αβ T Cell Regulation and CD40 Ligand Dependence in Murine Systemic Autoimmunity

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2464-2470

  Peng, Stanford L ^a,b   McNiff, Jennifer Madison ^a   Madaio, Michael P ^c   Ma, Jian ^a   Owen, Michael J ^d   Flavell, Richard A ^a,b   Hayday, Adrian C ^a,b   Craft, Joe ^a,e  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e LCI 609 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD40 ANTIGEN; CD40 LIGAND; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN;

ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BIOSYNTHESIS; GENETICS; IMMUNE COMPLEX DISEASE; IMMUNOLOGY; KIDNEY DISEASE; LYMPHOCYTOPENIA; METABOLISM; MOUSE; MOUSE MUTANT; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; PHYSIOLOGY; SKIN DISEASE; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD40; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CD40 LIGAND; IMMUNE COMPLEX DISEASES; KIDNEY DISEASES; LIGANDS; LYMPHOPENIA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED MRL LPR; MICE, MUTANT STRAINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SKIN DISEASES; T-LYMPHOCYTE SUBSETS;

EID: 0031092710     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Andrews, B. S., R. A. Eisenberg, A. N. Theonlopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J. Exp. Med. 148:1198.
2. Peng, S. L., M. P. Madaio, D. P. M. Hughes, I. N. Crispe, M. J. Owen, L. Wen, A. C. Hayday, and J. Craft. 1996. Murine lupus in the absence of αβ T cells. J. Immunol. 156:4041.
3. Wen, L., S. J. Roberts, J. L. Viney, F. S. Wong, C. Mallick, R. C. Findly, Q. Peng, J. E. Craft, M. J. Owen, and A. C. Hayday. 1994. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 369:654.
4. Wen, L., W. Pao, F. S. Wong, Q. Peng, J. Craft, B. Zheng, G. Kelsoe, L. Dianda, M. J. Owen, and A. C. Hayday. 1996. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non α/β" T cells. J. Exp. Med. 183:2271.
5. Peng, S. L., M. P. Madaio, A. C Hayday, and J. Craft. 1996. Propagation and regulation of systemic autoimmunity by γδ T cells. J. Immunol. 157:5689.
6. Mohan, C., Y. Shi, J. D. Laman, and S. K. Datta. 1995. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis. J. Immunol. 154:1470.
7. Ma, J., J. Xu, Q. Peng, J. Zhang, I. S. Grewal, R. A. Flavell, and J. Craft. 1996. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous immunoglobulin class switching with dichotomy of autoantibody responses. J. Immunol. 157: 417.
8. Banchereau, J., F. Bazan, D. Blanchard, F. Brière, J. P. Galizzi, C. van Kooten, Y. J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881.
9. Durie, F. H., T. M. Foy, S. R. Masters, J. D. Laman, and R. J. Noelle. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 15:406.
10. Horner, A. A., H. Jabara, N. Ramesh, and R. S. Geha. 1995. γ/δ T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J. Exp. Med. 181:1239.
11. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
12. Eisenberg, R. A., S. Y. Craven, C. L. Fisher, S. C. Morris, R. Rapoport, D. S. Pisetsky, and P. L. Cohen. 1989. The genetics of autoantibody production in MRL/lpr lupus mice. Clin. Exp. Rheumatol. 7:535.
13. Vlahakos, D. V., M. H. Foster, S. Adams, M. Katz, A. A. Ucci, K. J. Barrett, S. K. Datta, and M. P. Madaio. 1992. Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int. 41:1690.
14. Vlahakos, D., M. H. Foster, A. A. Ucci, K. J. Barrett, S. K. Datta, and M. P. Madaio. 1992. Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. J. Am. Soc. Nephrol. 2:1345.
15. + T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice. J. Exp. Med. 167:1713.
16. Jevnikar, A. M., M. J. Grusby, and L. H. Glimcher. 1994. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J. Exp. Med. 179:1137.
17. Koh, D.-R., A. Ho, A. Rahemutulla, W.-P. Fung-Leung, H. Griesser, and T.-W. Mak. 1995 Murine lupus in MRU/pr mice lacking CD4 or CD8 T cells. Eur. J. Immunol. 25:2558.
18. Mohan, C., and S. K. Datta. 1995. Lupus: key pathogenic mechanisms and contributing factors. Clin. Immunul. Immunopathol. 77:209.
19. + T cells. Nature 376:181.
20. Rothstein, T. L., J. K. Wang, D. J. Panka, L. C. Foote, Z Wang, B. Stanger, H. Cui, S. T. Ju, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163.
21. Mariani, S. M., B. Matiba, E. A. Armandola, and P. H. Krammer. 1994. The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice. Eur. J. Immunol. 24:3119.
22. Kagi, D., F. Vignaux, B. Ledermann, K. Burki, V. Depraetere, S. Nagata, H. Henganner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
23. Kagi, D., B. Ledermann, K. Burki, P. Seiler, B. Odermatt, K. J. Olsen, E. R. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
24. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370:650.
25. Walsh, C. M., M. Matloubian, C. C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. USA 91:10854.
26. Kobata, T., S. Jacquot, S. Kozlowski, K. Agematsu, S. F. Schlossman, and C. Morimoto. 1995. CD27-CD70 interactions regulate B-cell activation by T cells. Proc. Natl. Acad. Sci. USA 92:11249.
27. Kuiper, H. M., M. Brouwer, P. S. Linsley, and R. A. van Lier. 1995. Activated T cells can induce high levels of CTLA-4 expression on B cells. J. Immunol. 155:1776.
28. Abed, N. S., J. H. Chace, and J. S. Cowdery. 1994. T cell-independent and T cell-dependent B cell activation increases IFN-γR expression and renders B cells sensitive to IFN-γ-mediated inhibition. J. Immunol. 153:3369.
29. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
30. Renshaw, B. R., W. C. Fanslow III, R. J. Armitage, K. A Campbell, D. Liggitt, B. Wright, B. L. Davison, and C. R. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
31. Hughes, D. P. M., A. Hayday, J. E. Craft, M. J. Owen, and I. N. Crispe. 1995. T cells with the γ/δ T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-α-deficient lpr mice. J. Exp. Med. 182:233.
32. + T cells induce polyclonal Ig production by committed human B cells: enhancement by IL-5, specific inhibition of IgA synthesis by IL-4. J. Immunol. 148:1674.
33. Klinman, D. M., and A. D. Steinberg. 1987. Systemic autoimmune disease arises from polyclonal B cell activation. J. Exp. Med. 165:1755.
34. Katagiri, T., P. L. Cohen, and R. A. Eisenberg. 1988. The lpr gene causes an intrinsic T cell abnormality that is required for hyperproliferation. J. Exp. Med. 167:741.
35. Perkins, D. L., R. M. Glaser, C. A. Mahon, J. Michaelson, and A. Marshak-Rothstein. 1990. Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras. J. Immunol. 145:549.
36. Nemazee, D., C. Guiet, K. Buerki, and A. Marshak-Rothstein. 1991. B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras. J. Immunol. 147:2536.
37. Furukawa, F., H. Tanaka, K. Sekita, T. Nakamura, Y. Horiguchi, and Y. Hamashima. 1984. Dermatopathological studies on skin lesions of MRL mice. Arch. Dermatol. Res. 276:186.
38. Kanauchi, H., F. Furukawa, and S. Imamura. 1991. Characterization of cutaneous infiltrates in MRL/lpr mice monitored from onset to the full development of lupus erythematosus-like skin lesions. J. Invest. Dermatol. 96:478.
39. Miletic, V. D., and M. M. Frank. 1995. Complement-immunoglobulin interactions. Curr. Opin. Immunol. 7:41.