Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon γ in the epidermis

Journal of Experimental Medicine

Volumn 186, Issue 9, 1997, Pages 1451-1459

  Seery, John P ^a   Carroll, Joseph M ^a,c   Cattell, Victoria ^b   Watt, Fiona M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; DNA ANTIBODY; DOUBLE STRANDED DNA; GAMMA INTERFERON; HISTONE ANTIBODY; IMMUNOGLOBULIN G; INVOLUCRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN DEPOSITION; KERATINOCYTE; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; DNA; EPIDERMIS; FEMALE; GLOMERULONEPHRITIS; HISTONES; INTERFERON TYPE II; LUPUS NEPHRITIS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, INBRED MRL LPR; MICE, TRANSGENIC; ORGAN SPECIFICITY;

EID: 0030702821     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.9.1451     Document Type: Article

References (35)

1. Kotzin, B.L. 1996. Systemic lupus erythematosus. Cell. 85: 303-306.
2. Whaley, K. 1992. Diseases of the immune system. In Muir's Textbook of Pathology. R.N.M. MacSween and K. Whaley, editors. Edward Arnold, London, UK. 204-252.
3. Appel, G.B., F.G. Silva, C.L. Pirani, and D. Estes. 1978. Renal involvement in systemic lupus erythematosus (SLE): a study of 56 patients emphasizing histological classification. Medicine (Baltimore). 57:371-410.
4. Itoh, J., M. Nose, S. Takahashi, M. Ono, S. Terasaki, E. Kondoh, and M. Kyogoku. 1993. Induction of different types of glomerulonephritis by monoclonal antibodies derived from an MRL/lpr lupus mouse. Am. J. Pathol. 143:1436-1443.
5. Ronnblom, L.E., G.V. Alm, and K.E. Oberg. 1990. Possible induction of systemic lupus erythematosus by interferon-α in a patient with a malignant carcinoid tumour. J. Intern. Med. 227:207-210.
6. Graninger, W.B., W. Hassfeld, B.B. Pesau, K.P. Machold, C.C. Zielinski, and J.S. Smolen. 1991. Induction of systemic lupus erythematosus by interferon-γ in a patient with rheumatoid arthritis. J. Rheumatol. 18:1621-1622.
7. Jacob, C.O., P.H. van der Meide, and H.O. McDevitt. 1987. In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to γ interferon.J. Exp. Med. 166: 798-803.
8. Ozmen, L., D. Roman, M. Fountoulakis, G. Schmid, B. Ryffel, and G. Garrotta. 1995. Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-γ receptor inhibits the onset of glomerulonephritis. Eur. J. Immunol. 25:6-12.
9. Nicolleti, F., P. Meroni, R. Di Marco, W. Barcellini, M.O. Borghi, M. Gariglio, A. Mattina, S. Grasso, and S. Landolfo. 1992. In vivo treatment with a monoclonal antibody to interferon-γ neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse. Immunopharmacology. 24:11-16.
10. Kawashima, T., E.G. Zappi, T.S. Lieu, and R.D. Sontheimer. 1994. Impact of ultraviolet radiation on the cellular expression of Ro/SS-A - autoantigenic polypeptides. Dermatology. 189(Suppl. 1):6-10.
11. Norris, D. A. 1993. Pathomechanisms of photosensitive lupus erythematosus. J. Invest. Dermatol. 100:58S-68S.
12. Carroll, J.M., T. Crompton, J.P. Seery, and F.M. Watt. 1997. Transgenic mice expressing IFN-γ in the epidermis have eczema, hair hypopigmentation and hair loss. J. Invest. Dermatol. 108:412-422.
13. Rheinwald, J.G. 1989. Methods for clonal growth and serial cultivation of normal human epidermal keratinocytes and mesothelial cells. In Cell Growth and Division. A Practical Approach. R. Baserga, editor. IRL Press, Oxford, UK. 81-94.
14. Watt, F.M. 1994. Cultivation of human epidermal keratinocytes with a 3T3 feeder layer. In Cell Biology: A Laboratory Handbook. J.E. Cells, editor. Academic Press, Inc., Orlando, FL. 1:83-89.
15. Wheeler, G.N., A.E. Parker, C.L. Thomas, P. Ataliotis, D. Poynter, J. Arnemann, A.J. Rutman, S.C. Pidsley, F.M. Watt, D.A. Rees, et al. 1991. Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proc. Natl. Acad. Sci. USA. 88:4796-4800.
16. Kotzin, B.L., and E. Palmer. 1987. The contribution of NZW genes to lupus-like disease in (NZB X NZW)F1 mice. J. Exp. Med. 165:1237-1251.
17. Sarvetnick, N., J. Shizuru, D. Liggitt, L. Martin, B. McIntyre, A. Gregory, T. Parslow, and T. Stewart. 1990. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature (Lond.). 346:844-847.
18. Gu, D., L. Wogensen, N.A. Calcutt, C. Xia, S. Zhu, J.P. Merlie, H.S. Fox, J. Lindstrom, H.C. Powell, and N. Sarvetnick. 1995. Myasthenia gravis-like syndrome induced by expression of interferon γ in the neuromuscular junction. J. Exp. Med. 181:547-557.
19. Iwatsuki, K., H. Harada, J.Z. Zhang, K. Maruyama, and F. Kaneko. 1994. Regulation of pemphigus and desmosomal antigen expression by keratinocyte differentiation. Dermatology. 189 (Suppl. 1):67-71.
20. Liu, Z., L.A. Diaz, J.L. Troy, A.F. Taylor, D.J. Emery, J.A. Fairley, and G.J. Giudice. 1993. A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP 180. J. Clin. Invest. 92:2480-2488.
21. Labib, R.S., G.J. Anhalt, H.P. Patel, D.F. Mutasim, and L.A. Diaz. 1986. Molecular heterogeneity of bullous pemphigoid antigens as detected by immunoblotting. J. Immunol. 136: 1231-1235.
22. Sontheimer, R.D., and J.D. Gilliam. 1978. An immunofluorescence assay for double stranded DNA antibodies using the Crithidia luciliae kinetoplast as a double stranded DNA substrate. J. Lab. Clin. Med. 91:550-558.
23. Andrews, B.S., R.A. Eisenberg, A.N. Theofilopoulos, S. Izui, C.B. Wilson, P.J. McConahey, E.D. Murphy, J.B. Roths, and F.J. Dixon. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198-1215.
24. Lever, W.F., and G.S. Lever. 1983. Connective tissue diseases. In Histopathology of the Skin. W.F. Lever and G.S. Lever, editors. J.B. Lippincott, Philadelphia, PA. 445-471.
25. Steinberg, A.D. 1992. Concepts of pathogenesis of systemic lupus erythematosus. Clin. Immunol. Immunopathol. 63:19-22.
26. Foster, M.H., B. Cizman, and M.P. Madaio. 1993. Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins. Lab. Invest. 69:494-507.
27. Duits, A.J., H. Bootsma, R.H.W.M. Derksen, P.E. Spronk, L. Kater, C.G.M. Kallenberg, P.J.A. Capel, N.A.C. Westerdaal, G.Th. Spierenburg, F.H.J. Gmelig-Meyling, and J.G.J. van de Winkel. 1995. Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. Arthritis Rheum. 39:1832-1836.
28. Sarvetnick, N. 1996. Mechanisms of cytokine-mediated localized immunoprotection. J. Exp. Med. 184:1597-1600.
29. Bos, J.D., and M.L. Kapsenberg. 1993. The skin immune system: progress in cutaneous biology. Immunol. Today. 14:75-78.
30. Tan, E.M. 1989. Antinuclear antibodies: diagnostic markers for autoimmune disease and probes for cell biology. Adv. Immunol. 44:93-151.
31. Ma, J., J. Xu, M.P. Madaio, Q. Peng, J. Zhang, I.S. Grewal, R.A. Flavell, and J. Craft. 1996. Autoimmune lpr/lpr mice deficient in CD40 ligand. J. Immunol. 157:417-426.
32. Desai-Mehta, A., C. Mao, S. Rajagopalan, T. Robinson, and S.K. Datta. 1995. Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J. Clin. Invest. 95:531-541.
33. Baboonian, M., P.J. Venables, J. Booth, D.G. Williams, L.M. Roffe, and R.N. Maini. 1989. Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity. Clin. Exp. Immunol. 78:454-459.
34. Nickoloff, B.J., L.A. Turka, R.S. Mitra, and F.O. Nestle. 1995. Direct and indirect control of T-cell activation by keratinocytes. J. Invest. Dermatol. 105:25S-29S.
35. Garcia-Cozar, F.J., I.J. Molina, M.J. Cuadrado, M. Marubayashi, J. Pena and M. Santamaria. 1996. Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients. Clin. Exp. Immunol. 104:72-79.