A critical role for complement in maintenance of self-tolerance

Immunity

Volumn 9, Issue 5, 1998, Pages 721-731

  Prodeus, Andrey P ^a   Goerg, Siegfried ^a   Shen, Li Ming ^a   Pozdnyakova, Olga O ^a   Chu, Lisa ^a   Alicot, Elisabeth M ^a   Goodnow, Christopher C ^b   Carroll, Michael C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C3D RECEPTOR; COMPLEMENT COMPONENT C4; FAS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE;

EID: 0032211714     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80669-X     Document Type: Article

References (37)

1. Allman, D.M., Ferguson, S.E., and Cancro, M.P. (1992). Peripheral B cell maturation II: heat-stable antigen high splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151, 431-444.
2. Agnello, V. (1978). Association of systemic lupus erythematosus and SLE-like syndromes with hereditary and acquired complement deficiency states. Arthritis Rheum. 21, 146-152.
3. Ahearn, J.M., Fischer, M.B., Croix, D., Goerg, S., Ma, M., Xia, J., Zhou, X., Howard, R.G., Rothstein, T.L., and Carroll, M.C. (1996). Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4, 251-262.
4. Botto, M., Dell'Agnola, C., Bygrave, A.E., Thompson, E.M., Cook, H.T., Petry, F., Loos, M., Pandolfi, P.P., and Walport, M.J. (1998). Homozygous C1q deficiency causes glomemlonephritis associated with multiple apoptotic bodies. Nat. Genet. 19, 56-59.
5. Carroll, M.C. (1998a). The role of complement and complement receptors in induction and regulation of immunity. Annu. Rev. Immunol. 16, 545-568.
6. Carroll, M.C. (1998b). The lupus paradox. Nat. Genet. 19, 3-4.
7. Casciola-Rosen, L.A., Anhalt, G., and Rosen, A. (1994). Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J. Exp. Med. 179, 1317-1330.
8. Chan, O., and Shlomchik, M.J. (1998). A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J. Immunol. 160, 51-59.
9. Goodnow, C.C., Crosbie, J., Jorgensen, H., Brink, R.A., and Basten, A. (1989). Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342, 385-390.
10. Cooke, M.P., Heath, A.W., Shokat, K.M., Zeng, Y., Finkelman, F.D., Linsley, P.S., Howard, M., and Goodnow, C.C. (1994). Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179, 425-438.
11. Cotran, R.S., Kumar, V., and Robbins, S.L. (1994). Pathologic Basis of Disease (Philadelphia: W.B. Saunders).
12. Coutinho, A., Kazatchkine, M.D., and Avrameas, S. (1995). Natural autoantibodies. Curr. Opin. Immunol. 7, 812-818.
13. Croix, D.A., Ahearn, J.M., Rosengard, A., Han, S.-H., Ma, M., and Carroll, M.C. (1996). Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183, 1857-1864.
14. Cyster, J.G., and Goodnow, C.C. (1995). Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2, 13-24.
15. Cyster, J.G., Healy, J.I., Kishihara, K., Mak, T.W., Thomas, M.L., and Goodnow, C.C. (1996). Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381, 325-328.
16. Emlen, W., Jarusiripat, P., and Burdick, G. (1990). A new ELISA for the detection of double-stranded DNA antibodies. J. Immunol. Methods 132, 91-101.
17. Erikson, J., Radic, M.Z., Camper, S.A., Hardy, R.R., Carmack, C., and Weigert, M. (1991). Expression of anti-DNA immunoglobulin transgenes in non-immune mice. Nature 349, 331-334.
18. Fearon, D.T., and Carter, R.H. (1995). The CD19/CR2/TAPA-1 complex of b lymphocytes: linking natural to acquired immunity. Annu. Rev. Immunol. 13, 127-149.
19. Fischer, M., Ma, M., Goerg, S., Zhou, X., Xia, J., Finco, O., Man, S., Kelsoe, G., Rothstein, T.L., Howard, J., et al. (1996). Regulation of the B cell response to T-dependent antigens by classical pathway complement. J. Immunol. 757, 549-556.
20. Fischer, M.B., Goerg, S., Shen, L.M., Prodeus, A.P., Goodnow, C.C., Kelsoe, G., and Carroll, M.C. (1998a). Survival of germinal center B cells is dependent on expression of CD21/CD35. Science 280, 582-585.
21. Fischer, M.B., Ma, M., Hsu, N., and Carroll, M.C. (1998b). Local synthesis of C3 within the splenic lymphoid compartment can reconstitute the impaired immune response of CS-deficient mice. J. Immunol. 160, 2619-2625.
22. Fulcher, D.A., and Basten, A. (1994). Reduced life span of anergic self-reactive B cells in a double-transgenic model. J. Exp. Med. 179, 125-134.
23. Goodnow, C.C. (1996). Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA 93, 2264-2271.
24. Goodnow, C., Cyster, J.G., Hartley, S.B., Bell, S.E., Cooke, M.P., Healy, J.I., Akkaraju, S., Rathmell, J.C., Pogue, S.L., and Shokat, K.P. (1995). Self-tolerance checkpoints in B lymphocyte development. Adv. Immunol. 59, 279-369.
25. Greimers, R., Trebak, M., Moutschen, M., Jacobs, N., and Boniver, J. (1996). Improved four-color flow cytometry method using fluo-3 and triple immunofluorescent for analysis of intracellular calcium ion (Ca2+) fluxes among mouse lymph node B- and T-lymphocyte subsets. Cytometry 23, 205-217.
26. Inaoki, M., Sato, S., Weintraub, B.C., Goodnow, C.C., and Tedder, T.F. (1997). CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. J. Exp. Med. 186, 1923-1931.
27. Klaus, G.B., Humphrey, J.H., Kunkl, A., and Dongworth, D.W. (1980). The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory, Immunol. Rev. 53, 3-29.
28. Korb, L.C., and Ahearn, J.M. (1997). C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes. J. Immunol. 158, 4525-4528.
29. Michet, C.J., Jr., McKenna, C.H., Elveback, L.R., Kaslow, R.A., and Jurland, LT. (1985). Epidemiology of systemic lupus erythematosus and other connective tissue diseases in Rochester, Minnesota, 1950 through 1979. Mayo Clin. Proc. 60, 105-113.
30. Molina, H., Holers, V.M., Li, B., Fung, Y., Mariathasan, S., Goellner, J., Strauss-Schoenberger, J., Karr, R.W., and Chaplin, D.D. (1996). Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA 93, 3357-3361.
31. Nemazee, D.A., and Burki, K. (1989). Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337, 562-566.
32. Qin, D., Wu, J., Carroll, M.C., Burton, G.F., Szakal, A.K., and Tew, J.G. (1998). Antibody production and B cell-FDC communication via CD21-CD21 ligand. J. Immunol. 161, 4549-4554.
33. Pepys, M.B. (1972). Role of complement induction of the allergic response. Nature 237, 157-159.
34. Rathmell, J.C., Cooke, M.P., Ho, W.Y., Grein, J., Townsend, S.E., Davis, M.M., and Goodnow, C.C. (1995). CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature 376, 181-184.
35. Takahashi, T., Tanaka, M., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Suda, T., and Nagata, S. (1994). Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76, 969-976.
36. Theofilopoulos, A.N., and Dixon, F.J. (1985). Murine models of systemic lupus erythematosus. Adv. Immunol. 37, 269-390.
37. Walport, M.J., and Morgan, B.P. (1991). Complement deficiency and disease, Immunol. Today 12, 301-306.