Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 786-794

  Watanabe, Hiroshi ^a   Garnier, Gérard ^b   Circolo, Antonella ^b   Wetsel, Rick A ^b   Ruiz, Phil ^c   Holers, V Michael ^d   Boackle, Susan A ^d   Colten, Harvey R ^e   Gilkeson, Gary S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT BLOOD LEVEL; COMPLEMENT DEPOSITION; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNE COMPLEX NEPHRITIS; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOGENESIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034650431     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.786     Document Type: Article

References (48)

1. Carroll, M. C. 1998. The role of complement and complement receptors in induction and regulation of immunity. Annu. Rev. Immunol. 16:545.
2. Muller-Eberhard, H. J., and R. D. Schreiber. 1980. Molecular biology and chemistry of the alternative pathway of complement. Adv. Immunol. 29:1.
3. Schreiber, R. D., M. K. Pangburn, P. H. Lesavre, and H. J. Muller-Eberhard. 1978. Initiation of the alternative pathway of complement: recognition of activators by hound C3b and assembly of the entire pathway from six isolated proteins. Proc. Natl. Acad. Sci. USA 75:3948.
4. Garnier, G., A. Circolo, and H. R. Colten. 1996. Constitutive expression of murine complement factor B gene is regulated by the interaction of its upstream promoter with hepatocyte nuclear factor 4. J. Biol. Chem. 271:30205.
5. Holers, V. M. 1995. Complement. In Clinical Immunology: Principles and Practice, R. R. Rich, T. A, Fleisher, B. D. Schwartz, eds. Mosby, St. Louis, p. 363.
6. Morris, K. M., D. P. Aden, B. B. Knowles, and H. R. Colten. 1982. Complement biosynthesis by the human hepatoma-derived cell line HepG2. J. Clin. Invest. 70:906.
7. Whaley, K. 1980. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes. J. Exp. Med. 151:501.
8. Cole, F. S., E. E. Schneeberger, N. A. Lichtenberg, and H. R. Colten. 1982. Complement biosynthesis in human breast-milk macrophages and blood monocytes. Immunology 46:429.
9. Katz, Y., F. S. Cole, and R. C. Strunk. 1988. Synergism between γ interferon and lipopolysaccharide for synthesis of factor B, but not C2, in human fibroblasts. J. Exp. Med. 167:1.
10. Strunk, R. C., D. M. Eidlen, and R. J. Mason. 1988. Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J. Clin. Invest. 81:1419.
11. Ripoche, J., J. A. Mitchell, A. Erdei, C. Madin, B. Moffatt, T. Mokoena, S. Gordon, and R. B. Sim. 1988. Interferon γ induces synthesis of complement alternative pathway proteins by human endothelial cells in culture. J. Exp. Med. 168:1917.
12. Praz, F., and E. Ruuth. 1986. Growth-supporting activity of fragment Ba of the human alternative complement pathway for activated murine B lymphocytes. J. Exp. Med. 163:1349.
13. Peter, M. G., J. L. Ambrus, A. S. Fauci, and E. J. Brown. 1988. The Bb fragment of complement factor B acts as a B cell growth factor. J. Exp. Med. 168:1225.
14. Hall, R. E., R. M. Blaese, A. E. Davis III, J. M. Decker, B. F. Tack, H. R. Colten, and A. V. Muchmore. 1982. Cooperative interaction of factor B and other complement components with mononuclear cells in the antibody-independent lysis of xenogeneic erythrocytes. J. Exp. Med. 156:834.
15. Leijh, P. C. J., V. D. Barselaar, M. R. Daha, and R. V. Furth. 1981. Stimulation of the intracellular killing of Staphylococcus aureus by monocytes: regulation by immunoglobulin G and complement components C3/C3b and B/Bb. J. Immunol. 129:332.
16. Götze, O., C. Bianco, and Z. A. Cohn. 1979. The induction of macrophage spreading by factor B of the properdin system. J. Exp. Med. 149:372.
17. Czop, J., and V. Nussenzweig. 1976. Studies or the mechanism of solubilization of immune precipitates by serum. J. Exp. Med. 143:615.
18. Takahashi, M., B. F. Tack, and V, Nussenzweig. 1977. Requirements for the solubilization of immune aggregates by complement: assembly of a factor B-dependent C3-convertase on the immune complexes. J. Exp. Med. 145:86.
19. Takahashi, M., S. Takahashi, and S. Hirose. 1980. Solubilizalion of antigen-antibody complexes: a new function of complement as a regulator of immune reactions. Prog. Allergy 27:134.
20. Passwell, J., G. F. Schreiner, M. Nonaka, H. U. Beuscher, and H. R. Colten. 1988. Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis. J. Clin. Invest. 82:1676.
21. Manzi S., J. E. Rairie, A. B. Carpenter, R. H. Kelly, S. P. Jagarlapudi, S. M. Sereika, T. A. Medsger, and R. Ramsey-Goldman. 1996. Sensitivity and specificity of plasma and urine complement split products as indicators of lupus disease activity. Arthritis Rheum. 39:1178.
22. Carroll, M.C. 1998. The lupus paradox. Nat. Genet. 19:3.
23. Prodeus, A. P., S. Georg, L.-M. Shen, O. O. Pozdnyakova, L. Chu, E. M. Alicot, C. C. Goodnow, and M. C. Carroll. 1998. A critical role for complement in maintenance of self tolerance. Immunity 8:721.
24. Botto, M., C. Dell'Agnola, A. E. Bygrave, E. M. Thompson, H. T. Cook, F. Petry, M. Loos, P. P. Pandolfi, and M. J. Walport. 1998. Homozygous Clq deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19:56.
25. Fischer, M. B., M. Ma. S. Georg, X. Zhou, J. Xia, O. Finco, S. Han, G. Kelsoe, R. G. Howard, T. L. Rothstein, E. Kremmer, F. S. Rosen, and M. C. Carroll. 1996. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J. Immunol. 157:549.
26. Korb, L. C., and J. M. Ahearn. 1997. Clq binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J. Immunol. 158:4525.
27. Walport, M. J., K. A. Davies, and M. Botto. 1998. Clq and systemic lupus erythematosus. Immunobiology 199:265.
28. Quigg, R. J., A. Lim, M. Haas, J. J. Alexander, C. He, and M. C. Carroll. 1998. Immune complex glomerulonephritis in C4- and C3-deficient mice. Kidney Int. 53:320.
29. Sheerin, N. S., T. Springall, M. C. Carroll, B. Hartley, and S. H. Sacks. 1997. Protection against anti-glomerular basement membrane mediated nephritis in C3- and C-deficient mice. Clin. Exp. Immunol. 110:403.
30. Hebert, M-J. T. Takano, A. Papayianni, H. G. Rennke, A. Minto, D. J. Salant, M. C. Carroll, and H. R. Brady. 1998. Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternative pathways in neutrophil recruitment and proteinuria. Nephrol. Dial. Transplant. 13: 2799.
31. Quigg, R. J., Y. Kozono, D. Berthiaume, A. Lim, D. J. Salant, A. Weinfeld, P. Griffin, E. Kremmer, and V. M. Holers. 1998. Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor. J. Immunol. 160:4553.
32. Quigg, R. J., C. He, A. Lin, D. Berthiaume, J. J. Alexander, D. Kraus, and V. M. Holers. 1998. Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury. J. Exp. Med. 188:1321.
33. Watson, M. L., J. K. Rao, G. S. Gilkeson, P. Ruiz, E. M. Eicher, D. S. Pisetsky, A. Matsuzawa, J. M. Rochelle, and M. F. Seldin. 1992. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176:1645.
34. lpr mice. J. Clin. Invest. 101:696.
35. Vyse, T. J., and B. L. Kotzin. 1998. Genetic susceptibility to systemic lupus erythematosus. Annu. Rev. Immunol. 16:261.
36. Matsumoto, M., W. Fukuda, A. Circolo, J. Goellner, J. Strauss-Schoenberger, X. Wang, S. Fujita, T. Hidvegi, D. D. Chaplin, and H. R. Colten. 1997. Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc. Natl. Acad. Sci. USA 94:8720.
37. Peng S.L., and J. Craft. 1996. PCR-RFLP genotyping of murine MHC haplotypes. Biotechniques 21:362.
38. Gilkeson, G. S., J. Grudier, D. Karounos, and D. Pisetsky. 1989. Induction of anti-dsDNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142:1482.
39. Abdelmoula, M., F. Spertini, T. Shibata, Y. Gyotoku, S. Luzuy, P.-H. Lanbert, and S. Izui. 1989. IgG3 is the major source of cryoglobulins in mice. J. Immunol. 143:526.
40. Toth, C. A., D. Pohl, and Y. Agnello. 1986. Methods for detection of immune complexes by utilizing Clq or rheumatoid factors. In Manual of Clinical Laboratory Immunology, N. R. Rose, H. Friedman, and J. L. Fahey, eds. American Society for Microbiology, Washington, DC, p. 204.
41. Nose, M., M. Nishimura, M. R. Ito, J. Toh, T. Shibata, and T. Sugisaki. 1996. Arteritis in a novel congenic strain of mice derived from MRL/lpr lupus mice: genetic dissociation from glomerulonephritis and limited autoantibody production. Am. J. Pathol. 149:1763.
42. Fulpius, T., F. Spertini, L. Reininger, and S. Izui. 1993. Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor. Proc. Natl. Acad. Sci. USA 90:2345.
43. Lemoine, R., T. Berney, T. Shibata, T. Fulpius, Y. Gyotoku, H. Shimada, S. Sawada, and S. Izui. 1992. Induction of "wire-loop" lesions by murine monoclonal IgG3 cryoglobulins. Kidney Int. 41:65.
44. Fulpius, T., R. Lemoine, T. Berney, Y. Pastore, S. Moll, and S. Izui. 1996. Polymorphonuclear leukocytes play a key role in the generation of "wire-loop" lesions induced by a murine IgG3 rheumatoid factor. Kidney Int. 49:647.
45. Chan O. T. M., L. G. Hannum, A. M. Haberman, M. P. Madaio, and M. J. Shlomchik. 1999. A novel mouse with B cells but lacking serum antibody reveals an anlibody-independent role for B cells in murine lupus. J. Exp. Med. 189:1639.
46. Boackle, S. A., M. A. Morris, V. M. Holers, and D. R. Karp. 1998. Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells. J. Immunol. 161:6537.
47. Boackle, S. A., V. M. Holers, and D. K. Karp. 1997. CD21 augments antigen presentation in immune individuals. Eur. J. Immunol. 27:122.
48. Gilkeson, G. S., G. Gamier, A. Circolo, V. M. Holers, A. Feagin, R. Wetsel, and H. Colton. 1998. Modulation of renal disease in lupus mice deficient in complement component C3. Mol. Immunol. 35:36 (Abstr.).