The Natural History of Disease Expression in CD4 and CD8 Gene-Deleted New Zealand Black (NZB) Mice

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2676-2684

  Chen, Shao Yuan ^a   Takeoka, Yuichi ^a,e   Ansari, Aftab A ^b   Boyd, Richard ^c   Klinman, Dennis M ^d   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONASH UNIVERSITY   (Australia)

^d CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^e Nippon Zoki Pharmaceutical Co   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BIOSYNTHESIS; FLOW CYTOMETRY; GENE DELETION; GENETICS; MOUSE; MOUSE MUTANT; NEW ZEALAND BLACK MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; THYMUS; VASCULARIZATION;

ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CYTOKINES; FLOW CYTOMETRY; GENE DELETION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MICE; MICE, INBRED NZB; MICE, KNOCKOUT; THYMUS GLAND;

EID: 0030587080     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Theofilopoulos, A. N., and F. J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:269.
2. Theofilopoulos, A. N., G. J. Prud'Homme, and F. J. Dixon. 1985. Autoimmune aspects of systemic lupus erythematosus. Concepts Immunopathol. 1:190.
3. Cohen, P. L. 1993. T- and B-cell abnormalities in systemic lupus. J. Invest. Dermatol. 100:69S.
4. Whitmer, K. J., and M. E. Gershwin. 1994. The Pathogenesis of Autoimmunity in NZB mice. Semin. Clin. Immunol. 1:35.
5. + cells. Clin. Exp. Immunol. 90:260.
6. + T cells, and B cells in the kidneys of lupus-prone NZB/ NZW mice. Clin. Immunol. Immunopathol. 56:373.
7. Oliveira, G. G., P. R. Hutchings, I. M. Roitt, and P. M. Lydyard. 1994. Production of erythrocyte autoantibodies in NZB mice is inhibited by CD4 antibodies. Clin. Exp. Immunol. 96:297.
8. Wofsy, D., and W. E. Seaman. 1985. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J. Exp. Med. 161:378.
9. Watanabe, Y., M. Naiki, T. Wilson, D. Godfrey, B. L. Chiang, R. Boyd, A. Ansari, and M. E. Gershwin. 1993. Thymic microenvironmental abnormalities and thymic selection in NZB.H-2bm12 mice. J. Immunol. 150:4702.
10. Jenkinson, E. J., and J. J. Owen. 1990. T-cell differentiation in thymus organ cultures. Semin. Immunol. 2:51.
11. Boyd, R. L., and P. Hugo. 1991. Towards an integrated view of thymopoiesis. Immunol. Today 12:71.
12. Boyd, R. L., C. L. Tucek, D. I. Godfrey, D. J. Izon, T. J. Wilson, N. J. Davidson, A. G. Bean, H. M. Ladyman, M. A. Ritter, and P. Hugo. 1993. The thymic microenvironment. Immunol. Today 14:445.
13. Ritter, M. A., J. Rozing, and H. J. Schuurman. 1988. The true function of the thymus? Immunol. Today 9:189.
14. Shores, E. W., W. Van Ewijk, and A. Singer. 1991. Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur J. Immunol. 21:1657.
15. Kampinga, J., S. Berges, R. L. Boyd, P. Brekelmans, M. Colic, W. van Ewijk, M. D. Kendall, H. Ladyman, P. Nieuwenhuis, M. A. Ritter. 1989. Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature. Thymus 13:165.
16. Fung-Leung, W. P., M. W. Schilham, A. Rahemtulla, T. M. Kundig, M. Vollenweider, J. Potter, W. van Ewijk, and T. W. Mak. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443.
17. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180.
18. Gershwin, M. E., J. J. Castles, K. Erickson, and A. Ahmed. 1979. Studies of congenitally immunologic mutant New Zealand mice. II. Absence of T cell progenitor populations and B cell defects of congenitally athymic (nude) New Zealand black (NZB) mice. J. Immunol. 122:2020.
19. Gershwin, M. E., J. J. Castles, R. M. Ikeda, K. Erickson, and J. Montero. 1979. Studies of congenitally immunologie mutant New Zealand mice. I. Autoimmune features of hereditarily asplenic (Dh/+) NZB mice; reduction of naturally occurring thymocytotoxic antibody and normal suppressor function. J. Immunol. 122: 710.
20. Godfrey, D. I., D. J. Izon, C. L. Tucek, T. J. Wilson, and R. L. Boyd. 1990. The phenotypic heterogeneity of mouse thymic stromal cells. Immunology 70:66.
21. Wood, G. S., and R. A. Warnke. 1982. The immunologic phenotyping of bone marrow biopsies and aspirates: frozen section techniques. Blood 59:913.
22. Ohsugi, Y., M. E. Gershwin, A. Ahmed, R. R. Skelly, and D. R. Milich. 1982. Studies of congenitally immunologic mutant New Zealand mice. VI. Spontaneous and induced autoantibodies to red cells and DNA occur in New Zealand X-linked immunodeficient (Xid) mice without phenotypic alternations of the Xid gene or generalized polyclonal B cell activation. J. Immunol. 128:2220.
23. Villinger, F., S. Brar, A. Mayne, and N. Chikkala. 1995, Comparative sequence analysis of cytokine genes from human and nonhuman primates. J. Immunol. 155:3946.
24. Klinman, D. M., and A. D. Steinberg. 1987. Systemic autoimmune disease arises from polyclonal B cell activation. J. Exp. Med. 165:1755.
25. Sedgwick, J. D., and P. G. Holt. 1983. A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J. Immunol. Methods 57:301.
26. 1 mice. Arthritis Rheum. 29:1139.
27. Peng, S. L., M. P. Madaio, D. P. M. Hughes, I. N. Crispe, M. J. Owen, L. Wen, A. C. Hayday, and J. Craft. 1996. Murine lupus in the absence of alpha-beta T cells. J. Immunol 156:4041.
28. Wen, L., S. J. Roberts, J. L. Viney, F. S. Wong, C. Mallick, R. C. Findly, Q. Peng, J. E. Craft, M. J. Owen, and A. C. Hayday. 1994. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alpha beta(+) T cells. Nature 369:654.
29. Mombaerts, P., E. Mizoguchi, M. J. Grusby, L. H. Glimcher, A. K. Bhan, and S. Tonegawa. 1993. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 75:274.
30. Schuurman, H. J., H. Van Loveren, J. Rozing, and J. G. Vos. 1992. Chemicals trophic for the thymus: risk for immunodeficiency and autoimmunity. Int. J. Immunopharmacol. 14:369.
31. - cells that make TH2 cytokines and help B cells. Science 260:1802.
32. + T cells to a TH2 phenotype and its possible relationship to the onset of AIDS. Res. Immunol. 145:643.
33. + T cells: their activation and effector functions. Curr. Opin. Immunol. 6:453.
34. + T cell clones can provide B cell help. J. Immunol. 154:3118.
35. + B cells in the production of autoantibodies in murine systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 651:588.
36. Murakami, M., T. Tsubata, M. Okamoto, A. Shimizu, S. Kumagai, H. Imura, and T. Honjo. 1992. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357:77.
37. Hayakawa, K., R. R. Hardy, A. M. Stall, L. A. Herzenberg, and L. A. Herzenberg. 1986. Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage. Eur. J. Immunol. 16:1313.
38. O'Garra, A., and M. Howard. 1992. Cytokines and Ly-1 (B1) B cells. Int. Rev. Immunol. 8:219.
39. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J. Immunol. 143:103.
40. Jevnikar, A. M., M. J. Grusby, and L. H. Glimcher. 1994. Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J. Exp. Med. 179:1137.
41. Izui, S., L. Reininger, T. Shibata, and T. Berney. 1994. Pathogenesis of autoimmune hemolytic anemia in New Zealand black mice. Crit. Rev. Oncol. Hematol. 17:53.
42. Matechak, E. O., N. Killeen, S. M. Hedrick, and B. J. Fowlkes. 1996. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337.
43. al-Janadi, M., S. al-Balla, A. al-Dalaan, and S. Raziuddin. 1993. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J. Clin. Immunol. 13:58.
44. 1 mice. J. Clin. Invest. 94:585.
45. 1 mice. Am. J. Pathol. 144:927.
46. Chiang, B. L., E. Bearer, A. Ansari, K. Dorshkind, and M. E. Gershwin. 1990. The BM12 mutation and autoantibodies to dsDNA in NZB.H-2bm12 mice. J. Immunol. 145:94.