Nrf2 deficiency improves autoimmune nephritis caused by the fas mutation lpr

Kidney International

Volumn 65, Issue 5, 2004, Pages 1703-1713

  Morito, Naoki ^b   Yoh, Keigyou ^b   Hirayama, Aki ^b   Itoh, Ken ^b   Nose, Masato ^b   Koyama, Akio ^b   Yamamoto, Masayuki ^b   Takahashi, Satoru ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NONE

Author keywords

Apoptosis; Fas; Glutathione; Nrf2; Oxidative stress; TNF

Indexed keywords

AUTOANTIBODY; FAS ANTIGEN; GLUTATHIONE; NUCLEAR FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; APOPTOSIS; AUTOIMMUNE DISEASE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENETIC SUSCEPTIBILITY; GLOMERULONEPHRITIS; HYPERGAMMAGLOBULINEMIA; IMMUNOPATHOLOGY; LIFESPAN; LYMPHADENOPATHY; MOUSE; MUTATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SURVIVAL RATE; SURVIVAL TIME;

EID: 2342479119     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00565.x     Document Type: Conference Paper

References (50)

1. MOI P, CHAN K, ASUNIS I, et al: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region. Proc Natl Acad Sci USA 91:9926-9930, 1994
2. ITOH K, IGARASHI K, HAYASHI N, et al: Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Mol Cell Biol 15:4184-4193, 1995
3. ITOH K, ISHII T, WAKABAYASHI N, YAMAMOTO M: Regulatory mechanisms of cellular response to oxidative stress. Free Radic Res 31:319-324, 1999
4. ITOH K, CHIBA T, TAKAHASHI S, et al: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236:313-322, 1997
5. RUSHMORE TH, KING RG, PAULSON KE, PICKETT CB: Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds. Proc Nat Acad Sci USA 87:3826-3830, 1990
6. FAVREAU LV, PICKETT CB: Transcriptional regulation of the rat NAD(P)H: Quinone reductase gene. J Biol Chem 266:4556-4561, 1991
7. PRESTERA T, TALALAY P, ALAM J, et al: Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstream antioxidant-responsive elements (ARE). Mol Med 1:827-837, 1995
8. MULCAHY RT, WARTMAN MA, BAILEY HH, GIPP JJ: Constitutive and naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 272:7445-7454, 1997
9. ISHII T, ITOH K, TAXAHASHI S, et al: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023-16029, 2000
10. CHO HY, JEDLICKA AE, REDDY SP, et al: Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175-182, 2002
11. ENOMOTO A, ITOH K, NAGAYOSHI E, et al: High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 59:169-177, 2001
12. YOH K, ITOH K, ENOMOTO A, et al: Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int 60:1343-1353, 2001
13. MURPHY ED, ROTHS JB: Autoimmunity and lymphoproliferation: Induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice, in Genetic Control of Autoimmune Disease, edited by Rose NR, Bigazzi PE, Warner NL, New York, Elsevier, 1978, pp 207-221
14. HELYER BJ, HOWIE JB: Renal disease associated with positive lupus erythematosus tests in a crossbred strain of mice. Nature 197:197, 1963
15. ANDREWS BS, EISENBERG RA, THEOFILOPOULOS AN, et al: Spontaneous marine lupus-like syndromes: Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215, 1978
16. WATANABE-FUKUNAGA R, BRANNAN CI, COPELAND NG, et al: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314-317, 1992
17. RUSSELL, JH, RUSH B, WEAVER C, et al: Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA 90:4409-4413, 1993
18. COHEN PL, EISENBERG RA: lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243-269, 1991
19. TAKAHASHI S, NOSE M, SASAKI J, et al: IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis. J Immunol 147:515-519, 1991
20. IZUI S, KELLEY VE, MASUDA K, et al: Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol 133:227-233, 1984
21. NOSE M, NISHIMURA M, ITO MR, et al: Arteritis in a novel congenic strain of mice derived from MRL/lpr lupus mice: genetic dissociation from glomerulonephritis and limited autoantibody production. Am J Pathol 149:1763-1769, 1996
22. IWATA Y, WADA T, FURUICHI K, et al: p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol 14:57-67, 2003
23. SASAKI T, MURYOI T, SEKIGUCHI Y, et al: Monoclonal human anti-DNA antibodies from EB virus-transformed lymphocytes of systemic lupus erythematosus (SLE) patients. J Clin Immunol 5:246-253, 1985
24. JEVNIKAR AM, GRUSBY MJ, GLIMCHER LH: Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med 179:1137-1143, 1994
25. KIKAWADA E, LENDA DM, KELLEY VR: IL-12 deficiency in MRL-Fas (lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J Immunol 170:3915-3925, 2003
26. SCHWARTING A, WADA T, KINOSHITA K, et al: IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas (lpr) mice. J Immunol 161:494-503, 1998
27. YOKOYAMA H, KREFT B, KELLEY VR: Biphasic increase in circulating and renal TNF-alpha in MRL-lpr mice with differing regulatory mechanisms. Kidney Int 47:122-130, 1995
28. WADA T, NAITO T, GRIFFITHS RC, et al: Systemic autoimmune nephritogenic components induce CSF-1 and TNF-alpha in MRL kidneys. Kidney Int 52:934-941, 1997
29. YAMAMOTO K, LOSKUTOFF DJ: Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis. Lab Invest 80:1561-1570, 2000
30. BALOMENOS D, RUMOLD R, THEOFILOPOULOS AN: Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J Clin Invest 101:364-371, 1998
31. CARVALHO-PINTO CE, GARCIA MI, et al: Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 169:1058-1067, 2000
32. FOSSATI L, TAKAHASHI S, MERINO R, et al: An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Int Immunol 5:525-532, 1993
33. TARTAGLIA LA, AYRES TM, WONG GH, et al: A novel domain within the 55 kd TNF receptor signals cell death. Cell 74:845-853, 1993
34. ZHOU T, EDWARDS CK, YANG P, et al: Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor I. J Immunol 156:2661-2665, 1996
35. CHIBA T, TAKAHASHI S, SATO N, et al: Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur J Immunol 26:1164-1169, 1996
36. XU Y, JONES BE, NEUFELD DS, CZAJA MJ: Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity. Gastroenterology 115:1229-1237, 1998
37. COLELL A, GARCIA-RUIZ C, MIRANDA M, et al: Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115:1541-1551, 1998
38. MORITO N, YOH K, ITOH K, et al: Nrf2 regulates the sensitivity of death receptor signals through intra-cellular glutathione levels. Oncogene 22:9275-9281, 2003
39. CHEN TS, RICHIE JP, NAGASAWA HT, LANG CA: Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. Mech Ageing Dev 120:127-139, 2000
40. TIEGS G, WOLTER M, WENDEL A: Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol 38:627-631, 1989
41. GREEN DR, SCOTT DW: Activation-induced apoptosis in lymphocytes. Curr Opin Immunol 6:476-487, 1994
42. WESTENDORP MO, FRANK R, OCHSENBAUER C, et al: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497-500, 1995
43. BRUNNER T, MOGIL RJ, LAFACE D, et al: Cell-autonomous Fas (CD95)/Fas ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373:441-444, 1995
44. ROTHSTEIN TL, WANG JK, PANKA DJ, et al: Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163-165, 1995
45. VIGNAUX F, VIVIER E, MALISSEN B, et al: TCR/CD3 coupling to Fas-based cytotoxicity. J Exp Med 181:781-786, 1995
46. ADACHI M, SUEMATSU S, SUDA T, et al: Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci USA 93:2131-2136, 1996
47. MEISTER A: On the antioxidant effects of ascorbic acid and glutathione. Biochem Pharmacol 44:1905-1915, 1992
48. MEISTER A, LARSSON CR, SCRIVER AL, et al: The Metabolic and Molecular Basis of Inherited Disease, New York, McGraw-Hill, 1995, pp1461-1477
49. COLELL A, GARCIA-RUIZ C, MIRANDA M, et al: Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115:1541-1551, 1998
50. YANG XU, JONES BE, NEUFELD DS, CZAJA MJ: Glutathione modulates rat and mouse hepatocyte sensitivity to tumor necrosis factor toxicity. Gastroenterology 115:1229-1237, 1998