Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3

Journal of Immunology

Volumn 178, Issue 12, 2007, Pages 8195-8202

  Santiago Raber, Marie Laure ^a   Haraldsson, M Katarina ^b   Theofilopoulos, Argyrios N ^b   Kono, Dwight H ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CHROMATIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHROMATIN; CHROMOSOME 10; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 7; CONGENIC STRAIN; CONTROLLED STUDY; DISEASE MODEL; DISEASE PREDISPOSITION; FAS GENE; GENE; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; KIDNEY DISEASE; LMB1 GENE; LMB2 GENE; LMB3 GENE; LMB4 GENE; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SURVIVAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TELOMERE;

EID: 34250195048     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.12.8195     Document Type: Article

References (22)

1. Kono, D. H., and A. N. Theofilopoulos. 2006. Genetics of SLE in mice. Springer Semin. Immunopathol. 28: 83-96.
2. Watson, M. L., J. K. Rao, G. S. Gilkeson, P. Ruiz, E. M. Eicher, D. S. Pisetsky, A. Matsuzawa, J. M. Rochelle, and M. F. Seldin. 1992. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176: 1645-1656.
3. Wang, Y., M. Nose, T. Kamoto, M. Nishimura, and H. Hiai. 1997. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am. J. Pathol. 151; 1791-1798.
4. Nishihara, M., M. Terada, J. Kamogawa, Y. Ohashi, S. Mori, S. Nakatsuru, Y. Nakamura, and M. Nose. 1999. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: additive and hierarchical properties of polygenic inheritance. Arthritis Rheum. 42: 2616-2623.
5. c allele. Eur. J. Immunol. 30: 2027-2037.
6. Kamogawa, J., M. Terada, S. Mizuki, M. Nishihara, H. Yamamoto, S. Mori, Y. Abe, K. Morimoto, S. Nakatsuru, Y. Nakamura, and M. Nose. 2002. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum. 46; 1067-1074.
7. lpr mice. J. Clin. Invest. 101: 696-702.
8. Markel, P., P. Shu, C. Ebeling, G. A. Carlson, D. L. Nagle, J. S. Smutko, and K. J. Moore. 1997. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat. Genet. 17: 280-284.
9. Haraldsson, M. K., N. G. dela Paz, J. G. Kuan, G. S. Gilkeson, A. N. Theofilopoulos, and D. H. Kono. 2005. Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWFI mice. J. Immunol. 174; 5065-5073.
10. Kono, D. H., R. W. Burlingame, D. G. Owens, A. Kuramochi, R. S. Balderas, D. Balomenos, and A. N. Theofilopoulos. 1994. Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA 91: 10168-10172.
11. Lawson, B. R., G. J. Prud'homme, Y. Chang, H. A. Gardner, J. Kuan, D. H. Kono, and A. N. Theofilopoulos. 2000. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J. Clin. Invest. 106: 207-215.
12. Andrews, B. S., R. A. Eisenberg, A. N. Theofilopoulos, S. Izui, C. B. Wilson, P. J. McConahey, E. D. Murphy, J. B. Roths, and F. J. Dixon. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J. Exp. Med. 148: 1198-1215.
13. Burlingame, R. W., R. L. Rubin, R. S. Balderas, and A. N. Theofilopoulos. 1993. The genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J. Clin. Invest. 91: 1687-1696.
14. lpr mice. J. Immunol. 167: 3486-3493.
15. Santiago-Raber, M. L., B. R. Lawson, W. Dummer, M. Barnhouse, S. Koundouris, C. B. Wilson, D. H. Kono, and A. N. Theofilopoulos. 2001. The role of cyclin kinase inhibitor p21 in systemic autoimmunity. J. Immunol. 167: 4067-4074.
16. Lawson, B. R., R. Baccala, J. Song, M. Croft, D. H. Kono, and A. N. Theofilopoulos. 2004. Deficiency of the cyclin kinase inhibitor p21(WAF-1/ CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity. J. Exp. Med. 199: 547-557.
17. Peng, S. L., J. Moslehi, and J. Craft. 1997. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99: 1936-1946.
18. Haas, C. B. Ryffel, and H. M. Le. 1997. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J. Immunol. 158: 5484-5491.
19. Balomenos, D., R. Rumold, and A. N. Theofilopoulos. 1998. Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invest. 101: 364-371.
20. Mohan, C. Y. Yu, L. Morel, P. Yang, and E. K. Wakeland. 1999. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J. Immunol. 162: 6492-6502.
21. Zhu, J., X. Liu, C. Xie, M. Yan, Y. Yu, E. S. Sobel, E. K. Wakeland, and C. Mohan. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J. Clin. Invest. 115: 1869-1878.
22. Kong, P. L., L. Morel, B. P. Croker, and J. Craft. 2004. The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. J. Immunol. 172; 2785-2794.