Turning on LIGHT

Journal of Clinical Investigation

Volumn 108, Issue 12, 2001, Pages 1741-1742

  Granger, Steve W ^a   Ware, Carl F ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN LIGHT; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; CELL SURVIVAL; CHROMOSOME 9; HOMEOSTASIS; INFLAMMATION; LYMPHOID TISSUE; MOUSE; MULTIGENE FAMILY; NONHUMAN; NOTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0035667524     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI14651     Document Type: Note

References (19)

1. The TNF and TNF receptor superfamilies: Integrating mammalian biology
2. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
3. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction
4. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator
5. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
6. Development and maturation of secondary lymphoid tissues
7. Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth
8. LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response
9. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
10. Non-lymphocyte derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2-/- mice upon transfer of CD4+ CD45RB high T cells
11. Modulation of T-cell mediated immunity in tumor and graft-versushost disease models through the LIGHT co-stimulatory pathway
12. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor
13. The critical role of LIGHT, a TNF family member, in T cell development
14. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis
15. Comparative genomics of the MHC: Glimpses into the evolution of the adaptive immune system
16. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long term survival of CD4 T cells
17. Developing lymph nodes collect CD4+CD3-LTbeta+cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
18. Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells
19. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF