Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

Journal of Experimental Medicine

Volumn 196, Issue 12, 2002, Pages 1593-1604

  Hibbs, Margaret L ^a,c   Harder, Kenneth W ^a,c   Armes, Jane ^b,c   Kountouri, Nicole ^a,c   Quilici, Cathy ^a,c   Casagranda, Franca ^a,c   Dunn, Ashley R ^a,c   Tarlinton, David M ^a,c  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Autoimmune disease; B cell signal transduction; B cell tolerance; Lyn gain of function mutant mice; Src family kinase

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; CALCIUM; CD22 ANTIGEN; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATASE; PHOSPHOLIPASE C; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CALCIUM TRANSPORT; CELL COMMUNICATION AND CELL CONTACT; CIRCULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLOMERULONEPHRITIS; LETHALITY; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; LYMPHOCYTOSIS; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; CALCIUM; CELL SEPARATION; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GLOMERULONEPHRITIS; HUMANS; IMMUNOGLOBULINS; KIDNEY; LYMPH NODES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; POINT MUTATION; SIGNAL TRANSDUCTION; SPLEEN; SRC-FAMILY KINASES; UP-REGULATION;

EID: 0037121973     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020515     Document Type: Article

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