Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 29, 2009, Pages 12061-12066

  Kono, Dwight H ^a   Haraldsson, M Katarina ^a   Lawson, Brian R ^a   Pollard, K Michael ^a   Yi, Ting Koh ^a   Du, Xin ^a   Arnold, Carrie N ^a   Baccala, Roberto ^a,b   Silverman, Gregg J ^b   Beutler, Bruce A ^a   Theofilopoulos, Argyrios N ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmunity; Innate immunity; SLE; Unc93b1

Indexed keywords

ALUMINUM POTASSIUM SULFATE; AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; FREUND ADJUVANT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; NUCLEIC ACID; RHEUMATOID FACTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOPLASM; DENDRITIC CELL; ENDOSOME; GENE; GENE MUTATION; HUMORAL IMMUNITY; INTERFERON PRODUCTION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; UNC93B1 3D GENE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; B-LYMPHOCYTES; DENDRITIC CELLS; ENDOSOMES; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED MRL LPR; MUTATION; NUCLEIC ACIDS; PICRATES; RHEUMATOID FACTOR; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 67749135880     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905441106     Document Type: Article

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