Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome

Immunity

Volumn 16, Issue 4, 2002, Pages 499-508

  Salvador, Jesus M ^a   Hollander, M Christine ^a   Nguyen, Anh Thu ^a   Kopp, Jeffrey B ^b   Barisoni, Laura ^b   Moore, Jodene K ^a   Ashwell, Jonathan D ^a   Fornace Jr , Albert J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; HISTONE ANTIBODY; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CONTROLLED STUDY; DEATH; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GADD45A GENE; GENE; GENE DELETION; GENE DISRUPTION; GENE FUNCTION; GENE MUTATION; GLOMERULONEPHRITIS; HEMATOLOGIC DISEASE; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0036231177     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(02)00302-3     Document Type: Article

References (27)

1. Sequence and expression of a cDNA encoding MyD118: A novel myeloid differentiation primary response gene induced by multiple cytokines
2. The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
3. Isolation of interleukin 2-induced immediate-early genes
4. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
5. Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis
6. CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
7. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest
8. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents
9. The effect of thymectomy on lupus-prone mice
10. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1
11. Gadd45gamma is dispensable for normal mouse development and T-cell proliferation
12. Genomic instability in Gadd45a-deficient mice
13. Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency
14. Measurement of anti-DNA antibodies: A reappraisal using five different methods
15. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
16. GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector T(H)1 cells
17. The p53 pathway
18. Evidence for polyclonal T cell activation in murine models of systemic lupus erythematosus
19. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
20. P53-mediated DNA responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes
21. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
22. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21 WAF1/CIP1
23. CD4(+) T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens. A model to explain spontaneous t cell activation in lupus
24. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4
25. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFNγ production
26. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
27. The central region of Gadd45 is required for its interaction with p21/WAF1