메뉴 건너뛰기




Volumn 101, Issue 2, 1998, Pages 364-371

Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice

Author keywords

IFN ; Lupus; MRL lpr

Indexed keywords

BROXURIDINE; CYTOKINE; DNA ANTIBODY; DOUBLE STRANDED DNA; FAS ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

EID: 0032518439     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI750     Document Type: Article
Times cited : (343)

References (43)
  • 1
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 2
    • 0027497193 scopus 로고
    • T-cell subsets in autoimmunity
    • O'Garra, A., and K. Murphy. 1993. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880-886.
    • (1993) Curr. Opin. Immunol. , vol.5 , pp. 880-886
    • O'Garra, A.1    Murphy, K.2
  • 3
    • 0001853916 scopus 로고
    • Murine models of SLE
    • R.G. Lahita, editor. Churchill-Livingstone, Inc. New York
    • Theofilopoulos, A.N. 1992. Murine models of SLE. In Systemic Lupus Erythematosus. R.G. Lahita, editor. Churchill-Livingstone, Inc. New York. 121-194.
    • (1992) Systemic Lupus Erythematosus , pp. 121-194
    • Theofilopoulos, A.N.1
  • 4
    • 0001894541 scopus 로고
    • Cytokines and Autoimmunity
    • C.A. Bona, K. Siminovitch, M. Zanetti, and A.N. Theofilopoulos, editors. Harwood Academic Publishers, Langhorne, PA
    • Prud'homme, G.J. 1993. Cytokines and Autoimmunity. In Molecular Pathology of Autoimmunity. C.A. Bona, K. Siminovitch, M. Zanetti, and A.N. Theofilopoulos, editors. Harwood Academic Publishers, Langhorne, PA. 149-167.
    • (1993) Molecular Pathology of Autoimmunity , pp. 149-167
    • Prud'homme, G.J.1
  • 5
    • 0025232878 scopus 로고
    • In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse
    • Murray, L.J., R. Lee, and C. Martens. 1990. In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp-lpr/lpr mouse. Eur. J. Immunol. 20:163-170.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 163-170
    • Murray, L.J.1    Lee, R.2    Martens, C.3
  • 6
    • 0029032871 scopus 로고
    • Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β interleukin-10, and interferon-gamma mRNA in the lymph nodes of lupus-prone mice
    • Prud'homme, G.J., D.H. Kono, and A.N. Theofilopoulos. 1995. Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β interleukin-10, and interferon-gamma mRNA in the lymph nodes of lupus-prone mice. Mol. Immunol. 32:495-503.
    • (1995) Mol. Immunol. , vol.32 , pp. 495-503
    • Prud'homme, G.J.1    Kono, D.H.2    Theofilopoulos, A.N.3
  • 7
    • 0023571873 scopus 로고
    • In vivo treatment of (NZBxNZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon
    • Jacob, C.O., P.H. van der Meide, and H.O. McDevitt. 1987. In vivo treatment of (NZBxNZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. J. Exp. Med. 166:798-803.
    • (1987) J. Exp. Med. , vol.166 , pp. 798-803
    • Jacob, C.O.1    Van Der Meide, P.H.2    McDevitt, H.O.3
  • 8
    • 0028963222 scopus 로고
    • Experimental therapy of systemic lupus erythematosus: The treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis
    • Ozmen, L., D. Roman, M. Fountoulakis, G. Schmid, B. Ryffel, and G. Garotta. 1995. Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis. Eur. J. Immunol. 25:6-12.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 6-12
    • Ozmen, L.1    Roman, D.2    Fountoulakis, M.3    Schmid, G.4    Ryffel, B.5    Garotta, G.6
  • 9
    • 0029928187 scopus 로고    scopus 로고
    • Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice
    • Takahashi, S., L. Fossati, M. Iwamoto, R. Merino, R. Motta, T. Kobayakawa, and S. Izui. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97:1597-1604.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1597-1604
    • Takahashi, S.1    Fossati, L.2    Iwamoto, M.3    Merino, R.4    Motta, R.5    Kobayakawa, T.6    Izui, S.7
  • 10
    • 0029973242 scopus 로고    scopus 로고
    • Immunoregulation by interleukin-12
    • Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukocyte Biol. 59:505-511.
    • (1996) J. Leukocyte Biol. , vol.59 , pp. 505-511
    • Trinchieri, G.1    Gerosa, F.2
  • 11
    • 0029880442 scopus 로고    scopus 로고
    • The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice
    • Huang, F.-P., G.-J. Feng, G. Lindop, D.I. Stott, and F.Y. Liew. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J. Exp. Med. 183:1447-1459.
    • (1996) J. Exp. Med. , vol.183 , pp. 1447-1459
    • Huang, F.-P.1    Feng, G.-J.2    Lindop, G.3    Stott, D.I.4    Liew, F.Y.5
  • 12
    • 0026756611 scopus 로고
    • In vivo treatment with a monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse
    • Nicoletti, F., P. Meroni, R. DiMarco, W. Barcellini, M.O. Borghi, M. Gariglio, A. Mattina, S. Grasso, and S. Landolfo. 1992. In vivo treatment with a monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse. Immunopharmacology. 24:11-16.
    • (1992) Immunopharmacology , vol.24 , pp. 11-16
    • Nicoletti, F.1    Meroni, P.2    DiMarco, R.3    Barcellini, W.4    Borghi, M.O.5    Gariglio, M.6    Mattina, A.7    Grasso, S.8    Landolfo, S.9
  • 13
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton, D.K., S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science. 259:1739-1742.
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 15
    • 0027245507 scopus 로고
    • The genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates T-dependent immunization with self-antigen
    • Burlingame, R., R.L. Rubin, R.S. Balderas, and A.N. Theofilopoulos. 1993. The genesis and evolution of anti-chromatin autoantibodies in murine lupus implicates T-dependent immunization with self-antigen. J. Clin. Invest. 91: 1687-1696.
    • (1993) J. Clin. Invest. , vol.91 , pp. 1687-1696
    • Burlingame, R.1    Rubin, R.L.2    Balderas, R.S.3    Theofilopoulos, A.N.4
  • 16
    • 0028267677 scopus 로고
    • Turnover of naive- and memory-phenotype T cells
    • Tough, D.F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127-1135.
    • (1994) J. Exp. Med. , vol.179 , pp. 1127-1135
    • Tough, D.F.1    Sprent, J.2
  • 17
    • 0021173447 scopus 로고
    • Induction of various autoantibodies by mutant gene lpr in several strains of mice
    • Izui, S., V.E. Kelley, K. Masuda, H. Yoshida, J.B. Roths, and E.D. Murphy. 1984. Induction of various autoantibodies by mutant gene lpr in several strains of mice. J. Immunol. 133:227-233.
    • (1984) J. Immunol. , vol.133 , pp. 227-233
    • Izui, S.1    Kelley, V.E.2    Masuda, K.3    Yoshida, H.4    Roths, J.B.5    Murphy, E.D.6
  • 19
    • 0028848472 scopus 로고
    • Role of interferon-gamma in immune cell regulation
    • Young, H.A., and K.J. Hardy. 1995. Role of interferon-gamma in immune cell regulation. J. Leukocyte Biol. 58:373-381.
    • (1995) J. Leukocyte Biol. , vol.58 , pp. 373-381
    • Young, H.A.1    Hardy, K.J.2
  • 20
    • 0021142361 scopus 로고
    • Macrophage Ia expression, production of, and response to, macrophage-stimulating lymphokines in murine lupus strains
    • Kofler, R., R.D. Schreiber, F.J. Dixon, and A.N. Theofilopoulos. 1984. Macrophage Ia expression, production of, and response to, macrophage-stimulating lymphokines in murine lupus strains. Cell. Immunol. 87:92-100.
    • (1984) Cell. Immunol. , vol.87 , pp. 92-100
    • Kofler, R.1    Schreiber, R.D.2    Dixon, F.J.3    Theofilopoulos, A.N.4
  • 21
    • 0020319949 scopus 로고
    • Increase in macrophage Ia expression in autoimmune mice: Role of the lpr gene
    • Kelley, V.E. and J.B. Roths. 1982. Increase in macrophage Ia expression in autoimmune mice: role of the lpr gene. J. Immunol. 129:923-925.
    • (1982) J. Immunol. , vol.129 , pp. 923-925
    • Kelley, V.E.1    Roths, J.B.2
  • 22
    • 0019980516 scopus 로고
    • Spontaneous T-cell lymphokine production and enhanced macrophage Ia expression and tumoricidal activity in MRL-lpr mice
    • Lu, C.Y. and E.R. Unanue. 1982. Spontaneous T-cell lymphokine production and enhanced macrophage Ia expression and tumoricidal activity in MRL-lpr mice. Clin. Immunol. Immunopathol. 25:213-222.
    • (1982) Clin. Immunol. Immunopathol. , vol.25 , pp. 213-222
    • Lu, C.Y.1    Unanue, E.R.2
  • 23
    • 0024509487 scopus 로고
    • Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis
    • Wuthrich, R.P., M.A. Yui, G. Mazoujian, N. Nabavi, L.H. Glimcher, and V.E. Kelley. 1989. Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis. Am. J. Pathol. 134:45-51.
    • (1989) Am. J. Pathol. , vol.134 , pp. 45-51
    • Wuthrich, R.P.1    Yui, M.A.2    Mazoujian, G.3    Nabavi, N.4    Glimcher, L.H.5    Kelley, V.E.6
  • 24
    • 0019490514 scopus 로고
    • Analysis of T cell function in autoimmune murine strains. Defects in production of, and responsiveness to, interleukin 2
    • Altman, A., A.N. Theofilopoulos, R. Weiner, D.H. Katz, and F.J. Dixon. 1981. Analysis of T cell function in autoimmune murine strains. Defects in production of, and responsiveness to, interleukin 2. J. Exp. Med. 154:791-909.
    • (1981) J. Exp. Med. , vol.154 , pp. 791-909
    • Altman, A.1    Theofilopoulos, A.N.2    Weiner, R.3    Katz, D.H.4    Dixon, F.J.5
  • 25
    • 0019787151 scopus 로고
    • Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice hearing the lpr gene
    • Wofsy, D., E.D. Murphy, J.B. Roths, M.J. Dauphinee, S.B. Kipper, and N. Talal. 1981. Deficient interleukin 2 activity in MRL/Mp and C57BL/6J mice hearing the lpr gene. J. Exp. Med. 154:1671-1680.
    • (1981) J. Exp. Med. , vol.154 , pp. 1671-1680
    • Wofsy, D.1    Murphy, E.D.2    Roths, J.B.3    Dauphinee, M.J.4    Kipper, S.B.5    Talal, N.6
  • 26
    • 0020695011 scopus 로고
    • Identification of a B-cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of lpr/lpr genotype
    • Prud'homme, G.J., C.H. Park, T. Fieser, R. Kofler, F.J. Dixon, and A.N. Theofilopoulos. 1983. Identification of a B-cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of lpr/lpr genotype. J. Exp. Med. 157:730-742.
    • (1983) J. Exp. Med. , vol.157 , pp. 730-742
    • Prud'homme, G.J.1    Park, C.H.2    Fieser, T.3    Kofler, R.4    Dixon, F.J.5    Theofilopoulos, A.N.6
  • 27
    • 0024511891 scopus 로고
    • The abnormal T lymphocytes in lpr mice transcribe interferon-gamma and tumor necrosis factor-alpha genes spontaneously in vivo
    • Murray, L., and C. Martens. 1989. The abnormal T lymphocytes in lpr mice transcribe interferon-gamma and tumor necrosis factor-alpha genes spontaneously in vivo. Eur. J. Immunol. 19:563-565.
    • (1989) Eur. J. Immunol. , vol.19 , pp. 563-565
    • Murray, L.1    Martens, C.2
  • 28
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 29
    • 0031051747 scopus 로고    scopus 로고
    • Interferon-gamma is essential for destruction of β cells and development of insulin-dependent diabetes mellitus
    • von Herrath, M.G., and M.B.A. Oldstone. 1997. Interferon-gamma is essential for destruction of β cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185:531-539.
    • (1997) J. Exp. Med. , vol.185 , pp. 531-539
    • Von Herrath, M.G.1    Oldstone, M.B.A.2
  • 30
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan, C., S. Adams, V. Stanik, and S.K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177:1367-1381.
    • (1993) J. Exp. Med. , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3    Datta, S.K.4
  • 31
    • 0029953857 scopus 로고    scopus 로고
    • Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus
    • Kaliyaperumal, A., C. Mohan, W. Wu, and S.K. Datta. 1997. Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus. J. Exp. Med. 183:2459-2469.
    • (1997) J. Exp. Med. , vol.183 , pp. 2459-2469
    • Kaliyaperumal, A.1    Mohan, C.2    Wu, W.3    Datta, S.K.4
  • 32
    • 0031038173 scopus 로고    scopus 로고
    • Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice
    • Pearson, C.I., W. Van Ewijk, and H.O. McDevitt. 1997. Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice. J. Exp. Med. 185:583-599.
    • (1997) J. Exp. Med. , vol.185 , pp. 583-599
    • Pearson, C.I.1    Van Ewijk, W.2    McDevitt, H.O.3
  • 33
    • 0028268517 scopus 로고
    • Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double-negative T cells but not autoantibody production
    • Giese, T., and W.F. Davidson. 1994. Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double-negative T cells but not autoantibody production. J. Immunol. 152:2000-2010.
    • (1994) J. Immunol. , vol.152 , pp. 2000-2010
    • Giese, T.1    Davidson, W.F.2
  • 34
    • 0028898599 scopus 로고
    • Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I
    • Maldonado, M.A., R.A. Eisenberg, E. Roper, P.L. Cohen, and B.L. Kotzin. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med. 181:641-649.
    • (1995) J. Exp. Med. , vol.181 , pp. 641-649
    • Maldonado, M.A.1    Eisenberg, R.A.2    Roper, E.3    Cohen, P.L.4    Kotzin, B.L.5
  • 35
    • 0030878993 scopus 로고    scopus 로고
    • Interferon gamma (IFN-gamma) is necessary for the genes of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice
    • Balasa, B., C. Deng, J. Lee, L.M. Bradley, D.K. Dalton, P. Christados, and N. Sarvetnick. 1997. Interferon gamma (IFN-gamma) is necessary for the genes of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice. J. Exp. Med. 186:385-391.
    • (1997) J. Exp. Med. , vol.186 , pp. 385-391
    • Balasa, B.1    Deng, C.2    Lee, J.3    Bradley, L.M.4    Dalton, D.K.5    Christados, P.6    Sarvetnick, N.7
  • 38
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferon-gamma and interleukin-4 in murine lupus
    • Peng, S.L., J. Moslehi, and J. Craft. 1997. Roles of interferon-gamma and interleukin-4 in murine lupus. J. Clin. Invest. 99:1936-1946.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 39
    • 0031155269 scopus 로고    scopus 로고
    • IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice
    • Haas, C., B. Ryftel, and M. LeHir. 1997. IFN-γ is essential for the development of autoimmune glomerulonephritis in MRL/lpr mice. J. Immunol. 158: 5484-5491.
    • (1997) J. Immunol. , vol.158 , pp. 5484-5491
    • Haas, C.1    Ryftel, B.2    Lehir, M.3
  • 40
    • 0023874728 scopus 로고
    • Tumor necrosis factor alpha in murine autoimmune "lupus" nephritis
    • Jacob, C.O., and H.O. McDevitt. 1988. Tumor necrosis factor alpha in murine autoimmune "lupus" nephritis. Nature. 331:356-358.
    • (1988) Nature , vol.331 , pp. 356-358
    • Jacob, C.O.1    McDevitt, H.O.2
  • 42
    • 0031036084 scopus 로고    scopus 로고
    • Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome
    • Santiago, M.-L., L. Fossati, C. Jacquet, W. Muller, S. Izui, and L. Reininger. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185:65-70.
    • (1997) J. Exp. Med. , vol.185 , pp. 65-70
    • Santiago, M.-L.1    Fossati, L.2    Jacquet, C.3    Muller, W.4    Izui, S.5    Reininger, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.