Loci predisposing to autoimmunity in MRL-Fas(lpr) and C57BL/6-Fas(lpr) mice

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 696-702

  Vidal, Silvia ^a   Kono, Dwight H ^a   Theofilopoulos, Argyrios N ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Fas; Lpr; MRL; Susceptibility genes; Systemic lupus erythematosus

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOME 1; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC LINKAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0032006599     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1817     Document Type: Article

References (43)

1. Kono, D.H., and A.N. Theofilopoulos. 1996. Genetic contributions 10 SLE. J. Autoimmun. 9:437-152.
2. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagala. 1992. Lymphoproliferative disorder in mice explained by defects in Fas antigen that mediates apoplosis. Nature. 356:314-317.
3. cq: a novel mutant gene. Int. Rev. Immunol. 11:193-210.
4. Takahashi, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice caused by a point mutation in the Fas ligand. Cell. 76:969-976.
5. Chiang, B.L., E. Bearer, A. Ansari, K. Dorshkind, and M.E. Gershwin. 1990. The bm12 mutation and autoantibodies to dsDNA in NZB.H-2bm12 mice. J. Immunol. 145:94-101.
6. Merino, R., L. Fossati, M. Lacour, R. Lemoine, M. Higaki, and S. Izui. 1992. H-2 linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Ear. J. Immunol. 22:295-299.
7. Vyse, T.J., and B.L. Kotzin. 1996. Genetic basis of systemic lupus erythematosus. Curr. Opin. Immunol. 8:843-851.
8. Shultz, L.D., P.A. Schweitzer, T.V. Rajan, T. Yi, J.N. Ihle, RJ. Matthews, M.L. Thomas, and D.R. Beier. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell. 73:1445-1454.
9. Izui, S., M. Iwamoto, L. Fossati, R. Merino, T. Takahashi, and N. Ibnou-Zekri. 1995. The Yaa gene model of systemic lupus ervthematosus. Immunol. Rev. 144:137-156.
10. 1 mice. Proc. Natl. Acad. Sci. USA. 91:4062-4066.
11. Morel, L., U.H. Rudofsky, J.A. Longmate, J. Schiffenhauer, and E.K. Wakeland. 1994. Polygenic control of susceptibility to murine systemic lupus ervthematosus. Immunity. 1:219-229.
12. Kono, D.H., R.W. Burlingame, D.G. Owens, A. Kuramochi, R. Balderas, D. Balomenos, and A.N. Theofilopoulos. 1994. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA. 91:10168-10172.
13. Drake, C.G., S.J. Rozzo, H.F. Hirschfeld, N.P. Smarnworawong, E. Palmer, and B.L. Kotzin. 1995. Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J. Immunol. 154:2441-2447.
14. Watson, M.L., J.K. Rao, G.S. Gilkeson, P. Ruiz, E.M. Eicher, D.S. Pisetsky, A. Matsuzawa, J.M. Rochelle, and M.F. Seldin. 1992. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176:1645-1656.
15. Tsao, B.P., R.M. Cantor, K.C. Kalunian, C.J. Chen, H. Badsha, R. Singh, D.J. Wallace, R.C. Kitridou, S.L. Chen, N. Shen, et al. 1997. Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus. J. Clin. Invest. 99:725-731.
16. Theofilopouios, A.N., and F.J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269-390.
17. 1 mice: a new model of lupus-like disease. J. Exp. Med. 179:1429-1435.
18. Murphy, E.D., and J.B. Roths. 1977. New inbred strains. In Mouse News Letter. Volume 58. Oxford University Press, Oxford, UK. 51-52.
19. Hang, L., A.N. Theofilopoulos, and F.J. Dixon. 1982. A spontaneous rheumatoid arthritis-like disease in MRL/1 mice. J. Exp. Med. 155:1690-1701.
20. Burlingame, R.W., R.L. Ruhin, R.S. Balderas, and A.N. Theofilopoulos. 1993. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dcpendent immunization with sell antigen. J. Clin. Invest. 91:1687-1696.
21. Lincoln, S., M. Daly, and E.S. Lander. 1993. Constructing genetic maps with MAPMAKER/EXP 3.0. Whitehead Institute Technical Report 3rd. edition.
22. Lincoln, S., M. Daly, and E.S. Lander. 1993. Mapping genes controlling quantitative traits with MAPMAKER/QTL 1.1. Whitehead Institute Technical Report 2nd. edition.
23. Brown, D.M., A.P. Provost, M.J. Daly. E.S. Lander, and H.J. Jacob. 1996. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat. Genet. 12:44-51.
24. Lander, E.S., and L. Kruglyak. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11: 241-247.
25. Ratkay, L.G., L. Zhang, J. Tonzetich, and D. Waterfield. 1993. Complete Freund's adjuvant induces an earlier and more severe arthritis in MRL-lpr mice. J. Immunol. 151:5081-5087.
26. Koh, D.R., A. Ho, A. Rahemtulla, W.P. Fung-Leung, H. Griesser, and T.W. Mak, 1995. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur. J. Immunol. 25:2558-2562.
27. Morel, L., Y. Yu, K.R. Blenman, R.A. Caldwell, and E.K. Wakcland. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susccplibility genes derived from the SLE-prone NZM2410 strain. Mamm. Genome. 7:335-339.
28. Hirose, S., I. Sekigawa, S. Oxaki, H. Sato, and T. Shirai. 1984. Genetic regulation of hypcrgammaglobulinemia and the correlation to autoimmune traits in (NZB × NZW)F1 hybrid. Clin. Exp. Immunol. 58:694-702.
29. Rozzo, SJ., T.J. Vyse, C.G. Drake, and B.L. Kotzin. 1996. Effect of genetic background on the contribution of New Zealand Black loci to autoimmune lupus nephritis. Proc. Natl. Acad. Sci. USA. 93:15164-15168.
30. Vyse, T.J., C.G. Drake, S.J. Rozzo, E. Roper, S. Izui, and B.L. Kotzin. 1996. Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice. J. Clin. Invest. 98:1762-1772.
31. Minota, S., T. Yoshio, M. Iwamoto, A. Takeda, J. Masuyama, A. Mimori, A. Yamada, and S. Kano. 1996. Selective accumulation of antihistone an-tibodies in glomeruli of lupus-prone lpr mice. Clin, Immunol. Immunopathol. 80:82-87.
32. Izui, S., T. Berney, T. Shibata, and T. Fulpius. 1993. IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases. Ann. Rheum. Dis. 52:548-S54.
33. Weinberg, J.B., D.L. Granger, D.S. Pisetsky, M.F. Seldin, M.A. Misukonis, S.N. Mason, A.M. Pippen, P. Ruiz, E.R. Wood, and G.S. Gilkeson. 1994. The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-inonomethyl-L-arginine. J. Exp. Med. 179: 651-660.
34. 1 hybrids. J. Autoimmun. 4:595-606.
35. Vyse, T,J., L. Morel, F.J. Tanner, E.K. Wakeland, and B.L. Kotzin. 1996. Backcross analysis of genes linked to autoantibody production in New Zealand White mice. J. Immunol. 157:2719-2727.
36. Vyse, T.J., and J.A. Todd. 1996. Genetic analysis of autoimmune disease. Cell. 85:311-318.
37. IhIe, J.N., B.A. Witthuhn, F.W. Quelle, K. Yamamoto, and O. Silvennoinen. 1995. Signaling through the hematopoietic cytokine receptors. Ann. Rev. Immunol. 13:369-398.
38. Ambrus, J.L.J., J. Pippin, A. Joseph, C. Xu, D. Blumenthal, A. Tamayo, K. Claypool, D. McCourt, A. Srikiatchatochorn, and R.J. Ford. 1993. Identification of a cDNA for a human high-molecular-weight B cell growth factor. Proc. Natl. Acad. Sci. USA. 90:6330-6334.
39. al-Janadi, M., and S. Raziuddin. 1993. B cell hyperactivity is a function of T cell-derived cytokines in systemic lupus erythematosus. J. Rheumatol. 20: 1885-1891.
40. Matossian-Rogers, A., L. DeGiorgi, and S. Povey. 1983. Alloimmune interactions of a lymphoproliferalive disease-inducer gene Arp and linkage to Pep-7. Immunogenetics. 18:639-648.
41. 4L Boise, L.H., A.R. Gottschalk, J. Quintans, and C.B. Thompson. 1995. Bcl-2 and Bcl-2-related proteins in apoplosis regulation. Curr. Top. Microbiol. Immunol. 200:107-121.
42. Reap, E.A., N.J. Felix, P.A. Wolthusen, B.L. Kotzin, P.L. Cohen, and R. A. Eisenberg. 1995. Bcl-2 transgenic lpr mice show profound enhancement of lymphadenopathy. J. Immunol. 155:5455-5462.
43. De Bruijin, M.L., P.A. Peterson, and M.R. Jackson. 1996. Induction of heat-stable antigen expression by phagocytosis is involved in in vitro activation of unprimed CTL by macrophages. J. Immunol. 156:2686-2692.