus 로고
    • TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
    • Garlanda C., Anders H.J., Mantovani A. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol 2009, 30:439-446.
    • (2009) Trends Immunol , vol.30 , pp. 439-446
    • Garlanda, C.1    Anders, H.J.2    Mantovani, A.3
  • 244
    • 49249109576 scopus 로고    scopus 로고
    • Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
    • Lech M., Kulkarni O.P., Pfeiffer S., Savarese E., Krug A., Garlanda C., et al. Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens. J Exp Med 2008, 205:1879-1888.
    • (2008) J Exp Med , vol.205 , pp. 1879-1888
    • Lech, M.1    Kulkarni, O.P.2    Pfeiffer, S.3    Savarese, E.4    Krug, A.5    Garlanda, C.6
  • 245
    • 38849162227 scopus 로고    scopus 로고
    • Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodies
    • Frisoni L., McPhie L., Kang S.A., Monestier M., Madaio M., Satoh M., et al. Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodies. J Immunol 2007, 179:7959-7966.
    • (2007) J Immunol , vol.179 , pp. 7959-7966
    • Frisoni, L.1    McPhie, L.2    Kang, S.A.3    Monestier, M.4    Madaio, M.5    Satoh, M.6
  • 246
    • 0029939451 scopus 로고    scopus 로고
    • Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses
    • Ma J., Xu J., Madaio M.P., Peng Q., Zhang J., Grewal I.S., et al. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. J Immunol 1996, 157:417-426.
    • (1996) J Immunol , vol.157 , pp. 417-426
    • Ma, J.1    Xu, J.2    Madaio, M.P.3    Peng, Q.4    Zhang, J.5    Grewal, I.S.6
  • 247
    • 0031092710 scopus 로고    scopus 로고
    • Alpha-beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
    • Peng S.L., McNiff J.M., Madaio M.P., Ma J., Owen M.J., Flavell Ra., et al. alpha-beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol 1997, 158:2464-2470.
    • (1997) J Immunol , vol.158 , pp. 2464-2470
    • Peng, S.L.1    McNiff, J.M.2    Madaio, M.P.3    Ma, J.4    Owen, M.J.5    Flavell, R.6
  • 248
    • 0033568177 scopus 로고    scopus 로고
    • Role of the costimulatory molecule CD28 in the development of lupus in MRL/lpr mice
    • Tada Y., Nagasawa K., Ho A., Morito F., Koarada S., Ushiyama O., et al. Role of the costimulatory molecule CD28 in the development of lupus in MRL/lpr mice. J Immunol 1999, 163:3153-3159.
    • (1999) J Immunol , vol.163 , pp. 3153-3159
    • Tada, Y.1    Nagasawa, K.2    Ho, A.3    Morito, F.4    Koarada, S.5    Ushiyama, O.6
  • 249
    • 0033566957 scopus 로고    scopus 로고
    • B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-B7.1/B7.2 blocking antibodies
    • Liang B., Gee R.J., Kashgarian M.J., Sharpe A.H., Mamula M.J. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-B7.1/B7.2 blocking antibodies. J Immunol 1999, 163:2322-2329.
    • (1999) J Immunol , vol.163 , pp. 2322-2329
    • Liang, B.1    Gee, R.J.2    Kashgarian, M.J.3    Sharpe, A.H.4    Mamula, M.J.5
  • 250
    • 0028834366 scopus 로고
    • Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
    • Nakajima A., Azuma M., Kodera S., Nuriya S., Terashi A., Abe M., et al. Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur J Immunol 1995, 25:3060-3069.
    • (1995) Eur J Immunol , vol.25 , pp. 3060-3069
    • Nakajima, A.1    Azuma, M.2    Kodera, S.3    Nuriya, S.4    Terashi, A.5    Abe, M.6
  • 251
    • 77955484327 scopus 로고    scopus 로고
    • SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions
    • Detre C., Keszei M., Romero X., Tsokos G.C., Terhorst C. SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions. Semin Immunopathol 2010, 32(2):157-171.
    • (2010) Semin Immunopathol , vol.32 , Issue.2 , pp. 157-171
    • Detre, C.1    Keszei, M.2    Romero, X.3    Tsokos, G.C.4    Terhorst, C.5
  • 253
    • 29644436116 scopus 로고    scopus 로고
    • A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice
    • Komori H., Furukawa H., Mori S., Ito M.R., Terada M., Zhang M.C., et al. A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice. J Immunol 2006, 176:395-400.
    • (2006) J Immunol , vol.176 , pp. 395-400
    • Komori, H.1    Furukawa, H.2    Mori, S.3    Ito, M.R.4    Terada, M.5    Zhang, M.C.6
  • 254
    • 3242752599 scopus 로고    scopus 로고
    • Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease
    • Kevil C.G., Hicks M.J., He X., Zhang J., Ballantyne C.M., Raman C., et al. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am J Pathol 2004, 165:609-616.
    • (2004) Am J Pathol , vol.165 , pp. 609-616
    • Kevil, C.G.1    Hicks, M.J.2    He, X.3    Zhang, J.4    Ballantyne, C.M.5    Raman, C.6
  • 256
    • 0037320208 scopus 로고    scopus 로고
    • Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice
    • Braun D., Geraldes P., Demengeot J. Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 2003, 20:15-25.
    • (2003) J Autoimmun , vol.20 , pp. 15-25
    • Braun, D.1    Geraldes, P.2    Demengeot, J.3
  • 258
    • 14044278824 scopus 로고    scopus 로고
    • IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice
    • Mathian A., Weinberg A., Gallegos M., Banchereau J., Koutouzov S. IFN-alpha induces early lethal lupus in preautoimmune (New Zealand Black x New Zealand White) F1 but not in BALB/c mice. J Immunol 2005, 174:2499-2506.
    • (2005) J Immunol , vol.174 , pp. 2499-2506
    • Mathian, A.1    Weinberg, A.2    Gallegos, M.3    Banchereau, J.4    Koutouzov, S.5
  • 260
    • 3242805826 scopus 로고    scopus 로고
    • Type I IFN protects against murine lupus
    • Hron J.D., Peng S.L. Type I IFN protects against murine lupus. J Immunol 2004, 173:2134-2142.
    • (2004) J Immunol , vol.173 , pp. 2134-2142
    • Hron, J.D.1    Peng, S.L.2
  • 262
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferon-gamma and interleukin-4 in murine lupus
    • Peng S.L., Moslehi J., Craft J. Roles of interferon-gamma and interleukin-4 in murine lupus. J Clin Invest 1997, 99:1936-1946.
    • (1997) J Clin Invest , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 263
    • 0031155269 scopus 로고    scopus 로고
    • IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice
    • Haas C., Ryffel B., Le H.M. IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice. J Immunol 1997, 158:5484-5491.
    • (1997) J Immunol , vol.158 , pp. 5484-5491
    • Haas, C.1    Ryffel, B.2    Le, H.M.3
  • 264
    • 0032518439 scopus 로고    scopus 로고
    • Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice
    • Balomenos D., Rumold R., Theofilopoulos A.N. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 1998, 101:364-371.
    • (1998) J Clin Invest , vol.101 , pp. 364-371
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 265
    • 0032522778 scopus 로고    scopus 로고
    • IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice
    • Haas C., Ryffel B., Le Hir M. IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol 1998, 160:3713-3718.
    • (1998) J Immunol , vol.160 , pp. 3713-3718
    • Haas, C.1    Ryffel, B.2    Le Hir, M.3
  • 266
    • 0031859079 scopus 로고    scopus 로고
    • The prototypic Th2 autoimmunity induced by mercury is dependent on IFN- gamma and not Th1/Th2 imbalance
    • Kono D.H., Balomenos D., Pearson D.L., Park M.S., Hildebrandt B., Hultman P., et al. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN- gamma and not Th1/Th2 imbalance. J Immunol 1998, 161:234-240.
    • (1998) J Immunol , vol.161 , pp. 234-240
    • Kono, D.H.1    Balomenos, D.2    Pearson, D.L.3    Park, M.S.4    Hildebrandt, B.5    Hultman, P.6
  • 267
    • 0036233983 scopus 로고    scopus 로고
    • Transcription: tantalizing times for T cells
    • Ho I.C., Glimcher L.H. Transcription: tantalizing times for T cells. Cell. 2002, 109 Suppl:S109-120.
    • (2002) Cell. , vol.109 Suppl
    • Ho, I.C.1    Glimcher, L.H.2
  • 268
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • Peng S.L., Szabo S.J., Glimcher L.H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A 2002, 99:5545-5550.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 5545-5550
    • Peng, S.L.1    Szabo, S.J.2    Glimcher, L.H.3
  • 269
    • 66349134549 scopus 로고    scopus 로고
    • Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background
    • Shimohata H., Yamada A., Yoh K., Ishizaki K., Morito N., Yamagata K., et al. Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background. J Nephrol 2009, 22:123-129.
    • (2009) J Nephrol , vol.22 , pp. 123-129
    • Shimohata, H.1    Yamada, A.2    Yoh, K.3    Ishizaki, K.4    Morito, N.5    Yamagata, K.6
  • 270
    • 33646597302 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice
    • Reilly C.M., Olgun S., Goodwin D., Gogal R.M., Santo A., Romesburg J.W., et al. Interferon regulatory factor-1 gene deletion decreases glomerulonephritis in MRL/lpr mice. Eur J Immunol 2006, 36:1296-1308.
    • (2006) Eur J Immunol , vol.36 , pp. 1296-1308
    • Reilly, C.M.1    Olgun, S.2    Goodwin, D.3    Gogal, R.M.4    Santo, A.5    Romesburg, J.W.6
  • 271
    • 0036065808 scopus 로고    scopus 로고
    • Further checkpoints in Th1 development
    • Robinson D.S., O'Garra A. Further checkpoints in Th1 development. Immunity 2002, 16:755-758.
    • (2002) Immunity , vol.16 , pp. 755-758
    • Robinson, D.S.1    O'Garra, A.2
  • 272
    • 0035874769 scopus 로고    scopus 로고
    • Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRL-FAS(lprcg)/FAS(lprcg) mice
    • Yasuda T., Yoshimoto T., Tsubura A., Matsuzawa A. Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRL-FAS(lprcg)/FAS(lprcg) mice. Cell Immunol 2001, 210:77-86.
    • (2001) Cell Immunol , vol.210 , pp. 77-86
    • Yasuda, T.1    Yoshimoto, T.2    Tsubura, A.3    Matsuzawa, A.4
  • 274
    • 33746062790 scopus 로고    scopus 로고
    • STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus
    • Xu Z., Duan B., Croker B.P., Morel L. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 2006, 120:189-198.
    • (2006) Clin Immunol , vol.120 , pp. 189-198
    • Xu, Z.1    Duan, B.2    Croker, B.P.3    Morel, L.4
  • 275
    • 0037406914 scopus 로고    scopus 로고
    • Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis
    • Singh R.R., Saxena V., Zang S., Li L., Finkelman F.D., Witte D.P., et al. Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 2003, 170:4818-4825.
    • (2003) J Immunol , vol.170 , pp. 4818-4825
    • Singh, R.R.1    Saxena, V.2    Zang, S.3    Li, L.4    Finkelman, F.D.5    Witte, D.P.6
  • 276
    • 41849090456 scopus 로고    scopus 로고
    • IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice
    • Thibault D.L., Chu A.D., Graham K.L., Balboni I., Lee L.Y., Kohlmoos C., et al. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest 2008, 118:1417-1426.
    • (2008) J Clin Invest , vol.118 , pp. 1417-1426
    • Thibault, D.L.1    Chu, A.D.2    Graham, K.L.3    Balboni, I.4    Lee, L.Y.5    Kohlmoos, C.6
  • 279
    • 0035655155 scopus 로고    scopus 로고
    • Differential roles of osteopontin/Eta-1 in early and late lpr disease
    • Weber G.F., Cantor H. Differential roles of osteopontin/Eta-1 in early and late lpr disease. Clin Exp Immunol 2001, 126:578-583.
    • (2001) Clin Exp Immunol , vol.126 , pp. 578-583
    • Weber, G.F.1    Cantor, H.2
  • 280
    • 0025119946 scopus 로고
    • Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease
    • Patarca R., Wei F.Y., Singh P., Morasso M.I., Cantor H. Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease. J Exp Med 1990, 172:1177-1183.
    • (1990) J Exp Med , vol.172 , pp. 1177-1183
    • Patarca, R.1    Wei, F.Y.2    Singh, P.3    Morasso, M.I.4    Cantor, H.5
  • 281
    • 60149106103 scopus 로고    scopus 로고
    • Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    • Igawa T., Nakashima H., Sadanaga A., Masutani K., Miyake K., Shimizu S., et al. Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod Rheumatol 2009, 19:33-41.
    • (2009) Mod Rheumatol , vol.19 , pp. 33-41
    • Igawa, T.1    Nakashima, H.2    Sadanaga, A.3    Masutani, K.4    Miyake, K.5    Shimizu, S.6
  • 282
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier J.A., Sproule T.J., Foreman O., Spolski R., Shaffer D.J., Morse H.C., et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 2009, 106:1518-1523.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1518-1523
    • Bubier, J.A.1    Sproule, T.J.2    Foreman, O.3    Spolski, R.4    Shaffer, D.J.5    Morse, H.C.6
  • 283
    • 0031226001 scopus 로고    scopus 로고
    • The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion
    • Balomenos D., Rumold R., Theofilopoulos A.N. The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion. J Immunol 1997, 159:2265-2273.
    • (1997) J Immunol , vol.159 , pp. 2265-2273
    • Balomenos, D.1    Rumold, R.2    Theofilopoulos, A.N.3
  • 284
    • 0035949235 scopus 로고    scopus 로고
    • Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome
    • Brooks W.P., Lynes M.A. Effects of hemizygous CD45 expression in the autoimmune Fasl(gld/gld) syndrome. Cell Immunol 2001, 212:24-34.
    • (2001) Cell Immunol , vol.212 , pp. 24-34
    • Brooks, W.P.1    Lynes, M.A.2
  • 285
    • 0034650431 scopus 로고    scopus 로고
    • Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B
    • Watanabe H., Garnier G., Circolo A., Wetsel R.A., Ruiz P., Holers V.M., et al. Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B. J Immunol 2000, 164:786-794.
    • (2000) J Immunol , vol.164 , pp. 786-794
    • Watanabe, H.1    Garnier, G.2    Circolo, A.3    Wetsel, R.A.4    Ruiz, P.5    Holers, V.M.6
  • 286
    • 0024215452 scopus 로고
    • Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis
    • Passwell J., Schreiner G.F., Nonaka M., Beuscher H.U., Colten H.R. Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis. J Clin Invest 1988, 82:1676-1684.
    • (1988) J Clin Invest , vol.82 , pp. 1676-1684
    • Passwell, J.1    Schreiner, G.F.2    Nonaka, M.3    Beuscher, H.U.4    Colten, H.R.5
  • 287
    • 0347992784 scopus 로고    scopus 로고
    • Effects of complement factor D deficiency on the renal disease of MRL/lpr mice
    • Elliott M.K., Jarmi T., Ruiz P., Xu Y., Holers V.M., Gilkeson G.S. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice. Kidney Int 2004, 65:129-138.
    • (2004) Kidney Int , vol.65 , pp. 129-138
    • Elliott, M.K.1    Jarmi, T.2    Ruiz, P.3    Xu, Y.4    Holers, V.M.5    Gilkeson, G.S.6
  • 288
    • 0035873190 scopus 로고    scopus 로고
    • Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice
    • Sekine H., Reilly C.M., Molano I.D., Garnier G., Circolo A., Ruiz P., et al. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. J Immunol 2001, 166:6444-6451.
    • (2001) J Immunol , vol.166 , pp. 6444-6451
    • Sekine, H.1    Reilly, C.M.2    Molano, I.D.3    Garnier, G.4    Circolo, A.5    Ruiz, P.6
  • 289
    • 0036467412 scopus 로고    scopus 로고
    • Complement C4 is protective for lupus disease independent of C3
    • Einav S., Pozdnyakova O.O., Ma M., Carroll M.C. Complement C4 is protective for lupus disease independent of C3. J Immunol 2002, 168:1036-1041.
    • (2002) J Immunol , vol.168 , pp. 1036-1041
    • Einav, S.1    Pozdnyakova, O.O.2    Ma, M.3    Carroll, M.C.4
  • 290
    • 0036533640 scopus 로고    scopus 로고
    • Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice
    • Bao L., Haas M., Boackle S.A., Kraus D.M., Cunningham P.N., Park P., et al. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol 2002, 168:3601-3607.
    • (2002) J Immunol , vol.168 , pp. 3601-3607
    • Bao, L.1    Haas, M.2    Boackle, S.A.3    Kraus, D.M.4    Cunningham, P.N.5    Park, P.6
  • 291
    • 0036735306 scopus 로고    scopus 로고
    • Deletion of decay-accelerating factor (CD55) exacerbates autoimmune disease development in MRL/lpr mice
    • Miwa T., Maldonado M.A., Zhou L., Sun X., Luo H.Y., Cai D., et al. Deletion of decay-accelerating factor (CD55) exacerbates autoimmune disease development in MRL/lpr mice. Am J Pathol 2002, 161:1077-1086.
    • (2002) Am J Pathol , vol.161 , pp. 1077-1086
    • Miwa, T.1    Maldonado, M.A.2    Zhou, L.3    Sun, X.4    Luo, H.Y.5    Cai, D.6
  • 292
    • 34247842905 scopus 로고    scopus 로고
    • Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms
    • Miwa T., Maldonado M.A., Zhou L., Yamada K., Gilkeson G.S., Eisenberg R.A., et al. Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms. Am J Pathol 2007, 170:1258-1266.
    • (2007) Am J Pathol , vol.170 , pp. 1258-1266
    • Miwa, T.1    Maldonado, M.A.2    Zhou, L.3    Yamada, K.4    Gilkeson, G.S.5    Eisenberg, R.A.6
  • 293
    • 46949091514 scopus 로고    scopus 로고
    • Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse
    • Svenson J.L., EuDaly J., Ruiz P., Korach K.S., Gilkeson G.S. Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse. Clin Immunol 2008, 128:259-268.
    • (2008) Clin Immunol , vol.128 , pp. 259-268
    • Svenson, J.L.1    EuDaly, J.2    Ruiz, P.3    Korach, K.S.4    Gilkeson, G.S.5
  • 295
    • 0030983935 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus
    • Lloyd C.M., Gonzalo J.A., Salant D.J., Just J., Gutierrez-Ramos J.C. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest 1997, 100:963-971.
    • (1997) J Clin Invest , vol.100 , pp. 963-971
    • Lloyd, C.M.1    Gonzalo, J.A.2    Salant, D.J.3    Just, J.4    Gutierrez-Ramos, J.C.5
  • 296
    • 0031571332 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality
    • Bullard D.C., King P.D., Hicks M.J., Dupont B., Beaudet A.L., Elkon K.B. Intercellular adhesion molecule-1 deficiency protects MRL/MpJ-Fas(lpr) mice from early lethality. J Immunol 1997, 159:2058-2067.
    • (1997) J Immunol , vol.159 , pp. 2058-2067
    • Bullard, D.C.1    King, P.D.2    Hicks, M.J.3    Dupont, B.4    Beaudet, A.L.5    Elkon, K.B.6
  • 297
    • 46949104431 scopus 로고    scopus 로고
    • Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice
    • Norman M.U., James W.G., Hickey M.J. Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice. J Leukoc Biol. 2008, 84:68-76.
    • (2008) J Leukoc Biol. , vol.84 , pp. 68-76
    • Norman, M.U.1    James, W.G.2    Hickey, M.J.3
  • 298
    • 0030878992 scopus 로고    scopus 로고
    • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2
    • Gilkeson G.S., Mudgett J.S., Seldin M.F., Ruiz P., Alexander A.A., Misukonis M.A., et al. Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. J Exp Med 1997, 186:365-373.
    • (1997) J Exp Med , vol.186 , pp. 365-373
    • Gilkeson, G.S.1    Mudgett, J.S.2    Seldin, M.F.3    Ruiz, P.4    Alexander, A.A.5    Misukonis, M.A.6
  • 299
    • 0032512855 scopus 로고    scopus 로고
    • Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis
    • Clynes R., Dumitru C., Ravetch J.V. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998, 279:1052-1054.
    • (1998) Science , vol.279 , pp. 1052-1054
    • Clynes, R.1    Dumitru, C.2    Ravetch, J.V.3
  • 300
    • 17944384552 scopus 로고    scopus 로고
    • Resistance of Fc receptor-deficient mice to fatal glomerulonephritis
    • Park S.Y., Ueda S., Ohno H., Hamano Y., Tanaka M., Shiratori T., et al. Resistance of Fc receptor-deficient mice to fatal glomerulonephritis. J Clin Invest 1998, 102:1229-1238.
    • (1998) J Clin Invest , vol.102 , pp. 1229-1238
    • Park, S.Y.1    Ueda, S.2    Ohno, H.3    Hamano, Y.4    Tanaka, M.5    Shiratori, T.6
  • 301
    • 0033402848 scopus 로고    scopus 로고
    • Monocyte Chemoattractant Protein 1-dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in MRL-Fas(lpr) Mice
    • Tesch G.H., Maifert S., Schwarting A., Rollins B.J., Kelley V.R. Monocyte Chemoattractant Protein 1-dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in MRL-Fas(lpr) Mice. J Exp Med 1999, 190:1813-1824.
    • (1999) J Exp Med , vol.190 , pp. 1813-1824
    • Tesch, G.H.1    Maifert, S.2    Schwarting, A.3    Rollins, B.J.4    Kelley, V.R.5
  • 302
    • 33749509030 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice
    • Hoi A.Y., Hickey M.J., Hall P., Yamana J., O'Sullivan K.M., Santos L.L., et al. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. J Immunol 2006, 177:5687-5696.
    • (2006) J Immunol , vol.177 , pp. 5687-5696
    • Hoi, A.Y.1    Hickey, M.J.2    Hall, P.3    Yamana, J.4    O'Sullivan, K.M.5    Santos, L.L.6
  • 303
    • 65249086734 scopus 로고    scopus 로고
    • Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans
    • Liu K., Li Q.Z., Delgado-Vega A.M., Abelson A.K., Sanchez E., Kelly J.A., et al. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest 2009, 119:911-923.
    • (2009) J Clin Invest , vol.119 , pp. 911-923
    • Liu, K.1    Li, Q.Z.2    Delgado-Vega, A.M.3    Abelson, A.K.4    Sanchez, E.5    Kelly, J.A.6
  • 304
    • 33749321261 scopus 로고    scopus 로고
    • Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis
    • Yoshida M., Saiga K., Hato T., Iwaki S., Niiya T., Arita N., et al. Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis. Arthritis Rheum 2006, 54:2934-2943.
    • (2006) Arthritis Rheum , vol.54 , pp. 2934-2943
    • Yoshida, M.1    Saiga, K.2    Hato, T.3    Iwaki, S.4    Niiya, T.5    Arita, N.6
  • 305
    • 33845402233 scopus 로고    scopus 로고
    • Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice
    • He X., Schoeb T.R., Panoskaltsis-Mortari A., Zinn K.R., Kesterson R.A., Zhang J., et al. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice. J Immunol 2006, 177:8748-8756.
    • (2006) J Immunol , vol.177 , pp. 8748-8756
    • He, X.1    Schoeb, T.R.2    Panoskaltsis-Mortari, A.3    Zinn, K.R.4    Kesterson, R.A.5    Zhang, J.6
  • 306
    • 65249105407 scopus 로고    scopus 로고
    • Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis
    • Crowley S.D., Vasievich M.P., Ruiz P., Gould S.K., Parsons K.K., Pazmino A.K., et al. Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. J Clin Invest 2009, 119:943-953.
    • (2009) J Clin Invest , vol.119 , pp. 943-953
    • Crowley, S.D.1    Vasievich, M.P.2    Ruiz, P.3    Gould, S.K.4    Parsons, K.K.5    Pazmino, A.K.6
  • 307
    • 0030497923 scopus 로고    scopus 로고
    • Repertoires of antigen receptors in Tdt congenitally deficient mice
    • Komori T., Pricop L., Hatakeyama A., Bona C.A., Alt F.W. Repertoires of antigen receptors in Tdt congenitally deficient mice. Int Rev Immunol 1996, 13:317-325.
    • (1996) Int Rev Immunol , vol.13 , pp. 317-325
    • Komori, T.1    Pricop, L.2    Hatakeyama, A.3    Bona, C.A.4    Alt, F.W.5
  • 308
    • 0031572496 scopus 로고    scopus 로고
    • Autoantibodies in mice lacking terminal deoxynucleotidyl transferase: evidence for a role of N region addition in the polyreactivity and in the affinities of anti-DNA antibodies
    • Weller S., Conde C., Knapp A.M., Levallois H., Gilfillan S., Pasquali J.L., et al. Autoantibodies in mice lacking terminal deoxynucleotidyl transferase: evidence for a role of N region addition in the polyreactivity and in the affinities of anti-DNA antibodies. J Immunol 1997, 159:3890-3898.
    • (1997) J Immunol , vol.159 , pp. 3890-3898
    • Weller, S.1    Conde, C.2    Knapp, A.M.3    Levallois, H.4    Gilfillan, S.5    Pasquali, J.L.6
  • 309
    • 0033984311 scopus 로고    scopus 로고
    • Effect of a genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production by C57BL6 fas(lpr) mice
    • Molano I.D., Wloch M.K., Alexander A.A., Watanabe H., Gilkeson G.S. Effect of a genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production by C57BL6 fas(lpr) mice. Clin Immunol 2000, 94:24-32.
    • (2000) Clin Immunol , vol.94 , pp. 24-32
    • Molano, I.D.1    Wloch, M.K.2    Alexander, A.A.3    Watanabe, H.4    Gilkeson, G.S.5
  • 312
    • 34147129553 scopus 로고    scopus 로고
    • ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia
    • Feng X., Li H., Rumbin A.A., Wang X., La Cava A., Brechtelsbauer K., et al. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. Journal of lipid research 2007, 48:794-805.
    • (2007) Journal of lipid research , vol.48 , pp. 794-805
    • Feng, X.1    Li, H.2    Rumbin, A.A.3    Wang, X.4    La Cava, A.5    Brechtelsbauer, K.6
  • 313
    • 0032415287 scopus 로고    scopus 로고
    • Promiscuous subunit interactions: a possible mechanism for the regulation of protein kinase CK2
    • Allende C.C., Allende J.E. Promiscuous subunit interactions: a possible mechanism for the regulation of protein kinase CK2. J Cell Biochem Suppl. 1998, 31:129-136.
    • (1998) J Cell Biochem Suppl. , vol.31 , pp. 129-136
    • Allende, C.C.1    Allende, J.E.2
  • 315
    • 0026081171 scopus 로고
    • Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites
    • Spurney R.F., Ruiz P., Pisetsky D.S., Coffman T.M. Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. Kidney Int 1991, 39:95-102.
    • (1991) Kidney Int , vol.39 , pp. 95-102
    • Spurney, R.F.1    Ruiz, P.2    Pisetsky, D.S.3    Coffman, T.M.4
  • 316
    • 0027230775 scopus 로고
    • Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization
    • Rudofsky U.H., Evans B.D., Balaban S.L., Mottironi V.D., Gabrielsen A.E. Differences in expression of lupus nephritis in New Zealand mixed H-2z homozygous inbred strains of mice derived from New Zealand black and New Zealand white mice. Origins and initial characterization. Lab Invest 1993, 68:419-426.
    • (1993) Lab Invest , vol.68 , pp. 419-426
    • Rudofsky, U.H.1    Evans, B.D.2    Balaban, S.L.3    Mottironi, V.D.4    Gabrielsen, A.E.5
  • 317
    • 0027336832 scopus 로고
    • An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome
    • Fossati L., Takahashi S., Merino R., Iwamoto M., Aubry J.P., Nose M., et al. An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Int Immunol 1993, 5:525-532.
    • (1993) Int Immunol , vol.5 , pp. 525-532
    • Fossati, L.1    Takahashi, S.2    Merino, R.3    Iwamoto, M.4    Aubry, J.P.5    Nose, M.6
  • 318
    • 0027235801 scopus 로고
    • Morphological analysis of autoimmune disease in MRL-lpr, Yaa male mice with rapidly progressive systemic lupus erythematosus
    • Suzuka H., Yoshifusa H., Nakamura Y., Miyawaki S., Shibata Y. Morphological analysis of autoimmune disease in MRL-lpr, Yaa male mice with rapidly progressive systemic lupus erythematosus. Autoimmunity 1993, 14:275-282.
    • (1993) Autoimmunity , vol.14 , pp. 275-282
    • Suzuka, H.1    Yoshifusa, H.2    Nakamura, Y.3    Miyawaki, S.4    Shibata, Y.5
  • 319
    • 0027481688 scopus 로고
    • Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis
    • Kinjoh K., Kyogoku M., Good R.A. Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis. Proc Natl Acad Sci USA 1993, 90:3413-3417.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3413-3417
    • Kinjoh, K.1    Kyogoku, M.2    Good, R.A.3
  • 321
    • 34848819214 scopus 로고    scopus 로고
    • BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci
    • Haywood M.E., Gabriel L., Rose S.J., Rogers N.J., Izui S., Morley B.J. BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci. J Immunol 2007, 179:2428-2434.
    • (2007) J Immunol , vol.179 , pp. 2428-2434
    • Haywood, M.E.1    Gabriel, L.2    Rose, S.J.3    Rogers, N.J.4    Izui, S.5    Morley, B.J.6
  • 322
    • 0028355419 scopus 로고
    • (SWR x SJL)F1 mice: a new model of lupus-like disease
    • Vidal S., Gelpi C., Rodriguez-Sanchez J.L. (SWR x SJL)F1 mice: a new model of lupus-like disease. J Exp Med 1994, 179:1429-1435.
    • (1994) J Exp Med , vol.179 , pp. 1429-1435
    • Vidal, S.1    Gelpi, C.2    Rodriguez-Sanchez, J.L.3
  • 323
    • 0018253165 scopus 로고
    • Palmerston North mice, a new animal model of systemic lupus erythematosus
    • Walker S.E., Gray R.H., Fulton M., Wigley R.D., Schnitzer B. Palmerston North mice, a new animal model of systemic lupus erythematosus. J Lab Clin Med 1978, 92:932-945.
    • (1978) J Lab Clin Med , vol.92 , pp. 932-945
    • Walker, S.E.1    Gray, R.H.2    Fulton, M.3    Wigley, R.D.4    Schnitzer, B.5
  • 324
    • 0028077851 scopus 로고
    • Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function
    • Bignon J.S., Siminovitch K.A. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. Clin Immunol Immunopathol 1994, 73:168-179.
    • (1994) Clin Immunol Immunopathol , vol.73 , pp. 168-179
    • Bignon, J.S.1    Siminovitch, K.A.2
  • 325
    • 0030635831 scopus 로고    scopus 로고
    • Effects of mercury on the immune system
    • Pollard K.M., Hultman P. Effects of mercury on the immune system. Met Ions Biol Syst 1997, 34:421-440.
    • (1997) Met Ions Biol Syst , vol.34 , pp. 421-440
    • Pollard, K.M.1    Hultman, P.2
  • 326
    • 0002313961 scopus 로고    scopus 로고
    • Drug-induced lupus
    • Williams and Wilkens, Baltimore, D.J. Wallace, B.H. Hahn (Eds.)
    • Rubin R.L. Drug-induced lupus. Dubois' Lupus Erythematosus 1997, 871-901. Williams and Wilkens, Baltimore. D.J. Wallace, B.H. Hahn (Eds.).
    • (1997) Dubois' Lupus Erythematosus , pp. 871-901
    • Rubin, R.L.1
  • 327
    • 0028845353 scopus 로고
    • Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane
    • Satoh M., Kumar A., Kanwar Y.S., Reeves W.H. Anti-nuclear antibody production and immune-complex glomerulonephritis in BALB/c mice treated with pristane. Proc Natl Acad Sci USA 1995, 92:10934-10938.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10934-10938
    • Satoh, M.1    Kumar, A.2    Kanwar, Y.S.3    Reeves, W.H.4
  • 329
    • 0034830979 scopus 로고    scopus 로고
    • The NOD mouse as a model of SLE
    • Silveira P.A., Baxter A.G. The NOD mouse as a model of SLE. Autoimmunity 2001, 34:53-64.
    • (2001) Autoimmunity , vol.34 , pp. 53-64
    • Silveira, P.A.1    Baxter, A.G.2
  • 330
    • 0034254662 scopus 로고    scopus 로고
    • Linkage analysis of systemic lupus erythematosus induced in diabetes- prone nonobese diabetic mice by Mycobacterium bovis
    • Jordan M.A., Silveira P.A., Shepherd D.P., Chu C., Kinder S.J., Chen J., et al. Linkage analysis of systemic lupus erythematosus induced in diabetes- prone nonobese diabetic mice by Mycobacterium bovis. J Immunol 2000, 165:1673-1684.
    • (2000) J Immunol , vol.165 , pp. 1673-1684
    • Jordan, M.A.1    Silveira, P.A.2    Shepherd, D.P.3    Chu, C.4    Kinder, S.J.5    Chen, J.6
  • 332
    • 0034085594 scopus 로고    scopus 로고
    • Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice
    • Haywood M.E., Hogarth M.B., Slingsby J.H., Rose S.J., Allen P.J., Thompson E.M., et al. Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice. Arthritis Rheum 2000, 43:349-355.
    • (2000) Arthritis Rheum , vol.43 , pp. 349-355
    • Haywood, M.E.1    Hogarth, M.B.2    Slingsby, J.H.3    Rose, S.J.4    Allen, P.J.5    Thompson, E.M.6
  • 334
    • 0030587115 scopus 로고    scopus 로고
    • Backcross analysis of genes linked to autoantibody production in New Zealand White mice
    • Vyse T.J., Morel L., Tanner F.J., Wakeland E.K., Kotzin B.L. Backcross analysis of genes linked to autoantibody production in New Zealand White mice. J Immunol 1996, 157:2719-2727.
    • (1996) J Immunol , vol.157 , pp. 2719-2727
    • Vyse, T.J.1    Morel, L.2    Tanner, F.J.3    Wakeland, E.K.4    Kotzin, B.L.5
  • 335
    • 0033505045 scopus 로고    scopus 로고
    • Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance
    • Nishihara M., Terada M., Kamogawa J., Ohashi Y., Mori S., Nakatsuru S., et al. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum 1999, 42:2616-2623.
    • (1999) Arthritis Rheum , vol.42 , pp. 2616-2623
    • Nishihara, M.1    Terada, M.2    Kamogawa, J.3    Ohashi, Y.4    Mori, S.5    Nakatsuru, S.6
  • 336
    • 0035892906 scopus 로고    scopus 로고
    • Genetic contributions of nonautoimmune SWR mice toward lupus nephritis
    • Xie S., Chang S., Yang P., Jacob C., Kaliyaperumal A., Datta S.K., et al. Genetic contributions of nonautoimmune SWR mice toward lupus nephritis. J Immunol 2001, 167:7141-7149.
    • (2001) J Immunol , vol.167 , pp. 7141-7149
    • Xie, S.1    Chang, S.2    Yang, P.3    Jacob, C.4    Kaliyaperumal, A.5    Datta, S.K.6
  • 338
    • 0032776531 scopus 로고    scopus 로고
    • Multiplex inheritance of component phenotypes in a murine model of lupus
    • Morel L., Mohan C., Yu Y., Schiffenbauer J., Rudofsky U.H., Tian N., et al. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 1999, 10:176-181.
    • (1999) Mamm Genome , vol.10 , pp. 176-181
    • Morel, L.1    Mohan, C.2    Yu, Y.3    Schiffenbauer, J.4    Rudofsky, U.H.5    Tian, N.6
  • 340
    • 0034868803 scopus 로고    scopus 로고
    • NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci
    • Waters S.T., Fu S.M., Gaskin F., Deshmukh U.S., Sung S.S., Kannapell C.C., et al. NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Clin Immunol 2001, 100:372-383.
    • (2001) Clin Immunol , vol.100 , pp. 372-383
    • Waters, S.T.1    Fu, S.M.2    Gaskin, F.3    Deshmukh, U.S.4    Sung, S.S.5    Kannapell, C.C.6
  • 342
    • 0028942144 scopus 로고
    • Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner
    • Drake C.G., Rozzo S.J., Hirschfeld H.F., Smarnworawong N.P., Palmer E., Kotzin B.L. Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J Immunol 1995, 154:2441-2447.
    • (1995) J Immunol , vol.154 , pp. 2441-2447
    • Drake, C.G.1    Rozzo, S.J.2    Hirschfeld, H.F.3    Smarnworawong, N.P.4    Palmer, E.5    Kotzin, B.L.6
  • 343
    • 0031157347 scopus 로고    scopus 로고
    • Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice
    • Vyse T.J., Rozzo S.J., Drake C.G., Izui S., Kotzin B.L. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice. J Immunol 1997, 158:5566-5574.
    • (1997) J Immunol , vol.158 , pp. 5566-5574
    • Vyse, T.J.1    Rozzo, S.J.2    Drake, C.G.3    Izui, S.4    Kotzin, B.L.5
  • 344
    • 0030478149 scopus 로고    scopus 로고
    • Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis
    • Rozzo S.J., Vyse T.J., Drake C.G., Kotzin B.L. Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis. Proc Natl Acad Sci USA 1996, 93:15164-15168.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15164-15168
    • Rozzo, S.J.1    Vyse, T.J.2    Drake, C.G.3    Kotzin, B.L.4
  • 345
    • 13444278505 scopus 로고    scopus 로고
    • Genetic origin of lupus in NZB/SWR hybrids: lessons from an intercross study
    • Xie S., Li L., Chang S., Sharma R., Kaliyaperumal A., Datta S.K., et al. Genetic origin of lupus in NZB/SWR hybrids: lessons from an intercross study. Arthritis Rheum 2005, 52:659-667.
    • (2005) Arthritis Rheum , vol.52 , pp. 659-667
    • Xie, S.1    Li, L.2    Chang, S.3    Sharma, R.4    Kaliyaperumal, A.5    Datta, S.K.6
  • 346
    • 0032534737 scopus 로고    scopus 로고
    • Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus
    • Gu L., Weinreb A., Wang X.P., Zack D.J., Qiao J.H., Weisbart R., et al. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol 1998, 161:6999-7006.
    • (1998) J Immunol , vol.161 , pp. 6999-7006
    • Gu, L.1    Weinreb, A.2    Wang, X.P.3    Zack, D.J.4    Qiao, J.H.5    Weisbart, R.6
  • 347
    • 0037087451 scopus 로고    scopus 로고
    • A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus
    • Rahman Z.S., Tin S.K., Buenaventura P.N., Ho C.H., Yap E.P., Yong R.Y., et al. A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus. J Immunol 2002, 168:3042-3049.
    • (2002) J Immunol , vol.168 , pp. 3042-3049
    • Rahman, Z.S.1    Tin, S.K.2    Buenaventura, P.N.3    Ho, C.H.4    Yap, E.P.5    Yong, R.Y.6
  • 348
    • 0030708809 scopus 로고    scopus 로고
    • Host modifier genes affect mouse autoimmunity induced by the lpr gene
    • Wang Y., Nose M., Kamoto T., Nishimura M., Hiai H. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol 1997, 151:1791-1798.
    • (1997) Am J Pathol , vol.151 , pp. 1791-1798
    • Wang, Y.1    Nose, M.2    Kamoto, T.3    Nishimura, M.4    Hiai, H.5
  • 349
    • 1642339077 scopus 로고    scopus 로고
    • New loci from New Zealand Black and New Zealand White mice on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c
    • Rigby R.J., Rozzo S.J., Boyle J.J., Lewis M., Kotzin B.L., Vyse T.J. New loci from New Zealand Black and New Zealand White mice on chromosomes 4 and 12 contribute to lupus-like disease in the context of BALB/c. J Immunol 2004, 172:4609-4617.
    • (2004) J Immunol , vol.172 , pp. 4609-4617
    • Rigby, R.J.1    Rozzo, S.J.2    Boyle, J.J.3    Lewis, M.4    Kotzin, B.L.5    Vyse, T.J.6
  • 350
    • 21044458103 scopus 로고    scopus 로고
    • Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice
    • Miyazaki T., Ono M., Qu W.M., Zhang M.C., Mori S., Nakatsuru S., et al. Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice. Eur J Immunol 2005, 35:1510-1520.
    • (2005) Eur J Immunol , vol.35 , pp. 1510-1520
    • Miyazaki, T.1    Ono, M.2    Qu, W.M.3    Zhang, M.C.4    Mori, S.5    Nakatsuru, S.6
  • 351
    • 0031670363 scopus 로고    scopus 로고
    • Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW x BXSB) F1 mice
    • Ida A., Hirose S., Hamano Y., Kodera S., Jiang Y., Abe M., et al. Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW x BXSB) F1 mice. Eur J Immunol 1998, 28:2694-2703.
    • (1998) Eur J Immunol , vol.28 , pp. 2694-2703
    • Ida, A.1    Hirose, S.2    Hamano, Y.3    Kodera, S.4    Jiang, Y.5    Abe, M.6
  • 352
    • 0033957604 scopus 로고    scopus 로고
    • Genetic regulation of anti-erythrocyte autoantibodies and splenomegaly in autoimmune hemolytic anemia-prone new zealand black mice
    • Ochiai K., Ozaki S., Tanino A., Watanabe S., Ueno T., Mitsui K., et al. Genetic regulation of anti-erythrocyte autoantibodies and splenomegaly in autoimmune hemolytic anemia-prone new zealand black mice. Int Immunol 2000, 12:1-8.
    • (2000) Int Immunol , vol.12 , pp. 1-8
    • Ochiai, K.1    Ozaki, S.2    Tanino, A.3    Watanabe, S.4    Ueno, T.5    Mitsui, K.6
  • 354
    • 0028316937 scopus 로고
    • Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice
    • Drake C.G., Babcock S.K., Palmer E., Kotzin B.L. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice. Proc Natl Acad Sci USA 1994, 91:4062-4066.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4062-4066
    • Drake, C.G.1    Babcock, S.K.2    Palmer, E.3    Kotzin, B.L.4
  • 355
    • 0028589199 scopus 로고
    • Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice
    • Hirose S., Tsurui H., Nishimura H., Jiang Y., Shirai T. Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice. Int Immunol 1994, 6:1857-1864.
    • (1994) Int Immunol , vol.6 , pp. 1857-1864
    • Hirose, S.1    Tsurui, H.2    Nishimura, H.3    Jiang, Y.4    Shirai, T.5
  • 356
    • 0031567985 scopus 로고    scopus 로고
    • Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease
    • Jiang Y., Hirose S., Hamano Y., Kodera S., Tsurui H., Abe M., et al. Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease. J Immunol 1997, 158:992-997.
    • (1997) J Immunol , vol.158 , pp. 992-997
    • Jiang, Y.1    Hirose, S.2    Hamano, Y.3    Kodera, S.4    Tsurui, H.5    Abe, M.6
  • 357
    • 0033452605 scopus 로고    scopus 로고
    • Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice
    • Nakatsuru S., Terada M., Nishihara M., Kamogawa J., Miyazaki T., Qu W.M., et al. Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. Pathology international 1999, 49:974-982.
    • (1999) Pathology international , vol.49 , pp. 974-982
    • Nakatsuru, S.1    Terada, M.2    Nishihara, M.3    Kamogawa, J.4    Miyazaki, T.5    Qu, W.M.6
  • 358
    • 0026471742 scopus 로고
    • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci
    • Watson M.L., Rao J.K., Gilkeson G.S., Ruiz P., Eicher E.M., Pisetsky D.S., et al. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med 1992, 176:1645-1656.
    • (1992) J Exp Med , vol.176 , pp. 1645-1656
    • Watson, M.L.1    Rao, J.K.2    Gilkeson, G.S.3    Ruiz, P.4    Eicher, E.M.5    Pisetsky, D.S.6
  • 359
    • 0029913568 scopus 로고    scopus 로고
    • Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice
    • Vyse T.J., Drake C.G., Rozzo S.J., Roper E., Izui S., Kotzin B.L. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J Clin Invest 1996, 98:1762-1772.
    • (1996) J Clin Invest , vol.98 , pp. 1762-1772
    • Vyse, T.J.1    Drake, C.G.2    Rozzo, S.J.3    Roper, E.4    Izui, S.5    Kotzin, B.L.6
  • 360
    • 0037029604 scopus 로고    scopus 로고
    • Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice
    • Bolland S., Yim Y.S., Tus K., Wakeland E.K., Ravetch J.V. Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice. J Exp Med 2002, 195:1167-1174.
    • (2002) J Exp Med , vol.195 , pp. 1167-1174
    • Bolland, S.1    Yim, Y.S.2    Tus, K.3    Wakeland, E.K.4    Ravetch, J.V.5
  • 361
    • 0035424165 scopus 로고    scopus 로고
    • Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice
    • Haywood M.E., Vyse T.J., McDermott A., Thompson E.M., Ida A., Walport M.J., et al. Autoantigen glycoprotein 70 expression is regulated by a single locus, which acts as a checkpoint for pathogenic anti-glycoprotein 70 autoantibody production and hence for the corresponding development of severe nephritis, in lupus-prone PXSB mice. J Immunol 2001, 167:1728-1733.
    • (2001) J Immunol , vol.167 , pp. 1728-1733
    • Haywood, M.E.1    Vyse, T.J.2    McDermott, A.3    Thompson, E.M.4    Ida, A.5    Walport, M.J.6
  • 362
    • 0034658345 scopus 로고    scopus 로고
    • Enhanced susceptibility to lupus contributed from the nonautoimmune C57BL/10, but not C57BL/6, genome
    • Rozzo S.J., Vyse T.J., Menze K., Izui S., Kotzin B.L. Enhanced susceptibility to lupus contributed from the nonautoimmune C57BL/10, but not C57BL/6, genome. J Immunol 2000, 164:5515-5521.
    • (2000) J Immunol , vol.164 , pp. 5515-5521
    • Rozzo, S.J.1    Vyse, T.J.2    Menze, K.3    Izui, S.4    Kotzin, B.L.5
  • 363
    • 33846956830 scopus 로고    scopus 로고
    • Genetic control of the spontaneous activation of CD4(+) Th cells in systemic lupus erythematosus-prone (NZB x NZW) F(1) mice
    • Fujii T., Iida Y., Yomogida M., Ikeda K., Haga T., Jikumaru Y., et al. Genetic control of the spontaneous activation of CD4(+) Th cells in systemic lupus erythematosus-prone (NZB x NZW) F(1) mice. Genes Immun 2006, 7:647-654.
    • (2006) Genes Immun , vol.7 , pp. 647-654
    • Fujii, T.1    Iida, Y.2    Yomogida, M.3    Ikeda, K.4    Haga, T.5    Jikumaru, Y.6
  • 364
    • 0031771012 scopus 로고    scopus 로고
    • Linkage of a major quantitative trait locus to Yaa gene-induced lupus- like nephritis in (NZW x C57BL/6)F1 mice
    • Santiago M.L., Mary C., Parzy D., Jacquet C., Montagutelli X., Parkhouse R.M., et al. Linkage of a major quantitative trait locus to Yaa gene-induced lupus- like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol 1998, 28:4257-4267.
    • (1998) Eur J Immunol , vol.28 , pp. 4257-4267
    • Santiago, M.L.1    Mary, C.2    Parzy, D.3    Jacquet, C.4    Montagutelli, X.5    Parkhouse, R.M.6
  • 365
    • 0036226155 scopus 로고    scopus 로고
    • Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains
    • Kamogawa J., Terada M., Mizuki S., Nishihara M., Yamamoto H., Mori S., et al. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum 2002, 46:1067-1074.
    • (2002) Arthritis Rheum , vol.46 , pp. 1067-1074
    • Kamogawa, J.1    Terada, M.2    Mizuki, S.3    Nishihara, M.4    Yamamoto, H.5    Mori, S.6
  • 366
    • 0034254311 scopus 로고    scopus 로고
    • Genetic control of glycoprotein 70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus
    • Tucker R.M., Vyse T.J., Rozzo S., Roark C.L., Izui S., Kotzin B.L. Genetic control of glycoprotein 70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus. J Immunol 2000, 165:1665-1672.
    • (2000) J Immunol , vol.165 , pp. 1665-1672
    • Tucker, R.M.1    Vyse, T.J.2    Rozzo, S.3    Roark, C.L.4    Izui, S.5    Kotzin, B.L.6
  • 367
    • 77953583256 scopus 로고    scopus 로고
    • Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity
    • Choubey D., Duan X., Dickerson E., Ponomareva L., Panchanathan R., Shen H., et al. Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity. J Interferon Cytokine Res 2010, 30(6):371-380.
    • (2010) J Interferon Cytokine Res , vol.30 , Issue.6 , pp. 371-380
    • Choubey, D.1    Duan, X.2    Dickerson, E.3    Ponomareva, L.4    Panchanathan, R.5    Shen, H.6
  • 368
    • 29144512261 scopus 로고    scopus 로고
    • Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice
    • Cheung Y.H., Chang N.H., Cai Y.C., Bonventi G., MacLeod R., Wither J.E. Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice. J Immunol 2005, 175:8154-8164.
    • (2005) J Immunol , vol.175 , pp. 8154-8164
    • Cheung, Y.H.1    Chang, N.H.2    Cai, Y.C.3    Bonventi, G.4    MacLeod, R.5    Wither, J.E.6
  • 369
    • 0027145632 scopus 로고
    • Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    • Suda T., Takahashi T., Golstein P., Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993, 75:1169-1178.
    • (1993) Cell , vol.75 , pp. 1169-1178
    • Suda, T.1    Takahashi, T.2    Golstein, P.3    Nagata, S.4
  • 370
    • 33745161013 scopus 로고    scopus 로고
    • Regulation of B cell tolerance by the lupus susceptibility gene Ly108
    • Kumar K.R., Li L., Yan M., Bhaskarabhatla M., Mobley A.B., Nguyen C., et al. Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science 2006, 312:1665-1669.
    • (2006) Science , vol.312 , pp. 1665-1669
    • Kumar, K.R.1    Li, L.2    Yan, M.3    Bhaskarabhatla, M.4    Mobley, A.B.5    Nguyen, C.6
  • 371
    • 22544488365 scopus 로고    scopus 로고
    • Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene
    • Rahman Z.S., Manser T. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol 2005, 175:1440-1449.
    • (2005) J Immunol , vol.175 , pp. 1440-1449
    • Rahman, Z.S.1    Manser, T.2
  • 372
    • 0032840072 scopus 로고    scopus 로고
    • Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus
    • Jiang Y., Hirose S., Sanokawa-Akakura R., Abe M., Mi X., Li N., et al. Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol 1999, 11:1685-1691.
    • (1999) Int Immunol , vol.11 , pp. 1685-1691
    • Jiang, Y.1    Hirose, S.2    Sanokawa-Akakura, R.3    Abe, M.4    Mi, X.5    Li, N.6
  • 373
    • 0035652286 scopus 로고    scopus 로고
    • Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein
    • Boackle S.A., Holers V.M., Chen X., Szakonyi G., Karp D.R., Wakeland E.K., et al. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity 2001, 15:775-785.
    • (2001) Immunity , vol.15 , pp. 775-785
    • Boackle, S.A.1    Holers, V.M.2    Chen, X.3    Szakonyi, G.4    Karp, D.R.5    Wakeland, E.K.6
  • 375
    • 0026568919 scopus 로고
    • Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S. Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992, 356:314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.I.2    Copeland, N.G.3    Jenkins, N.A.4    Nagata, S.5
  • 378
    • 0034704180 scopus 로고    scopus 로고
    • An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity
    • Majeti R., Xu Z., Parslow T.G., Olson J.L., Daikh D.I., Killeen N., et al. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 2000, 103:1059-1070.
    • (2000) Cell , vol.103 , pp. 1059-1070
    • Majeti, R.1    Xu, Z.2    Parslow, T.G.3    Olson, J.L.4    Daikh, D.I.5    Killeen, N.6
  • 379
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • Takahashi T., Tanaka M., Brannan C.I., Jenkins N.A., Copeland N.G., Suda T., et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 1994, 76:969-976.
    • (1994) Cell , vol.76 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3    Jenkins, N.A.4    Copeland, N.G.5    Suda, T.6
  • 380
    • 0037730377 scopus 로고    scopus 로고
    • FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease
    • Yajima K., Nakamura A., Sugahara A., Takai T. FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease. Eur J Immunol 2003, 33:1020-1029.
    • (2003) Eur J Immunol , vol.33 , pp. 1020-1029
    • Yajima, K.1    Nakamura, A.2    Sugahara, A.3    Takai, T.4
  • 381
    • 0042886906 scopus 로고    scopus 로고
    • Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice
    • Drappa J., Kamen L.A., Chan E., Georgiev M., Ashany D., Marti F., et al. Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice. J Exp Med 2003, 198:809-821.
    • (2003) J Exp Med , vol.198 , pp. 809-821
    • Drappa, J.1    Kamen, L.A.2    Chan, E.3    Georgiev, M.4    Ashany, D.5    Marti, F.6
  • 382
  • 384
    • 0033049125 scopus 로고    scopus 로고
    • Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
    • Lai W.S., Carballo E., Strum J.R., Kennington E.A., Phillips R.S., Blackshear P.J. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 1999, 19:4311-4323.
    • (1999) Mol Cell Biol , vol.19 , pp. 4311-4323
    • Lai, W.S.1    Carballo, E.2    Strum, J.R.3    Kennington, E.A.4    Phillips, R.S.5    Blackshear, P.J.6
  • 386
    • 0033583479 scopus 로고    scopus 로고
    • Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
    • O'Keefe T.L., Williams G.T., Batista F.D., Neuberger M.S. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 1999, 189:1307-1313.
    • (1999) J Exp Med , vol.189 , pp. 1307-1313
    • O'Keefe, T.L.1    Williams, G.T.2    Batista, F.D.3    Neuberger, M.S.4
  • 387
    • 0035182146 scopus 로고    scopus 로고
    • Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn
    • Yu C.C., Yen T.S., Lowell C.A., DeFranco A.L. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol 2001, 11:34-38.
    • (2001) Curr Biol , vol.11 , pp. 34-38
    • Yu, C.C.1    Yen, T.S.2    Lowell, C.A.3    DeFranco, A.L.4
  • 388
    • 34247873196 scopus 로고    scopus 로고
    • The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease
    • Qian Y., Liu C., Hartupee J., Altuntas C.Z., Gulen M.F., Jane-Wit D., et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 2007, 8:247-256.
    • (2007) Nat Immunol , vol.8 , pp. 247-256
    • Qian, Y.1    Liu, C.2    Hartupee, J.3    Altuntas, C.Z.4    Gulen, M.F.5    Jane-Wit, D.6
  • 389
    • 51149112318 scopus 로고    scopus 로고
    • Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren's syndrome
    • Qian Y., Giltiay N., Xiao J., Wang Y., Tian J., Han S., et al. Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren's syndrome. Eur J Immunol 2008, 38:2219-2228.
    • (2008) Eur J Immunol , vol.38 , pp. 2219-2228
    • Qian, Y.1    Giltiay, N.2    Xiao, J.3    Wang, Y.4    Tian, J.5    Han, S.6
  • 390
    • 0037332043 scopus 로고    scopus 로고
    • Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor
    • Seshasayee D., Valdez P., Yan M., Dixit V.M., Tumas D., Grewal I.S. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003, 18:279-288.
    • (2003) Immunity , vol.18 , pp. 279-288
    • Seshasayee, D.1    Valdez, P.2    Yan, M.3    Dixit, V.M.4    Tumas, D.5    Grewal, I.S.6
  • 391
    • 0037108370 scopus 로고    scopus 로고
    • A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia
    • Kikuchi S., Pastore Y., Fossati-Jimack L., Kuroki A., Yoshida H., Fulpius T., et al. A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. J Immunol 2002, 169:4644-4650.
    • (2002) J Immunol , vol.169 , pp. 4644-4650
    • Kikuchi, S.1    Pastore, Y.2    Fossati-Jimack, L.3    Kuroki, A.4    Yoshida, H.5    Fulpius, T.6
  • 392
    • 0037331250 scopus 로고    scopus 로고
    • Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice
    • Matsumoto K., Watanabe N., Akikusa B., Kurasawa K., Matsumura R., Saito Y., et al. Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum 2003, 48:486-494.
    • (2003) Arthritis Rheum , vol.48 , pp. 486-494
    • Matsumoto, K.1    Watanabe, N.2    Akikusa, B.3    Kurasawa, K.4    Matsumura, R.5    Saito, Y.6
  • 393
    • 0036681645 scopus 로고    scopus 로고
    • A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus
    • Wu X., Jiang N., Deppong C., Singh J., Dolecki G., Mao D., et al. A role for the Cr2 gene in modifying autoantibody production in systemic lupus erythematosus. J Immunol 2002, 169:1587-1592.
    • (2002) J Immunol , vol.169 , pp. 1587-1592
    • Wu, X.1    Jiang, N.2    Deppong, C.3    Singh, J.4    Dolecki, G.5    Mao, D.6
  • 394
    • 0031239980 scopus 로고    scopus 로고
    • Autoantibody production and cytokine profiles of MHC class I (beta2- microglobulin) gene deleted New Zealand black (NZB) mice
    • Chen S.Y., Takeoka Y., Pike-Nobile L., Ansari A.A., Boyd R., Gershwin M.E. Autoantibody production and cytokine profiles of MHC class I (beta2- microglobulin) gene deleted New Zealand black (NZB) mice. Clin Immunol Immunopathol 1997, 84:318-327.
    • (1997) Clin Immunol Immunopathol , vol.84 , pp. 318-327
    • Chen, S.Y.1    Takeoka, Y.2    Pike-Nobile, L.3    Ansari, A.A.4    Boyd, R.5    Gershwin, M.E.6
  • 395
    • 0033168592 scopus 로고    scopus 로고
    • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice
    • Goulet J.L., Griffiths R.C., Ruiz P., Spurney R.F., Pisetsky D.S., Koller B.H., et al. Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. J Immunol 1999, 163:359-366.
    • (1999) J Immunol , vol.163 , pp. 359-366
    • Goulet, J.L.1    Griffiths, R.C.2    Ruiz, P.3    Spurney, R.F.4    Pisetsky, D.S.5    Koller, B.H.6
  • 397
    • 0037442214 scopus 로고    scopus 로고
    • Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice
    • Sun J., Matthias G., Mihatsch M.J., Georgopoulos K., Matthias P. Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice. J Immunol 2003, 170:1699-1706.
    • (2003) J Immunol , vol.170 , pp. 1699-1706
    • Sun, J.1    Matthias, G.2    Mihatsch, M.J.3    Georgopoulos, K.4    Matthias, P.5
  • 399
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002, 3:196-200.
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6
  • 400
    • 0031831859 scopus 로고    scopus 로고
    • IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL- Fas(lpr) mice
    • Schwarting A., Wada T., Kinoshita K., Tesch G., Kelley V.R. IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL- Fas(lpr) mice. J Immunol 1998, 161:494-503.
    • (1998) J Immunol , vol.161 , pp. 494-503
    • Schwarting, A.1    Wada, T.2    Kinoshita, K.3    Tesch, G.4    Kelley, V.R.5
  • 401
    • 0031225487 scopus 로고    scopus 로고
    • Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn)
    • Takahashi T., Yagi T., Kakinuma S., Kurokawa A., Okada T., Takatsu K., et al. Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn). J Immunol 1997, 159:2532-2541.
    • (1997) J Immunol , vol.159 , pp. 2532-2541
    • Takahashi, T.1    Yagi, T.2    Kakinuma, S.3    Kurokawa, A.4    Okada, T.5    Takatsu, K.6
  • 402
    • 0032926264 scopus 로고    scopus 로고
    • Nitric oxide and glomerulonephritis
    • Cattell V. Nitric oxide and glomerulonephritis. Semin Nephrol 1999, 19:277-287.
    • (1999) Semin Nephrol , vol.19 , pp. 277-287
    • Cattell, V.1
  • 403
    • 0030425799 scopus 로고    scopus 로고
    • T cells in murine lupus: propagation and regulation of disease
    • Peng S.L., Craft J. T cells in murine lupus: propagation and regulation of disease. Mol Biol Rep 1996, 23:247-251.
    • (1996) Mol Biol Rep , vol.23 , pp. 247-251
    • Peng, S.L.1    Craft, J.2
  • 404
    • 0030589323 scopus 로고    scopus 로고
    • Propagation and regulation of systemic autoimmunity by gammadelta T cells
    • Peng S.L., Madaio M.P., Hayday A.C., Craft J. Propagation and regulation of systemic autoimmunity by gammadelta T cells. J Immunol 1996, 157:5689-5698.
    • (1996) J Immunol , vol.157 , pp. 5689-5698
    • Peng, S.L.1    Madaio, M.P.2    Hayday, A.C.3    Craft, J.4
  • 405
    • 0029942841 scopus 로고    scopus 로고
    • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells
    • Wen L., Pao W., Wong F.S., Peng Q., Craft J., Zheng B., et al. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. J Exp Med 1996, 183:2271-2282.
    • (1996) J Exp Med , vol.183 , pp. 2271-2282
    • Wen, L.1    Pao, W.2    Wong, F.S.3    Peng, Q.4    Craft, J.5    Zheng, B.6
  • 406
    • 0035881242 scopus 로고    scopus 로고
    • The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus
    • Lawson B.R., Koundouris S.I., Barnhouse M., Dummer W., Baccala R., Kono D.H., et al. The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus. J Immunol 2001, 167:2354-2360.
    • (2001) J Immunol , vol.167 , pp. 2354-2360
    • Lawson, B.R.1    Koundouris, S.I.2    Barnhouse, M.3    Dummer, W.4    Baccala, R.5    Kono, D.H.6
  • 408
    • 0035478001 scopus 로고    scopus 로고
    • HLA-DR modulates autoantibody repertoire, but not mortality, in a humanized mouse model of systemic lupus erythematosus
    • Paisansinsup T., Vallejo A.N., Luthra H., David C.S. HLA-DR modulates autoantibody repertoire, but not mortality, in a humanized mouse model of systemic lupus erythematosus. J Immunol 2001, 167:4083-4090.
    • (2001) J Immunol , vol.167 , pp. 4083-4090
    • Paisansinsup, T.1    Vallejo, A.N.2    Luthra, H.3    David, C.S.4
  • 409
    • 0033947471 scopus 로고    scopus 로고
    • Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor
    • Kontoyiannis D., Kollias G. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumor necrosis factor. Eur J Immunol 2000, 30:2038-2047.
    • (2000) Eur J Immunol , vol.30 , pp. 2038-2047
    • Kontoyiannis, D.1    Kollias, G.2
  • 410
    • 0032534606 scopus 로고    scopus 로고
    • Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand Black x New Zealand White)F1 mice
    • Conde C., Weller S., Gilfillan S., Marcellin L., Martin T., Pasquali J.L. Terminal deoxynucleotidyl transferase deficiency reduces the incidence of autoimmune nephritis in (New Zealand Black x New Zealand White)F1 mice. J Immunol 1998, 161:7023-7030.
    • (1998) J Immunol , vol.161 , pp. 7023-7030
    • Conde, C.1    Weller, S.2    Gilfillan, S.3    Marcellin, L.4    Martin, T.5    Pasquali, J.L.6
  • 411
    • 49049120579 scopus 로고    scopus 로고
    • Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus
    • Santiago-Raber M.L., Kikuchi S., Borel P., Uematsu S., Akira S., Kotzin B.L., et al. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol 2008, 181:1556-1562.
    • (2008) J Immunol , vol.181 , pp. 1556-1562
    • Santiago-Raber, M.L.1    Kikuchi, S.2    Borel, P.3    Uematsu, S.4    Akira, S.5    Kotzin, B.L.6
  • 413
    • 77953182426 scopus 로고    scopus 로고
    • B cells as therapeutic targets in SLE
    • Sanz I., Lee F.E. B cells as therapeutic targets in SLE. Nat Rev Rheumatol 2010, 6:326-337.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 326-337
    • Sanz, I.1    Lee, F.E.2
  • 414
    • 70350647568 scopus 로고    scopus 로고
    • Logic and extent of miRNA-mediated control of autoimmune gene expression
    • Vinuesa C.G., Rigby R.J., Yu D. Logic and extent of miRNA-mediated control of autoimmune gene expression. Int Rev Immunol 2009, 28:112-138.
    • (2009) Int Rev Immunol , vol.28 , pp. 112-138
    • Vinuesa, C.G.1    Rigby, R.J.2    Yu, D.3
  • 415
    • 36048946330 scopus 로고    scopus 로고
    • Roquin suppresses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
    • Yu D., Tan H.A., Hu X., Athanasopoulos V., Simpson N., Silva D.G., et al. Roquin suppresses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 2007, 450:299-303.
    • (2007) Nature , vol.450 , pp. 299-303
    • Yu, D.1    Tan, H.A.2    Hu, X.3    Athanasopoulos, V.4    Simpson, N.5    Silva, D.G.6
  • 416
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N., Gatenby P.A., Wilson A., Malik S., Fulcher D.A., Tangye S.G., et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010, 62:234-344.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-344
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3    Malik, S.4    Fulcher, D.A.5    Tangye, S.G.6
  • 417
    • 34447624878 scopus 로고    scopus 로고
    • B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity
    • Pao L.I., Lam K.P., Henderson J.M., Kutok J.L., Alimzhanov M., Nitschke L., et al. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 2007, 27:35-48.
    • (2007) Immunity , vol.27 , pp. 35-48
    • Pao, L.I.1    Lam, K.P.2    Henderson, J.M.3    Kutok, J.L.4    Alimzhanov, M.5    Nitschke, L.6
  • 420
    • 77953196382 scopus 로고    scopus 로고
    • Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • Kyttaris V.C., Zhang Z., Kuchroo V.K., Oukka M., Tsokos G.C. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J Immunol 2010, 184:4605-4609.
    • (2010) J Immunol , vol.184 , pp. 4605-4609
    • Kyttaris, V.C.1    Zhang, Z.2    Kuchroo, V.K.3    Oukka, M.4    Tsokos, G.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.