Defective T cell activation and autoimmune disorder in Stra13-deficient mice

Nature Immunology

Volumn 2, Issue 11, 2001, Pages 1040-1047

  Sun, Hong ^a   Lu, Binfeng ^b   Li, Rong Qin ^a   Flavell, Richard A ^b   Taneja, Reshma ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; HELIX LOOP HELIX PROTEIN; TRANSCRIPTION FACTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; GLOMERULUS; HYPERPLASIA; IMMUNE COMPLEX DEPOSITION; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; LYMPHOID ORGAN; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

AGING; ANIMALS; ANTIGENS, CD95; APOPTOSIS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHIMERA; CYTOKINES; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENOTYPE; GLOMERULONEPHRITIS; HOMEODOMAIN PROTEINS; HYPERPLASIA; IMMUNE COMPLEX DISEASES; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN;

EID: 0035175548     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni721     Document Type: Article

References (38)

1. CD28/B7 system of T cell costimulation
2. The anatomy of T-cell activation and tolerance
3. In vivo activation of antigen-specific CD4 T cells
4. Functional diversity of helper T lymphocytes
5. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells
6. Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
7. The bHLH gene Hes1 is essential for expansion of early T cell precursors
8. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms
9. Interleukin-2: Inception, impact, and implications
10. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
11. Control of inflammation, cytokine expression, and germinal center formation by BCL-6
12. Peanut lectin binding properties of germinal centres of mouse lymphoid tissue
13. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
14. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
15. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
16. Die and let live: Eliminating dangerous lymphocytes
17. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor
18. Fas ligand mediates activation-induced cell death in human T lymphocytes
19. Activation-induced T cell death: Resistance or susceptibility correlate with cell surface fas ligand expression and T helper phenotype
20. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
21. + T cells
22. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
23. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
24. Review article: Molecular signals and genetic reprogramming in peripheral T-cell differentiation
25. Cell fate decision: T-helper 1 and 2 subsets in immune responses
26. Transcriptional regulation of T lymphocyte development and function
27. Lineage commitment in the immune system: The T helper lymphocyte grows up
28. The role of NF-AT transcription factors in T cell activation and differentiation (1)
29. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
30. The regulation and roles of Rel/NK-κB transcription factors during lymphocyte activation
31. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1
32. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene
33. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
34. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
35. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
36. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
37. Cross regulatory interaction between Stra13 and USF results in functional antagonism
38. Assignment of Stra13 to the sub-telomeric region of mouse chromosome 6 by in situ hybridization