EMK protein kinase-null mice: Dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways

Developmental Biology

Volumn 214, Issue 1, 1999, Pages 87-101

  Bessone, Stéphanie ^a   Vidal, Frédérique ^a   Le Bouc, Yves ^c   Epelbaum, Jacques ^b   Bluet Pajot, Marie Thérèse ^b   Darmon, Michel ^a,d  

^a INSERM   (France)

^b CENTRE PAUL BROCA   (France)

^c ARMAND TROUSSEAU HOSPITAL   (France)

^d UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

EMK; Fertility; Gene trap; GH; Growth; IGF I; IGFBP3; MARK; PRL; Protein kinase

Indexed keywords

GROWTH HORMONE; MICROTUBULE ASSOCIATED PROTEIN; PROLACTIN; PROTEIN KINASE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; CELL POLARITY; DWARFISM; EMBRYO; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE INACTIVATION; HORMONAL REGULATION; HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; MALE; MICROTUBULE ASSEMBLY; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STEM CELL; SUBFERTILITY;

EID: 0033215228     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1999.9379     Document Type: Article

References (45)

1. Baker J., Liu J. P., Robertson E. J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell. 75:1993;73-82.
2. Baker J., Hardy M. P., Zhou J., Bondy C., Lupu F., Bellve A. R., Efstratiadis A. Effects of an Igf1 gene null mutation on mouse reproduction. Mol. Endocrinol. 10:1996;903-918.
3. Bohm H., Brinkmann V., Drab M., Henske A., Kurzchalia T. V. Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity. Curr. Biol. 7:1997;603-606.
4. Bradley, A.1987. Production and analysis of chimaeric mice. In Teratocarcinomas and Embryonic Stem Cells (E. Robertson, Ed.), pp. 113-152. IRL Press, Oxford.
5. Cukierski M. A., Sina J. L., Prahalada S., Robertson R. T. Effects of seminal vesicle and coagulating gland ablation on fertility in rats. Reprod. Toxicol. 5:1991;347-352.
6. Djordijijevic D., Zhang J., Priam M., Viollet C., Gourdji D., Kordon C., Epelbaum J. Effect of 17beta-estradiol on somatostatin receptor expression and inhibitory effects on growth hormone and prolactin release in rat pituitary cell cultures. Endocrinology. 139:1998;2272-2277.
7. Donahue L. R., Beamer W. G. Growth hormone deficiency in "little" mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4. J. Endocrinol. 136:1993;91-104.
8. Drewes G., Ebneth A., Preuss U., Mandelkow E. M., Mandelkow E. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell. 89:1997;297-308.
9. Drewes G., Ebneth A., Mandelkow E. M. MAPs, MARKs and microtubule dynamics. Trends Biochem. Sci. 23:1998;307-311.
10. Feuilloley M., Contesse V., Lefebvre H., Delarue C., Vaudry H. Effects of selective disruption of cytoskeletal elements on steroid secretion by human adrenocortical slices. Am. J. Physiol. 266:1994;202-210.
11. Forrester L. M., Nagy A., Sam M., Watt A., Stevenson L., Bernstein A., Joyner A. L., Wurst W. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Proc. Natl. Acad. Sci. USA. 93:1996;1677-1682.
12. Friedrich G., Soriano P. Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1991;1513-1523.
13. Frohman M. A., Dush M. K., Martin G. R. Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. USA. 85:1988;8998-9002.
14. Gossler A., Doetschman T., Korn R., Serfling E., Kemler R. Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc. Natl. Acad. Sci. USA. 83:1986;9065-9069.
15. Gossler A., Joyner A. L., Rossant J., Skarnes W. C. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science. 244:1989;463-465.
16. Guo S., Kemphues K. J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81:1995;611-620.
17. Guo S., Kemphues K. J. Caenorhabditis elegans. Nature. 382:1996;455-458.
18. Hardouin S., Gourmelen M., Noguiez P., Seurin D., Roghani M., Le B. Y., Povoa G., Merimee T. J., Hossenlopp P., Binoux M. Molecular forms of serum insulin-like growth factor (IGF)-binding proteins in man: Relationships with growth hormone and IGFs and physiological significance. J. Clin. Endocrinol. Metab. 69:1989;1291-1301.
19. Hinuma S., Habata Y., Fujii R., Kawamata Y., Hosoya M., Fukusumi S., Kitada C., Masuo Y., Asano T., Matsumoto H., Sekiguchi M., Kurokawa T., Nishimura O., Onda H., Fujino M. A prolactin-releasing peptide in the brain. Nature. 393:1998;272-276.
20. Horseman N. D., Zhao W., Montecino R. E., Tanaka M., Nakashima K., Engle S. J., Smith F., Markoff E., Dorshkind K. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. Embo J. 16:1997;6926-6935.
21. Hossenlopp P., Seurin D., Segovia Q. B., Hardouin S., Binoux M. Analysis of serum insulin-like growth factor binding proteins using western blotting: Use of the method for titration of the binding proteins and competitive binding studies. Anal. Biochem. 154:1986;138-143.
22. Inglis J. D., Lee M., Hill R. E. Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm. Genome. 4:1993;401-403.
23. Jaenisch R., Harbers K., Schnieke A., Lohler J., Chumakov I., Jahner D., Grotkopp D., Hoffmann E. Germline integration of moloney murine leukemia virus at the Mov13 locus leads to recessive lethal mutation and early embryonic death. Cell. 32:1983;209-216.
24. Jean-Faucher C., Guilbaud C., Manin M., Jean C. Developmental and hormonal regulation of specific proteins in mouse vas deferens and seminal vesicle. Int. J. Dev. Biol. 35:1991;77-82.
25. Kirk J. M., Trainer P. J., Majrowski W. H., Murphy J., Savage M. O., Besser G. M. Treatment with GHRH(1-29)NH2 in children with idiopathic short stature induces a sustained increase in growth velocity. Clin. Endocrinol. 41:1994;487-493.
26. Lee S. L., Sadovsky Y., Swirnoff A. H., Polish J. A., Goda P., Gavrilina G., Milbrandt J. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 273:1996;1219-1221.
27. Lemmey A. B., Glassford J., Flick S. H., Holly J. M., Pell J. M. Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I. J. Endocrinology. 154:1997;319-328.
28. Levin D. E., Bishop J. M. A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA. 87:1990;8272-8276.
29. Lin S. C., Lin C. R., Gukovsky I., Lusis A. J., Sawchenko P. E., Rosenfeld M. G. Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature. 364:1993;208-213.
30. Liu J. P., Baker J., Perkins A. S., Robertson E. J., Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 75:1993;59-72.
31. Matsuno A., Takekoshi S., Sanno N., Utsunomiya H., Ohsugi Y., Saito N., Kanemitsu H., Tamura A., Nagashima T., Osamura R. Y., Watanabe K. Modulation of protein kinases and microtubule-associated proteins and changes in ultrastructure in female rat pituitary cells: Effects of estrogen and bromocriptine. J. Histochem. Cytochem. 45:1997;805-813.
32. Moller C., Arner P., Sonnenfeld T., Norstedt G. Quantitative comparison of insulin-like growth factor mRNA levels in human and rat tissues analyzed by a solution hybridization assay. J. Mol. Endocrinol. 7:1991;213-222.
33. Nagel B. H., Palmbach M., Petersen D., Ranke M. B. Magnetic resonance images of 91 children with different causes of short stature: Pituitary size reflects growth hormone secretion. Eur. J. Pediatr. 156:1997;758-763.
34. Ormandy C. J., Camus A., Barra J., Damotte D., Lucas B., Buteau H., Edery M., Brousse N., Babinet C., Binart N., Kelly P. A. Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 11:1997;167-178.
35. Powell B. L., Hollingshead P., Warburton C., Dowd M., Pitts M. S., Dalton D., Gillett N., Stewart T. A. IGF-I is required for normal embryonic growth in mice. Genes Dev. 7:1993;2609-2617.
36. Rantala M. L. Causes and outcome of infertility in previously unexamined couples. Acta. Obstet. Gynecol. Scand. 67:1988;429-432.
37. Ryan K. D., Schwartz N. B. Changes in serum hormone levels associated with male-induced ovulation in group-housed adult female mice. Endocrinology. 106:1980;959-966.
38. Skarnes W. C., Auerbach B. A., Joyner A. L. A gene trap approach in mouse embryonic stem cells: The lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 6:1992;903-918.
39. Sornson M. W., Wu W., Dasen J. S., Flynn S. E., Norman D. J., O'Connell S. M., Gukovsky I., Carriere C., Ryan A. K., Miller A. P., Zuo L., Gleiberman A. S., Andersen B., Beamer W. G., Rosenfeld M. G. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 384:1996;327-333.
40. Spiteri-Grech J., Bartlett J. M., Nieschlag E. Regulation of testicular insulin-like growth factor-I in pubertal growth hormone-deficient male rats. J. Endocrinol. 131:1991;279-285.
41. Sugisaki T., Yamada T., Takamatsu K., Noguchi T. The influence of endocrine factors on the serum concentrations of insulin-like growth factor-I (IGF-I) and IGF-binding proteins. J. Endocrinol. 138:1993;467-477.
42. Smithies O., Gregg R. G., Boggs S. S., Koralewski M. A., Kucherlapati R. S. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 317:1985;230-234.
43. Spira A. Epidemiology of human reproduction. Hum. Reprod. 1:1986;111-115.
44. Thomas K. R., Capecchi M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell. 51:1987;503-512.
45. Tooze S. A., Flatmark T., Tooze J., Huttner W. B. Characterization of the immature secretory granule, an intermediate in granule biogenesis. J. Cell Biol. 115:1991;1491-1503.