Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFα overproduction

Journal of Clinical Investigation

Volumn 100, Issue 5, 1997, Pages 986-995

  Carballo, Ester ^a   Gilkeson, Gary S ^b   Blackshear, Perry J ^a,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Arthritis; Autoimmunity; Extramedullary hematopoiesis; Inflammation; Myelopoiesis

Indexed keywords

BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; GENETIC RECOMBINATION; IN SITU HYBRIDIZATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RNA ANALYSIS; STEM CELL; SYNDROME;

EID: 0030882906     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119649     Document Type: Article

References (51)

1. Lai, W.S., D.J. Stumpo, and P.J. Blackshear. 1990. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J. Biol. Chem. 265:16556-16563.
2. Varnum, B.C., R.W. Lim, V.P. Sukhatme, and H.R. Herschman. 1989. Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene. 4: 119-120.
3. DuBois, R.N., N.W. McLane, K. Ryder, L.F. Lau, and D.A. Nathans. 1990. Growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J. Biol. Chem. 265:19185-19191.
4. 1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor. DNA Cell Biol. 12:73-88.
5. Varnum, B.C., Q. Ma, T. Chi, B. Fletcher, and H.R. Herschman. 1991. The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol. Cell. Biol. 11:1754-1758.
6. Taylor, G.A., W.S. Lai, R.J. Oakey, M.F. Seldin, T.B. Shows, R.L. Eddy, Jr., and P.J. Blackshear. 1991. The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic. Acids Res. 19:3454.
7. Worthington, M.T., B.T. Amann, D. Nathans, and J.M. Berg. 1996. Metal binding properties and secondary structure of the zinc-binding domain of Nup475. Proc. Natl. Acad. Sci. USA. 93:13754-13759.
8. Taylor, G.A., M.J. Thompson, W.S. Lai, and P.J. Blackshear. 1995. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen activated protein kinase in vitro. J. Biol. Chem. 270:13341-13347.
9. Taylor, G.A., M.J. Thompson, W.S. Lai, and P.J. Blackshear. 1996. Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. Mol. Endocrinol. 10:140-146.
10. Taylor, G.A., E. Carballo, D.M. Lee, W.S. Lai, M.J. Thompson, D.D. Patel, D.I. Schenkman, G.S. Gilkeson, H.E. Broxmeyer, B.F. Haynes, and P.J. Blackshear. 1996. A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 4:445-454.
11. Rosenberg, A.E. 1994. Skeletal system and soft tissue tumors. In Robbins Pathologic Basis of Disease. 5th ed. R.S. Cotran, V. Kumar, and S.L. Robbins, editors. W.B. Saunders Co., Philadelphia. 1247-1255.
12. Theofilopoulos, A.N., and F.J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269-390.
13. Hoffman, R., and M.N. Silverstein. 1995. Agnogenic myeloid metaplasia. In Hematology. Basic Principles and Practice. 2nd ed. R. Hoffman, E.J. Benz, Jr., S.J. Shattil, B. Furie, H.J. Cohen, and L.E. Silverstein, editors. Churchill-Livingstone, Inc., New York. 1160-1174.
14. Schwartz, R.S. 1993. Autoimmunity and autoimmune diseases. In Fundamental Immunology. 3rd ed. W.E. Paul, editor. Raven Press, New York. 1033-1097.
15. Keffer, J., L. Probert, H. Cazlaris, S. Georgopoulos, E. Kaslaris, D. Kioussis, and G. Kollias. 1991. Transgenic mice expressing tumor necrosis factor: a predictive genetic model of arthritis. EMBO (Eur. Mol. Biol. Organ.) J. 10:4025-4031.
16. Cheng, J., K. Tursken, Q.-C. Yu, H. Schreiber, and M. Teng. 1992. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNFα transgenic mice. Genes Dev. 6:1444-1456.
17. Ulich, T.R., S.S. Shin, and J. del Castillo. 1993. Haematologic effects of TNF. Res. Immunol. 144:347-354.
18. Sheehan, K.C.F., N.H. Ruddle, and R.D. Schreiber. 1989. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J. Immunol. 142:3884-3893.
19. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
20. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, A.M. Stall, and F.W. Alt. 1992. RAG-2 (-/-) mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
21. Schuler, W., I.J. Weiler, A. Schuler, R.A. Phillips, N. Rosenberg, T.W. Mak, J.F. Kearney, R.P. Perry, and M.J. Bosma. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell. 46:963-972.
22. Stumpo, D.J., J.M. Graff, K.A. Albert, P. Greengard, and P.J. Blackshear. 1989. Molecular cloning, characterization and expression of a cDNA encoding the 80 to 87 kDa myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc. Natl. Acad. Sci. USA. 86:4012-4016.
23. Lai, W.S., M.J. Thompson, G.A. Taylor, Y. Liu, and P.J. Blackshear. 1995. Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. J. Biol. Chem. 270:25266-25272.
24. Linton, M.F., J.B. Atkinson, and S. Fazio. 1995. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. Science (Wash. DC). 267:1034-1037.
25. Bishop, C.E., and D. Hatat. 1987. Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis. Nucleic. Acids Res. 15:2959-2969.
26. Keighren, M., and J.D. West. 1993. Analysis of cell ploidy in historical sections of mouse tissues by DNA-DNA in situ hybridization with digoxigenin-labelled probes. Histochem. J. 25:30-44.
27. Ding, A., S.D. Wright, and C. Nathan. 1987. Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). J. Exp. Med. 165:733-749.
28. Tucker, S.B., R.V. Pierre, and R.E. Jordon. 1977. Rapid identification of monocytes in a mixed mononuclear cell preparation. J. Immunol. Methods 14: 267-269.
29. Warren, M.K., and S.N. Vogel. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons. J. Immunol. 134:982-989.
30. 2+, and adherence. J. Cell. Physiol. 117:189-194.
31. Kruisbeek, A.M. 1995. In vitro assays for mouse lymphocyte function. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons Inc., New York.
32. Sato, S., D.A. Steeber, and T.F. Tedder. 1995. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc. Natl. Acad. Sci. USA. 92:11558-11562.
33. Nishimura, Y., M. Eto, T. Maeda, K. Hiromatsu, N. Kobayashi, K. Nomoto, Y.Y. Kong, and K. Nomoto. 1994. Inhibition of skin xenograft rejection by depleting T-cell receptor αβ-bearing cells without T-cell receptor γδ-bearing cells or natural killer cells by monoclonal antibody. Immunology. 83:196-204.
34. Blackshear, P.J. 1984. Systems for polyacrylamide gel electrophoresis. Methods Enzymol. 104:237-255.
35. Kull, F.C., Jr., and J.M. Besterman. 1990. Drug-induced alterations of tumor necrosis factor-mediated cytotoxicity: discrimination of early versus late stage action. J. Cell. Biochem. 42:1-12.
36. Chomczynski, P. 1993. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 15:532-537.
37. Tso, J.Y., X.H. Sun, T.H. Kao, K.S. Reece, and R. Wu. 1985. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:2485-2502.
38. Krams, S.M., K. Dorshkind, and M.E. Gershwin. 1989. Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J. Exp. Med. 170:1919-1930.
39. Haskins, K., M. Portas, B. Bergman, K. Lafferty, and B. Bradley. 1989. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. Natl. Acad. Sci. USA. 86:8000-8004.
40. Ashany, A., J. Hines, A. Gharavi, J. Mouradian, and K.B. Elkon. 1992. Analysis of autoantibody production in SCID-systemic lupus erythematosus (SLE) chimeras. Clin. Exp. Immunol. 88:84-90.
41. Duchosal, M.A., P.J. McConahey, C.A. Robinson, and F.J. Dixon. 1990. Transfer of human systemic lupus crythematosus in severe combined immunodeficient (SCID) mice. J. Exp. Med. 172:985-988.
42. Krall, W.J., P.M. Challita, L.S. Perlmutter, D.C. Skelton, and D.B. Koln. 1994. Cells expressing human glucocerebrosidase from a retroviral vector repopulate macrophages and central nervous system microglia after murine bone marrow transplantation. Blood. 83:2737-2748.
43. Han, J., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 171:465-475.
44. Kruys, V., K. Kemmer, A. Shakhov, V. Jongeneel, and B. Beutler. 1992. Constitutive activity of the tumor necrosis factor promoter is canceled by the 3′ untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. Proc. Natl. Acad. Sci. USA. 89:673-677.
45. Gearing, A.J.H., P. Beckett, M. Christodoulou, M. Churchill, J. Clements, A.H. Davidson, A.M. Drummond, W.A. Galloway, R. Gilbert, J.L. Gordon, et al. 1994. Processing of tumor necrosis factor-α precursor by metalloproteinases. Nature (Lond.). 370:555-557.
46. McGeehan, G.M., J.D. Becherer, R.C. Bast, Jr., C.M. Boyer, B. Champion, K.M. Connolly, J.G. Conway, P. Furdon, S. Karp, S. Kidao, et al. 1994. Regulation of tumor necrosis factor-α processing by a metalloproteinase inhibitor. Nature (Lond.). 370:558-561.
47. Gilbert, H.S., V. Praloran, and E.R. Stanley. 1989. Increased circulating CSF-1 (M-CSF) in myeloproliferative disease: association with myeloid metaplasia and peripheral bone marrow extension. Blood. 74:1231-1234.
48. Kaushansky, K., V.C. Broudy, J.M. Harlan, and J.W. Adamson. 1988. Tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo. J. Immunol. 141:3410-3415.
49. Dexter, T.M., T.D. Allen, and L.G. Lajtha. 1977. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell. Physiol. 91:335-344.
50. Karlsson, S., P.H. Correll, and L. Xu. 1993. Gene transfer and bone marrow transplantation with special reference to Gaucher's disease. Bone Marrow Transplant. 11 (Suppl. 1):124-127.
51. Freas-Lutz, D.L., P.H. Correll, S.F. Dougherty, L. Xu, D.H. Pluznik, and S. Karlsson. 1994. Expression of human glucocerebrosidase in murine macrophages: identification of efficient retroviral vectors. Exp. Hematol. (Charlottesv.). 22:857-865.