Genetic control of glycoprotein 70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus

Journal of Immunology

Volumn 165, Issue 3, 2000, Pages 1665-1672

  Tucker, Rebecca M ^a   Vyse, Timothy J ^a,b,d   Rozzo, Stephen ^a   Roark, Christina L ^a   Izui, Shozo ^c   Kotzin, Brian L ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^d IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 13; CHROMOSOME 2; CHROMOSOME 4; CONTROLLED STUDY; GENE MAPPING; IMMUNE COMPLEX DISEASE; MOUSE; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0034254311     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.3.1665     Document Type: Article

References (55)

1. Theofilopoulos, A. N. 1992. Murine models of systemic lupus erythematosus. In Systemic Lupus Erythematosus. R. G. Lahita, ed. Churchill Livingstone, New York, p. 121.
2. Kotzin, B. L. 1996. Systemic lupus erythematosus. Cell 85:303.
3. Izui, S., V. E. Kelley, K. Masuda, H. Yoshida, J. B. Roths, and E. D. Murphy. 1984. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133:227.
4. Yoshiki, T., R. C. Mellors, M. Strand, and J. T. August. 1974. The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis in New Zealand mice. J. Exp. Med. 140:1011.
5. Izui, S., P. J. McConahey, A. N. Theofilopoulos, and F. J. Dixon. 1979. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J. Exp. Med. 149:1099.
6. 2 mice with murine lupus nephritis. J. Exp. Med. 154:517.
7. Izui, S., J. H. Elder, P. J. McConahey, and F. J. Dixon. 1981. Identification of retroviral gp70 and anti-gp70 antibodies involved in circulating immune complexes in NZB × NZW mice. J. Exp. Med. 153:1151.
8. 1 hybrid and the correlation to renal disease. J. Immunol. 130:740.
9. 1 mice. J. Exp. Med. 165:1237.
10. Vyse, T. J., C. G. Drake, S. J. Rozzo, E. Roper, S. Izui, and B. L. Kotzin. 1996. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J. Clin. Invest. 98: 1762.
11. Madaio, M. P., J. Carlson, J. Cataldo, A. Ucci, P. Migliorini, and O. Pankewycz. 1987. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. Immunol. 138:2883.
12. Raz, E., M. Brezis, E. Rosenmann, and D. Eilat. 1989. Anti-DNA antibodies hind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney, J. Immunol. 142:3076.
13. Tsao, B. P., K. Ohnishi, H. Cheroutre, B. Mitchell, M. Teitell, P. Mixter, M. Kronenberg, and B. H. Hahn. 1992. Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice. J. Immunol. 149:350.
14. 1 mice. Eur. J. Immunol. 28:4257.
15. Vyse, T. J., R. K. Halterman, S. J. Rozzo, S. Izui, and B. L. Kotzin. 1999. Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus. Proc. Natl. Acad. Sci. USA 96:8098.
16. Rozzo, S. J., T. J. Vyse, C. S. David, E. Palmer, S. Izui, and B. L. Kotzin. 1999. Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice. J. Immunol. 162:2623.
17. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
18. Izui, S., I. Hara, L. M. Hang, J. H. Elder, P. J. McConahey, and F. J. Dixon. 1984. Association of elevated serum glycoprotein gp70 with increased gp70 immune complex formation and accelerated lupus nephritis in autoimmune male BXSB mice. Clin. Exp. Immunol. 56:272.
19. Elder, J. R. F. C. Jensen, M. L. Bryant, and R. A. Lerner. 1977. Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family. Nature 267:23.
20. Hara, I., S. Izui, P. J. McConahey, J. H. Elder, F. C. Jensen, and F. J. Dixon. 1981. Induction of high serum levels of retroviral env gene products (gp70) in mice by bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA 78:4397.
21. Hara, I., S. Izui, and F. J. Dixon. 1982. Murine serum glycoprotein gp70 behaves as an acute phase reactant. J. Exp. Med. 155:345.
22. Rozzo, S. J., T. J. Vyse, C. G. Drake, and B. L. Kotzin. 1996. Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis. Proc. Natl. Acad. Sci. USA 93:15164.
23. Vyse, T. J., S. J. Rozzo, C. G. Drake, S. Izui, and B. L. Kotzin. 1997. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice. J. Immunol. 158:5566.
24. Vyse, T. J., S. J. Rozzo, C. G. Drake, V. B. Appel, M. Lemeur, S. Izui, E. Palmer, and B. L. Kotzin. 1998. Contributions of Ea(z) and Eb(z) MHC genes to lupus susceptibility in New Zealand mice. J. Immunol. 160:2757.
25. Merino, R., L. Fossati, M. Lacour, R. Lemoine, M. Higaki, and S. Izui. 1992. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur. J. Immunol. 22:295.
26. Vyse, T. J., and B. L. Kotzin. 1998. Genetic susceptibility to systemic lupus erythematosus. Annu. Rev. Immunol. 16:261.
27. Wakeland, E. K., A. E. Wandstrat, K. Liu, and L. Morel. 1999. Genetic dissection of systemic lupus erythematosus. Curr. Opin. Immunol. 11:701.
28. Rosner, B. 1990. Hypothesis testing: categorical data. In Fundamentals of Biostatistics. PWS-KENT Publishing Co., Boston, p. 318.
29. Lincoln, S. E., M. Daly, and E. S. Lander. 1992. Mapping Genes Controlling Quantitative Traits with MAPMAKER/QTL 1.1. Whitehead Institute, Cambridge.
30. Lander, E., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241.
31. 1 mice. Proc. Natl Acad. Sci. USA 91:4062.
32. Drake, C. G., S. J. Rozzo, H. F. Hirschfeld, N. P. Smarnworawong, E. Palmer, and B. L. Kotzin. 1995. Analysis of the New Zealand Black contribution to lupus-like renal disease: multiple genes that operate in a threshold manner. J. Immunol. 154:2441.
33. Morel, L., U. H. Rudofsky, J. A. Longmate, J. Schiffenbauer, and E. K. Wakeland. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1:219.
34. Kono, D. H., R. W. Burlingame, D. G. Owens, A. Kuramochi, R. S. Balderas, D. Balomenos, and A. N. Theofilopoulos. 1994. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad Sci. USA 91:10168.
35. 1 mice. Int. Immunol. 6:1857.
36. Izui, S., P. H. Lambert, and P. A. Miescher. 1977. Failure to detect circulating DNA-anti-DNA complexes by four radioimmunological methods in patients with systemic lupus erythematosus. Clin. Exp. Immunol. 30:384.
37. Gauthier, V. J., and W. Emlen. 1997. Immune complexes in systemic lupus erythematosus. In Dubois' Lupus Erythematosus. D. J. Wallace and B. H. Hahn, eds. Williams & Wilkins, Baltimore, p. 207.
38. Izui, S., P. H. Lambert, and P. A. Miescher. 1976. In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA: a possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus. J. Exp. Med. 144:428.
39. Bernstein, K. A., R. D. Valerio, and J. B. Lefkowitn. 1995. Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex. J. Immunol. 154:2424.
40. Kramers, C., M. N. Hylkema, M. C. van Bruggen, R. van de Lagemaat, H. B. Dijkman, K. J. Assmann, R. J. Smeenk, and J. H. Berden. 1994. Antinucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J. Clin. Invest. 94:568.
41. Schmiedeke, T., F. Stoeckl, S. Müller, Y. Sugisaki, S. Batsford, R. Woitas, and A. Vogt. 1992. Glomerular immune complex deposits in murine lupus models may contain histones. Clin. Exp. Immunol. 90:453.
42. Knight, J. G., and D. D. Adams. 1978. Three genes for lupus nephritis in NZB × NZW mice. J. Exp. Med. 147:1653.
43. 1 hybrid mice. Eur. J. Immunol. 16:1631.
44. Hirose, S., K. Kinoshita, S. Nozawa, H. Nishimura, and T. Shirai. 1990. Effects of major histocompatibility complex on autoimmune disease of H-2-congenic New Zealand mice. Int. Immunol. 2:1091.
45. Shigemoto, K., S. Kubo, Y. Itoh, G. Tate, S. Handa, and N. Maruyama. 1992. Expression and structure of serum gp70 as an acute phase protein in NZB mice. Mol. Immunol. 29:573.
46. Itoh, Y., N. Maruyama, M. Kitamura, T. Shirasawa, K. Shigemoto, and T. Koike. 1992. Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes. Clin. Exp. Immunol. 88:356.
47. Elder, J. H., J. W. Gautsch, F. C. Jensen, R. A. Lerner, T. M. Chused, H. C. Morse, J. W. Hartley, and W. P. Rowe. 1980. Differential expression of two distinct xenotropic viruses in NZB mice. Clin. Immunol. Immunopathol. 15:493.
48. Oliver, P. L., and J. P. Stoye. 1999. Genetic analysis of Cv1, a gene controlling transcription of endogenous murine polytropic proviruses. J. Virol. 73:8227.
49. Maruyama, N., and C. O. Lindstrom. 1983. H-2-linked regulation of serum gp70 production in mice. Immunogenetics 17:507.
50. Maruyama, N., C. O. Lindstrom, H. Sato, and F. J. Dixon. 1983. Serum gp70 production regulated by a gene on murine chromosome 7. Immunogenetics 18: 365.
51. Risser, R., J. M. Horowitz, and J. McCubrey. 1983. Endogenous mouse leukemia viruses. Annu. Rev. Genet. 17:85.
52. Talal, N., E. Flescher, and H. Dang. 1992. Are endogenous retroviruses involved in human autoimmune disease? J. Autoimmun. 5(Suppl. A):61.
53. Bengtsson, A., J. Blomberg, O. Nived, R. Pipkorn, L. Toth, and G. Sturfelt. 1996. Selective antibody reactivity with peptides from human endogenous retroviruses and nonviral poly(amino acids) in patients with systemic lupus erythematosus. Arthritis Rheum. 39:1654.
54. Blomberg, J., O. Nived, R. Pipkorn, A. Bengtsson, D. Erlinge, and G. Sturfelt. 1994. Increased antiretroviral antibody reactivity in sera from a defined population of patients with systemic lupus erythematosus: correlation with autoantibodies and clinical manifestations. Arthritis Rheum. 37:57.
55. Krieg, A. M., and A. D. Steinberg. 1990. Retroviruses and autoimmunity. J. Autoimmun. 3:137.