Genetic modifiers of systemic lupus erythematosus in FcγRIIB-/- mice

Journal of Experimental Medicine

Volumn 195, Issue 9, 2002, Pages 1167-1174

  Bolland, Silvia ^a   Yim, Young Sun ^b   Tus, Katalin ^b   Wakeland, Edward K ^b   Ravetch, Jeffrey V ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Autoantibodies; Glomerulonephritis; lpr; Sle1; Yaa

Indexed keywords

AUTOANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; CHROMOSOME MAP; CONTROLLED STUDY; DISEASE SEVERITY; DNA MODIFICATION; EPISTASIS; EXPERIMENTAL MOUSE; GENE LOCUS; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HYBRID; MOUSE; NONHUMAN; PATHOGENICITY; PHENOTYPE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIGENS, CD; CHROMOSOME MAPPING; DISEASE MODELS, ANIMAL; LINKAGE (GENETICS); LOD SCORE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; PROTEINURIA; RECEPTORS, IGG; SPLEEN;

EID: 0037029604     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020165     Document Type: Article

References (37)

1. Systemic lupus erythematosus
2. The basis of autoimmunity: Part II. Genetic predisposition
3. Genetic analysis of autoimmune disease
4. The genetics of complex autoimmune diseases: Non-MHC susceptibility genes
5. Delineating the genetic basis of systemic lupus erythematosus
6. The role of MHC class II molecules in susceptibility and resistance to autoimmunity
7. A new look at MHC and autoimmune disease
8. Genetic contributions to lupus-like disease in (NZB X NZW)F1 mice
9. Evidence for an interferoninducible gene, Ifi202, in the susceptibility to systemic lupus
10. Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice
11. Functional dissection of systemic lupus erythematosus using congenic mouse strains
12. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
13. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
14. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
15. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies
16. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
17. Spontaneous autoimmune disease in FcγRII deficient mice results from strain-specific epistasis
18. Cb1-b regulates the CD28 dependence of T-cell activation
19. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cb1-b
20. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
21. Molecular basis of the motheaten phenotype
22. IgG Fc receptors
23. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis
24. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors
25. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
26. Fcγ receptor IIB-deficient mice develop Goodpasture's syndrome upon immunization with type IV collagen: A novel murine model for autoimmune glomerular basement membrane disease
27. Deletion of Fcγ receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis
28. The Yaa gene model of systemic lupus erythematosus
29. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice
30. Loci predisposing to autoimmunity in MRL-Fas 1pr and C57BL/6-Fas lpr mice
31. Apoptosis Fas and systemic autoimmunity: The MRL-lpr/lpr model
32. The role of Fas in autoimmune diabetes
33. Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus
34. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
35. Augmented humoral and anaphylactic responses in Fcγ RII-deficient mice
36. Polygenic control of susceptibility to murine systemic lupus erythematosus
37. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results