A LAT mutation that inhibits T cell development yet induces lymphoproliferation

Science

Volumn 296, Issue 5575, 2002, Pages 2040-2043

  Sommers, Connie L ^a   Park, Cheung Seog ^a   Lee, Jan ^a   Feng, Chiguang ^a   Fuller, Claudette L ^a   Grinberg, Alexander ^a   Hildebrand, Jay A ^a   Lacaná, Emanuela ^a   Menon, Rashmi K ^a   Shores, Elizabeth W ^a   Samelson, Lawrence E ^a   Love, Paul E ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; DISEASES; PROTEINS;

LYMPHOPROLIFERATION;

CELLS;

CALCIUM ION; INTERLEUKIN 2; ISOENZYME; LAT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN; RAS PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; TYROSINE; UNCLASSIFIED DRUG;

BIOCHEMISTRY; MUTATION;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CALCIUM TRANSPORT; CELL DEATH; CELL MATURATION; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE MUTATION; HOMOZYGOTE; IMMUNOPATHOGENESIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGENS, CD5; AUTOIMMUNE DISEASES; CALCIUM; CALCIUM SIGNALING; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; INTERLEUKIN-2; ISOENZYMES; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PHENOTYPE; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; POINT MUTATION; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0037076975     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1069066     Document Type: Article

References (22)