Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice: Additive and hierarchical properties of polygenic inheritance

Arthritis and Rheumatism

Volumn 42, Issue 12, 1999, Pages 2616-2623

  Nishihara, Miyuki ^a   Terada, Miho ^a   Kamogawa, Junji ^a   Ohashi, Yuichi ^a   Mori, Shiro ^b   Nakatsuru, Shuichi ^c   Nakamura, Yusuke ^d   Nose, Masato ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Department of Pharmacology   (Japan)

^c 600 8815   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; MICROSATELLITE DNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; MALE; MARKER GENE; MOUSE; MULTIFACTORIAL INHERITANCE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIALOADENITIS; SPECIES DIFFERENCE;

ANIMALS; AUTOIMMUNE DISEASES; HOMOZYGOTE; INCIDENCE; MICE; MICE, INBRED C3H; MICE, INBRED MRL LPR; SIALADENITIS;

EID: 0033505045     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199912)42:12<2616::AID-ANR16>3.0.CO;2-O     Document Type: Article

References (43)

1. Moutsopoulos HM, Tzioufas AG. Miscellaneous disorders: Sjögren's syndrome. In: Klippel JH, Dieppe PA, editors. Rheumatology. London: Mosby-Year Book Europe; 1994. p. 6:27.1-12.
2. Hinzova E, Ivanyi D, Sula K, Horejs J, Dostal C, Drizhal I. HLA-Dw3 in Sjögren's syndrome. Tissue Antigens 1977;9:8-10.
3. Wilson RW, Provost TT, Bias WB, Alexander EL, Edlow DW, Hochberg MC, et al. Sjögren's syndrome: influence of multiple HLA-D region alloantigens on clinical and serologic expression. Arthritis Rheum 1984;27:1245-53.
4. Reveille JD, Macleod MJ, Whittington K, Arnett FC. Specific amino acid residues in the second hypervariable region of HLA-DQA1 and DQB1 chain genes promote the Ro (SS-A)/La (SS-B) autoantibody responses. J Immunol 1991;146:3871-6.
5. 577), with susceptibility to Sjögren's syndrome. Arthritis Rheum 1997;40:1685-92.
6. Murphy ED, Roths JB. Autoimmunity and lymphoproliferation: induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice. In: Rose NR, Bigazzi PE, Warner NL, editors. Genetic control of autoimmune disease. New York: Elsevier North Holland; 1978. p. 207-20.
7. Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, et al. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J Exp Med 1978;148:1198-215.
8. Murphy ED. Lymphoproliferation (lpr) and other single-locus models for murine lupus. In: Gershwin ME, Merchant B, editors. Immunologic defects in laboratory animals. New York: Plenum Press; 1981. p. 143-73.
9. Altman A, Theofilopoulos AN, Weiner R, Katz DH, Dixon FJ. Analysis of T cell function in autoimmune murine strains: defects in production of and responsiveness to interleukin 2. J Exp Med 1981;154:791-808.
10. Hang L, Theofilopoulos AN, Dixon FJ. A spontaneous rheumatoid arthritis-like disease in MRL/l mice. J Exp Med 1982;155: 1690-701.
11. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol 1985;37:269-390.
12. Hoffman RW, Alspaugh MA, Waggie KS, Durham JB, Walker SE. Sjögren's syndrome in MRL/l and MRL/n mice. Arthritis Rheum 1984;27:157-65.
13. Jonsson R, Tarkowski A, Bäckman K, Holmdahl R, Klareskog L. Sialadenitis in the MRL/l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells. Immunology 1987;60:611-6.
14. Hamano H, Saito I, Haneji N, Mitsuhashi Y, Miyasaka N, Hayashi Y. Expressions of cytokine genes during development of autoimmune sialadenitis in MRL/lpr mice. Eur J Immunol 1993;23: 2387-91.
15. Hayashi Y, Haneji N, Hamano H. Pathogenesis of Sjögren's syndrome-like autoimmune lesions in MRL/lpr mice. Pathol Int 1994;44:559-68.
16. Hayashi Y, Haneji N, Hamano H. Cytokine gene expression and autoantibody production in Sjögren's syndrome of MRL/lpr mice. Autoimmunity 1996;23:269-77.
17. Skarstein K, Holmdahl R, Johannessen AC, Jonsson R. Oligoclonality of T cells in salivary glands of autoimmune MRL/lpr mice. Immunology 1994;81:497-501.
18. β gene usage during specific stages of the development of autoimmune sialadenitis in the MRL/lpr mouse model of Sjögren's syndrome. Arthritis Rheum 1995;38:1077-84.
19. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992;356: 314-7.
20. + T cells. Nature 1995;376:181-4.
21. Ashany D, Song X, Lacy E, Nikolic-Zugic J, Friedman SM, Elkon KB. Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway. Proc Natl Acad Sci U S A 1995;92:11225-9.
22. Izui S, Kelley VE, Masuda K, Yoshida H, Roths JB, Murphy ED. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J Immunol 1984;133:227-33.
23. Nose M, Nishimura M, Kyogoku M. Analysis of granulomatous arteritis in MRL/Mp autoimmune disease mice hearing lymphoproliferative genes: the use of mouse genetics to dissociate the development of arteritis and glomerulonephritis. Am J Pathol 1989;135:271-80.
24. Sneller MC, Straus SE, Jaffe ES, Jaffe JS, Fleisher TA, Stetler-Stevenson M, et al. A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. J Clin Invest 1992; 90:334-41.
25. Rieux-Laucat F, Le Deist F, Hivroz C, Roberts IA, Debatin KM, Fischer A, de Villartay JP. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 1995;268:1347-9.
26. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middelton LA, Lin AY, et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995;81:935-46.
27. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-7.
28. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987;1:174-81.
29. Nagamine K, Peterson P, Scott HS, Kudoh J, Minoshima S, Heino M, et al. Positional cloning of the APECED gene. Nat Genet 1997;17:393-8.
30. The Finnish-German APECED Consortium. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 1997;17: 399-403.
31. Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, et al. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med 1992;176:1645-56.
32. Wang Y, Nose M, Kamoto T, Nishimura M, Hiai H. Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol 1997;151:1791-8.
33. lpr mice. J Clin Invest 1998;101:696-702.
34. Drake CG, Babcock SK, Palmer E, Kotzin BL. Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW) F1 mice. Proc Natl Acad Sci U S A 1994;91:4062-6.
35. Morel L, Rudofsky UH, Longmate JA, Schiffenbauer J, Wakeland EK. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1994;1:219-29.
36. Kono DH, Burlingame RW, Owens DG, Kuramochi A, Balderas RS, Balomenos D, et al. Lupus susceptibility loci in New Zealand mice. Proc Natl Acad Sci U S A 1994;91:10168-72.
37. Rozzo SJ, Vyse TJ, Drake CG, Kotzin BL. Effect of genetic background on the contribution of New Zealand black loci to autoimmune lupus nephritis. Proc Natl Acad Sci U S A 1996;93: 15164-8.
38. Vyse TJ, Rozzo SJ, Drake CG, Izui S, Kotzin BL. Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand black mice. J Immunol 1997;158:5566-74.
39. Hogarth MB, Slingsby JH, Allen PJ, Thompson EM, Chandler P, Davies KA, et al. Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice. J Immunol 1998;161:2753-61.
40. Cornall RJ, Prins J-B, Todd JA, Pressey A, DeLarato NH, Wicker LS, et al. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature 1991; 353:262-5.
41. Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, et al. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat Genet 1993;4:404-9.
42. Rodrigues NR, Cornall RJ, Chandler P, Simpson E, Wicker LS, Peterson LB, et al. Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to chromosome 4. Mamm Genome 1994;5:167-70.
43. . exchange activity. Proc Natl Acad Sci U S A 1994;91:5898-902.