Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65

Advances in Immunology

Volumn 79, Issue , 2001, Pages 93-128

  Yablonski, D ^a   Weiss, A ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; LAT PROTEIN; PROTEIN BLNK; PROTEIN SLP 65; PROTEIN SLP 76; UNCLASSIFIED DRUG;

B LYMPHOCYTE; BINDING AFFINITY; HUMAN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0034768532     PISSN: 00652776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-2776(01)79003-7     Document Type: Review

References (123)

1. Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adpator protein
2. Grf4O, a novel Grb2 family member, is involved in T cell signaling through interactions with SLP-76 and LAT
3. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors
4. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling
5. Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Feγ receptors I and II/III
6. Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development
7. A complex of the Grb2 adaptor protein. SOS exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells
8. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
9. Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells
10. Phospholipase C-γ as a signal transducing element
11. SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte and T lymphocyte lineage and is regulated during T cell maturation and activation
12. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
13. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
14. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
15. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
16. Functional independence and interdependence of the src homology domains of phospholipase C-γ in B-cell receptor signal transduction
17. RasGRP links T-cell receptor signaling to Ras
18. GRID: A novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28
19. Linker for activation of T cells (LAT) a novel immunohistochemical marker for T cells. NK cells, mast cells and megakaryocytes
20. SLP-76 and Vav function in separate, but overlapping pathways to augment interleuken-2 promoter activity
21. Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity
22. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
23. Xid-like phenotypes: A B cell signalosome takes shape
24. BLNK: A central linker protein in B cell activation
25. 651
26. Multiple p21ras effector pathways reguate nuclear factor of activated T cells
27. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor γ-chain and linker for activator of T cells (LAT) in platelets stimulated by collagen and convulxin
28. Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLCg SH2 domains
29. Cutting edge: BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of fabricus
30. A BASII/SLP-76-related adaptor protein MIST/CLNK involved in IgE receptor-mediated mast cell degranulation
31. At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor
32. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets
33. Lck regulates Vav activation of members of the rho family of GTPases
34. 2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
35. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
36. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
37. SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells
38. Defects in Actin Cap Formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
39. Pleiotropic contributions of phospholipase C-g1 (PLC-g1) to T-cell antigen receptor-mediated signaling: Reconstitution studies of a PLC-γ1-deficient Jurkat T-cell line
40. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
41. Cutting edge: Association of phospholipase C-γ2 src homology 2 domains with BLNK is critical for B cell antigen receptor signaling
42. Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane
43. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells
44. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through aIIbb3 and collagen receptors
45. Abnormal development and function of B lymphocytes in mice deficient in the signaling adaptor protein SLP-65
46. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation
47. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
48. Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells
49. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: Immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions
50. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation
51. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cb1/Sli-1
52. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation
53. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
54. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
55. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc
56. The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
57. Indentification of an atypical Grb2 carboxy-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and independent recruitment of Gab1 to receptor tyrosine kinases
58. An essential role for BLNK in human B cell development
59. Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase Cγ1 activation in T cells
60. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
61. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
62. Three domains of SLP-76 are required for its optimal function in a T cell line
63. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation
64. In vitro and in vivo macrophage function can occur independently of SLP-76
65. Requirement for B cell linker protein (BLNK) in B cell development
66. CD3 stimulation causes phosphorylation of phospholipase C-γ1 on serine and tyrosine residues in a human T cell line
67. LAT is required for tyrosine phosphorylation of phospholipase Cγ2 and platelet activation by the collagen receptor GPVI
68. NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein
69. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
70. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
71. T cell antigen receptor signal transduction
72. Molecular cloning and expression of human Grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to Gab-1
73. A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen
74. Regulation of Vav-SLP-76 binding by ZAP-76 and its relevance to TCRζ/CD3 induction of interleukin-2
75. Fyn-T-Fyb-SLP-76 interactions define a T-cell receptorζ/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
76. Transcription factors of the NFAT family: Regulation and function
77. SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: The guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases
78. Characterization of Grb2-binding proteins in human platelets activated by Fγy RIIA cross-linking
79. LAT is essential for FcεRI-mediated mast cell activation
80. lck: A role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex
81. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and Immunity
82. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
83. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1
84. Cytoskeletal rearrangement during migration and activation of T lymphocytes
85. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment
86. GRB2 and phospholipase C-γ1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
87. SH2 domains recognize specific phosphopeptide sequences
88. Specific motifs recognized by the SH2 domains of Csk, 3BP2 fps/fes, GRB-2, HCP, SHC, Syk, and Var
89. The amino-terminal src homology 2 domain of phospholipase Cγ 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase Cγ1
90. JNK is involved in signal integration during costimulation of T lymphocytes
91. Interaction of SLP adaptors with the SH2 domain of Tec family kinases
92. A role for Bruton's tyrosine kinase in B cell antigen receptormediated activation of phospholipase C-γ2
93. Requirement of Phospholipase C-γ2 activation in surface immunoglobulin M-induced B cell apoptosis
94. p95vav associates with tyrosine phosphorylated SLP-76 in antigen-stimulated T cells
95. Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcε receptor type 1 stimulation of mast cells
96. Killer cell inhibitory receptor recognition of human leukocyte antigen (HLA) class I blocks formation of a pp36/PLC-y signaling complex in human natural killer (NK) cells
97. T cell antigen-receptor signal transduction
98. T cell receptor-mediated signs and signals governing T cell development
99. Novel isoform of lymphoid adaptor FYN-T-binding protein (Fyb-130) interacts with SLP-76 and up-regulates interleukin 2 production
100. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors
101. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
102. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
103. Collagen receptor signaling in platelets: Extending the role of the ITAM
104. Molecular cloning of the cDNA encoding pp36, a tyrosinephosphorylated adaptor protein selectively expressed by T cells and natural killer cells
105. Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ-1
106. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
107. Functional complementation of BLNK by SLP-76 and LAT linker proteins
108. p21ras and calcineurin synergize to regulate the nuclear factor of activated t cells
109. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
110. Association of Nck with tyrosinephosphorylated phosphorylated SLP-76 in activated T lymphocytes
111. Membrane compartmentation is required for efficient T cell activation
112. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK-SLP-65-deficient mice
113. An Nck-Pak1 signaling module is required for T cell receptor-mediated activation of NFAT, but not of JNK
114. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell
115. Identification of a PLC-γ1 SH3 domain-binding site in SLP-76, required for TCR-mediated activation of PLC-γ1 and NFAT
116. Cb1 suppresses B cell receptor-mediated phospholipase C (PLC)-γ2 activation by regulating B cell linker protein-PLC-γ2 binding
117. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
118. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
119. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
120. Essential role of LAT in T cell development
121. Association of Grb2. Gads and phospholipase C-γ1 with phosphorylated LAT tyrosine residues