Role of inducible costimulator in the development of lupus in MRL/lpr mice

Clinical Immunology

Volumn 120, Issue 2, 2006, Pages 179-188

  Tada, Yoshifumi ^a   Koarada, Syuichi ^a   Tomiyoshi, Yoshiyuki ^b   Morito, Fumitaka ^a   Mitamura, Mio ^a   Haruta, Yoshio ^a   Ohta, Akihide ^a   Nagasawa, Kohei ^a  

^a SAGA UNIVERSITY   (Japan)

^b Saga Prefectural Hospital Kouseikan   (Japan)

Author keywords

Glomerulonephritis; Inducible costimulator; Lupus; MRL lpr mice

Indexed keywords

CD3 ANTIBODY; CELL PROTEIN; INDUCIBLE COSTIMULATOR PROTEIN; INTERLEUKIN 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; GLOMERULONEPHRITIS; LYMPHADENOPATHY; MEMORY T LYMPHOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; TH1 CELL; VASCULITIS; WILD TYPE;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GLOMERULONEPHRITIS; IMMUNOGLOBULINS; KIDNEY; LUPUS; LYMPHATIC DISEASES; MICE; MICE, INBRED MRL LPR; MICE, KNOCKOUT; SPLEEN; SPLENOMEGALY; T-LYMPHOCYTES;

EID: 33746093259     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2006.02.009     Document Type: Article

References (49)

1. Cohen P.L., and Eisenberg R.A. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9 (1991) 243-269
2. Theofilopoulos A.N., and Dixon F.J. Murine models of systemic lupus erythematosus. Adv. Immunol. 37 (1985) 269-390
3. Andrews B.S., Eisenberg R.A., Theofilopoulos A.N., Izui S., Wilson C.B., McConahey P.J., Murphy E.D., Roths J.B., and Dixon F.J. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J. Exp. Med. 148 (1978) 1198-1215
4. Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., and Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356 (1992) 314-317
5. Watson M.L., Rao J.K., Gilkeson G.S., Ruiz P., Eicher E.M., Pisetsky D.S., Matsuzawa A., Rochelle J.M., and Seldin M.F. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestation and renal disease-modifying loci. J. Exp. Med. 176 (1992) 1645-1656
6. Russell J.H., Rush B., Weaver C., and Wang R. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 4409-4413
7. Bossu P., Singer G.G., Andres P., Ettinger R., Marshak-Rothstein A., and Abbas A.K. Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151 (1993) 7233-7239
8. Santoro T.J., Portanova J.P., and Kotzin B.L. The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice. J. Exp. Med. 167 (1988) 1713-1718
9. Jabs D.A., Burek C.L., Hu Q., Kuppers R.C., Lee B., and Prendergast R.A. Anti-CD4 monoclonal antibody therapy suppresses autoimmune diseases in MRL/Mp-lpr/lpr mice. Cell. Immunol. 141 (1992) 496-507
10. Henrickson M., Giannini E.H., and Hirsch R. Reduction of mortality and lymphoadenopathy in MRL-lpr/lpr mice treated with nonmitogenic anti-CD3 monoclonal antibody. Arthritis Rheum. 37 (1994) 587-594
11. Koh D.R., Ho A., Rahemtulla A., Fung-Leung W.P., Griesser H., and Mak T.W. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur. J. Immunol. 25 (1995) 2558-2562
12. Peng S.L., Madaio M.P., Hughes D.P., Crispe I.N., Owen M.J., Wen L., Hayday A.C., and Craft J. Murine lupus in the absence of αβ T cells. J. Immunol. 156 (1996) 4041-4049
13. Bretscher P. The two-signal model of lymphocyte activation twenty-one years later. Immunol. Today 13 (1992) 74-76
14. Linsley P.S., and Ledbetter J.A. The role of the CD28 receptor during T-cell responses to antigen. Annu. Rev. Immunol. 11 (1993) 191-212
15. June C.H., Bluestone J.A., Nadler L.M., and Thompson C.B. The B7 and CD28 receptor families. Immunol. Today 15 (1994) 321-331
16. Finck B.K., Linsley P.S., and Wofsy D. Treatment of murine lupus with CTLA4Ig. Science 265 (1994) 1225-1257
17. Tada Y., Nagasawa K., Ho A., Morito F., Koarada S., Ushiyama O., Suzuki N., Ohta A., and Mak T.W. Role of the costimulatory molecule CD28 in the development of lupus in MRL/lpr mice. J. Immunol. 163 (1999) 3153-3159
18. Hutloff A., Dittrich A.M., Beier K.C., Eljaschewitsch B., Kraft R., Anagnostopoulos I., and Kroczek R.A. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 397 (1999) 263-266
19. Yoshinaga S.K., Whoriskey J.S., Khare S.D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M.A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dai T., Duncan G., Elliott G.S., Hui A., McCabe S.M., Scully S., Shahinian A., Shaklee C.L., Van G., Mak T.W., and Senaldi G. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402 (1999) 827-832
20. Swallow M.M., Wallin J.J., and Sha W.C. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα. Immunity 11 (1999) 423-432
21. Coyle A.J., Leha S., Lloyd C., Tian J., Delaney T., Manning S., Nguyen T., Burwell T., Schneider H., Gonzalo J.A., Gosselin M., Owen L.R., Rudd C.E., and Gutierrez-Ramos J.C. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13 (2000) 95-105
22. Tafuri A., Shahinian A., Bladt F., Yoshinaga S.K., Jordana M., Wakeham A., Boucher L.M., Bouchard D., Chan V.S., Duncan G., Odermatt B., Ho A., Itie A., Horan T., Whoriskey J.S., Pawson T., Penninger J.N., Ohashi P.S., and Mak T.W. ICOS is essential for effective T-helper-cell responses. Nature 409 (2001) 105-109
23. McAdam A.J., Greenwald R.J., Levin M.A., Chernova T., Malenkovich N., Ling V., Freeman G.J., and Sharpe A.H. ICOS is critical for CD40-mediated antibody class switching. Nature 409 (2001) 102-105
24. Dong C., Juedes A.E., Temann U.A., Shresta S., Allison J.P., Ruddle N.H., and Flavell R.A. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409 (2001) 97-101
25. Rottman J.B., Smith T., Tonra J.R., Ganley K., Bloom T., Silva R., Pierce B., Gutierrez-Ramos J.C., Özkaynak E., and Coyle A.J. The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat. Immunol. 605 (2001) 605-611
26. Nurieva R.I., Treuting P., Duong J., Flavell R.A., and Dong C. Inducible costimulator is essential for collagen-induced arthritis. J. Clin. Invest. 111 (2003) 701-706
27. Iwai H., Kozono Y., Hirose S., Akiba H., Yagita H., Okumura K., Kohsaka H., Miyasaka N., and Azuma M. Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J. Immunol. 169 (2002) 4332-4339
28. Gonzalo J.A., Tian J., Delaney T., Corcoran J., Rottman J.B., Lora J., Al-garawi A., Kroczek R., Gutierrez-Ramos J.C., and Coyle A.J. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2 (2001) 597-604
29. Iwai H., Abe M., Hirose S., Tsushima F., Tezuka K., Akiba H., Yagita H., Okumura K., Kohsaka H., Miyasaka N., and Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J. Immunol. 171 (2003) 2848-2854
30. Maldonado M.A., MacDonald G.C., Kakkanaiah V.N., Fecho K., Dransfield M., Sekiguchi D., Cohen P.L., and Eisenberg R.A. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo. J. Immunol. 163 (1999) 3138-3142
31. Shirai A., Conover J., and Klinman D.M. Increased activation and altered ratio of interferon-gamma: interleukin-4 secreting cells in MRL-lpr/lpr mice. Autoimmunity 21 (1995) 107-116
32. Takahashi S., Fossati L., Iwamoto M., Merino R., Motta R., Kobayakawa T., and Izui S. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97 (1996) 1597-1604
33. Balomenos D., Rumold R., and Theofilopoulos A.N. Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101 (1998) 364-371
34. Peng S.L., Moslehi J., and Craft J. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99 (1997) 1936-1946
35. lpr mice. J. Immunol. 161 (1998) 494-503
36. Haas C., Ryffel B., and Le Hir M. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J. Immunol. 158 (1997) 5484-5491
37. Kikawada E., Lenda D.M., and Kelley V.R. IL-12 deficiency in MRL-Fas(lpr) mice delays nephritis and intrarenal IFN-gamma expression, and diminishes systemic pathology. J. Immunol. 170 (2003) 3915-3925
38. lpr mice. J. Immunol. 163 (1999) 6884-6891
39. Huang F.P., Feng G.J., Lindop G., Stott D.I., and Liew F.Y. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J. Exp. Med. 183 (1996) 1447-1459
40. Wofsy D., Murphy E.D., Roths J.B., Dauphinee M.J., Kipper S.B., and Talal N. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice bearing the lpr gene. J. Exp. Med. 154 (1981) 1671-1680
41. Altman A., Theofilopoulos A.N., Weiner R., Katz D.H., and Dixon F.J. Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2. J. Exp. Med. 154 (1981) 791-808
42. Radvanyi L.G., Raju K., Spaner D., Mills G.B., and Miller R.G. Interleukin-2 reverses the defect in activation-induced apoptosis in T cells from autoimmune lpr mice. Cell. Immunol. 183 (1998) 1-12
43. Nurieva R.I., Duong J., Kishikawa H., Dianzani U., Rojo J.M., Ho I., Flavell R.A., and Dong C. Transcriptional regulation of Th2 differentiation by inducible costimulator. Immunity 18 (2003) 801-811
44. Gilkeson G.S., Mudgett J.S., Seldin M.F., Ruiz P., Alexander A.A., Misukonis M.A., Pisetsky D.S., and Weinberg J.B. Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. J. Exp. Med. 186 (1997) 365-373
45. Nose M., Nishimura M., and Kyogoku M. Analysis of granulomatous arteritis in MRL/Mp autoimmune disease mice bearing lymphoproliferative genes. The use of mouse genetics to dissociate the development of arteritis and glomerulonephritis. Am. J. Pathol. 135 (1989) 271-280
46. Shlomchik M.J., Madaio M.P., Ni D., Trounstein M., and Huszar D. The role of B cells in lpr/lpr-induced autoimmunity. J. Exp. Med. 180 (1994) 1295-1306
47. Takahashi S., Nose M., Sasaki J., Yamamoto T., and Kyogoku M. IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis. J. Immunol. 147 (1991) 515-519
48. Lemoine R., Berney T., Shibata T., Fulpius T., Gyotoku Y., Shimada H., Sawada S., and Izui S. Induction of "wire-loop" lesions by murine monoclonal IgG3 cryoglobulins. Kidney Int. 41 (1992) 65-72
49. lpr mice: uncoupling of autoantibodies and T cell responses in lupus. J. Am. Soc. Nephrol. 17 (2006) 122-130