Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Faslpr mice from autoimmune disease

American Journal of Pathology

Volumn 165, Issue 2, 2004, Pages 609-616

  Kevil, Christopher G ^a   Hicks, M John ^b   He, Xiaodong ^c   Zhang, Junxuan ^c   Ballantyne, Christie M ^b   Raman, Chander ^d   Schoeb, Trenton R ^c   Bullard, Daniel C ^c  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d and Clinical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BETA2 INTEGRIN; CD11B ANTIGEN; CELL ADHESION MOLECULE; DNA ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; GLOMERULONEPHRITIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 3242752599     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63325-1     Document Type: Article

References (50)

1. Mok CC, Lau CS: Pathogenesis of systemic lupus erythematosus. J Clin Pathol 2003, 56:481-490
2. Mageed RA, Prud'homme GJ: Immunopathology and the gene therapy of lupus. Gene Ther 2003, 10:861-874
3. Pollard KM, Hultman P, Kono DH: Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity. Ann NY Acad Sci 2003, 987:236-239
4. Cravens PD, Lipsky PE: Dendritic cells, chemokine receptors and autoimmune inflammatory diseases. Immunol Cell Biol 2002, 80:497-505
5. Sturfelt G: The complement system in systemic lupus erythematosus. Scand J Rheumatol 2002, 31:129-132
6. Kelley VR, Wuthrich RP: Cytokines in the pathogenesis of systemic lupus erythematosus. Semin Nephrol 1999, 19:57-66
7. McMurray RW: Adhesion molecules in autoimmune disease. Semin Arthritis Rheum 1996, 25:215-233
8. Kevil CG, Bullard DC: Roles of leukocyte/endothelial cell adhesion molecules in the pathogenesis of vasculitis. Am J Med 1999, 106:677-687
9. Kevil CG, Bullard DC. Cell Adhesion Molecules in the Rheumatic Diseases. Philadelphia, Lippincott Williams and Wilkins, 2001, pp 478-489
10. Theofilopoulos AN, Dixon FJ: Murine models of systemic lupus erythematosus. Adv Immunol 1985, 37:269-391
11. lpr mice from early lethality. J Immunol 1997, 159:2058-2067
12. Lloyd CM, Gonzalo JA, Salant DJ, Just J, Gutierrez-Ramos JC: Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest 1997, 100:963-971
13. McHale JF, Harari OA, Marshall D, Haskard DO: TNF-a and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice. J Immunol 1999, 163:3993-4000
14. Marshall D, Dangerfield JP, Bhatia VK, Larbi KY, Nourshargh S, Haskard DO: MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha. Rheumatology (Oxford) 2003, 42:929-934
15. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314
16. Harris ES, McIntyre TM, Prescott SM, Zimmerman GA: The leukocyte integrins. J Biol Chem 2000, 275:23409-23412
17. Lu H, Smith CW, Perrard J, Bullard DC, Tang L, Beaudet AL, Entman ML, Ballantyne CM: LFA-1 is sufficient in mediating neutrophil transmigration in Mac-1 deficient mice. J Clin Invest 1997, 99:1340-1350
18. Ding ZM, Babensee JE, Simon SI, Lu H, Perrard JL, Bullard DC, Dai XY, Bromley SK, Dustin ML, Entman ML, Smith CW, Ballantyne CM: Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 1999, 163:5029-5038
19. Scharffetter-Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, McArthur M, Lorenzo I, Kaplan S, Ley K, Smith CW, Montgomery CA, Rich S, Beaudet AL: Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med 1998, 188:119-131
20. Austin III HA, Muenz LR, Joyce KM, Antonovych TT, Balow JE: Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 1984, 25:689-695
21. Szalai AJ, Weaver CT, McCrory MA, van Ginkel FW, Reiman RM, Kearney JF, Marion TN, Volanakis JE: Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene. Arthritis Rheum 2003, 48:1602-1611
22. Dustin ML: The immunological synapse. Arthritis Res 2002, 3(Suppl 4):S119-S125
23. Salomon B, Bluestone JA: LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 1998, 161:5138-5142
24. Ni HT, Deeths MJ, Li W, Mueller DL, Mescher MF: Signaling pathways activated by leukocyte function-associated Ag-1-dependent costimulation. J Immunol 1999, 162:5183-5189
25. Moy VT, Brian AA: Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1. J Exp Med 1992, 175:1-7
26. Lohoff M, Koch A, Rollinghoff M: Two signals are involved in polyclonal B cell stimulation by T helper type 2 cells: a role for LFA-1 molecules and interleukin 4. Eur J Immunol 1992, 22:599-602
27. Kelly JA, Moser KL, Harley JB: The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun 2002, 1(Suppl 3):S71-S85
28. Takeuchi T, Amano K, Sekine H, Koide J, Abe T: Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J Clin Invest 1993, 92:3008-3016
29. Takasaki Y, Abe K, Tokano Y, Hashimoto H: The expression of LFA-1, ICAM-1, CD80 and CD86 molecules in lupus patients: implication for immunotherapy. Intern Med 1999, 38:175-177
30. Kootstra CJ, Van Der Giezen DM, Van Krieken JH, De Heer E, Bruijn JA: Effective treatment of experimental lupus nephritis by combined administration of anti-CD11a and anti-CD54 antibodies. Clin Exp Immunol 1997, 108:324-332
31. Connolly MK, Kitchens EA, Chan B, Jardieu P, Wofsy D: Treatment of murine lupus with monoclonal antibodies to lymphocyte function-associated antigen-1: dose-dependent inhibition of autoantibody production and blockade of the immune response to therapy. Clin Immunol Immunopathol 1994, 72:198-203
32. Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, Yang J, Chang S, Hemati N, Richardson B: Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest 1996, 97:2866-2871
33. Richardson BC: Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J Nutr 2002, 132:2401S-2405S
34. Lu Q, Kaplan M, Ray D, Zacharek S, Gutsch D, Richardson B: Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus. Arthritis Rheum 2002, 46:1282-1291
35. Lu Q, Ray D, Gutsch D, Richardson B: Effect of DNA methylation and chromatin structure on ITGAL expression. Blood 2002, 99:4503-4508
36. Tang T, Rosenkranz A, Assmann KJM, Goodman MJ, Gutierrez-Ramos JC, Carroll MC, Cotran RS, Mayadas TN: A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med 1997, 186:1853-1863
37. Soma J, Saito T, Ootaka T, Sato H, Abe K: Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I. Am J Kidney Dis 1996, 28:685-694
38. Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR: Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr mice. J Immunol 2000, 164:6046-6056
39. Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ: B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. J Immunol 1999, 163:2322-2329
40. Liang B, Kashgarian MJ, Sharpe AH, Mamula MJ: Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus. J Immunol 2000, 165:3436-3443
41. Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell RA, Craft J: Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. J Immunol 1996, 157:417-426
42. Damle NK, Klussman K, Aruffo A: Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells. J Immunol 1992, 148:665-671
43. Carpenito C, Pyszniak AM, Takei F: ICAM-2 provides a costimulatory signal for T cell stimulation by allogeneic class II MHC. Scand J Immunol 1997, 45:248-254
44. Carlos TM, Harlan JM: Leukocyte-endothelial adhesion molecules. Blood 1994, 84:2068-2101
45. Gottlieb A, Krueger JG, Bright R, Ling M, Lebwohl M, Kang S, Feldman S, Spellman M, Wittkowski K, Ochs HD, Jardieu P, Bauer R, White M, Dedrick R, Garovoy M: Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis. J Am Acad Dermatol 2000, 42:428-435
46. Papp K, Bissonnette R, Krueger JG, Carey W, Gratton D, Gulliver WP, Lui H, Lynde CW, Magee A, Minier D, Ouellet JP, Patel P, Shapiro J, Shear NH, Kramer S, Walicke P, Bauer R, Dedrick RL, Kim SS, White M, Garovoy MR: The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody. J Am Acad Dermatol 2001, 45:665-674
47. Dedrick RL, Walicke P, Garovoy M: Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody. Transpl Immunol 2002, 9:181-186
48. Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters Jr JC, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC: Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science 2002, 295:1086-1089
49. Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001, 7:687-692
50. Weitz-Schmidt G: Lymphocyte function-associated antigen-1 blockade by statins: molecular basis and biological relevance, Endothelium 2003, 10:43-47